Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “HANDEDNESS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 937 records · Page 52Linked to original sources
PubMed1985

Imbalance of hemispheric functions in the major psychoses: a study of handedness in the People's Republic of China.

A study of hand preference and eye dominance in schizophrenia, manic-depressive psychosis, and normal controls was carried out in the People's Republic of China. An excess of sinistrality was found in both men and women schizophrenics, but not in manic-depressive patients. Both the manic-depressive and schizophrenic psychoses are characterized by a significant excess of left eye dominance and by an increasing divergence between eye and hand dominance when compared to the controls. The major published studies investigating hand preference in psychopathology are reviewed, and possible interpretations of the conflicting findings are suggested.

Adolescent↗
PubMed1991

Reimpressed selective breeding for lateralization of handedness in mice.

Eleven generations of bidirectional selection for lateralization produced 2 lines of mice that differ markedly in degree of asymmetry for hand preference. The foundation population was derived from 6 distantly related inbred strains and 2 stocks of wild mice, M. castaneus. HI line matings were made using mice that exhibited consistent right or left paw use in a food reaching task and LO line matings were made using mice with little overall paw preference. All matings were made without regard to the expressed directions of asymmetry. Line differences emerged at the third generation and increased thereafter. Selection was relaxed at generation 12 and the lines were maintained by random within-line mating. At generation 28 selective breeding was reimpressed for 3 generations. Results indicated that between-line divergence in degree of lateralization had remained high during 17 generations of relaxed selection. Mice of the HI line are more strongly lateralized than mice of the unselected HET population. Mice of the LO line are more weakly lateralized than controls. The selected lines may provide a useful mammalian genetic resource for studying the neurobiology of cerebral lateralization.

Animals↗
PubMed1992

Activity of the hypothalamic-pituitary-adrenal axis in mice selected for left- or right-handedness.

Asymmetry in brain modulation of the immune system has been previously described. In mice, paw preference has been shown to be associated with immune reactivity but the mechanisms involved in such an association are not yet known. The autonomic nervous system and the neuroendocrine system are considered as major candidates for neural influences on the immune system. In the present study, the activity of the hypothalamic-pituitary-adrenal (HPA) axis of adult female mice selected for paw preference (left-handers vs. right-handers) was assessed by measuring both adrenocorticotropic hormone (ACTH) and corticosterone plasma levels, as well as the in vitro responses of hypothalamus and adrenocortical cells to various hormone releasing stimuli. The results reported here showed no difference in the activity of the HPA axis between left- and right-handed mice, suggesting that this neuroendocrine axis is not implicated in the association between functional brain asymmetry and immune reactivity. However, our results do not exclude the possibility that the HPA axis could play a role in such an association under other circumstances, such as during development or stressful situations.

Adrenocorticotropic Hormone↗
PubMed1977

Asymmetries of the skull and handedness. Phrenology revisited.

Some of the asymmetries noted in cerebral computerized transaxial tomography (CTT) studies are reflected in the shape of the skull resulting most often in backward protrusion of the occipital bone on the left and a less striking forward protrusion of the right frontal bone. Asymmetries are less marked in left-handed individuals but the opposite features, i.e. forward protrusion of the left frontal bone and posterior protrusion of the right occipital bone, are more frequent in left handers than in right handers.

Adult↗