Taste dysfunction in burning mouth syndrome.
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Bile acids have been proposed to be important in the pathophysiology of the syndrome of "bile reflux gastritis" after surgery. To examine the role of cholestyramine, an ion exchange resin that binds bile acids, on symptoms of this syndrome, we did a randomized, double-blind crossover study on 16 patients. No differences in frequency of abdominal pain, nausea, vomiting, or bitter taste were observed among cholestyramine (4 g, three times daily for 3 weeks), placebo, and routine (dietary restriction and ad libitum antacid) treatment periods. We conclude that this regimen of cholestyramine was ineffective in symptomatic treatment of bile reflux gastritis.
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Divers performing electrical welding/cutting underwater often complain about a metallic taste in the mouth, strictly related to their work. In a nationwide clinical investigation, professional commercial divers were examined orally. The majority of the divers complained about a metallic taste. An increased surface deterioration of dental amalgam was detected in those divers who had performed electrical welding/cutting during the previous two years. In addition, after clinical and bacteriological examination, divers were found to belong to a caries risk group. In order to study the intraoral electrical activity, several actual dives were performed. When they were welding or cutting, the electrical activity registered intraorally in dental amalgam test samples was too low in magnitude to explain the metallic taste and the clinical appearance of the amalgam. The divers were dressed in a dry-suit and full-face mask. When leakage occurred or when a hot-water heated suit was used higher electrical activity was registered. This activity was still not of a magnitude, which could explain the symptoms theoretically, although a metallic taste and a subjective change in the divers dental amalgam were provoked. No increased levels of Hg and Cu could be detected in saliva, blood or urine. The flux density of the intraoral magnetic field created by a current of 650 ADC was calculated and measured to be 1.15 mT, which is approximately 25 times stronger than that of the earth. When exposing divers in-vivo to a field generated by a 200 ADC current, no symptoms other than magnetophosphenes were reported, such as metallic taste. The divers helmets offered almost no shielding effect towards the magnetic field. In-vitro exposure of dental amalgams to a magnetic field (1.15 mT; 50 Hz) increased the mobility of cupper and especially mercurity in the superficial layers of the amalgam after 24 h exposure, and gave rise to slight morphological changes within the amalgam.
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Complaints of taste and smell dysfunction unaccompanied by symptoms of neurological or nasal problems are not uncommon. However, "I can't taste" is not necessarily an accurate symptom description. Complaints tend to reflect the common confusion between taste sensations (that is, salt, sour, sweet, bitter) and flavor sensations (including taste, smell, temperature, and texture). A number of questions have been identified that help classify symptoms according to the type of dysfunction (taste, smell, or both): whether the problem is quantitative (reduced or absent sensation) or qualitative (distorted sensations); and what might have caused the dysfunction. Directed questioning can yield a clinical history that predicts chemosensory function and identifies the most likely cause of the problem. Questions were assessed by comparing the self-reports of taste and smell symptoms to the clinical evaluation of chemosensory function for 101 new patients seen in the Taste and Smell Center at the University of Connecticut Health Center in 1983.
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An electrogustometric study of 225 cases of Hansen's disease revealed impairment of taste in 55.1% of the cases. It was related to the duration of the disease, and was seen in 74.6% of the cases of lepromatous leprosy, 49.3% of the cases of borderline leprosy, and 41.3% of tuberculoid leprosy cases. Only in lepromatous cases was complete ageusia seen (9.39% of cases). All of the cases having lesions in the oropharynx and those with facial nerve palsy revealed impairment of taste, but it was not related to the type of antileprosy drug used or to the development of ENL reaction.
A 32 year old man affected by grade 1 astrocytoma of the right sylvian region and epileptic seizures, presented gustatory hallucinations as a post-ictal symptom. Spikes of very low voltage during sleep were the only epileptic abnormalities found on his EEG. It is suggested that post-ictal as well as ictal gustatory hallucinations may be a localizing symptom of glioma involving the sylvian region. Furthermore, if systematically searched for, sleep related microspikes may become an EEG sign useful for the diagnosis of brain tumour in patients with epileptic seizures and no epileptic discharges on the awake EEG.
The author present, for pediatristist of primary care of health, a alarm factors, in the psychic evolution of children will can develop a child psychoses. The author in two groups has classified them: major signs and minors signs, he was giving a characteristics and patterns for to be valuated.
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This review examines the contributions made by anorexia, loss of taste, malabsorption and disturbances of intermediary metabolism to the cachexia of cancer. Methods of nutritional assessment are outlined and mention is made of the usefulness of nutritional support as an adjunct to anti-cancer therapies.