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At least 937 records · Page 52Linked to original sources
PubMed2004

1,2-Ethanedithiol-induced erythema multiforme-like contact dermatitis.

Contact dermatitis simulating erythema multiforme can be caused by many allergens. The chemical agent 1,2-ethanedithiol, which serves as a protective group in chemical synthesis, has hitherto only been implicated as an irritant. We report on a 22-year-old female chemistry student who developed widespread erythema multiforme-like lesions after local contact with 1,2-ethanedithiol. Many target lesions were observed bilaterally on her hands, forearms, arms, and on her forehead. One such lesion was histologically compatible with erythema multiforme. The patient had a positive patch test to 1,2-ethanedithiol, whereas none of 30 healthy subjects showed a positive reaction. However, eight of the 30 controls (26.7%) developed irritant reactions to 1,2-ethanedithiol. Cautious handling of the compound is a prudent precaution.

Adrenal Cortex Hormones↗
PubMed1995

[Erythema exsudativum multiforme major].

UNLABELLED: Erythema exudativum multiforme major (EEMM), also know as Stevens-Johnson syndrome, may cause severe conjunctival and corneal alterations. The etiology remains unknown. The aim of are study was to evaluate the clinical course, therapy and prognosis of ocular involvement. PATIENTS AND METHODS: In a retrospective study, we evaluated ten patients with EEMM who were treated between 1986 and 1994 at the University Eye Clinic Tübingen. RESULTS: The age of the four female and six male patients varied between 5 and 70 years. Drugs as a possible precipitating factor were found in all cases (acetylsalicylicacid, sulfonamide, erythromycin, cotrimoxazole, Valproinicacid, paracetamol). Eight patients experienced an infection at the same time. Clinically, we were able to differentiate two groups regarding severity of the disease. Seven patients were characterized by ocular alterations that only involved the conjunctiva, leading to conjunctival scars. In those cases local treatment with antibiotics and corticosteroids was effective. In the second group severe ocular damage occurred, with symblephara, keratinization and consecutive perforating keratoplasty. Secondary infections became evident in a total of six cases from the two groups. SUMMARY: Drugs as a possible precipitating factor could be identified in all cases. In eight of ten patients previous infection was known. This agrees with literatures reports of viral infections (e.g. herpes simplex) as cofactors causing EEMM, especially for the aggressive form, remains unresolved. The danger of possible superinfection should always be taken into consideration.

Adolescent↗
PubMed2003

Activity of Tumor Necrosis Factor-alpha (TNF-alpha) and its soluble type I receptor (p55TNF-R) in some drug-induced cutaneous reactions.

Plasma concentration of TNF-alpha and its type I receptor (p55TNF-R) was examined in 126 patients with drug-induced skin reactions using immunoenzymatic ELISA method. Patients were subdivided into 6 groups: maculopapular eruptions (ME), erythema multiforme (EM), erythema multiforme coexisting with erythema nodosum (EMN), hyperergic vasculitis (HV), Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). In the acute clinical stage highly significant (p<0.001) or significant (p<0.01) elevation of mean plasma concentrations of the cytokine and its receptor was found in all examined groups in comparison with the control. Clearing of clinical symptoms was connected with considerable decrease (p<0.001, p<0.01) of mean plasma levels of the both proteins in comparison with the before treatment values. TNF-alpha concentrations still remained significantly more elevated than those observed in the control. The results indicate that plasma activity of TNF-alpha and its p55 receptor change with the clinical course of the examined drug-induced skin reactions, which suggests the partake of both proteins in the pathogenesis of these diseases.

Adolescent↗
PubMed1996

Erythema multiforme-like reaction associated with radiotherapy.

Generalized cutaneous reactions in association with radiotherapy have in the past been grouped into erythema multiforme (EM) and erythema multiforme-like reactions, the latter being reactions that do not strictly fit the accepted clinical and/or histological criteria for EM, yet have similar findings or presentations. Though usually benign and self-limiting, the progression to Stevens-Johnson syndrome, a potentially fatal form of erythema multiforme, has been reported. Presented here is a case study of a less severe radiation-induced erythema-like reaction.

Breast Neoplasms↗
PubMed1990

[HLA pattern in patients with post-herpetic erythema exsudativum multiforme].

33 patients suffering from postherpetic erythema multiforme (PEM) were investigated with special reference to histocompatibility typing. In comparison with a control group (n = 54), we found strikingly high levels of HLA-DR1 and HLA-DR4 as well as a significantly elevated level of HLA-Cw3 in our patients (p less than 0.01).

Erythema Multiforme↗
PubMed1999

Lupus erythematosus with antiphospholipid syndrome and erythema multiforme-like lesions.

The occurrence of erythema multiforme (EM) in patients with lupus erythematosus (LE) has been described previously as a coincidental association. In contrast, LE with EM-like lesions and a peculiar immunological pattern, including positive rheumatoid factor, antinuclear antibodies and a serum antibody against an extract of human tissues recently recognized as similar to Ro (SSA), constitutes an established entity named Rowell's syndrome. We describe a woman with LE and long-standing widespread vesiculobullous and necrotic haemorrhagic EM-like lesions in combination with Ro (SSA) and scl-70 antibodies and the typical laboratory findings of the antiphospholipid syndrome (APS), namely lupus anticoagulant, anticardiolipin antibodies and prolonged activated partial thromboplastin time. This case could conceivably be consistent with a diagnosis of Rowell's syndrome, if the latter is regarded as a clinicopathological spectrum. However, the coexistence of LE, persistent EM-like disease and incomplete APS may also fulfil the diagnostic criteria for the 'multiple autoimmune syndromes'. We speculate that the laboratory markers of APS play a pivotal part in such an unusual clinical presentation.

Adult↗
PubMed1990

Drug-induced, photosensitive, erythema multiforme-like eruption: possible role for cell adhesion molecules in a flare induced by Rhus dermatitis.

Drug-induced, photosensitive erythema multiforme has not been reported, although drugs and sunlight are listed among precipitating factors in erythema multiforme. We describe a case of a drug-induced erythema multiforme-like eruption in a photodistribution that was reproduced by clinical challenge with the drug and sunlight. On contact with Rhus verniciflua, the Japanese lacquer tree, the patient had a flare of the eruption, which was limited to the areas previously exposed to sun. Immunohistochemical studies suggested that the keratinocytes in the skin that retain teh photoactivated substances may facilitate epidermal invasion of lymphocytes by persistent expression of intercellular adhesion molecule-1.

Adult↗
PubMed1999

[Erythema exsudativum multiforme with macroglobulinemia].

A case of a 47-year-old man with skin lesions of erythema multiforme and macroglobulinemia is reported. Histological changes corresponded with mixed dermoepidermal type of erythema multiforme and direct immunofluorescence showed fibrillar band with anti-IgM and anti-fibrin on basement membrane. Further examination revealed serum monoclonal IgM kappa with traces in urine. Association or coincidence of these findings is discussed.

Erythema Multiforme↗
PubMed1981

Cutaneous manifestations of systemic disease.

The skin should not be thought of as an isolated organ system. When the skin is involved by disease, other organs may be affected as well. Cutaneous xanthomas commonly occur with plasma lipid abnormalities, necrobiosis lipoidica diabeticorum with diabetes mellitus, and the porphyrias with altered heme synthesis. Erythema multiforme and erythema nodosum may be considered hypersensitivity reactions, occurring in response to a wide range of inciting agents, including infections, drugs, neoplasms, and rarely, collagen vascular diseases.

Adult↗
PubMed1986

Value of the assay for IgA-containing circulating immune complexes in Henoch-Schönlein purpura.

Using a modified Raji cell radioimmunoassay, IgA- and IgG-containing circulating immune complexes (IgA-CIC, IgG-CIC) were examined in the sera of 10 patients with Henoch-Schönlein purpura (HSP) and compared with those in the sera of patients with systemic lupus erythematosus (SLE), erythema multiforme (EM), erythema nodosum (EN) and Schamberg's disease. The mean level of IgA-CIC in HSP (233 micrograms/ml) was statistically higher than that in samples from healthy blood donors (14 micrograms/ml; p less than 0.05). In the other diseases, the mean values of IgA-CIC (SLE, 72 micrograms/ml; EM, EN, 0 microgram/ml; Schamberg's disease, 5 micrograms/ml) were not statistically different from that of normal controls. The IgA-CIC level in HSP rose markedly during the active phase of the cutaneous manifestation (233 micrograms/ml), declining to the normal range during remission (4 micrograms/ml; p less than 0.05). On the contrary, IgG-CIC did not increase during either phase. There was an isolated patient in whom IgA-CIC seemed to correlate with the clinical events of cutaneous and systemic involvement. The timing was such that a change in the level of IgA-CIC generally preceded disease activity. These findings suggest that IgA-CIC may be an etiologic factor in the cutaneous and systemic involvements of HSP, and the laboratory test for IgA-CIC is not only useful as a research tool, but also valuable as a predictive indicator of disease activity.

Adolescent↗
PubMed1985

The histologic spectrum of the reactive inflammatory vascular dermatoses.

The varied histopathology of the reactive inflammatory vascular dermatoses requires close cooperation between the clinician and the pathologist. This article presents an overview of the histology of this group of dermatoses, including the figurate erythemas, the pigmented purpuric eruptions, urticaria and urticarial vasculitis, Sweet's syndrome, erythema multiforme, and erythema nodosum.

Dermatitis↗