Prediction of diabetic retinopathy from color vision data.
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We have used a subthreshold summation protocol to analyze spatial color-color interaction. By means of a CRT color monitor, we measured the threshold contours for a spatial frequency of 0.5 cycles/degree. Heterochromatic flicker photometry was used to obtain isoluminance. The results suggest that the blue-yellow (b-y) and red-green (r-g) contrast thresholds remained unchanged by the addition of fixed r-g and b-y subthreshold pedestals. Our subthreshold summation data then support the stochastic independence of colorvision mechanisms derived from Mullen and Sankeralli's work [Vision Res. 39, 733 (1999)] despite the differences that exist between the two experimental methods.
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BACKGROUND: Visual assessment of cerebrospinal fluid (CSF) for xanthochromia (yellow color) is practiced by the majority of laboratories worldwide as a means of diagnosing intracranical bleeds. METHODS: Colorimetric and spectrophotometric analysis of CSF samples for recognizing the presence of bilirubin either in low concentrations or in the presence of hemolysed blood. RESULTS: The experiments provide the physiological and colorimetric basis for abandoning visual assessment of CSF for xanthochromia. CONCLUSIONS: We strongly recommend relying on spectrophotometry as the analytical method of choice.
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The major neurons and neural circuits that are involved in the transmission of color signals through the human retina to produce the color and spatially opponent P cell or midget ganglion cell responses are described. The older findings of single cone to midget bipolar connectivity is reviewed, and the single midget bipolar cell to midget ganglion cell connectivity as revealed by a recent serial section electron microscope study is described in detail. Our present knowledge concerning the discrimination of the blue-cone subtype from the other longer wavelength cones in the human at the outer plexiform layer is summarized, and our most recent findings concerning horizontal cell connectivity to the different spectral types of cones are discussed. Finally, a hypothetical pathway is proposed for color-opponent surrounds of midget ganglion cells using both horizontal cells at the outer plexiform layer and amacrine cell pathways at the inner plexiform layer.