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PubMed1976

Different allotypic susceptibility of mice to Rickett-sia tsutsugamushi.

Some lines of mice and random-bred mice show different susceptibility to infection with Rickettsia tsutsugamushi, displayed mainly in the development of overt infection. The latter is most markedly manifested in random-bred and Swiss mice, causing high death rates and massive accumulation of rickettsiae in the peritoneum. Black mice respond to inoculation with asymptomatic infection with no microscopically detectable rickettsiae. The infection is accompanied in either case by immunological response and persistence of the agent in mice. One of the mechanisms of resistance to R. tsutsugamushi in some mouse lines is due to phagocytosis at the inoculation site of the main mass of rickettsiae by macrophages which digest the agent and retain their viability.

Animals↗
PubMed1976

Cytological investigation of Rickettsia tsutsugamushi infection of mice with different allotypic susceptibility to the agent.

Cytological and cytochemical studies on Swiss and random-bred white mice susceptible to Rickettsia tsutsugamushi infection as well as resistant C57 Black 6 and CBA mice revealed a clear-cut relationship between the severity of infection and the pattern of macrophage reaction. In highly susceptible mice the fatal infection was accompanied by death of macrophages and necrotisation of the peritoneal exudate cells. The resistant mice showed no clinical signs but developed an intensive macrophage reaction, and the main mass of the inoculated rickettsiae died at the inoculation site, the macrophages remaining viable. Phagocytosis and digestion of rickettsiae were accompanied by markedly increased activities of hydrolytic and oxidizing-reducing enzymes.

Acid Phosphatase↗