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PubMedDate not supplied

Craniofacial chondrosarcomas: imaging findings in 15 untreated cases.

Radiographic findings of 15 untreated chondrosarcomas of the cranial and facial bones were reviewed. These tumors have a propensity to occur in the wall of a maxillary sinus, at the junction of sphenoid and ethmoid sinuses and vomer, and at the undersurface of the sphenoid bone. Because of its slow-growing nature, chondrosarcomas tend to be large, multilobulated, and sharply demarcated when detected. Frequent bone changes are a combination of erosion and destruction, with sharp transitional zones and absent periosteal reaction. Tumor matrix calcifications, not necessarily chondroid, are almost always present. Both CT and MR may be necessary for thorough evaluation of tumor extent.

Adolescent↗
PubMed1989

Xylosyl transfer to the core protein precursor of the rat chondrosarcoma proteoglycan.

Rat chondrosarcoma chondrocytes were labeled with [3H]serine or [3H]mannose as a precursor. Intracellular proteoglycan core protein precursor was purified from cell lysates by immunoprecipitation with polyclonal antibodies against the hyaluronic acid-binding region, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The core precursor was eluted from the gels and treated with alkaline borohydride in order to convert serine residues substituted with xylose or N-acetylgalactosamine to alanine (or with alkaline sulfite to convert them to cysteic acid). After acid hydrolysis, the proportions of labeled serine and alanine (or cysteic acid) were determined by high performance liquid chromatography, and the results were compared with those obtained for the completed proteoglycan molecules isolated from the same cultures. In the completed proteoglycans, about 55% of the serine residues were substituted with xylose or N-acetylgalactosamine, while the corresponding figure for the intracellular precursor molecules was less than 5%. These results indicate, in agreement with our previous kinetic data, that the major part of the xylosyl transfer to the chondrosarcoma proteoglycan core protein precursor must occur late in the processing sequence, i.e. after about 85% of its intracellular lifetime and no more than 7 min before the addition of the rest of the chondroitin sulfate chain. The ratio of [3H]mannose to [3H]fucose in the core precursor was about 19, while that for the complete proteoglycan was about 2. This indicates the presence of high mannose, N-linked oligosaccharides on the core protein precursor which are converted to the complex forms on the completed proteoglycan. These data provide further support that the core precursor resides mainly in the pre-Golgi compartment and that xylosylation occurs mainly in a Golgi compartment.

Acetylgalactosamine↗
PubMed1989

[Malignant soft tissue tumors of the hand: report of 2 malignant fibrous histiocytomas and 2 extraskeletal myxoid chondrosarcomas].

The authors discusses two malignant tumors of the soft tissue of the hand: the malignant fibrous histiocytoma and the extraskeletal myxoid chondrosarcoma. With each tumor two patients were involved. One patient with malignant fibrous histiocytoma required amputation at the fourth and fifth carpometacarpal joints, one patient with extraskeletal myxoid chondrosarcoma amputation in the proximal third of the forearm. Both remained free of metastases. Also the other two patients after surgical excision and amputation in the third metacarpal bone respectively, are free of recurrences or metastases till now.

Adult↗
PubMed1989

Myxoid chondrosarcoma of the mediastinum.

We report a unique case of primary myxoid chondrosarcoma in the posterior mediastinum. This lesion clinically mimicked a neurogenic tumor due to its location and dumbbell appearance. The histogenesis of this tumor is discussed and a skeletal origin from the thoracic vertebrae is suggested. It is concluded that myxoid chondrosarcoma has to be distinguished for the differential diagnosis among the long list of myxoid tumors arising in the posterior mediastinum.

Chondrosarcoma↗
PubMed1989

Chondrosarcoma and malignant lymphoma.

We describe two primary malignancies occurring simultaneously. The coexistence of chondrosarcoma and malignant lymphoma, small lymphocytic type (MLSL) (WDLL) is a rare occurrence. In this case, the untreated malignant lymphoma appears to have increased the aggressiveness of the chondrosarcoma through its adverse effect on the host's immune system.

Chondrosarcoma↗
PubMedDate not supplied

Intracerebral mesenchymal chondrosarcoma.

The current case report deals with a 14-year-old girl with an intracerebral mesenchymal chondrosarcoma which has been recognized in two males and two females varying from 25 to 59 years of age. Three of the five patients had an associated malignant glioma. The present girl died eight years after her initial neurologic deficits and never received any definitive treatment for her deep seated neoplasm. These unique sarcomas may be confused with vascular lesions and have not been found to spread through the neuraxis. This unusual primary intracerebral mesenchymal chondrosarcoma appears to represent a field phenomenon with cartilaginous differentiation of glial and mesenchymal elements in the central nervous system.

Adolescent↗
PubMedDate not supplied

[Chondrosarcoma of the larynx: review of the Western literature and presentation of a new case].

We present the case of a 70 year old man with cricoid chondrosarcoma treated with total laryngectomy. This report reviews the occidental literature, with nine cases reported by national authors in the las 25 years. We have recollected 104 laryngeal chondrosarcoma, in all. Clinical and diagnostical data, location, and treatment were analysed and compared with our case.

Aged↗
PubMed1989

Chondrosarcoma of the larynx.

Two cases of laryngeal chondrosarcoma are described. The first exhibited a fibrosarcomatous differentiation, which is a rare finding in chondrosarcoma and usually indicates poor prognosis. The second was found in a larynx six years after Teflon injections for the treatment of vocal cord paralysis. The possibility of Teflon as a tumorigenic factor in this case is raised.

Aged↗
PubMed1978

Mandibular metastasis of an extraskeletal myxoid chondrosarcoma arising on the plantar surface of the foot: report of case.

This paper presented a discussion of the initial appearance and atypical clinical course, histopathology, treatment, and prognosis of a case of extraskeletal myxoid chondrosarcoma that originated on the plantar surface of the left foot and that metastasized to the mandible. The clinical behavior of this neoplasm, as reported, is distinctively less aggressive and therefore thought to have a better prognosis than chondrosarcoma of bone. Contrary to the biologic behavior reported in the literature, however, our patient had a less than six-year remission from the neoplasm.

Adult↗
PubMed1989

Chondrosarcoma of the spine.

Twenty patients were diagnosed as having chondrosarcoma of bone that originated in the spine and, except for one, were treated surgically at the Mayo Clinic. The patients' ages ranged from eighteen to seventy years. Pain in the area of involvement was the first symptom in nearly all patients. Nearly one-half of the patients had detected a mass before being diagnosed. In addition, nine patients had neurological symptoms and signs when they were first seen. All patients had a surgical biopsy of the lesion, often combined with decompressive laminectomy. Five patients received postoperative radiation therapy in various dosages. No patient received adjunctive chemotherapy. All but five patients died of local progression of the disease. The five-year survival rate was 55 per cent. The median length of survival was six years. Although it is rare, chondrosarcoma of the spine can usually be identified on radiographs. Preoperative assessment must include computed tomography, magnetic resonance imaging, and, possibly, arteriography to assess the precise extent of the disease. Although surgical ablation often is technically difficult, a wide excision should be attempted. If this is not obtainable, postoperative radiation therapy should be considered.

Adolescent↗
PubMed1979

Chondrosarcoma of the maxilla: report of case.

Chondrosarcomas of the jaws are rare tumors; an additional case in the maxilla is described. The literature that discusses the pathogenesis of the tumor, its biological behavior, and the preferred treatment is reviewed. The histologic differentiation between chondrosarcoma and benign cartilagenous tumors is discussed.

Adult↗
PubMed1987

[Mesenchymal chondrosarcoma. Anatomico-clinical, immunohistochemical and ultrastructural study. Apropos of a case].

One case of mesenchymal chondrosarcoma of the mandible is reported in a 18 years-old man. The patient noted swelling and pain and roentgenography showed an osteolytic lesion of the right mandible. Histologically, the feature was obvious with chondroid sheets of round ovoid or elongated cells. Immunohistochemically, numerous cells had positive S-100 protein and vimentin. The electron microscopy showed numerous undifferentiated cells and also fibroblastic and cartilaginous cells. The prognosis of this tumor, usually bad, cannot be yet appreciated in this case (follow-up of only 3 months). The histogenesis of this peculiar variety of chondrosarcoma is discussed.

Adolescent↗
PubMed1988

Dedifferentiated chondrosarcoma of bone with leiomyosarcomatous mesenchymal component: a case report.

Dedifferentiated chondrosarcomas are well-described aggressive tumors arising from low-grade chondrosarcomas and containing high-grade mesenchymal sarcomatous components. These tumors are important to consider in the differential diagnosis of well-defined lytic lesions in the pelvis associated with large soft-tissue components. We present the plain film, computed tomographic, and angiographic findings of the first such reported tumor containing a leiomyosarcomatous component.

Bone Neoplasms↗
PubMedDate not supplied

Chondrosarcoma of the trachea. A case report and literature review.

The cytologic presentation of a case of chondrosarcoma of the trachea in a 72-year-old man is described. A mass detected on routine chest roentgenogram and defined by CT scan was used to make a touch imprint smear during partial tumor resection. The cytologic findings included round or polygonal cells with occasional binucleation, round hyperchromatic nuclei and prominent nucleoli, present in an amorphous pink-violet or light-blue background containing fragments of chondroid tissue. The histopathology was interpreted as a low-grade chondrosarcoma. Cartilaginous tumors of the trachea should be considered in the differential diagnosis of upper airway obstruction.

Aged↗
PubMed1988

[Compression of the median nerve by chondrosarcoma of the hand].

The authors report a case of median nerve compression due to a chondrosarcoma of the wrist. A 30 year-old right handed man complained of typical symptoms of median nerve compression. X-ray examination showed normal findings. During operation a more proximal lumbrical origin was the only abnormal finding. After nerve decompression pain relief was prompt. Six months later the patient again complained of symptoms of median nerve compression. Now X-ray examination showed scattered punctuate calcific densities of dystrophic calcification. The tumor was histologically shown to be a chondrosarcoma. It was treated by wide local excision and radiation therapy.

Adult↗