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Materials for selective tissue heating in a radiofrequency electromagnetic field for the combined chemothermal treatment of brain tumors.

A technique of creating localized heating by implanting metallic materials in the brain and inserting the head into a radiofrequency electromagnetic field is described. The heating properties of various materials for implantation were studied, and the two best materials were carbon steel rods and Hysterloy (1000 and 655 cal/g-min, respectively). Heating of these materials was done primarily by eddy current since their heating rates were significantly affected by their shapes and orientation in the field, rods oriented parallel to the field producing the most heat. There is evidence that warmer cells have a greater uptake of chemotherapeutic agents. This suggests a combined therapeutic approach employing localized brain heating in conjunction with systemic or intrathecal chemotherapy. In this way, large doses of chemotherapeutic drugs might be concentrated in a warmed brain tumor while toxicity is prevented by keeping the rest of the brain and body hypothermic.

Alloys↗

The prevalence of symptoms attributed to electromagnetic field exposure: a cross-sectional representative survey in Switzerland.

OBJECTIVES: To investigate health risk perception as well as to assess the prevalence of self-reported symptoms attributed to electromagnetic fields (EMF) and other environmental exposures in the general population of Switzerland. METHODS: Between May and June 2004, telephone interviews of a representative sample of the Swiss population (n=2048, >14 years old) about: (1) health symptoms attributed to five environmental factors (one of which was EMF), (2) health risk perception related to 12 environmental risk factors (five of which were different EMF sources). RESULTS: We found a prevalence of 5% (95% CI 4-6%) for electromagnetic hypersensitivity (EHS) in our study sample. The most common health complaints among EHS individuals were sleep disorders (43%) and headaches (34%), which were mostly attributed to power lines and mobile phone handsets. In addition, 53 percent (95% CI 51-55%) were worried about adverse health effects from EMF, without attributing their own health symptoms to them. CONCLUSIONS: The large proportion of the population who is concerned or attributes own symptoms to EMF may cause societal conflicts given the ubiquity of EMF in our everyday life.

Adolescent↗

Male proportion in offspring of parents exposed to strong static and extremely low-frequency electromagnetic fields in Norway.

Reduced male proportion in offspring of male carbon setters prompted a study into whether offspring of workers exposed to strong static and extremely low-frequency electromagnetic fields (ELF) had a deviant sex ratio. The study was based on all births in Norway 1970-1993. The reference population was offspring of parents not exposed to ELF. The male proportion in offspring of men in aluminum works was 50.38%, RR 0.98 (0.94-1.03), in manganese works 47.32%, RR 0.92 (0.83-1.02), in factories producing iron 50.03%, RR 0.97 (0.93-1.02), in nickel works 48.27%, RR 0.94 (0.84-1.05), and in electric wire production 47.20%, RR 0.92 (0.80-1.05). In the offspring of women in aluminum works, the male proportion was 37.04%, RR 0.72 (0.59-0.90), in all smelter works grouped together, 45.13%, RR 0.88 (0.79-0.99). The male proportion in the reference population was 51.42%. The male proportion in offspring of men in industries with ELF, was slightly reduced, while offspring of women was significantly reduced.

Aluminum↗

Radiofrequency electromagnetic fields have no effect on the in vivo proliferation of the 9L brain tumor.

The intracranial 9L tumor model was used to determine if exposure to a radiofrequency (RF) electromagnetic field similar to those used in cellular telephone has any effects on the growth of a central nervous system tumor. Fischer 344 rats implanted with different numbers of 9L gliosarcoma cells were exposed to 835.62 MHz frequency-modulated continuous wave (FMCW) or 847.74 MHz code division multiple access (CDMA) RF field with nominal slot-average specific absorption rates in the brain of 0.75 +/- 0.25 W/kg. The animals were exposed to the RF field for 4 h a day, 5 days a week starting 4 weeks prior to and up to 150 days after the implantation of tumor cells. Among sham-exposed animals injected with 2 to 10 viable cells (group 1), the median survival was 70 days, with 27% of the animals surviving at 150 days. The median survival length and final survival fraction for animals injected with 11 to 36 viable cells (group 2) were 52 days and 14%, respectively, while the values for those injected with 37 to 100 cells (group 3) were 45 days and 0%. The animals exposed to CDMA or FMCW had similar survival parameters, and the statistical comparison of the survival curves for each of the groups 1, 2 and 3 showed no significant differences compared to sham-exposed controls.

Animals↗

Effects of electromagnetic fields on fecundity in the chicken.

Egg production was reduced when young laying hens were kept in contact with metal cages while being continuously exposed to the following cw fields: a vhf field at a frequency of 260 MHz, with an incident power that decreased from 100 to 4mW during the experiment; a uhf field at a frequency of 915 MHz, with an incident power of 800 mW during the first 2.5 weeks, zero during the following week, and 200 mW for the remainder of the experiment; a uhf field at 2.435 GHz, with an incident power of 800 mW; an elf electric field at a frequency of 60 Hz, with a calculated value of field strength of 1600 V/m; an elf magnetic field at 60 Hz, with a value of magnetic flux density of 1.4G. With the exception of the hens exposed to the uhf field at 915 MHz, all other treated groups laid significantly less eggs than the controls (p smaller than or equal to 0.01). This reduction (similar 15% less than the controls) began with the first 4-week production period. The egg production curves for the hens exposed to the vhf field at 260 MHz and to the uhf field at 2.435 GHz were approximately the same beginning with the sixth week of production, and they maintained comparable production levels for the remainder of the experiment. An 8% total drop in production also was experienced in the group of birds exposed to the 915-MHz field, which pulsed because of equipment failure. Egg production rate curves for the birds in the elf electric and magnetic fields were substantially different from those exhibited by birds in the other electromagnetic fields. The birds in the E-field regained a production level comparable to the controls after 11 weeks production, whereas those in the B-field dropped to 31% production, which was approximately 40% poorer than the controls by the twelfth week of production. Fertility of cocks and hens was not affected by continuous low-power vhf and uhf near-zone electromagnetic exposure or elf electric or magnetic field treatment. Fertility was exceptionally good, except for the controls and the hens exposed to the elf electric field. The hatchs of fertile and of total eggs were not significantly influenced by exposure to any of the five fields. A considerably lower incidence of male chicks was noted in the elf magnetic field treatment (32.3%). The sex ratio in the other groups appeared to be relatively normal. No macroscopic abnormalities attributable to treatments were noted in the chicks hatched or in the dead embryos.

Animals↗

[Biological effects of electromagnetic fields].

Since several epidemiological studies have indicated an elevated risk for certain types of cancer in both living and working environments where exposure to an extremely low-frequency electromagnetic field (ELF) occurs, public concern about ELF has been increasing because it is impossible to imagine life today without electricity. We reviewed studies on biological effects of ELF with respect to their cytological and biochemical effects, including mutagenicity, clastogenicity and carcinogenicity. The studies can be summarized as follow: 1) There is evidence that outer surface of the cell membrane is the primary locus for ELF-induced cellular alterations. 2) ELF modulate the proliferation of normal as well as transformed cells in vivo and in vitro. The magnitude of the proliferative effects depends on ELF intensity, exposure duration and other cellular factors. 3) No studies clearly demonstrate deleterious effects of ELF exposure on mammalian reproduction and development, but several suggest such effects. 4) Reported evidence does not demonstrate that the ELF acts as a cancer initiator. However, it might act as a promoter or affect tumor progression. Further observations and epidemiological studies of ELF must be accompanied by laboratory experiments to evaluate biological and health effects.

Animals↗

Effects of global system for mobile communications 1800 MHz radiofrequency electromagnetic fields on gene and protein expression in MCF-7 cells.

Despite many studies over a decade, it still remains ambiguous as to the real biological effects induced by radiofrequency electromagnetic fields (RF EMF) utilized in mobile telephony. Here we investigated global gene and protein responses to RF EMF simulating the Global System for Mobile Communications (GSM) 1800 MHz signal in human breast cancer cell line MCF-7 using genomic and proteomic approaches. GeneChip analysis identified a handful of consistent changed genes after exposure to RF EMF at specific absorption rates (SAR) of up to 3.5 W/kg for 24 h. However, these differentially transcribed genes could not be further confirmed by real-time RT-PCR assay. Meanwhile, systematic proteome analysis of the MCF-7 cells revealed that a few but different proteins were differentially expressed under continuous or intermittent RF EMF exposure at SAR of 3.5 W/kg for 24 h or less, implying that the observed effects might have occurred by chance. Overall, the present study does not provide convincing evidence that RF EMF exposure under current experimental conditions can produce distinct effects on gene and protein expression in the MCF-7 cells.

Breast Neoplasms↗

Electromagnetic fields and cancer in children residing near Norwegian high-voltage power lines.

The aim of the nested case-control study reported here was to test the hypothesis that exposure to electromagnetic fields of the type generated by high-voltage power lines increases the incidence of cancer in children aged 0-14 years. The study population comprised children who during at least one of the years 1960, 1970, 1980, 1985, 1987, or 1989 had lived in a census ward crossed by a high-voltage power line. The cases were diagnosed from 1965 to 1989 and were matched to controls by year of birth, sex, and municipality. Exposure to electric and magnetic fields was calculated by means of computer programs in which power line characteristics and distance were taken into account. No association was found between exposure to time-weighted average exposure to magnetic fields and cancer at all sites, brain tumors, lymphoma, or leukemia. Cancer at other sites showed elevated odds ratios in the two highest exposure categories in some, but not all, measures of exposure. This study provides little support for an association between children's exposure to magnetic fields and cancer and no support for an association between leukemia and such exposure, but no firm conclusions can be drawn owing to the small numbers involved.

Adolescent↗

Exposure to low-frequency pulsed electromagnetic fields increases mitogen-induced lymphocyte proliferation in Down's syndrome.

We previously reported that exposure of human mitogen-stimulated peripheral blood lymphocytes (PBL) to extremely low frequency pulsed electromagnetic fields (PEMFs) could restore the defective proliferative capability of PBL from aged subjects. The effects of exposure to PEMFs were studied in PBL from 25 patients with Down's syndrome (DS), a syndrome of premature aging characterized by precocious immune system derangement, including age-related defective PBL proliferative capability. PBL were stimulated with different doses of phytohemagglutinin, and cell proliferation was assessed by measuring the incorporation of tritiated thymidine. After PEMF-exposure, a significant increase in cell proliferation was observed in cells from DS children and young adults, but it was much more evident in PBL from relatively aged DS patients. The age-related effect of PEMFs on DS lymphocytes demonstrates that age must be considered a major variable when studies on DS are performed, and confirms that DS must be regarded as a syndrome of accelerated aging.

Adolescent↗

Post-continuous whole body exposure of rabbits to 650 MHz electromagnetic fields: effects on liver, spleen, and brain.

This study deals with the effects of post (12 or 18 months) whole body continuous (2 years) exposure of rabbits to 650 MHz electromagnetic fields (EMF) that are characteristic of those produced by broadcasting stations, on body weight and body mass, on the morphology of liver, spleen and brain, and on apoptosis rates and glycogen distribution in the liver. Two groups of rabbits were continuously exposed for 2 years to EMF of 650 MHz followed by 12 months (group 1) or 18 months (group 2) of post-exposure; a third group (group 3) was sham exposed. It was shown that the changes in apoptosis rates were conditional during the time of exposure, but not on a specific organ and that the whole body continuous exposure gave rise to modifications whose types and intensities were related to the time of post-exposure (12 or 18 months, respectively), the type of organ, and the individual animal. A number of effects were observed only in group 1, and not in group 2, which suggests some kind of adaptive response or of long-term recovery in the rabbits following continuous exposure to 650 MHz EMF.

Animals↗