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At least 919 records · Page 51Linked to original sources
PubMed1977

Cytological investigation of biopsy performed in sarcoidosis.

One of the most frequent appearance of sarcoidosis is the enlargement of mediastinal lymph-nodes. The clinical picture first of all must be distinguished from the malignant processes and seldom from lymph-node tuberculosis. At our clinic material was obtained for cytological examination in two ways: through mediastinoscopy in the course of which we had opportunity of histological evaluation too and by means of transbronchial thin-needle puncture respectively and only cytological examination was performed with this material. We carried out investigations in 155 patients sent to our clinic on account of the suspicion of sarcoidosis. According to the course of disease or rather other examinations 123 out of 155 patients suffered from sarcoidosis and in 112 of these cases that is in 91% the diagnosis was verified by the help of cytological examination. In the smears epithelioid cell groups were generally found in large number but Langhans' giant cells could be produced only in 21 cases. In 70 of 123 patients mediastinoscopy and in 53 transbronchial thin-needle biopsy was accomplished. Through cytological investigation of material obtained mediastinoscopically we attained nearly 100% positivity rate and 80% by the help of thin-needle biopsy. Although forasmuch as the transbronchial puncture does not need special intervention because it can be carried out in the course of routine bronchoscopy we think the application of the procedure reasonable not only in finding metastasis if it involves the hypertrophy of mediastinal lymph-nodes. In this way we spare the patient from further examinations. The cytological finding, of course, must be always fitted in clinical picture but on the basis of our experience the close cooperation between the clinician and cytologist assures the avoidance of wrong diagnosis.

Biopsy, Needle↗
PubMed2001

[Tuberculin sensitivity in children at the time of diagnosis of tuberculosis of intrathoracic lymph nodes].

Trends in RM with 2 TU PPD-L were analysed in 71 children at the time of detection of tuberculosis of intrathoracic lymph nodes (TITLN). The disease is often diagnosed in children getting infected with tuberculosis infection. Monotonous tuberculin tests represent the most frequent variant of tuberculin allergy at the time of TITLN diagnosis in children. Careful follow-up of children with monotonous RM (2 TU) may improve TITLN outcomes.

Adolescent↗
PubMedDate not supplied

Extrapulmonary tuberculosis: clinical and epidemiologic spectrum of 636 cases.

BACKGROUND: The aim of this study was to evaluate the percentage and characteristics of extrapulmonary tuberculosis (EPTB) cases in a Turkish industrial city, Kocaeli (population: 1,203,335) and to illustrate its extent as a serious health problem for this city and country. METHODS: We investigated the results of microbiologic, radiologic, and histopathologic findings of patients with extrapulmonary tuberculosis, retrospectively, who were admitted to four Tuberculous Dispensaries between 1996 and 2000. RESULTS: Six hundred thirty six cases were diagnosed with EPTB. Three hundred forty five were males (54.2%) and 291, females (45.8%). Mean age of patient cases was 22.5+/-17.1 years (range, 1-86 years); 41.4% of cases were <15 years of age and 30.9%, between 20 and 39 years of age. Contact history with tuberculosis cases was determined in 242 cases (38%); of these, 194 were <15 years of age (80.2%). The most common form of EPTB was observed to be lymph node tuberculosis (56.3%); of these cases, 256 (71.5%) had involvement in intrathoracic, 92 (25.7%) in cervical, and 10 (2.8%) in axillary lymph nodes. The second most frequent extrapulmonary form was pleural tuberculosis (31.1%). EPTB was diagnosed by histopathologic methods in 229 patients (36.0%) and by microbiologic methods in 27 (4.2%); tuberculin skin test was significantly positive (>10 mm) in 95.5% of patients. When cases were classified according to severity, 87 cases (13.7%) were found severe and 549 (86.3%) as less severe EPTB. Five hundred sixty one cases (88.2%) lived in urban areas and 75 (11.8%), in rural areas. CONCLUSIONS: EPTB is very common in early adulthood in the Kocaeli region, with lymph nodes the most common localization.

Adolescent↗