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At least 937 records · Page 52Linked to original sources

Pacinian neurofibroma.

At rare intervals in the literature, reports have appeared of a skin tumour containing structures resembling Pacinian corpuscles. Four such tumours collected over the course of 20 years are described and the literature reviewed.

Adolescent↗

Giant appendicular neurofibroma. A light and immunohistochemical study.

A case of solitary appendicular neurofibromatosis is presented. The neurogenous nature of the lesion was emphasized by the positive reaction for S-100 protein. Attention is directed towards the morphological differences between neurogenous hyperplasia, which is a reactive common place feature in the elderly, and the present example of neoplastic nerve growth, which produced a gigantic appendix. A review of the literature failed to disclose any previous case unassociated with von Recklinghausen's disease.

Adult↗

Giant pigmented tumour of the scalp--a diffuse neurofibroma or a congenital naevus showing neurofibromatous changes? Immunohistochemical and electron microscopic studies.

A case of giant pigmented tumour of the scalp which developed in a 47-year-old woman is reported. Macroscopically, the tumour showed a peculiar two-layered structure, consisting of an upper non-pigmented and a lower pigmented portion. Histologically, it was composed of elongated neurofibromatous tumour cells with abundant collagen fibres in the non-pigmented portion and round naevus-like cells with abundant melanin pigment in the pigmented portion. S-100 protein and neurone-specific enolase were demonstrated in most of the tumour cells, but neurofilament and myelin basic protein were not detected. Electron microscopy revealed melanosomes in the tumour cells of the pigmented portion. These findings might support a melanocytic origin for the tumour, but the lack of superficial pigmentation and the associated hair loss were against this. The tumour may represent an example of duality of neural crest differentiation.

Carboxylesterase↗