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At least 937 records · Page 52Linked to original sources
PubMed1984

[Criteria for hemostasis in kidney transplant patients. Comparison of patients undergoing immunosuppression with cyclosporin and azathioprine steroids].

Studies on one-year function conducted by the European Multicenter Trial showed that, after renal allograft transplantation, bleeding complications were only found in patients treated with cyclosporin as compared with those treated with azathioprin/steroids. To investigate a possible relationship between the bleeding tendency and the cyclosporin treatment, 18 parameters of hemostasis were studied in 11 patients, 6 of whom received cyclosporin A and the other 5 conventional treatment with azathioprin/steroids. Bleeding tendency could not be related to any specific coagulation parameter. Of interest is that clot retraction was significantly lower in the cyclosporin group (88 +/- 9% vs. 125 +/- 10%). Considering the fact that the skin bleeding time according to Ivy was normal in all patients, the clinical significance of the lower levels of the clot retraction appears to be minor. Discriminant analysis showed that these significantly lower clot retraction values could not be related to the lower platelet count levels in platelet rich plasma (205 000 +/- 85 000/mm3 vs. 280 000 +/- 67 000/mm3) but were associated with cyclosporin A treatment. All factor-VIII related activities were elevated in both groups. The main difference between the cyclosporin group and the conventionally treated group was significantly elevated levels of factor VIII procoagulant antigen (VIII: CAg) (cyclosporin A treated group: VIII: CAg 435 +/- 145%, conventionally treated group: VIII: CAg 215 +/- 99%). These results suggest hypercoagulability rather than bleeding tendency under cyclosporin treatment.

Adult↗
PubMed1984

[Hemostasis and tumor invasion. Therapeutic implications].

Plasminogen activator activity (PAA) has been detected in various tumor cells or in their excretion products. In some cell systems PAA is a symptom of cell transformation, but its amount is questionably correlated with the invasiveness of the tumor cells. Procoagulant and aggregation activities on platelets, have been demonstrated in various tumor cells. There are weakly correlated with the metastatic potential of these cells. In vivo, the treatment of animals by modifiers of the hemostasis, or of the fibrinolysis systems provides contradictory results. Some reduction of metastatic diffusion and increase of life span have been noted with Warfarin. Clinical trials are scarce and their methodology is debatable. When conclusive, a lengthening of the life span has been observed, but not a reduction of the metastatic spread as metastases were still present.

Animals↗
PubMed1978

[Hemostasis in hereditary hemorrhagic telangiectasia (author's transl)].

The investigation of a girl aged 8 with hereditary hemorrhagic telangiectasia showed an abnormality of primary hemostasis. The bleeding time was at the upper end of normal and platelet adhesiveness was decreased to a variable extent. Platelet life span was shortened, presumably due to the telangiectatic lesions typical of this disease. Platelet aggregation and ADP-content were normal as was the plasma coagulation system.

Blood Coagulation↗
PubMed1983

Efficacy of membrane filtration, influence on hemostasis, immunoglobulins and inflammation mediators during daily plasma exchanges.

Plasma exchange (PE) by membrane filtration was performed with the following hollow fibers: cellulose-diacetate (Plasmaflo 01, Plasmaflo 02, Asahi, Japan), polypropylene (Plasmaflux, Fresenius, FRG) and polymethylmethacrylate (Plasmax, Toray, Japan). The elimination-coefficient (EC) for certain plasma proteins was calculated. With all hollow fibers no correlation between the EC for about ten plasma proteins with a molecular weight of 54.000 dalton up to 2.400.000 dalton. The mean EC-values for the fibers studied were: 0.32 (Plasmaflo 01), 0.52 (Plasmaflo 02), 0.52 (Plasmaflux) and 0.58 (Plasmax). Membrane filtration performed with the single needle technique using either Plasmaflo 02 or Plasmaflux resulted in a significantly lower efficiency with mean EC-values of 0.33 and 0.32 respectively. After three or four days of PE treatment using three liters of 3% human albumin solution as replacement fluid several alterations in parameters of hemostasis were altered: Antithrombin III levels dropped to 35% of normal value after each plasma exchange but increased to normal range within 24 hours during the observed period of four consecutive PE, Fibrinogen concentration dropped permanently to a preexchange value of 40% of the initial concentration after three plasma exchanges. A 40-50% decrease was also observed for prothrombin, plasminogen and alpha-2-macroglobulin after plasma exchange. A decrease in the platelet count ranging from 5 to 25% after each plasma exchange was observed but returned to the initial level before the next treatment. The concentrations of IgG IgA and IgM decreased to less than 20% of preexchange values and C 3 and C 4 to 20-30: of preexchange values after three plasma exchanges.(ABSTRACT TRUNCATED AT 250 WORDS)

Filtration↗
PubMedDate not supplied

[Comparison of the effects of 2 anesthesiologic technics on hemostasis].

Results of hemocoagulation test in anesthesia performed upon 17 patients treated with Ethrane and 17 treated with NLA are reported in this paper. Normotest, Thrombotest and PTT are within normal limits. The two groups studied, however, showed a drop in the percentages of the Normotest and Thrombotest and a reduced PTT. Differences in base values (pre-operatory) and those on the first post-operatory day were calculated for each of the two groups of patients. No statistically significant variations were noted comparing these with the Student T test. Our results, as well as those of other authors, show that NLA and Ethrane do not clinically alter patient hemostasis. Considering that no significant bleeding was noted during surgery, we have arrived at the conclusion that these two anesthetic agents have a stabilizing effect on organic homeostasis, in emergency cases, thus protecting the hemostatic equilibrium.

Adult↗
PubMed1983

[Changes in various hemostasis indices during transient coronary insufficiency with different durations of myocardial ischemia].

Experiments on 93 white random-bred male rats weighing 200 +/- 10 g have shown that during myocardial ischemia under transitory coronary insufficiency, there is an increase in platelet adhesive capacity, acceleration of fibrinogenesis, staged time course of formation of the fibrin-platelet structure of the blood clot, depression of its velocity and lysis degree, as well as of fibrin polymerization. Postischemic reperfusion of the coronary blood flow is not followed by normalization of all the hemostatic indicators under study even after a short-term (10 min) myocardial ischemia. Reperfusion after a long-term (40 min) ischemia gives rise to depression of coagulation and fibrinolytic activity, while that after a still longer ischemia (120 min) is characterized by discordant changes in the parameters of the systems indicated. It is assumed that similar shifts in hemostasis can be observed in patients with different patterns of coronary insufficiency.

Animals↗
PubMed1983

[Postoperative changes in hemostasis by heparin/dihydroergotamine prevention].

Coagulation studies and the J-125-fibrinogen-uptake-test for diagnosis of deep vein thrombosis were carried out in 244 and 288 patients resp. undergoing vaginal or abdominal hysterectomy. They were given a prophylaxis with 2 X 5000 IU calcium heparin (Calciparin) or 2 X 5000 IU sodium heparin with 0.5 mg dihydroergotamine (Heparin-Dihydergot). Control patients received acenocoumarol (Sintrom). The incidence of deep vein thrombosis was lowest in the heparin/dihydroergotamine group and was 5.9%. With calcium heparin prophylaxis it was 15.5%, and with acenocoumarol 12.2%. Plasma heparin levels and parameters of coagulation, fibrinolysis and platelet function showed that after 8 days of heparin prophylaxis with or without dihydroergotamine there is no change in hemostasis towards an increasing hypo- or hypercoagulability. Coagulation changes and the incidence of postoperative wound hematoma were identical using heparin alone or in combination with dihydroergotamine. Thus the improved effectiveness of heparin/dihydroergotamine in prevention of deep vein thrombosis which has been shown in the fibrinogen test cannot be explained by an effect onto the coagulation parameters studied. It is pointed out that a peridural anesthesia can be carried out in low-dose heparin and heparin/dihydroergotamine prophylaxis without the risk of bleeding and that the incidence of wound hematoma can be reduced by correct choice of the site of injection.

Blood Coagulation Tests↗
PubMed1981

[Antithrombin III and its role in normal and pathological hemostasis].

The paper is a survey on the latest up-to-date data on the character, determination methods, physiology, pathophysiology and clinical significance of one of most important factors of anticoagulation system--antithrombin III. Its normal activity is of essential importance for physiological hemostasis. It could be reduced via diminished production, increased elimination and intensified consumption, particularly in case of concomitant grave states and diseases. The enhanced activity of antithrombin III, found most frequently in the treatment with indirect anticoagulants, renal transplantations, and application of anabolic steroids, has given no data of clinical importance so far. Numerous of the outlined problems remain still not sufficiently elucidated.

Antithrombin III↗
PubMed1982

Primary hemostasis after massive transfusion for injury.

Primary hemostasis, the formation of a platelet plug, was studied in 22 injured patients receiving an average of 21 transfusions during the operation for control of bleeding. The storage age of the blood averaged 15 days; no platelet transfusions were given. Platelet counts (PLT) and bleeding time (BT) were studied intraoperatively; postoperatively at 6 hours, 25 hours, day 2, day 4; and during convalescence (8 days to 3 months). Serial PLT and BT levels were correlated with the number of transfusions and age of blood. During operation, the PLT fell to 109,000/mm3 and the BT was greater than 15 minutes. Thrombocytopenia did not correlate with the number of transfusions or age of blood. The PLT averaged 106,000/mm3 at 6 hours and then fell significantly to 73,000/mm3 at 15 hours and to 76,000/mm3 on day 2. The PLT rose significantly to 110,000/mm3 by day four and increased to supernormal levels by convalescence. The BT remained elevated at 6 hours, 15 hours, day 2, and day 4, and declined to normal by convalescence. Thrombocytopenia and prolonged BT after massive transfusion for injury indicate platelet dysfunction which may protect against disseminated intravascular coagulation. Correction of the thrombocytopenia should be reserved for patients with bleeding.

Bleeding Time↗
PubMed1978

Comparative effects of aspirin and acetaminophen on hemostasis.

Aspirin, even in small doses, has a profound and relatively long-lasting effect on platelet function and hemostasis. This usually produces few clinical problems. However, if a patient has an underlying hemostatic defect, undergoes surgery or sustains an injury, or is a newborn, severe hemorrhage is a potential risk. Aspirin is contraindicated in these clinical contexts. In contrast, acetaminophen has no effect on the hemostatic mechanism unless massive overdose results in hepatic necrosis with depression of synthesis of coagulation factors. Acetaminophen can be used when indicated in clinical situations where the use of aspirin may be potentially dangerous.

Acetaminophen↗
PubMed1981

Optic nerve clipping for hemostasis during enucleation.

An instrument is described for sectioning the optic nerve during enucleation that has several advantages over presently used techniques. the instrument applies a nonreactive, tantalum clip around the optic nerve, and a built-in knife blade transects the nerve anterior to the clip. In addition to providing rapid and effective hemostasis of the vessels within and surrounding the optic nerve, the device cuts only tissue that is encompassed by the clip and not extraneous structures.

Hemostasis, Surgical↗
PubMedDate not supplied

Effects of zomepirac on hemostasis in healthy adults and on platelet function in vitro.

Zomepirac, a new nonnarcotic analgesic, was studied in 25 healthy adults for possible effects on hemostasis. Given in a single 200-mg dose or for 15 days at 300 mg/day, zomepirac prolonged template bleeding time and caused transient decreases in platelet adhesiveness, in stimulated platelet aggregation, and in the release of platelet serotonin. The short duration of these effects contrasts with the known week-long duration of the effects of aspirin. Data from in vitro platelet function studies, correlated with plasma level determinations, indicate that these effects on platelet function in man are probably dependent only on the presence of intact zomepirac and not on any metabolites. The qualitative effects of zomepirac on platelets are assumed to be the consequence of reversible inhibition of prostaglandin synthetase in these cells. Platelet concentration and the humoral clotting mechanism were not affected by zomepirac. Although no unusual bleeding has been noted in patients given zomepirc postoperatively, it should be used with the same caution as aspirin in patients with known defects in platelet function or coagulation.

Adult↗
PubMed1995

Thrombosis and hemostasis testing at the point of care.

Point-of-care testing provides current, accurate information relating to thrombosis and hemostasis in patients. Several forces are driving point-of-care testing, particularly economic factors and improved technology. Point-of-care testing has the potential to improve patient management and to decrease integrated costs, although this remains to be shown. For such testing to be successful, the technology must be complemented by hospital-wide point-of-care testing programs. The role of the laboratorian and pathologist will become important for coordinating programs, maintaining quality assurance, and promoting quality improvement.

Hemostasis↗
PubMedDate not supplied

[A method for hemostasis in transvesical adenomectomy].

The hemostatic techniques proposed by the authors in transvesical adenomectomy implies U-form replaceable catgut ligatures placed with circular capture of the cervix vesicae and prostate capsule followed by their urethral stretching out. The technique is applicable in different adenoma sizes, prostate and cervix vesicae sclerosis. The procedure was used in 112 cases. Blood loss measured in 54 patients averaged 160 ml which is less than under other techniques of adenomectomy. Postoperative hemorrhage was observed in 1 patient (0.9%). Lethality was 1.8%. Long-term postoperative infectious complications occurred in 4.5%, organic ones (bladder cervical stricture) in 1.8% of the examinees. The technique is recommended for introduction into clinical practice as simple to perform, warranting reliable hemostasis and reduced intraoperative bleeding.

Aged↗
PubMed1993

[Hemostasis techniques in transvesical excision of a prostatic adenoma].

A technique for hemostasis in performance of transcystic adenomectomy by means of the four U-like removable catgut ligatures has been suggested. Two hundred and sixty-three transcystic adenomectomies were performed. Early postoperative bleeding was noted in 1 (0.4%) patient, the late one--in 2 ((0.8%). The average duration postoperative hospitalization was 18.8 days.

Blood Loss, Surgical↗
PubMed1993

[Effects of natural protease inhibitors on hemostasis and serum proteolysis blockers in patients with pulmonary tuberculosis].

Changes in hemostasis and basic serum antiproteases (alpha 1 protease inhibitor--alpha 1-PI and alpha 2-macroglobulin--alpha 2-MG) were followed up in patients with infiltrative pulmonary tuberculosis in the destruction phase. 65 patients received chemotherapy in combination with contrykal inhalations, 63 patients were given glucocorticoid hormones and prodectin. It was found that natural protease inhibitors produced a marked clinical response, abated more rapidly thrombohemorrhagic syndrome, promoted normalization of coagulation and fibrinolysis. Replacement aerosol therapy with antiprotease agents reestablished the concentration of alpha 1-PI, but had no effect on that of alpha 2-MG. This may contribute to reparative processes in pulmonary tissue which ran without significant signs of sclerosis. The results obtained may be used by clinicians choosing methods of pathogenetic therapy.

Adolescent↗
PubMedDate not supplied

[The thrombocytic link in hemostasis and the immunity system of patients with HIV infection].

To find out possible relationships between disturbances in the thrombocytic element of hemostasis and in the immune system (the count of lymphocytes CD4, the concentration of IgG, the content of circulating immune complexes), 18 adult patients with HIV infection were examined, and in 8 of them thrombocytopenia was diagnosed. 10 patients without thrombocytopenia formed the control group. The study revealed that with the development of thrombocytopenia in patients with HIV infection the aggregation capacity of their blood platelets decreased, which correlated (p < 0.01) with a decrease in the count of lymphocytes CD4; this was indicative of the progress of immunodeficiency.

Acquired Immunodeficiency Syndrome↗
PubMed1995

[Hemostasis in pregnancy and antenatal fetal distress].

Study of the hemostasis system of pregnant women at risk of developing fetal distress in the third gestation trimester showed the prognostic significance of platelet aggregation test as an additional method of diagnosis of placental insufficiency. If platelet aggregation index is more than 70%, a woman should be included in the group at risk of developing ante- or intranatal fetal distress.

Adult↗