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At least 919 records · Page 51Linked to original sources

Ray dynamics in a long-range acoustic propagation experiment.

A ray-based wave-field description is employed in the interpretation of broadband basin-scale acoustic propagation measurements obtained during the Acoustic Thermometry of Ocean Climate program's 1994 Acoustic Engineering Test. Acoustic observables of interest are wavefront time spread, probability density function (PDF) of intensity, vertical extension of acoustic energy in the reception finale, and the transition region between temporally resolved and unresolved wavefronts. Ray-based numerical simulation results that include both mesoscale and internal-wave-induced sound-speed perturbations are shown to be consistent with measurements of all the aforementioned observables, even though the underlying ray trajectories are predominantly chaotic, that is, exponentially sensitive to initial and environmental conditions. Much of the analysis exploits results that relate to the subject of ray chaos; these results follow from the Hamiltonian structure of the ray equations. Further, it is shown that the collection of the many eigenrays that form one of the resolved arrivals is nonlocal, both spatially and as a function of launch angle, which places severe restrictions on theories that are based on a perturbation expansion about a background ray.

Journal Article↗

Acoustic effects of the ATOC signal (75 Hz, 195 dB) on dolphins and whales.

The Acoustic Thermometry of Ocean Climate (ATOC) program of Scripps Institution of Oceanography and the Applied Physics Laboratory, University of Washington, will broadcast a low-frequency 75-Hz phase modulated acoustic signal over ocean basins in order to study ocean temperatures on a global scale and examine the effects of global warming. One of the major concerns is the possible effect of the ATOC signal on marine life, especially on dolphins and whales. In order to address this issue, the hearing sensitivity of a false killer whale (Pseudorca crassidens) and a Risso's dolphin (Grampus griseus) to the ATOC sound was measured behaviorally. A staircase procedure with the signal levels being changed in 1-dB steps was used to measure the animals' threshold to the actual ATOC coded signal. The results indicate that small odontocetes such as the Pseudorca and Grampus swimming directly above the ATOC source will not hear the signal unless they dive to a depth of approximately 400 m. A sound propagation analysis suggests that the sound-pressure level at ranges greater than 0.5 km will be less than 130 dB for depths down to about 500 m. Several species of baleen whales produce sounds much greater than 170-180 dB. With the ATOC source on the axis of the deep sound channel (greater than 800 m), the ATOC signal will probably have minimal physical and physiological effects on cetaceans.

Acoustics↗

Heat capacity of a strongly interacting Fermi gas.

We have measured the heat capacity of an optically trapped, strongly interacting Fermi gas of atoms. A precise addition of energy to the gas is followed by single-parameter thermometry, which determines the empirical temperature parameter of the gas cloud. Our measurements reveal a clear transition in the heat capacity. The energy and the spatial profile of the gas are computed using a theory of the crossover from Fermi to Bose superfluids at finite temperatures. The theory calibrates the empirical temperature parameter, yields excellent agreement with the data, and predicts the onset of superfluidity at the observed transition point.

Journal Article↗

Comment on "Zircon thermometer reveals minimum melting conditions on earliest Earth" II.

Watson and Harrison (Reports, 6 May 2005, p. 841) interpreted low temperatures (approximately 700 degrees C) for Hadean zircons as evidence of the existence of wet, minimum-melting conditions within 200 million years of solar system formation. However, high-temperature melts (approximately 900 degrees C) are zircon-undersaturated and crystallize zircon only after substantial temperature drop during fractional crystallization. Zircon thermometry cannot distinguish between low- and high-temperature Hadean igneous sources.

Comment↗

Temperature and surface-ocean water balance of the mid-holocene tropical western pacific

Skeletal Sr/Ca and 18O/16O ratios in corals from the Great Barrier Reef, Australia, indicate that the tropical ocean surface approximately 5350 years ago was 1 degrees C warmer and enriched in 18O by 0.5 per mil relative to modern seawater. The results suggest that the temperature increase enhanced the evaporative enrichment of 18O in seawater. Transport of part of the additional atmospheric water vapor to extratropical latitudes may have sustained the 18O/16O anomaly. The reduced glacial-Holocene shift in seawater 18O/16O ratio produced by the mid-Holocene 18O enrichment may help to reconcile the different temperature histories for the last deglaciation given by coral Sr/Ca thermometry and foraminiferal oxygen-isotope records.

Journal Article↗

Touch detection of neonatal hypothermia in Nepal.

The use of touch by health workers to detect hypothermia was examined in 250 newborns in Nepal. Palpation of the feet shows fair interobserver agreement (kappa = 0.4-0.7) and high sensitivity (>80%) but low specificity (36%-74%) compared with axillary thermometry. Traditional birth attendants should feel an infant's feet to detect hypothermia.

Developing Countries↗

Microwave cyclodestruction: evaluation on human eyes.

AIMS: The study was set up to evaluate the effect of microwave cyclodestruction on human eyes. METHODS: Two human eyes were studied. For treatment a horn shaped 5.8 GHz microwave applicator and fibre optic thermometry were used. Just before enucleation, the rectangular (2 x 3 mm) microwave aperture was placed onto the conjunctiva at a position 1-2 mm posterior to the corneal scleral limbus. Each of three to four treatment spots was targeted to receive a thermal dose of 54 degrees C for 1 minute. Clinical, gross, and histopathological evaluations were performed. RESULTS: Clinical evaluations of the treatment sites (immediately after microwave application) revealed no evidence of conjunctival or scleral damage. Trace fluorescein 2% uptake was noted within the targeted zones. The first eye was sectioned along the equatorial axis. Examination of the ciliary body and pars plana revealed whitening of the ciliary processes and depigmentation. Histopathological evaluations revealed ciliary epithelial necrosis with pigment dispersion. The vascularity of the ciliary processes showed focal disruption and haemorrhage. The underlying ciliary muscle and sclera appeared to be unaffected. No other findings could be attributed to microwave cyclodestruction. CONCLUSION: The results of this phase I toxicity study suggest that microwave heating can be used to damage preferentially the epithelial layers of the human ciliary body.

Aged↗

Taking babies' temperatures: science versus social taboos in battle over Baby Check.

Baby Check, a scoring system for assessing the severity of illness in babies under 6 months old, has not met with the success its developers expected. The inclusion of rectal temperature in the assessment was strongly opposed by the Royal College of Midwives, which refused to alter its view despite evidence of the safety and accuracy of rectal thermometry. British parents appear not to like rectal thermometers either. Most other medical bodies have supported Baby Check and the reason for midwives' opposition may have more to do with professional pique at not being consulted than clinical wisdom.

Body Temperature↗

Optical diagnostics for thin film processing.

Optical diagnostics are used to probe the plasma or neutral gas above the substrate, particles in the gas or on the surface, the film surface and reactor walls, the film itself, and the substrate during thin film processing. The development and application of optical probes are highlighted, in particular for analyzing plasma/gas phase intermediates and products and film composition, and performing metrology, thermometry, and endpoint detection and control. Probing etching (particularly plasma etching) and deposition (particularly epitaxy) are emphasized.

Journal Article↗

MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study.

The feasibility and safety of magnetic resonance (MR) imaging-guided focused ultrasound surgery for uterine leiomyomas is reported. Sequential sonications were delivered to nine targets. Temperature-sensitive phase-difference MR imaging monitored the location of the focus and measured tissue temperature elevations, ensuring therapeutic dose. MR images and hysterectomy specimens were evaluated. Six leiomyomas received full therapeutic doses, and 98.5% of the sonications were visualized. MR thermometry was successful in all sonications and cases. Focal necrotic lesions were seen in all cases at MR, and five were pathologically confirmed. MR imaging-guided focused ultrasound causes thermocoagulation and necrosis in uterine leiomyomas and is feasible and safe, without serious consequences.

Adult↗

Radiofrequency ablation: modeling the enhanced temperature response to adjuvant NaCl pretreatment.

PURPOSE: To characterize the effects of volume and concentration of adjuvant NaCl pretreatment on radiofrequency (RF) ablation and to model these results to determine their applicability to in vivo systems. MATERIALS AND METHODS: Standardized 1-L 5% agar phantoms were constructed with central wells of varying volume that were filled with a protein-based polymer gel of varying NaCl concentration (0%-35%). RF ablation to the maximum system current output (2000 mA) was applied to internally cooled 2-cm electrodes placed in the center of the gel wells. Remote thermometry was performed 20 mm from the electrode. Temperatures generated within the phantom were then used to model the response surface by using regression analysis. The generated model was then applied to previously published in vivo data to determine its applicability to a porcine liver tissue model. Statistical analyses included one-way analysis of variance to compare the temperatures reached with different NaCl concentrations and volumes with those reached without NaCl. In addition, modeled functions were evaluated for goodness of fit and the statistical significance of their coefficients. RESULTS: NaCl volume and concentration had significant effects on RF-generated heating of the agar phantoms. The mean maximum temperature, 91.4 degree C +/- 0.8 (SD), was reached with 3.5 mL of 10% NaCl gel. This was significantly higher than the mean temperature reached in phantoms containing 0% NaCl gel, 40.3 degree C +/- 4.9 (P <.001). Heat increases to the maximum temperature correlated strongly with the deposited RF energy, with maximum temperatures limited by the current output of the RF generator. The response surface was defined by a generator energy-dependent region and a generator current-limited region, which were best modeled by a modified gamma-variate function and an exponential function, respectively (r2 = 0.92). This model correlated well with previously published in vivo data (r2 = 0.86). CONCLUSION: Modulation of electrical conductivity has different effects on RF ablation response that are dependent on generator capabilities and the volume and concentration of NaCl pretreatment.

Animals↗

Computer analysis of processor status.

The authors describe the use of a desk-top computer to analyze processor status. Quality control data (sensitometry, densitometry, thermometry, etc.) are collected conventionally. Analysis of the data is subsequently performed using specially designed software. This computer analysis results in a small savings in time and in greatly improved management and presentation of quality control data.

Diagnosis, Computer-Assisted↗

Temperature mapping with MR imaging of molecular diffusion: application to hyperthermia.

Efficacy and safety considerations for hyperthermia (HT) cancer therapy require accurate temperature measurements throughout the heated volume. Noninvasive thermometry methods have been proposed, including magnetic resonance (MR) imaging based on the temperature dependence of the relaxation time T1. However, the temperature accuracy achieved to date with T1 measurements does not fulfill the HT requirements (1 degree C/cm). The authors propose to use molecular diffusion, for which temperature dependence is well known. Molecular diffusion is more sensitive than T1 and can be determined with high accuracy with MR imaging. Diffusion and derived temperature images were obtained with a 2 X 2-mm pixel size in a polyacrylamide gel phantom heated inside the head coil of a clinical 0.5-T whole-body MR imaging system by means of a modified clinical HT device made compatible with the system. Temperatures determined from these images with 0.8-cm2 regions of interest were found to be within 0.5 degrees C of those recorded with thermocouples placed inside the gel. The utility of this method in clinical hyperthermia is enhanced by its potential to also help monitor blood perfusion.

Diffusion↗

Soft-tissue sarcomas: MR imaging and MR spectroscopy for prognosis and therapy monitoring. Work in progress.

The authors studied the usefulness of hydrogen-1 T2 measurements and phosphorus-31 magnetic resonance (MR) spectroscopy as indicators of prognosis and monitors of response to therapy in a group of patients with soft-tissue sarcomas. All eight patients were treated with combined local hyperthermia and fractionated radiation therapy, followed by surgical resection of the tumor. Each patient underwent T2 measurements and five patients underwent MR spectroscopy (phase encoded in one dimension) before treatment, after the first hyperthermia treatment, at the end of the therapy course, and just before surgery. Catheter thermometry was performed at each hyperthermia treatment. The T2 and MR spectroscopic variables were compared with thermometric data and the histologic findings from the complete surgical specimen. Changes in T2 correlated with histologic grade of tumor and thermometric data. The pretherapy tumor pH correlated positively, and changes during therapy in pH, ratio of phosphocreatine to inorganic phosphate (Pi), ratio of nucleoside triphosphate to Pi, and the phosphomonoester signal-to-noise ratio correlated negatively, with the percentage of tumor necrosis on the surgical specimen. These preliminary data suggest MR imaging and MR spectroscopy may be useful in the evaluation of such patients before and during therapy.

Adult↗

Malignant liver tumors treated with MR imaging-guided laser-induced thermotherapy: technique and prospective results.

PURPOSE: To evaluate magnetic resonance (MR) imaging-guided laser-induced thermotherapy (LITT) of liver metastases. MATERIALS AND METHODS: In a phase II study, 20 patients with 33 metastases from colorectal carcinoma (75%) or other primary tumors (25%) underwent LITT. MR thermometry performed with fast low-angle shot sequences was used to monitor therapy on-line, and dynamic and static contrast material-enhanced MR images enabled estimation of the degree of resultant necrosis. Follow-up studies were performed 3 months after thermotherapy. RESULTS: The thermosequences enabled accurate on-line monitoring in 85% of lesions. In 69% of lesions 20 mm in diameter or smaller, contrast-enhanced MR images depicted substantial necrosis, with a local tumor control rate of 69% after 6 months and 44% after 12 months. Among lesions larger than 20 mm, necrosis was frequently incomplete, with a local control rate of only 41% after 6 months and 27% after 12 months. CONCLUSION: MR imaging-guided LITT of liver metastases is a safe and promising therapy for liver metastases.

Adult↗

MR compatibility of Guglielmi detachable coils.

Guglielmi detachable endovascular coils were evaluated for magnetic resonance (MR) compatability at 1.5 T. Tests to determine magnetic field attraction (deflection angle and Petri-dish displacement methods), heating (infrared thermometry), and artifact production (beef phantom) were performed. Adverse event data were reviewed for MR imaging in 142 patients in whom the coils were implanted to treat intracranial aneurysms. There was no magnetic field attraction, the temperature increased 0.2 degrees C, and only a mild signal void relative to the size and shape of the coil was produced. All patients underwent MR imaging without incident. The Guglielmi coils are compatible with MR imaging at static magnetic field strengths of 1.5 T or less.

Aneurysm↗

Internally cooled power laser for MR-guided interstitial laser-induced thermotherapy of liver lesions: initial clinical results.

PURPOSE: To evaluate experimentally and clinically an internally cooled power laser system for percutaneous treatment of liver metastases, with magnetic resonance (MR) imaging guidance, to increase the volume of coagulative necrosis with single laser beam applications. MATERIALS AND METHODS: The power laser system consisted of standard cannulation paraphernalia and a specially designed 7-F protective catheter for cooling the laser tip during treatment to avoid carbonization. A microdome laser beam applicator with a laser tip diameter of 0.95 mm kept the entire device as small as possible. After the unit was tested in 40 porcine livers, 532 laser beam applications (mean power, 27.5 W [range, 22.1-30.0 W]; mean application time, 19.8 minutes [range, 14-30 minutes]) were performed with MR guidance in 127 patients with 318 liver metastases. The safety of the procedure and the volume of induced necrosis were evaluated. RESULTS: In vitro, cuboid areas of coagulative necrosis with a mean greatest diameter of 4.3 cm +/- 0.5 (SD) were demonstrated after single applications. In vivo, MR thermometry allowed accurate demarcation of changes induced by heat, with a mean diameter of necrosis of 3.3 cm +/- 1.4. No carbonization or vaporization of tissue or damage of equipment occurred during treatment. CONCLUSION: This power laser system can increase the volume of laser-induced necrosis in liver metastases with a single application, thereby simplifying and accelerating the treatment of larger lesions.

Animals↗

Radio-frequency tissue ablation: effect of pharmacologic modulation of blood flow on coagulation diameter.

PURPOSE: To determine whether vasoactive pharmacologic agents can alter radio-frequency (RF)-induced coagulation necrosis by modulating hepatic blood flow. MATERIALS AND METHODS: RF ablation was performed in normal, in vivo porcine liver with 1.5-cm internally cooled electrodes and a standardized RF application (i.e., 500 mA for 10 minutes). Ablation was performed without (n = 9) and with pharmacologic modulation of blood flow with halothane (n = 7), vasopressin (n = 6), or epinephrine (n = 7). Laser Doppler techniques were used to quantify changes in hepatic blood flow. Remote thermometry was also performed. Blood flow was correlated with both induced coagulation necrosis and tissue temperatures. RESULTS: Halothane reduced mean blood flow (+/- SD) to 46.1% +/- 8.5 of normal, and vasopressin increased mean blood flow to 132.7% +/- 13.9. Epinephrine caused increased hepatic blood flow centrally (171.1% +/- 31.7) but not peripherally (102.8% +/- 15.4). Mean coagulation diameter was 1.4 cm +/- 0.3 with vasopressin, 2.2 cm +/- 0.4 with normal blood flow, and 3.2 cm +/- 0.1 with halothane (P < .01). After epinephrine infusion, mean coagulation measured 2.3 cm +/- 0.3 peripherally and 1.4 cm +/- 0.5 centrally (P < .01). A linear correlation between coagulation diameter and blood flow was demonstrated (r2 = 0.78). Temperatures 10 and 15 mm from the electrode correlated with both blood flow and coagulation diameter (r2 = 0.65 and 0.60, respectively). CONCLUSION: The coagulation necrosis achieved for a standardized RF application correlates with relative tissue perfusion. Pharmacologic reduction of blood flow during thermally mediated percutaneous ablation may induce greater coagulation necrosis.

Anesthetics, Inhalation↗