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PubMed1996

Lorazepam impairs perceptual integration of visual forms: a central effect.

Previous studies have shown a lorazepam effect on visual perception. We tested whether this impairment resulted from a peripheral effect induced by benzodiazepines. A first experiment showed that a single dose of lorazepam induces an oculomotor imbalance without impairing visual acuity or accommodation. In a second experiment, we tested whether the impairment induced by lorazepam on visual perception still occurred in monocular vision. Subjects matched incomplete forms controlled on the spacing and alignment of their local contour elements. A reference object was first displayed and followed by two laterally displayed objects, a target and a distractor. The distractor was the mirror-reversed version of the target. Performance was impaired in the lorazepam group when the reference was an incomplete form with a spacing of 10.8' or 22.2' of arc. These results were not correlated with sedation. They confirm that lorazepam has a central deleterious effect on visual perception. A post-hoc analysis also suggested that lorazepam-treated subjects used asymmetry in the stimuli as a compensatory strategy. This result is discussed in relation to previous hypotheses about the physiological mechanisms that determine the effects of lorazepam on visual perception.

Accommodation, Ocular↗
PubMed1977

[Results of objective accommodation determination in eyes with alternating functional central scotoma (alternating strabismus) (author's transl)].

Objective determination of monocular accommodation in young eyes revealed a different behaviour in strabismus alternans from that in normal binocular vision. This manifested itself by strongly differing individual responses, less correct values in physiological and unphysiological accommodation tests, and different reactions on hindering clear vision that cannot be compensated by refraction changes. The possibility of central scotoma, persisting during fixation and varying in density, occurring in alternating strabismus, is discussed.

Accommodation, Ocular↗
PubMed1975

[Posttraumatic unilateral aphakia and contact lens -binocular functions of grown-ups].

The binocular results are only subnormal and comparable to former squinting patients. The results are better if one succeeds in reaching a visual acuity of at least 1.0. One can try to prevent a divergence by prescribing a contact lens as early as possible. Presbyopic patients have better binocular functions because the lost accommodation is the most interfering component (factor). It has disadvantageous effects especially on those patients who are yet presbyopic. The aniseikonia is in contrary to this not an as important interfering factor.

Accommodation, Ocular↗
PubMed1997

Retinal projections to the accommodation-related area in the rostral superior colliculus of the cat.

Results of previous studies have indicated that the rostral superior colliculus (SC) plays an important part in the control of accommodation. The present study was carried out to investigate retinal projections to the accommodation-related area in the rostral SC. We injected WGA-HRP into the accommodation-related area in the rostral SC of the cat, where accommodative responses were elicited by stimulation with weak currents of less than 20 microA. Following injection of WGA-HRP into the accommodation-related area in the rostral SC, retrogradely labeled ganglion cells were observed mainly in the area centralis. Projections from the contralateral eye were denser than those from the ipsilateral eye. Almost all retrogradely labeled cells were classified as gamma-cells owing to their small cell-body diameters and thin dendrites, although a few were classified as alpha-cells. These findings suggest that the accommodation-related area in the rostral SC is located in the portion corresponding to the area of representation of the central visual field and receives mainly gamma-cell projections.

Accommodation, Ocular↗
PubMedDate not supplied

Analysis of accommodation function with ultrasonography.

The aim of this study was to present a new method that uses ultrasonography to analyse accommodation function, and to do a preliminary investigation of its possible use in clinical practice. Using the method of continuous ultrasonographic biometry, changes in lens thickness were measured during accommodation. From these measurements response latency and duration were determined. Normal values for latency and duration were obtained by measuring 20 healthy subjects of different ages. Measurements were also performed on three patients with different accommodation disorders: diabetes, Adie's syndrome and third nerve palsy. Normal response latency is 394 ms (+/-46 SD) and independent of are. Normal response duration increases with age from an average 306 ms at 15 years-of-age to an average 954 ms at 55 years-of-age. Normal latency as well as duration appear to have a large interindividual variability. The diabetic patient had a delayed latency but a normal response duration. The patient with Adie's syndrome had a delayed latency and prolonged duration. The patient with third nerve palsy had a normal latency and duration. We conclude that ultrasonographically determine latency and duration give additional information on accommodation function that is more complete and objective than maximum accommodative amplitude alone. The results in our patients suggest that, in selected cases, this information may aid in the diagnosis and management of patient's complaints.

Accommodation, Ocular↗
PubMedDate not supplied

A behavioral link between the oculomotor and cardiovascular systems.

Although the eyes and the heart serve very different purposes, each receives autonomic innervation. Capitalizing on recent theoretical and technological innovations in the understanding and assessment of oculomotor and cardiovascular behavior, three experiments measured behavioral covariation between the oculomotor and cardiovascular systems. Measures of dark focus and dark vergence indexed oculomotor tone, and the spectral decomposition of variations in heart rate indexed cardiovascular control mechanisms. In Experiment 1, individual differences in cardiovascular parameters could predict individuals' dark vergence (R2 = .806) but not their dark focus (R2 = .404). In Experiment 2, the same parameters were measured from subjects who experience either panic attacks (n = 11) or blood phobia (n = 9). Heart rate was positively correlated with dark vergence and the two subject groups were separable based on both oculomotor and cardiovascular variables. Using a within-subjects approach, Experiment 3 found that both dark vergence and dark focus tended to be nearer during sympathetic dominance of the heart than during parasympathetic dominance, within-subjects variations in cardiovascular parameters could predict dark focus, and between-subjects variations in interbeat intervals could predict dark vergence. Shared patterns of autonomic activation may be responsible for this eye-heart link.

Accommodation, Ocular↗
PubMed1997

Anticipatory locomotor adjustments for accommodating versus avoiding level changes in humans.

The control of locomotion has been studied from various perspectives related to the tasks of pattern generation, equilibrium control or adaptation to the environment. The last of these locomotor components has received comparably less attention, specifically pertaining to anticipatory adjustments. Continuing the work which has been conducted on both humans and cats, the present paper explores the nature of the differences in anticipatory locomotor adjustments for obstacle avoidance versus the accommodation to level changes. Six subjects walked in six different environments including no obstructions, a simple obstacle, two different level changes (a platform and stairs), and a combination of an obstacle with each respective level change. Full dynamic analyses allowed comparison of muscle torques as well as muscle power generated and absorbed at the lower limb joints across conditions. It was found that the previously shown robust lower limb reorganization characterized by a knee flexor generation strategy was upheld in all conditions when the obstacle was present. Pure level changes involved an augmentation of the ongoing hip strategy inherent in normal level walking. In the compound environment of obstructed level changes, subjects chose to combine an augmentation of hip flexor power with a reorganization to active knee flexion. The results are discussed from the point of view of general principles of mechanical coordination and the exploitation of intersegmental dynamics for foot transport.

Accommodation, Ocular↗
PubMed2006

Visual angle is the critical variable mediating gain-related effects in manual control.

Theoretically visual gain has been identified as a control variable in models of isometric force. However, visual gain is typically confounded with visual angle and distance, and the relative contribution of visual gain, distance, and angle to the control of force remains unclear. This study manipulated visual gain, distance, and angle in three experiments to examine the visual information properties used to regulate the control of a constant level of isometric force. Young adults performed a flexion motion of the index finger of the dominant hand in 20 s trials under a range of parameter values of the three visual variables. The findings demonstrate that the amount and structure of the force fluctuations were organized around the variable of visual angle, rather than gain or distance. Furthermore, the amount and structure of the force fluctuations changed considerably up to 1 degrees , with little change higher than a 1 degrees visual angle. Visual angle is the critical informational variable for the visuomotor system during the control of isometric force.

Accommodation, Ocular↗
PubMed2006

Focusing on body sites: the role of spatial attention in action perception.

Humans use the same representations to code self-produced and observed actions. Neurophysiological evidence for this view comes from the discovery of the so-called mirror neurons in premotor cortex of the macaque monkey. These neurons respond when the monkey performs a particular action but also when it observes the same behavior in another individual. In humans, such direct links between perception and action seem to mediate action priming, where a response is facilitated when a similar action is observed. An issue that has not been fully resolved concerns the role of selective attention in these processes. Action priming appears to be an automatic process in the sense that the observed action can be irrelevant to the observer's task and nevertheless prime similar responses. However, it is not known whether attention has to be oriented to the action for these processes to be engaged. It is demonstrated here that spatial attention indeed has to be oriented to the action related body site for action priming to take place. Furthermore, if attention is oriented to the appropriate body site, there need be no visual cues to action for action priming to emerge.

Accommodation, Ocular↗
PubMed1999

Listing's plane rotation with convergence: role of disparity, accommodation, and depth perception.

Earlier studies have reported temporal rotation of Listing's plane with convergence of the eyes causing torsion, which is dependent on eye elevation. The amount by which the planes rotate differs from study to study. To gain insight into the functional significance of the temporal tilt of Listing's plane for vision, we examined whether the rotation of the plane depends on the visual conditions, namely on the stimuli driving vergence. In different conditions, accommodative vergence, disparity-vergence, combinations of disparity with accommodation or depth perception were used and the resulting rotation of Listing's plane was measured. Our findings show, for the first time, that the relationship between convergence and Listing's-plane temporal rotation depends on the stimuli driving vergence. When the stimulus contains only disparity cues, vergence and Listing's plane rotate immediately and consistently among subjects. Accommodative vergence, the mutual couplings between vergence and accommodation, can influence the orientation of Listing's plane, but they do so in a idiosyncratic way. The largest rotation was elicited by stereograms combining disparity-vergence with depth perception. These findings support the idea of a functional role of Listing's plane rotation for binocular vision, perhaps for depth perception.

Accommodation, Ocular↗
PubMed1997

The clinical pharmacology of single doses of otilonium bromide in healthy volunteers.

OBJECTIVE: Otilonium is a smooth muscle spasmolytic with greater affinity for receptors in the smooth muscle of distal than proximal gut in rats. This study was the first to compare distal and proximal GI transit effects in human subjects. METHODS: Using an increasing dose design for the safe exploration of clinical and supraclinical single dose levels, two groups of eight volunteers received either 40, 120 and 200 mg or 80, 160 and 240 mg otilonium. Gastric emptying of 400 ml 10% glucose solution was assessed by epigastric impedance (EI), orocaecal transit time (OCTT) by the lactulose breath-hydrogen method and whole gut transit time (WGTT) by the method of Hinton et al. [1]. Potential anticholinergic effects were assessed via visual accommodation using the RAF rule and saliva flow in response to sucking a sweet. RESULTS: Median WGTT after 120 mg significantly increased by 4.1 h relative to placebo, but at higher doses median changes relative to placebo were not significant due to wide increases in group variance. The EI t50% was delayed by 1.4 min when results from the two highest doses were combined and compared with placebo; this small difference was statistically significant but seems unlikely to achieve physiological or clinical significance. OCTT, visual accommodation and saliva flow were unaltered. Otilonium bromide was well tolerated at all doses, due mainly to low systemic absorption.

Accommodation, Ocular↗