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[Evaluation of loretadine therapy by rhino-manometry in patients with allergic rhinitis].

The authors evaluated the nasal flow and resistance by rhinomanometry in 21 children suffering from ragweed allergy during the season. After this process the loratadine was administered for 1 month. During the therapy the nasal parameters were checked at 2 and 4 weeks, again. The loratadine significantly decreased the nasal resistance in 18 children and improved the nasal airflow in 17 cases. In the second part of the examination 15 ragweed sensitized children were undergone nasal allergen-specific challenge after 40 minutes taken loratadine. The nasal parameters were checked after 30 minutes and 6-8 hours. The statistical analyzes proved that loratadine can prevent and inhibit the early and late-phase of Type I hypersensitivity in contrast of the 12 children who were challenged without loratadine administration. They showed nasal obstruction. Based on the results, loratadine can be considered very effective antihistamine-antiallergenic drug which improves the quality of life of the allergic patients.

Adolescent↗

Percutaneous transhepatic cholangioscopic lithotripsy and change of biliary manometry patterns.

BACKGROUND/AIMS: Percutaneous transhepatic cholangioscopic lithotripsy (PTCSL) is used to remove bile duct stones. This work aims to evaluate the clinical usefulness of PTCSL and the reversibility of the terminal bile duct dysfunctions after PTCSL. METHODOLOGY: Thirty patients who underwent PTCSL using mechanical and/or electrohydraulic lithotripsy over the past 10 years (20 patients with common bile duct stones and 10 with intrahepatic bile duct stones) were evaluated. Terminal bile ductal pressure was measured using the percutaneous transhepatic biliary drainage (PTBD) tube prior to and after lithotripsy by means of variable-load cholangiomanometry. RESULTS: Complete stone extraction was possible in 26 patients (86.7%). The other 4 patients had intrahepatic stones. Complications included 2 cases of hemobilia, one of pneumonia, and 3 of localized peritonitis. Of 26 patients without residual stones, only 4 patients had a linear pressure flow (P-F) pattern which indicates normal biliary tract function prior to lithotripsy. In 17 of 22 patients with other type P-F patterns, however, these types also changed to a linear pattern after complete removal of stones. The P-F pattern of the other 5 patients remained unchanged. CONCLUSIONS: PTCSL is a safe and efficient method treating biliary tract lesions while preserving the function of the sphincter of Oddi. The terminal biliary tract function normalized after stone removal. Thus, PTCSL was useful for patients with complicated bile duct stones not accessible to endoscopic retrograde management.

Bile Ducts↗

Urinary manometry in patients with spinal cord injury: neurourological considerations in the rehabilitation of acute and chronic neurogenic bladder.

Recordings of pressure within the bladder, urethra, rectum, and external anal sphincter with image intensification and videotaping were carried out in spinal cord injury patients with complete and incomplete lesions, during spinal shock and in the chronic stage. The behavior of the external urethral sphincter and the somatic and visceral motor reflexes of the sacral segments were studied, during and after spinal shock. During spinal shock the majority of patients retained sacral somatomotor activity, in the absence of visceromotor activity, and resistance values at the external urethral sphincter remained high. Vascular oscillations were recorded in the membranous urethra. The highest resistance found in the membranous urethra was at the distal part of the external sphincter.

Acute Disease↗

Diffuse gastrointestinal dysmotility by ultrasonography, manometry and breath tests in colonic inertia.

Patients with colonic inertia, the most severe form of chronic functional constipation, may present with a more diffuse panenteric motility disorder. We describe a case of a woman with severe longstanding colonic inertia associated with chronic functional dyspepsia and defective gastric, gallbladder and small intestinal motility, as confirmed by several diagnostic tests including two breath tests with the 13C-stable isotope. A subclinical form of authonomic sympathetic neuropathy was diagnosed, providing a possible pathophysiological explanation for the presence of simultaneous multiple motility defects of the gastrointestinal tract.

Adult↗