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PubMed2007

Reduced endothelial progenitor cells in European and South Asian men with atherosclerosis.

BACKGROUND: Circulating endothelial progenitor cells (EPCs) play a role in the repair and regeneration of the endothelium and may represent a novel cardiovascular risk factor. South Asian subjects have an increased risk of cardiovascular disease which is not fully explained by known risk factors. This study examined associations of EPCs with atherosclerosis and possible ethnic differences in EPCs. MATERIALS AND METHODS: A population sample of 58 European and South Asian adult men was enriched with the recruitment of an additional 59 European and South Asian men with known coronary disease. The coronary artery calcification score was measured by multi-slice computerized tomography (CT), carotid and femoral intima-media thickness (IMT), and femoral plaques were measured by ultrasound. The subjects were further subdivided into three categories of coronary artery disease on the basis of coronary artery calcification score and clinical history. Total EPCs and non-senescent EPCs (ns-EPCs) were quantified after 5 days cell culture and the number of late outgrowth colonies was measured over a 6-week test period. Circulating CD34+ haematopoietic precursor cells were measured by flow cytometry. RESULTS: Individuals with femoral plaques had reduced total and ns-EPCs. The number of ns-EPCs were reduced in individuals with the most coronary atheroma and were inversely related to the coronary calcification score and femoral IMT. These relationships persisted after multivariate adjustment for other risk factors. The numbers of late outgrowth colonies or circulating CD34+ cells were unrelated to the presence of atherosclerosis. There were no differences in the number of EPCs between European and South Asian subjects. CONCLUSION: The number of EPCs are reduced in subjects with atherosclerosis independent of other risk factors. Reduction in EPC numbers may be an independent risk factor for atherosclerosis but does not explain ethnic differences in cardiovascular risk.

Aged↗

PubMed1998

Erbium:YAG laser resurfacing in Asians.

BACKGROUND: Although laser resurfacing has become increasingly popular in the treatment of Caucasian skin, concerns about healing and postinflammatory pigmentary changes have limited its use in Asian skin. OBJECTIVE: The purpose of this study was to determine the efficacy and safety of the Erbium(ER):YAG laser used in the treatment of Asian skin. METHODS: Fifty Asian individuals with Rhytids, scars, pigmentary alteration, and a variety of cutaneous growth were treated with the Erbium:YAG laser. Patients were evaluated for clinical efficacy, wound healing, post-operative erythema, and post-inflammatory pigmentary changes. RESULTS: Significant improvement was noted in all individuals. Shorter periods for re-epithelization and erythema duration were noted when compared to previously reported results following carbon dioxide laser resurfacing. CONCLUSION: The Erbium:YAG laser is safe and effective in the treatment of Asian skin.

Adolescent↗

PubMed1988

Opiate antagonist nalmefene inhibits ethanol-induced flushing in Asians: a preliminary study.

Ethanol-induced flushing (EIF) occurs in up to 80% of Asians and is characterized by facial flushing, tachycardia, and increased cardiac output. Since endogenous opiates and prostaglandins may be mediators of flushing syndromes, we attempted to block EIF in four Asian flushers with single doses of either the opiate antagonist nalmefene, or the prostaglandin synthesis inhibitor indomethacin. Nonflushers (2 Caucasian, 2 Asian) and four Asian flushers were given on separate days water, ethanol (0.4 g/kg p.o.), ethanol plus nalmefene (2 mg i.v.), or ethanol plus indomethacin (50 mg p.o.). Ethanol concentrations of flushers and nonflushers were similar. Mean (+/- SEM) plasma acetaldehyde concentrations of flushers (28.2 +/- 11.8 microM) were significantly greater than nonflushers (1.4 +/- 0.5 microM) following ethanol ingestion (p less than 0.001). Ethanol alone always induced a significant rise in facial skin temperature [mean area under the curve (AUC) = 5142 +/- 648 % delta T x min, p less than 0.01] and of pulse (mean AUC = 1622 +/- 120 bpm x min, p less than 0.001) in flushers compared to water ingestion. A single dose of nalmefene (2 mg i.v.) but not indomethacin (50 mg p.o.), reduced the mean (+/- SEM) ethanol-induced rise in facial skin temperature of flushers by 58 +/- 14% (p less than 0.05) without changing plasma acetaldehyde concentrations. These data are preliminary evidence that the opiate antagonist, nalmefene, blocks some of the vascular manifestations of EIF without altering the elevated plasma concentrations of acetaldehyde.

Acetaldehyde↗

PubMed2000

Organ donation and culture: a comparison of Asian American and European American beliefs, attitudes, and behaviors.

The well-known gap between organ-donor supply and demand in the United States is particularly acute for Asian Americans. Lower participation in organ donation programs by Asian Americans has been hypothesized as one explanation for this observation. This study finds that, relative to European Americans, Asian Americans hold more negative attitudes toward and participate less frequently in a large, urban organ-donor program. The study also hypothesizes and test possible reasons for subcultural differences in attitudes toward donation. Two cultural belief constructs hypothesized to more strongly predict Asian American attitudes and behaviors appear to impact both groups equally. Reasons for these results along with public policy implications and future research directions are discussed.

Black or African American↗

PubMed1994

Comparison of aminoglycoside pharmacokinetics in Asian, Hispanic, and Caucasian patients by using population pharmacokinetic methods.

A population pharmacokinetic model for aminoglycosides was developed from 24 Hispanic, 16 Asian, and 22 Caucasian patients. A nonparametric expectation maximization algorithm for population modeling was used. With this one-compartment model, the parameters were the slope of the apparent volume of distribution versus weight (VS) and the slope of the elimination rate constant versus the creatinine clearance rate (KS). The mean VS (+/- standard deviation) was not different at 0.264 (+/- 0.05), 0.248 (+/- 0.055), and 0.260 (+/- 0.080) liter/kg of body weight for Asian, Hispanic, and Caucasian populations, respectively (P > 0.10). The KS means +/- standard deviations were 0.00424 +/- 0.00129, 0.00404 +/- 0.00160 and 0.00394 0.00103 [h(ml/min/1.73 m2)]-1 +/- for Hispanic, Asian, and Caucasian populations, respectively. Again, there was no statistical difference among the groups (P > 0.10). In conclusion, there are no differences in aminoglycoside pharmacokinetics among Asian, Hispanic, and Caucasian patients.

Adult↗

PubMed2005

Immunogenicity of routine vaccination against diphtheria, tetanus, and Haemophilus influenzae type b in Asian infants born in the United Kingdom.

AIM: To determine the immunogenicity of routine vaccination against diphtheria, tetanus, and Haemophilus influenzae type b (Hib) in Asian infants born in the UK, and whether maternal antibody suppression occurs. METHODS: A cohort study with 80% power, within 95% confidence limits, to show that 80% or fewer Asian infants would respond with an anti-PRP antibody concentration >0.15 microg/ml. Infants of South Asian origin born in Berkshire were enrolled at two general practices in Reading: 41 Asian families sequentially asked to participate within 2 weeks of birth; 36 infants were enrolled and 34 completed the study. Main outcome measures were: antibody concentration against diphtheria, tetanus, and Hib expressed as geometric mean titres (GMT) and proportion of infants about a threshold protective antibody concentration. RESULTS: Median age for completing primary vaccination course was 5 months. All 34 achieved anti-PRP antibody concentration of >0.15 microg/ml, 33 were >1.0 microg/ml, and the GMT was 15.0 microg/ml. All infants developed protective antibody concentration >0.1 IU/ml for tetanus and diphtheria; the respective GMTs were 1.94 and 5.57 IU/ml. Infants with high (>0.25 IU/ml) antibody concentrations against diphtheria and tetanus at 2 months achieved lower antibody concentrations after their three dose course than those with low concentrations (<0.1 IU/ml) (p = 0.06 and 0.03, respectively). CONCLUSIONS: Despite evidence for maternal antibody suppression of the response to tetanus and diphtheria vaccination, excellent antibody responses were achieved by routine vaccination according to the accelerated schedule. High vaccine coverage should be encouraged to provide protection against the possibility of imported infection.

Antibodies, Bacterial↗

PubMed2005

An excess of widespread pain among South Asians: are low levels of vitamin D implicated?

BACKGROUND: Anecdotal reports from rheumatologists in the United Kingdom suggest that patients from South Asian backgrounds are more likely to report widespread body pain. OBJECTIVE: To confirm the presence of an excess of widespread pain in South Asians, and to evaluate the relationship of their symptoms with levels of 25-OH vitamin D. METHODS: Two population studies involving over 3135 subjects were carried out in the North West and Midlands areas of England. RESULTS: The first study confirmed an excess of widespread pain among South Asians (OR = 1.6, 95% CI 1.3 to 2.1). The second smaller study conducted only among young women also showed a similar excess of widespread pain among South Asians (OR = 1.8, 95% CI 0.7 to 4.7) and found that low levels of 25-OH vitamin D (<10 ng/ml) were more common among those with widespread pain (OR = 3.5, 95% CI 0.4 to 31.0). CONCLUSIONS: Owing to the small numbers, the relationship between 25-OH vitamin D and widespread pain must be considered preliminary and requires further investigation. However, it may be one potentially treatable cause of widespread pain.

Adolescent↗

PubMed2005

Stereotype content model explains prejudice for an envied outgroup: Scale of anti-Asian American Stereotypes.

The Stereotype Content Model hypothesizes anti-Asian American stereotypes differentiating two dimensions: (excessive) competence and (deficient) sociability. The Scale of Anti-Asian American Stereotypes (SAAAS) shows this envious mixed prejudice in six studies. Study 1 began with 131 racial attitude items. Studies 2 and 3 tested 684 respondents on a focused 25-item version. Studies 4 and 5 tested the final 25-item SAAAS on 222 respondents at three campuses; scores predicted outgroup friendships, cultural experiences, and (over)estimated campus presence. Study 6 showed that allegedly low sociability, rather than excessively high competence, drives rejection of Asian Americans, consistent with system justification theory. The SAAAS demonstrates mixed, envious anti-Asian American prejudice, contrasting with more-often-studied contemptuous racial prejudices (i.e., against Blacks).

Analysis of Variance↗

PubMed2005

Attitudes toward rape: a comparison between Asian and Caucasian college students.

The purpose of this study is to investigate differences in attitudes toward rape between Asian and Caucasian college students. The Attitudes Toward Rape scale was used to measure beliefs about rape in a convenience sample of 169 college students. Three items regarding stranger rape myths were added. Findings suggest that Asian students are more likely than Caucasian students to believe women should be held responsible for preventing rape and to view sex as the primary motivation for rape. Asians also have stronger beliefs than Caucasians do that victims cause the rape and that most rapists are strangers. This research suggests that outreach programs can play an important role in providing information, education, and prevention regarding rape and that males and Asian students should be target populations for such programs.

Adult↗

PubMed2005

Centile values for serum lipids and blood pressure for Asian Indian adolescents.

BACKGROUND: Reference data for plasma lipids and blood pressure are not available for Asian Indian adolescents. This study aimed to develop representative age- and sex- specific percentile reference data for serum lipids [total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), non-HDL cholesterol] and blood pressure for urban Asian Indian adolescents aged 14-18 years. The sample consisted of 680 boys and 521 girls aged 14-18 years from the cross-sectional population survey, Epidemiological Study of Adolescents and Young Adults (ESAY) for whom the data for serum lipid levels and blood pressure were recorded. Smoothed age- and sex- specific 5th, 10th, 25th, 50th, 75th, 85th, 90th and 95th percentiles where derived using LMS regression. RESULTS: Percentile-based reference data for serum lipids and blood pressure are presented for adolescent Asian Indian boys and girls for the first time. Asian Indian adolescents had lower levels of serum TC, LDL-C and HDL-C and higher TG than their counterparts in the USA. Interesting trends in TC and HDL-C levels where observed, which might reflect changes in dietary pattern and physical activity in this age group in India. CONCLUSION: These reference data could be used to identify adolescents with an elevated risk of developing dyslipidemia, hypertension and cardiovascular disorders, to plan and implement preventive policies, and to study temporal trends.

Adolescent↗

PubMed2026

Genomic reconstruction of the Pakistani Roma reveals dual South Asian ancestry, medieval bottlenecks, and the early dispersal routes of the Romani people.

The Roma people represent one of the largest and most historically enigmatic diasporas in Eurasia, illuminating human migration patterns and cultural resilience across continents. Despite extensive research on European Roma as the diaspora endpoint, the genetic legacy of their putative South Asian source populations remains critically underexplored, leaving fundamental gaps in understanding the pre-diaspora demographic structure and early dispersal dynamics. This study uniquely positions Pakistani Roma as a potential ancestral reservoir, offering a rare window into the pre-migration phase distinct from derived European Roma populations shaped by centuries of post-dispersal admixture. We analyze 82 Pakistani Roma from Punjab using high-resolution genome-wide SNP data and comprehensive mitochondrial haplogroup profiling to reconstruct their genetic origins, population structure, and historical trajectory. Analyses reveal a dual ancestry profile comprising 50-82% Indus Valley related, 20-30% Onge related, and up to 26% Steppe derived components, with three distinct subgroups exhibiting varying affinities along a South Asian to Central Western Eurasian continuum reflecting jati-like endogamy. A severe demographic bottleneck ~800 years ago coincides with medieval socio-political upheavals, while major Eurasian admixture is dated to ~660 years ago. Mitochondrial haplogroups H (45.12%) and M (26.83%) underscore dual maternal influences from West and South Eurasia. Pakistani Roma retain substantially higher South Asian ancestry than their European counterparts, establishing them as a genetically distinct population preserving the ancestral pre-diaspora state. These findings redefine the Romani origin narrative and underscore the critical value of understudied South Asian minorities in reconstructing complex human migration pathways and diaspora formation mechanisms.

Humans↗

PubMed2004

Ethnic differences in cardiovascular responses to laboratory stress: a comparison between asian and white americans.

Compared to other ethnic groups, Asian Americans show significantly lower rates of cardiovascular disease (CVD). We tested the hypothesis that Asian Americans would show reduced cardiovascular responses to laboratory stressors than Caucasians. Forty-three Asians (18 men, 25 women) and 77 Caucasians (36 men, 41 women) with a mean age of 24 years (SD = 3.93) participated in a stress reactivity protocol consisting of four tasks (speech, serial subtraction, mirror tracing, handgrip) while heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were measured. Asian Americans demonstrated overall lower reactivity across tasks for SBP F(1,117 = 7.48, p < .01) and a trend toward lower HR response F(1,117 = 3.18, p < .10). A significant ethnicity by task interaction was observed for HR reactivity F(3,351 = 2.94, p < .05) such that Caucasians showed greater responses for the subtraction task.

Adult↗

PubMed2002

School nursing in an underserved multiethnic Asian community: experiences and outcomes.

Based on an Asian faculty's previous work, University of South Alabama College of Nursing conducted a project targeting the Asian population in Bayou La Batre, Alabama. The Helene Fuld Health Trust, HSBC, Trustee funded the project to demonstrate effective models for involving nursing students and faculty members in community-based practice. This project provided health services and developed educational programs for this underserved population. To facilitate entry into the Asian community, the College established clinical sites at 2 schools in Bayou La Batre that had the highest concentration of Asians in Mobile County's public school system. The purpose of the project was to develop a new curriculum, to involve nursing students in community-based practice, and to provide health care services in the community. The health services, educational programs, and community instructional activities generated substantial outcomes for the targeted population as well as nursing students. Nursing students learned to assess aggregates, plan, and evaluate interventions. The learning outcomes of the nursing students were evaluated using objectives developed in accordance with Bloom's (1956) Taxonomy. The project not only complemented and expanded existing school health services and programs but also filled the void in some health service and program areas. Preliminary evaluation of the project revealed overwhelmingly positive feedback from both the nursing students and Bayou La Batre school teachers. This article also explores the implications of the newly issued "National Standards for Culturally and Linguistically Appropriate Services in Health Care" for nursing education in the contexts of the Census 2000 and the megatrend of globalization.

Alabama↗

PubMed2006

Blood mercury reporting in NHANES: identifying Asian, Pacific Islander, Native American, and multiracial groups.

INTRODUCTION: Asians, Pacific Islanders, and Native Americans are a potentially high-risk group for dietary exposure to methylmercury through fish consumption. However, blood mercury levels in this group have not been identified in recent reports of the National Health and Nutrition Examination Survey (NHANES) for the years 1999-2002. METHODS: We used NHANES data from 1999-2002 to obtain population estimates of blood mercury levels among women of childbearing age classified as belonging to the "other" racial/ethnic group (Asian, Pacific Islander, Native American, and multiracial; n = 140). Blood mercury levels in this group were compared with those among all other women participants, classified as Mexican American, non-Hispanic black, non-Hispanic white, and "other" Hispanic. RESULTS: An estimated 16.59 +/- 4.0% (mean +/- SE) of adult female participants who self-identified as Asian, Pacific Islander, Native American, or multiracial (n = 140) had blood mercury levels > or = 5.8 microg/L, and 27.26 +/- 4.22% had levels > or = 3.5 microg/L. Among remaining survey participants (n = 3,497), 5.08 +/- 0.90% had blood mercury levels > or = 5.8 microg/L, and 10.86 +/- 1.45% had levels > or = 3.5 microg/L. CONCLUSIONS: Study subjects in NHANES who self-identified as Asian, Pacific Islander, Native American, or multiracial had a higher prevalence of elevated blood mercury than all other racial/ethnic participants in the survey. Future studies should address reasons for the high mercury levels in this group and explore possible interventions for lowering risk of methylmercury exposure in this population.

Adolescent↗

PubMed1998

Substance abuse among Southeast Asians in the U.S.: implications for practice and research.

The literature on Asian-American substance use has shown a general increase in consumption and related problems due, in part, to the effects of acculturation toward U.S. drinking norms. Southeast Asians are the most recent of Asian groups to come to the U.S., and have done so following an immigration and refugee experience that was among the most traumatic in recent memory resulting in significant levels of psychosocial distress. The combined influences of mental health disorders, which frequently co-occur with substance abuse, and acculturation pressures suggest that a significant increase in substance abuse problems may be in progress for Southeast Asian immigrants. Preliminary evidence appears to bear out this hypothesis. The current article outlines the literature on substance abuse among Vietnamese, Cambodians and Laotians in the U.S., and makes tentative recommendations for assessment, treatment and future research.

Acculturation↗

PubMed2002

Understanding and treating the ethnically Asian client: a collectivist approach.

Asian clients represent a growing population of clients seeking professional assistance for a variety of social and emotional difficulties. Ethnically Asian clients often have a collective notion of "self" which is highly influenced by family and culture. Clinical work with Asian clients requires very different treatment strategies than those used in work with western clients whose notion of "self" is far more individualistic. The cultural issues at play in the development of a "Collective Self" are described in the article along with common crisis situations which often require the Asian client to seek treatment.

Adaptation, Psychological↗

PubMed2003

Representations of desires in some recent gay Asian-American writings.

This article explores conceptions of same-sex sexual behavior and desires by American gay males who grew up in Pacific Island or Asian societies. In the absence of systematic survey data, representations, which are not assumed to be autobiographical, by two South Asian émigrés to Canada (Badruddin Khan and Shyam Selvadurai), two second generation Filipino-Americans (Joël Tan and Ricardo Ramos), a second generation Chinese-Hawaiian (Norman Wong) and three men of Chinese descent born and raised in Southeast Asia (Lawrence Chua, Justin Chin, and T. C. Huo) are examined. The unsatisfying script of sexual submission of Asians to whites is particularly central, except for the South Asians. These books provide recurrent evidence of role distance, of switching roles (often without rewriting a dominance-submission conception of insertion-reception) and of some degree of reconceiving the (sexual) self.

Asian↗

PubMed2006

Asian American adolescents' first sexual intercourse: gender and acculturation differences.

CONTEXT: Interventions aimed at adolescents need to be culturally specific. The dearth of data on Asian American adolescents has made it difficult to meet their needs. METHODS: Data from the National Longitudinal Study of Adolescent Health were used, with a sample of 323 Asian American female adolescents and 366 Asian American male adolescents. Logistic regression analysis was used to assess the association between acculturation at Wave 1 (1995) and sexual experience at Wave 2 (1996), controlling for demographic, psychosocial and family variables. RESULTS: Overall, 24% of young women and 20% of young men had had sexual intercourse. Among young women, the most acculturated were more likely to have had sexual intercourse than the least acculturated (odds ratio, 4.9); acculturation was not associated with sexual intercourse for young men. Medium and high levels of parental attachment were associated with decreased odds of sexual experience for young women (0.4 and 0.2), but not for young men. Binge drinking was associated with an increased risk of sexual experience for young women (6.4), and tobacco use was associated with increased risk for young men (3.0). CONCLUSIONS: Like all adolescents, Asian Americans are at high risk for the consequences of sexual activity. For this fast-growing population, there is a crucial need for preventive programs that are culturally sensitive, inclusive of family and gender-specific.

Acculturation↗