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Taxi drivers' exceptional memory of street names.

In this paper, we explore the nature of taxi drivers' serial recall of street names. The main question is whether the memory of verbal material benefits from the possibility of using visuospatial associations and knowledge concerning large-scale environment. In two experiments, expert taxi drivers' recall of street names was superior to that of control groups. In Experiment 1, experts' superiority of memory was greater when the street names reflected a visuospatially continuous route than when the street names were located along a straight line across the map without spatial continuity or were presented in random order. In Experiment 2, the expert taxi drivers recalled spatially continuously organized lists much better than they recalled lists of street names belonging to the same semantic category or lists presented in alphabetical order. This result also suggests that interitem associations, which are based on spatial co-occurrence, are efficient in comparison with other mnemonics.

Adult↗

Familiarity and pronounceability of nouns and names.

Ratings of familiarity and pronounceability were obtained from a random sample of 199 surnames (selected from over 80,000 entries in the Purdue University phone book) and 199 nouns (from the Kucera-Francis, 1967, word database). The distributions of ratings for nouns versus names are substantially different: Nouns were rated as more familiar and easier to pronounce than surnames. Frequency and familiarity were more closely related in the proper name pool than the word pool, although both correlations were modest. Ratings of familiarity and pronounceability were highly related for both groups. A production experiment showed that rated pronounceability was highly related to the time taken to produce a name. These data confirm the common belief that there are differences in the statistical and distributional properties of words as compared to proper names. The value of using frequency and the ratings of familiarity and pronounceability for predicting variations in actual pronunciations of words and names are discussed.

Adult↗

Age of acquisition, not word frequency, affects object naming, not object recognition.

Word frequency is widely believed to affect object naming speed, despite several studies in which it has been reported that frequency effects may be redundant upon age of acquisition. We report, first, a reanalysis of data from the study by Oldfield and Wingfield (1965), which is standardly cited as evidence for a word frequency effect in object naming; then we report two new experiments. The reanalysis of Oldfield and Wingfield shows that age of acquisition is the major determinant of naming speed, and that frequency plays no independent role when its correlation with other variables is taken into account. In Experiment 1, age of acquisition and phoneme length proved to be the primary determinants of object naming speed. Frequency, prototypicality, and imageability had no independent effect. In Experiment 2, subjects classified objects into two semantic categories (natural or man-made). Prototypicality and semantic category were the only variables to have a significant effect on reaction time, with no effect of age of acquisition, frequency, imageability, or word length. We conclude that age of acquisition, not word frequency, affects the retrieval and/or execution of object names, not the process of object recognition. The locus of this effect is discussed, along with the possibility that words learned in early childhood may be more resistant to the effects of brain injury in at least some adult aphasics than words learned somewhat later.

Adult↗

On the naming of color words and color patches.

Subjects can name color words faster than they can name color patches. To account for that effect, a generic model of naming is described which assumes that words access the mental lexicon directly, whereas color patches do so only indirectly via an initial imaginal or semantic representation. However, Lund (1927) reported that the naming advantage for words disappeared when all the items to be named on a page were the same (i.e., they were blocked). In the present study, three experiments are reported that were designed to provide a clearer empirical definition of Lund's blocking effect and to ascertain the extent to which it requires a modification of the generic model. The blocked lists had 50 items arranged into 10 blocks, with each block homogeneous with respect to color. The block lengths were either all a predictable length of 5 items or they varied randomly from 1 to 9 items. The data indicated the following: (1) The blocking effect occurred even when the task required a full identification of each item, and (2) the blocking effect was confined to within-block transitions. Blocking seemed to eliminate the word advantage by allowing the subject to re-use the lexical entry used for the immediately prior items, which is consistent with the generic model.

Color Perception↗

Associative priming in color naming: interference and facilitation.

In Experiment 1, color-naming interference for target stimuli following associated primes was greater in a group making a lexical decision to the prime than in a group reading the prime silently. High-frequency targets were responded to more quickly than low-frequency targets. In Experiment 2, with subjects naming the prime, there was evidence of associative interference when the prime and the target were grouped temporally but not when the intertrial interval was comparable with the prime-target interval. Associative primes presented at a short (120-msec) prime-target stimulus onset asynchrony facilitated color naming in Experiment 3. Taken together, the results suggest that the effect of faster processing of the base word in a color-naming task is facilitatory and that color-naming priming interference arises when associative prime processing increases conflict between word and color responses by enhancing phonological or articulatory activation of the base word.

Adult↗

Phonological priming effects on speech onset latencies and viewing times in object naming.

An earlier experiment (Meyer, Sleiderink, & Levelt, 1998) had shown that speakers naming object pairs usually inspected the objects in the required order of mention (left object first) and that the viewing time for the left object depended on the word frequency of its name. In the present experiment, object pairs were presented simultaneously with auditory distractor words that could be phonologically related or unrelated to the name of the object to be named first. The speech onset latencies and the viewing times for that object were shorter after related distractors than after unrelated distractors. Since this phonological priming effect, like the word frequency effect, most likely arises during word-form retrieval, we conclude that the shift of gaze from the first to the second object is initiated after the word form of the first object's name has been accessed.

Adult↗

Look-alike and sound-alike drug names: the problem and the solution.

This list of 645 pairs of look-alike and sound-alike drug names (1,290 names are shown; they are listed both ways), has been complied to graphically emphasize the importance for the pharmaceutical industry, the United States Adopted Name (USAN) Council, and Food and Drug Administration (FDA) to select new names with great care. It also stresses to health professionals the necessity of writing legibly, writing complete orders, speaking slowly and clearly when giving verbal orders, carefully reading prescription orders, knowing what is wrong with patients, maintaining records of previous drugs patients have received, and learning about new drug products. It also indicates that patients must be educated about the medications they are taking. Your cooperation in alerting the authors of names they may have overlooked or of new problems would be greatly appreciated. When a sufficient number of additions are received, an updated list will be published.

Drug Information Services↗

Sequential effects in naming: a time-criterion account.

S. J. Lupker, P. Brown, and L. Colombo (1997) reported that target naming latencies are strongly affected by the difficulty of the other stimuli in a trial block, an effect they attributed to readers' strategic use of a time criterion to guide responding. In the present research, the authors asked whether there are also trial-by-trial ("sequential") effects by examining naming latency as a function of the difficulty of the preceding stimulus. In Experiment 1, both nonwords and high-frequency regular words were named more rapidly following a word than a nonword. Experiments 2, 3, and 4 were parallel experiments involving a variety of stimulus types (e.g., high- and low-frequency inconsistent words, easy and hard nonwords). In all cases, similar sequential effects were observed (i.e., all stimulus types had shorter latencies following an easier-to-name than a harder-to-name stimulus). In terms of the time-criterion account, criterion placement appears to be affected by the relative difficulty of the preceding stimulus in a way that is independent of stimulus type.

Adult↗

The influence of methylene blue and L-NAME on the development of streptozotocin-induced diabetes in rats.

The cytokine-induced overproduction of nitric oxide by immunocompetent cells with subsequent development of oxidative stress is suggested to be one of important pathophysiological mechanisms of the pancreatic beta cells damage in streptozotocin-induced experimental diabetes. The aim of our study was to compare the influence of two nitric oxide inhibiting compounds: methylene blue and L-NAME (N-omega-nitro-L-arginine-methyl ester) on the streptozotocin diabetes development and the oxidative stress parameters in male rats. Blood glucose, glycated haemoglobin, serum malondialdehyde concentration and erythrocyte superoxide dismutase activity were measured in control, diabetic (streptozotocin 70 mg/kg i.p.), methylene blue (50 mg/kg in the food), and diabetic group treated simultaneously with methylene blue (10 animals in each group). In the second experiment the L-NAME was used instead of methylene blue. It was found that both methylene blue and L-NAME partially suppressed the development of diabetes, but did not unambiguously influence the oxidative stress parameters. We conclude, that both methylene blue and L-NAME partially suppress the development of streptozotocin-induced diabetes in rats. The precise mechanism of this effect is not clear. We failed to demonstrate clear effect of methylene blue and/or L-NAME on oxidative stress development in diabetic rats.

Animals↗

Effect of N-acetylcysteine and L-NAME on aluminium phosphide induced cardiovascular toxicity in rats.

AIM: To investigate the protective effects of N-acetylcysteine (NAC) and Nomega-Nitro-L-arginine methyl ester (L-NAME) on aluminium phosphide (AlP) poisoning induced hemodynamic changes, myocardial oxygen free radical injury and on survival time in rats. METHODS: AlP (12.5 mg/kg) was administered intragastrically under urethane anaesthesia. The effect of pre- and post-treatment with NAC and L-NAME alone and in combination was studied on haemodynamic parameters [blood pressure (BP), heart rate (HR), and electrocardiogram (ECG)] and biochemical parameters (malonyldialdehyde, catalase, and glutathione peroxidase). RESULTS: AlP caused significant hypotension, tachycardia, ECG abnormalities, and finally marked bradycardia. The mean survival time was (90 +/- 10) min. There was significant increase in myocardial malonyldialdehyde (MDA), and decrease in catalase and glutathione peroxidase (GSH Px) levels. NAC infusion (6.25 mg . kg-1 . min-1, iv for 30 min) caused insignificant hemodynamic and biochemical changes. Pre- and post-treatment of NAC with AlP significantly increased the survival time, stabilized BP, HR, and ECG, decreased MDA and increased GSH Px levels compared to AlP group. L-NAME infusion (1 mg . kg-1 . min-1, iv for 60 min) as such caused significant rise in BP but precipitated ECG abnormalities. Pre- and post-treatment of L-NAME with AlP neither improved the survival time nor the biochemical parameters despite significant rise in BP. Co-administration of both the drugs with AlP worsened the hemodynamic and biochemical parameters with reduction in the survival time as compared to AlP. CONCLUSION: NAC increased the survival time by reducing myocardial oxidative injury whereas L-NAME showed no such protective effects in rats exposed to AlP.

Acetylcysteine↗

Picture naming by children with hearing loss: II. Effect of phonologically related auditory distractors.

Thirty children with hearing loss (HL) and 129 typically developing (TD) children representing comparable ages, vocabulary abilities, or phonology skills named pictures while attempting to ignore auditory distractors. The picture-distractor pairs were constructed to represent phonologically congruent or conflicting onset relations, for example, the picture "duck" with distractors of /[symbol: see text]/or /[symbol: see text]/, respectively. In children with good phoneme discrimination, congruent distractors speeded naming and conflicting distractors slowed naming, relative to a control condition. Effects were similar in HL and TD subgroups. In children with poorer phoneme discrimination, conflicting distractors did not influence naming in the HL subgroup, regardless of discrimination status, and consistently slowed naming only for discriminated contrasts in the TD subgroup. Phonologic representations appear suitably fine-grained in HL children with good auditory perceptual abilities but may be less well specified, more holistic, and/or less auditory-linguistically based in HL children with poorer auditory perceptual abilities. Results are discussed in terms of the heterogeneous nature of phonologic processing in children with HL.

Adolescent↗

Influence of L-NAME and L-Arg on ischaemia-reperfusion induced gastric mucosa damage.

OBJECTIVE: The aim of this study was to investigate effects of L-NAME and L-Arginine on gastric mucosal injury induced by ischaemia-reperfusion. METHODS: In the experiment, 20 New Zealand rabbits were used (2700-3000 g). Celiac artery was clamped for 30 min for ischaemia and then 60 min of reperfusion followed this after all rabbits were anaesthetized. In the Sham-control group (G 1, n = 5), laparotomy was performed, and the celiac artery was prepared without clipping. Group 2 (Untreated, n = 5) rabbits were only subjected to ischaemia-reperfusion. Group 3 (n = 5) rabbits had L-Arginine Methyl Ester (L-Arg) 3 mg/kg/min as i.v. infusion during the first 15 min of the reperfusion. Group 4 (n = 5) rabbits had a nitric oxide inhibitor NG-nitro-L-arginine methyl ester (L-NAME) 100 micrograms/kg/min i.v. during the first 15 min of the reperfusion. After 60 min of reperfusion, the rabbits were killed, and their stomachs were removed for histopathologic evaluation and determination of malondialdehyde (MDA) level. RESULTS: After ischaemia-reperfusion, Untreated group had macroscopic necrosis involving 50 +/- 6% of total gastric mucosa area and deep mucosal necrosis involving 10 +/- 5% of mucosal strips. In the group treated with L-NAME, macroscopic mucosal necrosis involved 52 +/- 6% of total gastric mucosa area and deep mucosal necrosis involved 11 +/- 3% of mucosal strips (both p > 0.05 versus Untreated group). L-Arg treatment significantly reduced macroscopic mucosal necrosis area to 20 +/- 6% and deep mucosal necrosis to 3 +/- 1% (both p < 0.05 versus Untreated group and L-NAME group). MDA level in the L-Arg group was significantly lower when compared to control and L-NAME group MDA level (p < 0.05). CONCLUSION: These results suggest that NO increase induced by L-Arginine injection is involved in the protection of gastric mucosa after ischaemia-reperfusion.

Animals↗

[Naming difficulties seen in a case of alexia with agraphia caused by a left postero-inferior temporal lesion].

A 71-year-old right-handed man presented writing and reading difficulties as well as naming difficulties. Neuropsychological examinations revealed mild fluent type aphasia accompanied by alexia and agraphia predominantly affecting kanji and also severe naming difficulties. Brain MRI showed cerebral subcortical hemorrhage extending from the anterior one-third of the left temporal lobe to the temporo-occipital junction involving the fusiform gyrus. The analysis of the several reported cases with severe alexia with agraphia for kanji including ours revealed a close correlation between the severity of kanji writing disturbances and that of naming difficulties. It was also shown that cases with severe naming difficulties had lesion extending anteriorly to the anterior middle temporal gyrus or medially to the parahippocampal gyrus, suggesting that the disconnection between the parahippocampal gyrus and other cortices including the temporal lobe was essential for production of naming difficulties.

Aged↗

Concurrent validity of the MAE visual naming test.

Deficient confrontation naming has been observed in a number of neurological illnesses, as well as in aphasia and normal aging. The Visual Naming Test (VNT) of the Multilingual Aphasia Examination (MAE) is a standardized measure of confrontation naming. One hundred patients, consecutively referred for neuropsychological evaluation, were administered the VNT, Boston Naming Test (BNT), and WAIS-R. Concurrent validity of the two confrontation naming measures was demonstrated by their high intertest agreement. Performance on the VNT was found to be related to a unique ability separate from general intellectual functioning. Suggestions regarding the clinical use of the VNT are discussed.

Journal Article↗

Normative implications of the relationship between reading vocabulary and Boston Naming Test performance.

The 60-item Boston Naming Test (BNT) was published in 1983 with norms described as provisional. One recent finding (Thompson & Heaton, 1989) suggests that verbal intelligence, and the Wechsler Adult Intelligence Scale (WA1S)-Revised Vocabulary subtest, in particular, is strongly correlated with BNT performance, and that education is moderately so. High false-positive rates for naming deficit may conceivably result from the application of the published norms with subjects of lower verbal abilities or limited educational backgrounds. To further explore the relationship of naming to other verbal abilities, analyses were undertaken of the correlations between Level 7-9 Gates-MacGinite Reading Vocabulary Test (G-MRVT) and BNT data from 97 schizophrenic, bipolar, and normal subjects. Reading vocabulary is strongly correlated with BNT performance, and the nature of this relationship is essentially the same across the three diagnostic groups. Application of the published norms would have resulted in a high false-positive rate for naming deficit in all groups among subjects with reading vocabularies equivalent to twelfth grade or less. As a word-recognition based reading exercise, the G-MRVT is likely to provide a brain-compromise-resistant index against which the adequacy of naming performances can be assessed. Accordingly, G-MRVT based BNT performance expectation guidelines are presented for use as a complement to the published norms. Other implications are discussed.

Journal Article↗

[Effects of SNP and L-NAME on spermatogenesis in rats].

OBJECTIVE: To observe the effects of nitric oxide(NO) on the DNA ploidy of germ cells and to evaluate the role of NO in modulating spermatogenesis by using SNP, a donor of NO and N-nitro-l-arginine-mythel-ester(L-NAME), an inhibitor of nitric oxide synthese(NOS) in rats physically in vivo. METHODS: Forty adult male, Sprague-Dawley rats (60-70 days) were divided into four groups, and injected ultraperitoneally with one of the following agents (once a day, for 12 days): SNP, L-NAME and SNP + L-NAME with normal saline. Two hours after the last injection the rats were sacrificed. The sera were collected and stored at -70 degrees C for subsequent hormone assay. The concentration of serum testosterone was measured by radioimmunoassay. Serum NOx- (nitrite/nitrate) concentration was measured by Greiss method. DNA of spermatogenic cells was detected by flow cytometry(FCM), and the percentage of 1c, 2c and 4c germ cells calculated. RESULTS: In the SNP treatment group, the serum concentration of NOx- was higher, testosterone concentration was lower and the number of 1c cells was smaller compared with the control group. However, in rats treated with L-NAME, the concentration of NOx- was significantly lower, testosterone concentration was higher and the number of 1c cells was larger compared with the control group(P < 0.01). No changes were observed in the SNP + L-NAME group. CONCLUSION: Enhancing ectogenous NO will suppress spermatogenesis while inhibiting NO productive pathway will promote it.

Animals↗

The role of typography in differentiating look-alike/sound-alike drug names.

Until recently, when errors occurred in the course of caring for patients, blame was assigned to the healthcare professionals closest to the incident rather than examining the larger system and the actions that led up to the event. Now, the medical profession is embracing expertise and methodologies used in other fields to improve its own systems in relation to patient safety issues. This exploratory study, part of a Master's of Design thesis project, was a response to the problem of errors that occur due to confusion between look-alike/sound-alike drug names (medication names that have orthographic and/or phonetic similarities). The study attempts to provide a visual means to help differentiate problematic names using formal typographic and graphic cues. The FDA's Name Differentiation Project recommendations and other typographic alternatives were considered to address issues of attention and cognition. Eleven acute care nurses participated in testing that consisted of word-recognition tasks and questions intended to elicit opinions regarding the visual treatment of look-alike/sound-alike names in the context of a label prototype. Though limited in sample size, testing provided insight into the kinds of typographic differentiation that might be effective in a high-risk situation.

Canada↗

[Development of the database on nonproprietary names of drugs].

This paper describes the outline of the database of nonproprietary names of drugs and the characteristics of its online search system. The database includes the records of officially authorized names by WHO, International Nonproprietary Names (INN), and those by Japanese Government, Japanese Accepted Names (JAN). The INN file is merged with the JAN file. The online retrieval system is designed to enable search for drugs by generic names adopted on an international level and a national level in both English and Japanese. It is operated with INQ (DBMS) in the NEC ACOS-6 computer. Data from INN are updated once a year, and those from JAN are added whenever the official announcement of newly approved drugs are published in Yakumu-Koho (official pharmaceutical gazette).

Database Management Systems↗