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At least 937 records · Page 52Linked to original sources
PubMed1992

Detection of squamous cell cancer and pre-cancerous lesions by imaging of tissue autofluorescence in the hamster cheek pouch model.

Early detection of invasive and pre-invasive neoplasms of the aerodigestive tract will ultimately improve the management of patients with these lesions. This paper describes the use of quantitative fluorescence imaging of early squamous cell carcinomas in an animal model. Dysplasia, carcinoma in situ and invasive cancers were imaged exploiting tumour autofluorescence. Mapped biopsies were obtained from areas imaged determining a sensitivity of 100% and specificity of 80%. Autofluorescence imaging is an excellent method of detecting neoplasms of the aerodigestive tract.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1999

Placental glutathione S-transferase isoenzyme expression during promotion of two-stage hamster cheek-pouch carcinogenesis.

Glutathione S-transferases (GSTs) are the products of a multigene family. A well-established function of GSTs is to metabolize carcinogens by catalysing the conjugation of electrophilic substrates to glutathione. Whether placental GST (GST-P) is expressed during the promotion of two-stage hamster buccal-pouch mucosa (HBPM) carcinogenesis was investigated here, using 7,12-dimethylbenz[a]anthracene (DMBA) as the initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as the promoter. Cytoplasmic and nuclear staining for GST-P was seen in pouches treated with DMBA for 4 or 16 weeks, as well as in those treated with DMBA for 4 weeks and then TPA for 12 weeks. No GST-P positivity was seen in any pouches treated with only TPA or with mineral oil for either 4 or 16 weeks. The average number of GST-P-stained foci in the groups treated with DMBA for 16 weeks (246 +/- 96; mean +/- SD) or DMBA for 4 weeks followed by TPA for 12 weeks (186 +/- 67) was significantly higher than in pouches treated with only DMBA for 4 weeks (97 +/- 24). These results demonstrate that TPA alone is not sufficient for GST-P expression in hamster buccal pouch mucosa. However, after being initiated with DMBA, then promoted with TPA, GST-P activity is induced in hamster buccal pouch mucosa during squamous-cell carcinogenesis. This underpins the suggestion that GST-P may play an important part during the promotion stage of oral carcinogenesis.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1978

A subcutaneous pedicled cheek flap for reconstruction of alar defects.

The anatomy of the blood supply around the alar region was studied and showed that a large flap of nasolabial skin would survive on a narrow subcutaneous pedicle containing sufficient arteries and veins to justify the term "axial patterned flap". The secondary defect is closed with another nasolabial flap. In many cases a definitive single stage repair may be achieved. In others, some secondary revision has been required.

Adult↗