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PubMed2004

The effect of a triclosan/copolymer/fluoride liquid dentifrice on interproximal enamel remineralization and fluoride uptake.

BACKGROUND: The authors measured the enamel remineralization of dental interproximal surfaces by a triclosan/copolymer/fluoride liquid dentifrice to test its performance against that of a standard toothpaste. METHODS: In a randomized, crossover, blinded, in situ protocol, the authors fitted 19 healthy adult subjects with mandibular appliances holding bilateral, interproximal bovine enamel slabs. They measured initial abrasion levels and fluoride content. In a two-phase crossover protocol, they evaluated the percentage of surface mineral recovery, or SMR, and fluoride uptake caused by the experimental dentifrice and a fluoride-containing traditional control toothpaste. RESULTS: Abrasion depths were similar and not different statistically (P > .05). The interproximal blocks exposed to the triclosan-containing liquid dentifrice had a mean fluoride uptake that was nearly 100 parts per million (13.1 percent) greater than that achieved with the American Dental Association-accepted control dentifrice. This finding, while not statistically significant, may indicate enhanced performance of the experimental dentifrice because the initial enamel slab abrasion depths were shown to be quite uniform. Moreover, the blocks exposed to the experimental toothpaste had a 49.8 percent SMR, while the positive control blocks had an SMR of only 36.9 percent. This enhanced remineralization performance was statistically significant (P < .05). CONCLUSIONS: This is the first study to show enhanced performance of a triclosan-containing liquid dentifrice in preventing interproximal dental caries. The difference in percentage of SMR was statistically significant and is likely to be clinically relevant. CLINICAL IMPLICATION: The results of this preliminary study offer evidence supporting clinicians' recommendation of the new liquid dentifrice to patients who are prone to developing interproximal carious lesions.

Adolescent↗
PubMed2006

Influence of rinsing and expectoration after toothbrushing on fluoride dose and ingested amount by use of conventional and children's fluoride dentifrices.

The purpose of this study was to assess the amount of ingested fluoride and the fluoride dose to which children are subjected during toothbrushing with a conventional dentifrice (1500 ppm F) and a children's dentifrice with special flavor (1100 ppm F) and evaluate the influence of rinsing and expectoration after brushing. Six brushings followed by 6 residue collections (3 per dentifrice) were performed by 42 Brazilian children (aged 20 to 30 months). The concentration of fluoride in the residues and dentifrices was determined. The amount ingested was obtained by the difference principal. 64.3% of the children did not expectorate or rinse after brushing. For both toothpastes, no significant difference was found for fluoride doses comparing children that rinsed to those that did not rinse (p > or = 0.05). When children's toothpaste was used, children who did not expectorate were exposed to a higher dose than those who did expectorate (p = 0.032). The same was not observed when conventional toothpaste (p = 0.081) was used. In conclusion, rinsing and expectoration after brushing had no influence on the dose of fluoride to which children were exposed by use of the dentifrices. However, expectoration was directly associated to the fluoride dose when the children's dentifrice was used.

Cariostatic Agents↗
PubMed2005

Fluoride release/uptake of glass-ionomer cements and polyacid-modified composite resins.

The aim of this study was to investigate the fluoride release and fluoride recharge behaviors of two conventional glass-ionomer cements (GICs) and two polyacid-modified composite resins (PMCRs) after exposure to mouthwash and toothpaste. Fluoride released from the materials was measured at 1st, 2nd, 3rd, 4th, 7th, 14th, 21st, and 28th days. At 28th day, the specimens were divided into three groups. Specimens in the control group were stored in deionized water. For the other two groups, the specimens were exposed to 0.05% NaF solution and fluoridated toothpaste for one month. After refluoridation, fluoride amount was measured at 30th, 31st, 32nd, 36th, 44th, 52nd, and 60th days. All materials released fluoride. The highest amount of fluoride was obtained during the first 24 hours, and there was a statistically significant difference between the amounts of fluoride released from GICs and PMCRs (p < 0.0001). After exposure to mouthwash and fluoridated toothpaste, all materials were recharged and continued releasing fluoride. While the amount of fluoride release from the materials increased after reflouridation, the increase was higher in GICs.

Cariostatic Agents↗
PubMed1998

[Use of fluorides in children: recommendations of the European Academy for Pediatric Dentistry].

The European Academy of Paediatric Dentistry (EAPD) strongly endorses that fluoride use should be part of any preventive programme for the control of dental caries in children. Each child under the care of a dentist should have a carefully planned programme appropriate to the level of caries risk and age of each child. Such a preventive programme should be reevaluated at least every six or 12 months and changed according to the patient's risk and the improvement or not of his or her's overall health. It is the combination of the use of an appropriate fluoride toothpaste with good oral hygiene that is the key to good dental health. This policy document deals with guidelines for systemic use of fluorides, fluoride supplements, topical methods (varnishes, mouthrinses and gels) and toothpastes. Moreover some recommendations are given to toothpaste manufacturers.

Age Factors↗
PubMed1999

Laboratory enamel solubility reduction and fluoride uptake from enamelon dentifrice.

The presence of calcium-releasing ingredients in toothpastes containing sodium fluoride is usually avoided to prevent loss of active fluoride due to the formation of the insoluble calcium salt. The purpose of this study was to determine the bio-availability of fluoride from Enamelon Toothpaste (E), which simultaneously supplies fluoride, calcium and phosphate salts from a dual dispensing package. Fluoride uptake into artificially lesioned enamel cores due to the use of the test dentifrice (E) diluted 1:3 in whole human saliva was compared to that from a clinically proven effective sodium fluoride/silica USP reference toothpaste (C) and a non-fluoride control (E-w/o F). Enamel solubility reduction due to the use of E, C and E-w/o F was measured by determining the quantity of phosphate released to lactic acid buffer before and after treatment of the crowns of molars with 1:3 slurries of the dentifrices in water. Fluoride uptakes and enamel solubility reductions were 5031 +/- 158 ppm and 21.6 +/- 2.2% for E, 1915 +/- 39 ppm and 13.6 +/- 2.0% for C, and -3 +/- 2 ppm and 0.8 +/- 1.7% for E-w/o F. The fluoride uptake and enamel solubility reductions from E were significantly greater than from C (p < 0.001, Fisher LSD), and both fluoride-containing dentifrices significantly outperformed E-w/o F (p < 0.001). The laboratory results indicate that the calcium and phosphate salts delivered by the remineralizing Enamelon dentifrice increase the bioavailability of fluoride to substantially exceed that of the clinically proven standard dentifrice.

Analysis of Variance↗
PubMed1999

A six-week clinical efficacy study of a new dentifrice for the removal of extrinsic tooth stain.

The objective of this double-blind clinical study was to investigate the tooth whitening efficacy of a new dentifrice (Colgate Tartar Control Plus Whitening Fluoride Toothpaste) for the removal of extrinsic tooth stain, through a comparison with two commercially available dentifrices, Aquafresh Whitening Toothpaste with Fluoride, and Crest Regular Fluoride Toothpaste. Following a baseline examination for extrinsic tooth stain area and intensity, qualifying adult male and female subjects from the Mississauga, Ontario, Canada area were randomized into three treatment groups which were balanced for age, gender, and level of extrinsic tooth stain. Subjects were instructed to brush their teeth twice daily (morning and evening) for one minute with their assigned dentifrice using a soft-bristled toothbrush. Examinations for extrinsic tooth stain were repeated after six weeks' use of the study dentifrices. One hundred twenty-two (122) subjects complied with the protocol and completed the entire study. At the six-week examination, subjects assigned to the Colgate Tartar Control Plus Whitening treatment group and subjects assigned to the Aquafresh Whitening treatment group exhibited statistically lower levels (p < 0.0001) of extrinsic tooth stain area and intensity than did those subjects assigned to the Crest Regular Fluoride treatment group. Further, subjects assigned to the Colgate Tartar Control Plus Whitening treatment group exhibited significantly lower levels of extrinsic tooth stain area and intensity than did those assigned to the Aquafresh Whitening treatment group (p < 0.0001).

Adolescent↗
PubMed1999

A six-week clinical efficacy study of three commercially available dentifrices for the removal of extrinsic tooth stain.

The objective of this double-blind clinical study was to compare the extrinsic tooth stain removal efficacy of three commercially available dentifrices: Colgate Platinum Whitening Toothpaste with Fluoride, Aquafresh Advanced Whitening Toothpaste with Fluoride, and Crest Regular Fluoride Toothpaste. Following a baseline examination for extrinsic tooth stain, qualifying adult male and female subjects from the Toronto, Ontario, Canada are were randomized into three treatment groups which were balanced for age, gender, tobacco habits, and level of extrinsic tooth stain using the Lobene Stain Index. Subjects were instructed to brush their teeth twice daily (morning and evening) for one minute with their assigned dentifrice using a soft-bristled toothbrush. Examinations for extrinsic tooth stain were repeated after six weeks' use of the study dentifrices. One-hundred forty-nine (149) subjects complied with the protocol and completed the entire study. At the six-week examination, subjects assigned to the Colgate Platinum treatment group exhibited statistically significant reductions (p < 0.05) from baseline level with respect to extrinsic tooth stain area (49.4% reduction) and extrinsic tooth stain intensity (52.4% reduction). Statistically significant reductions (p < 0.05) for both extrinsic tooth stain parameters were also exhibited by the subjects assigned to the Aquafresh Whitening treatment group (14.0% reduction for area, 15.5% reduction for intensity). Both tooth whitening treatments provided statistically significantly greater reductions (p < 0.05) in extrinsic tooth stain than did the Crest Regular Fluoride dentifrice, which exhibited a small increase in the extrinsic tooth stain parameters over the course of the study. Additionally, the Colgate Platinum dentifrice provided statistically significantly (p < 0.05) greater removal of extrinsic tooth stain over the course of this six-week study than did the Aquafresh Whitening dentifrice. Thus, the results of the double-blind clinical study support the conclusion that the two tooth whitening dentifrices, Colgate Platinum and Aquafresh Whitening, provide significantly greater (p < 0.05) removal of extrinsic tooth stain than does Crest Regular Fluoride, a sodium fluoride/silica dentifrice. Further, the results of the study support the conclusion that Colgate Platinum dentifrice provides a greater (p < 0.05) level of extrinsic tooth stain removal efficacy than does Aquafresh Whitening dentifrice.

Adult↗
PubMed1999

The clinical effectiveness of a dentifrice containing triclosan and a copolymer for controlling breath odor measured organoleptically twelve hours after toothbrushing.

The objective of this double-blind clinical study was to investigate the effectiveness of a dentifrice containing triclosan and a copolymer, Colgate Total Toothpaste, for controlling breath odor twelve hours after brushing the teeth compared to a placebo dentifrice which did not contain triclosan or a copolymer. Breath odor was evaluated by a panel of four expert judges using a nine-point hedonic scale. Following a baseline evaluation of breath odor, prospective study subjects who presented scores above the threshold value for unpleasant breath odor were stratified by score, and randomized into two treatment groups. Subjects were provided with a soft-bristled toothbrush, and brushed their teeth thoroughly in their regular and customary manner with their assigned dentifrice. Subjects refrained from dental hygiene, breath mints, or mouth rinses for the next twelve hours, after which they were once again evaluated for breath odor. Sixty-three (63) adult male and female subjects from the Mississauga, Ontario, Canada area participated in the study. At twelve hours after brushing their teeth, subjects in both dentifrice treatment groups presented mean breath odor scores which were statistically significantly lower than the mean scores observed at baseline. However, the difference between the mean twelve-hour breath odor scores differed significantly between the two dentifrices. The mean twelve-hour breath odor score for the Colgate Total Toothpaste group was 4.77, which is within the range of values corresponding to pleasant breath odor; the mean twelve-hour breath odor score for the placebo group was 6.05, which is above the value corresponding to unpleasant breath odor. Thus, the results of this double-blind clinical study support the conclusion that Colgate Total Toothpaste provides effective control of breath odor at twelve hours after brushing the teeth.

Adolescent↗
PubMed2002

A study to assess the tooth whitening efficacy of a new dentifrice formulation variant containing a special grade of silica: a six-week study on adults.

The objective of this double-blind clinical study was to investigate the tooth whitening efficacy of a formulation variant of a commercially available dentifrice (Colgate Total Plus Whitening Toothpaste) obtained by the addition of high cleaning silica, relative to that of its currently marketed formulation (Colgate Total Toothpaste). Following a baseline examination, qualifying adult male and female subjects were randomized into two treatment groups which were balanced for age, gender and level of extrinsic tooth stain. Subjects were instructed to brush their teeth twice daily (morning and evening) for one minute with their assigned dentifrice, using a soft-bristled toothbrush. After one, and again after two weeks' use of the assigned dentifrices, a randomly selected panel of subjects was examined for soft tissue findings. Examinations for extrinsic tooth stain were repeated for all subjects after six weeks' use of the study dentifrices. Ninety-seven (97) subjects complied with the protocol and completed the entire study. At the six-week examination, subjects assigned to the new dentifrice formulation group exhibited statistically significantly (p < 0.05) lower levels of extrinsic tooth stain area and extrinsic tooth stain intensity than did those subjects assigned to the Colgate Total Toothpaste group. Thus, the results of this double-blind clinical study support the conclusion that the new dentifrice formulation variant is efficacious for the removal of extrinsic tooth stain.

Adult↗
PubMed2002

Clinical efficacy of a new tooth whitening dentifrice.

The objective of this double-blind clinical study was to investigate the tooth whitening efficacy of a variation in formula of a commercially available dentifrice (Colgate Total Toothpaste). The variation (Colgate Total Plus Whitening Toothpaste) was the addition of high cleaning silica to the existing formulation. Following a baseline examination for extrinsic tooth stain, qualifying adult male and female subjects from the Mississauga, Ontario, Canada area were randomized into two treatment groups which were balanced for gender, age and level of extrinsic tooth stain. Subjects were instructed to brush their teeth twice daily (morning and evening) for one minute with their assigned dentifrice, using a soft-bristled toothbrush. Examinations for extrinsic tooth stain were repeated after six weeks' use of the study dentifrices. Ninety-three (93) subjects complied with the protocol and completed the entire study. At the six-week examination, subjects assigned to the new dentifrice formulation group exhibited statistically significantly lower levels of extrinsic tooth stain area and extrinsic tooth stain intensity than did those subjects assigned to the Colgate Total Toothpaste group.

Adult↗
PubMed2002

The clinical efficacy of a new tooth whitening dentifrice formulation: a six-month study in adults.

The objective of this double-blind clinical study was to investigate the tooth whitening efficacy of a formulation variant of a commercially available dentifrice (Colgate Total Plus Whitening Toothpaste) obtained by the addition of high-cleaning silica, relative to that of its currently marketed formulation (Colgate Total Toothpaste). Following a baseline examination for extrinsic tooth stain, qualifying adult male and female subjects from New Jersey and Florida were randomized into two treatment groups which were balanced for gender, age, and level of extrinsic tooth stain. Subjects were instructed to brush their teeth twice daily (morning and evening) for one minute with their assigned dentifrice using a soft-bristled toothbrush. Examinations for extrinsic tooth stain were repeated after six-weeks', three-months' and six-months' use of the study dentifrices. Eighty-six (86) subjects complied with the protocol and completed the entire study. At the six-month examination, subjects assigned to the new dentifrice formulation group exhibited statistically significantly lower levels of extrinsic tooth stain area and extrinsic tooth stain intensity than did those subjects assigned to the Colgate Total Toothpaste group. Thus, the results of this double-blind clinical study support the conclusion that the new dentifrice formulation variant is efficacious, compared to the control dentifrice, for the removal of extrinsic tooth stain.

Adult↗
PubMed1992

Two-year longitudinal study of a peroxide-fluoride rinse on decalcification in adolescent orthodontic patients.

The purpose of the present study was to determine if once daily use of a 1.5% H2O2 rinse with 0.05% NaF was more effective in preventing decalcification in adolescent orthodontic patients than comparable use of a 0.05% NaF rinse without H2O2, or in patients using no rinse at all. Ninety-five subjects were selected consecutively from adolescents scheduled to receive fixed orthodontic treatment on both dental arches. Three groups were formed that were matched in percentages for age and sex. The first group (control group, n = 35) used a 1100 ppm F toothpaste only. The second group (NaF rinse group, n = 30) used both the same toothpaste and a once daily 0.05% NaF rinse. The third group (H2O2-NaF rinse group, n = 30) used the toothpaste and a once daily rinse containing both 0.05% NaF and 1.5% H2O2. Decalcification was assessed single-blind on the facial surfaces of all erupted teeth at baseline (before appliances were placed), and 3 months after fixed appliances were removed. The difference between baseline and post-treatment decalcification levels determined the incidence of decalcification during orthodontic treatment. Since the first molars were found to have the highest decalcification scores, separate analyses of variance were carried out for the whole mouth and first molar assessments. A p value of less than 0.05 was considered statistically significant. The results showed no significant differences between any of the groups before orthodontic treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed2003

In vitro efficacy of Colgate Total advanced fresh.

Generally, clinical studies using organoleptic judges, gas chromatography, or a sulfide monitor have been employed in the assessment of treatments for the control of oral malodor. However, these studies can be expensive and time consuming. Also, for agents whose safety has not been proven, these methods are not appropriate. Therefore, in vitro assessment is a critical step toward developing a new technology or implementing changes to an existing formula. The in vitro methods employed in this study combined basic microbiology methods, such as growth inhibition and zone of inhibition experiments. In addition, a newly developed, in vitro, volatile sulfur compounds (VSC) experiment that combined the essential elements of zone of inhibition, head space analysis, and dynamic flow cell techniques was also employed. The in vitro VSC method has been validated using technologies clinically proven to control oral malodor. All in vitro experiments have demonstrated that Colgate Total Advanced Fresh toothpaste has efficacy similar to that of the original Colgate Total toothpaste and that both variants showed superior efficacy to the control toothpaste. These results have been corroborated by clinical study results.

Actinomyces↗
PubMed2003

Clinical effectiveness of a triclosan/copolymer/sodium-fluoride dentifrice in controlling oral malodor: a three-week clinical trial.

The purpose of this study was to compare the effectiveness of a commercially available, clinically proven, American Dental Association (ADA)-Accepted dentifrice containing 0.30% triclosan, 2% polyvinylmethylether/maleic acid (PVM/MA) copolymer, and 0.243% sodium fluoride in a 10% high-cleaning silica base (Colgate Total Advanced Fresh) to a commercially available, clinically proven, ADA-Accepted control dentifrice containing 0.243% sodium fluoride in a silica base (Colgate Cavity Protection Winterfresh Gel) for the management of oral malodor in a 3-week, randomized, double-blind longitudinal clinical trial. A panel of four expert judges used a nine-point hedonic scale to evaluate breath odor using a protocol designed in concordance with the ADA Draft Acceptance Program Guidelines for Products Used in the Management of Oral Malodor. After a baseline evaluation, prospective study subjects who scored above the threshold value for unpleasant breath odor were stratified by score and randomized into two treatment groups. Subjects were provided with a soft-bristled toothbrush and brushed their teeth thoroughly in their regular and customary manner for 1 minute with their assigned dentifrice, twice daily. Before oral-malodor evaluations, the subjects refrained from eating odorigenic foods and did not use dental hygiene procedures, breath mints, or mouth rinses. Eighty-one adult men and women from Chengdu, China, completed the study. Throughout the study, the mean breath-odor scores observed in the Colgate Total Advanced Fresh toothpaste group for both daytime and overnight were within the range of values associated with pleasant breath odor, were statistically significantly lower than the corresponding mean scores for the control group, and also represented statistically significant reductions from baseline. Relative to the baseline score, more than 80% of the subjects in the Colgate Total Advanced Fresh toothpaste group demonstrated a 3.2 or more unit reduction in organoleptic scores at every postbaseline breath-odor evaluation. Thus, the overall results of the double-blind clinical study support the conclusions that Colgate Total Advanced Fresh toothpaste is efficacious for the control of oral malodor for up to 12 hours in the daytime and up to 12 hours overnight.

Adolescent↗
PubMed1992

Clinical study on the effect of amine fluoride/stannous fluoride on exposed root surfaces.

The aim of this study was to assess the remineralizing effect of an amine fluoride (AmF)- and stannous fluoride (SnF2)-containing toothpaste and mouthrinse on exposed root surfaces. A total of 44 adults participated in the 20-week, double-blind study and were grouped as follows: (1) 20 participants (mean age 45.7 years) used an AmF/SnF2 experimental toothpaste plus AmF/SnF2 (Meridol) mouthwash, and (2) 24 participants (mean age 48.8 years) used an NaF-containing toothpaste and mouthrinse. Root caries index (RCI) and root surface scores were determined by a modified method of Katz (J Dent Res, 1984). RCI mean values showed decreases of approximately 47% in the AmF/SnF2 group, and 10% in the NaF group. With respect to root caries scores, the number of persons with decreased softened (non-carious) surfaces between the baseline and control examinations was statistically significant (p less than 0.05) in the AmF/SnF2 group but not significant in the NaF group. A statistically significant difference (p less than 0.05) in the results of the groups favored the AmF/SnF2 subgroup. Thus, the data point to a possible remineralizing effect of topically applied AmF/SnF2 on softened root caries surfaces.

Amines↗
PubMedDate not supplied

Effect of luting cement on dental biofilm composition and secondary caries around metallic restorations in situ.

Since the importance of luting cement on secondary caries in enamel and dentin is unknown, an in situ crossover study was conducted in three phases over 21 days using a fluoride-containing toothpaste. One hundred and twenty-six metallic restorations were cemented into the dentinoenamel junction of slabs of human teeth with zinc phosphate (ZP), resin-modified glass ionomer (GI) or resinous cement (RC). The slabs were inserted onto flanges of the removable partial acrylic dentures of 14 volunteers and covered with gauze to enhance dental plaque accumulation. The volunteers used fluoride toothpaste (1.100 microg F/g, w/w). After 21 days, the biofilm that formed on the slabs was collected for biochemical and microbiological analyses, and the demineralization in enamel-dentin around the restorations was evaluated. The fluoride concentration of biofilm in the GI group was higher (p<0.05) than the ZP and RC groups. Also, the concentration of Zinc in biofilm formed on the slabs cemented with ZP was higher (p<0.05) than the other groups. However, the effect of the luting material on enamel or dentin demineralization was not statistically significant (p>0.05). The data suggest that when fluoride toothpaste is used, the anticariogenic property of the luting cement may not be relevant to the reduction of secondary caries.

Adult↗
PubMed2004

In vivo enamel fluoride uptake after use of fluoride products.

PURPOSE: To evaluate fluoride uptake in enamel after use of products containing different fluoride components of distinct oral hygiene regimen in vivo. METHODS: 84 healthy subjects (24 females and 60 males aged 19-26 years, mean 22.2) recruited from the students attending the courses of the Medical Faculty of the University of Sassari, Italy, were randomly assigned to one of four treatments groups: A: treated with a dentifrice containing sodium monofluorophosphate (1250 ppm F-); B: treated with dentifrice with 1250 ppm F- from AmF; C: treated with an AmF toothpaste (1250 ppm F-) and a mouth rinse with 250 ppm F- from AmF; or D: treated with a NaMFP toothpaste (1250 ppm F-) plus 1250 ppm NaMFP varnish. Acid-etched enamel microbiopsies on the vestibular surface of the first maxillary premolar were collected at baseline (to), after 20 days of test product use (t1) and after 24 hours without treatment (t2). Fluoride concentration was measured using an ion-specific electrode. All measurements were made in triplicate and analyzed statistically using two-way factorial ANOVA for independent samples standard weighted-means analysis. RESULTS: The fluoride uptake in the enamel shows a considerable variation between the groups. Significant differences were found both within all products in terms of fluoride concentration in enamel for (P < 0.0001 for two-way ANOVA, and later Tukey HSD test). After 20 days of treatment, the group using AmF toothpaste plus AmF mouthrinse had a higher fluoride uptake than the groups using either of the other products (P < 0.05). In conclusion, all products lead to an appreciable amount of fluoride uptake in enamel; AmF products led to higher concentrations. The concentration of fluoride accumulated during treatment phase remained high after 24 hours following the cessation of use.

Adult↗
PubMed2005

[The effect of regular scaling on periodontal health in fixed orthodontic treatment].

PURPOSE: The purpose of this study was to investigate the effect of scaling and teeth brushing with YAHAO toothpaste (eugenol and borax cream) on periodontal health in fixed orthodontic treatment. METHODS: 48 patients who needed fixed orthodontics were chosen to enroll a single-blind randomized study. The patients were randomly divided into two groups: the control group and the treatment group. Patients in the treatment group were treated with scaling and teeth brushing with YAHAO toothpaste. The changes of GI, PLI and SBI were recorded at the beginning of the treatment and after 3 months. SPSS 10.0 software package was used for Student's t test and Chi-square test. RESULTS: There was no significant difference in the periodontal indexes between the two groups before treatment. But there was a statistically significant difference in the incidence of gingivitis (P<0.01) between the two groups after treatment. CONCLUSION: The increase in the periodontal index and the rate of gingivitis in the treatment group were statistically significantly lower than that in the control group, which means that using scaling and teeth brushing with YAHAO toothpaste can effectively reduce the rate of gingivitis.

Anti-Infective Agents↗