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PubMed2005

Endocrine disruptive effects of polychlorinated biphenyls on the thyroid gland in female rats.

Polychlorinated biphenyls (PCBs) are persistent environmental pollutants. Aroclor 1221 (A1221) and Aroclor 1254 (A1254) are commercial PCB mixtures with low and high number of chlorination, respectively. We have comparatively investigated effects of A1221 and A1254 on serum levels of thyroid hormones and thyroid gland histology in adult female Wistar rats. Animals were subcutaneously injected with A1221 (10 mg/kg) or A1254 (10 mg/kg) for six weeks. One group of animals served as control. At the end, all animals were decapitated and trunk blood collected. Serum levels of triiodothyronine (T3) and thyroxine (T4) were measured by the electrochemiluminescence immunoassay method. Thyroid glands were removed for histopathological examination under light microscopy. Serum total T4 levels were significantly increased in A1221- and A1254-treated rats (p < 0.05). Serum free T4 levels were significantly increased in the A1254-treated rats (p < 0.01), but not in the A1221-treated rats. In contrast, the treatment with A1221 caused a significant increase in serum free T3 concentrations (p < 0.05) but not with A1254. Notably, either A1221 or A1254 caused distinct histopathological changes, such as formation of many microfollicles in the thyroid gland, which mimic the changes seen in thyrotoxicosis. In conclusion, both PCB mixtures induce toxic effects in the thyroid gland regardless of their degree of chlorination. We suggest that these environmental contaminants may disrupt thyroid hormone homeostasis in exposed individuals and thus pose a threat to human health.

Animals↗
PubMed1987

[Primary non-Hodgkin's lymphoma of the thyroid gland].

It is reported on a patient with low-malignant primary non-Hodgkin lymphoma of the thyroid gland with hitherto 7-year absence of recidivity after exclusive operative therapy. The course is critically discussed in the light of the literature. Conclusions relate to the diagnostic and therapeutic regimen within clinical treatment, cytology, antibody diagnostics, operation and combined therapy in lymphomas of the thyroid gland and Hashimoto's thyroiditis.

Adult↗
PubMed2005

Langerhans cell histiocytosis presenting as a thyroid gland mass.

We report 2 cases of Langerhans cell histiocytosis (LCH) presenting as a thyroid mass. The first case is a 45-year-old woman with a 13-year history of diabetes insipidus who presented with an enlarging thyroid mass with substernal extension. The second case is a 29-year-old man who presented with an enlarging thyroid mass and skin lesions. Histologic evaluation of the thyroid gland in both cases revealed extensive involvement by LCH, confirmed by immunohistochemical analysis showing Langerhans cells that were positive for CD1a and S-100 protein. Langerhans cell histiocytosis can rarely involve the thyroid gland in adults, and we have identified 30 cases reported in literature. Most patients had evidence of LCH involving other anatomic sites, as was true in these 2 cases, and the diagnosis was initially established by examination of other sites in a subset of patients. Affected patients frequently have diabetes insipidus, as was true in case 1. Thyroid gland involvement as the initial presentation of LCH is a rare phenomenon that can result in misdiagnosis.

Adenocarcinoma, Papillary↗
PubMed1990

Nonpigmented papillary carcinoma in a black thyroid gland.

A case of papillary thyroid carcinoma occurring in a 27-year-old man with black thyroid syndrome is reported. The tumor, in contrast to the remaining thyroid, was not pigmented. The significance and potential utility of the differential pigmentation are discussed.

Adult↗
PubMed1975

The aetiology and diagnosis of malignant tumours of the thyroid gland.

Known aetiological factors of thyroid tumours are: genetic, hormonal, irradiation and auto-immune thyroiditis. Some medullary carcinomas are familial. Thyroid-stimulating hormone plays a significant part in the initiation and maintenance of many well-differentiated thyroid carcinomas. Small doses of irradiation in childhood and probably also in adolescence may induce a papillary or follicular carcinoma. Some malignant lymphomas develop in a previous auto-immune thyroiditis. Diagnosis of a malignant thyroid tumour is usually obvious once there has been extrathyroidal spread. Intrathyroidal tumours are suspect if they are hard and irregular. The real diagnostic problem is the clinically solitary nodule which is smooth, firm and mobile in a euthyroid patient. Ultrasound and scanning may increase or decrease the suspicion of malignancy but excisional biopsy is the only certain diagnostic procedure.

Adenocarcinoma↗
PubMedDate not supplied

[Galectin-3 in differential diagnosis and prognosis of follicular tumors of the thyroid gland].

Differential diagnosis between follicular thyroid tumours (FTT) is difficult both at cytological and histological levels. Infiltrative growth is authentic criterion of malignancy. Immunohistochemical reaction (PAP-method) with galectin-3 antibodies was used. The results allow to make differential diagnosis of thyroid tumours before the surgery. Immunohistochemical identification of galectin-3 in the tissue of follicular adenomas with grave dysplasia and follicular carcinoma is an unfavourable prognostic sign.

Adenocarcinoma, Follicular↗
PubMed1993

[Possibilities and limitations in the morphologic study of the thyroid gland].

The comparative evaluation of thyroid pathology in different regions should include biopsy and autopsy examination. Morphological research (cytological and histological methods) implies 3 steps: preoperative, intraoperative and postoperative. The results of cytological and histological examination should be properly used by clinicians. For successful comparative ecological research it is necessary to use reliable methods of investigation of thyroid goiter and thyroid tumours. These methods provide evaluation of real morphofunctional state of thyroid pathology in different regions.

Autopsy↗
PubMed1993

[In vitro effects of anesthetics on hydrogen peroxide generating system of the thyroid gland].

Effects of anesthetics on thyroidal hydrogen peroxide generating system was studied using porcine thyroid follicles. This system is indispensable in thyroid hormone synthesis and seems also to play an important role in regulation of thyroid hormone release. The results indicated that H2O2 generation was controlled by Ca2+ ion mobilization and protein kinase-C linked signal transduction system. It was also demonstrated that thiopental, halothane, and enflurane had inhibitory effects on H2O2 generation system in thyroid follicle cells, and 50% inhibitory concentrations (IC50) of each anesthetic drug were 60 microM, 2.5% and 4.0%, respectively. Other anesthetic agents, such as local anesthetics and major tranquilizers did not show any inhibitory effects on porcine thyroid peroxidase activity as well as on the regulation of thyroid hormone release. Other than inhaled anesthetic agents, thiopental only is thought to have an antithyroid effects in clinical situation.

Anesthetics↗
PubMed1998

[Thyroid gland carcinoma].

Carcinoma of the thyroid is a rare tumour, comprising approximately 1% of human malignancies. Thyroid carcinoma is classified according to its origin (thyroid follicular cell or calcitonin-producing C cell) and grade of differentiation (differentiated, poorly differentiated or anaplastic). Due to their different biology, genetical background and clinical course, which result in fundamentally different therapeutic strategies, the various types of thyroid carcinoma have attracted a lot of interest by both clinicians and pathologists. This review article deals with the most important aspects (definition, epidemiology, clinical course, prognosis, differential diagnosis and genetic background) of the various thyroid carcinomas.

Adenocarcinoma, Follicular↗
PubMed1996

Argyrophilic nucleolar organizer regions in proliferative lesions of the thyroid gland.

OBJECTIVE: To analyze various argyrophilic nucleolar organizer regions (AgNOR) parameters in proliferative lesions of the thyroid gland and to determine to what extent these parameters are influenced by the type of lesion or malignancy. STUDY DESIGN: AgNORs were studied by light microscopy with the help of a semiautomated image analysis system in the normal thyroid gland (n = 6), nodular hyperplasia (n = 12), thyroid hyperfunction (n = 6); follicular adenoma (n = 21), oxyphilic adenoma (n = 10), follicular carcinoma (n = 10), oxyphilic carcinoma (n = 9), papillary adenocarcinoma (n = 14), and giant (n = 6) and small cell anaplastic carcinoma (n = 4). The investigated parameters included the number and area of AgNOR dots, the number of separate AgNOR locations, the ratio of the AgNOR dot area to the nuclear area and the area of single AgNOR dots. RESULTS: The number and area of AgNOR dots were low in all the lesions, with the exception of giant cell anaplastic carcinoma. The number of separate AgNOR locations was the lowest in oxyphilic cell tumors and medium in papillary adenocarcinoma, while in all other lesions and normal thyroid it had higher values. The ratio of AgNOR area to the nuclear area and the area of single dots were similar in proliferative lesions and normal thyroid. In all proliferative lesions and in normal thyroid, there was a significant positive correlation (P < or = .0001) between the area or number of AgNOR dots on the one hand and nuclear area on the other. CONCLUSION: The results indicate that in thyroid proliferative lesions, AgNOR values, particularly the number of separate AgNOR locations, correlate with the type of lesion but not with malignancy. Very typical are single clusters of dots within nuclei in oxyphilic tumors, malignant and benign, and in papillary adenocarcinomas, more or less often accompanied by single dots.

Adult↗
PubMed1977

A radioimmunoassay for 3,3',5'-L-triiodothyronine (reverse T3): assessment of thyroid gland content and serum measurements in conditions of normal and altered thyroidal economy and following administration of thyrotropin releasing hormone (TRH) and thyrotropin (TSH).

The present report describes the development of a radioimmunoassay for 3,3',5'-L-triiodothyronine (reverse T3) which is performed on unextracted serum. Utilizing this radioimmunoassay, 21 normal subjects had a mean (+/-SD) serum reverse T3 level of 60 +/- 12 ng/100 ml, 17 of 19 hyperthyroid patients had elevated serum reverse T3 levels, and 10 of 11 hypothyroid subjects had decreased serum reverse T3 concentrations. Thyroidal secretion of reverse T3 was assessed by measurements in samples obtained from the internal carotid artery and jugular vein of sheep following the administration of thyrotropin releasing hormone (TRH) or bovine thyrotropin (TSH). Reverse T3 levels were increased 45-60 min after TRH administration, but TSH administration produced inconsistent alterations in reverse T3, although 18 of 27 samples obtained after TSH injection were higher than their average respective baseline concentration and the mean peak reverse T3 level was 14% higher than baseline. Following TRH administration to 10 normal human subjects, mean serum reverse T3 levels significantly increased from 53.6 ng/100 ml to 56.3ng/100 ml (P less than .05). The thyroid gland content of reverse T3 in human autopsy material was 6.5 +/- 1.5 microng/g tissue. Both pregnancy and estrogen administration were associated with increases in serum reverse T3 concentrations presumably because of their ability to augment thyroxine binding globulin synthesis.

Adult↗
PubMed1977

[Thyroid gland metastases: presentation of 2 cases].

Metastases of the thyroid gland originate mostly from carcinomas of the urogenital tract, the lungs or the digestive organs. Though they are thought to be rather uncommon, they may give rise to delicate therapeutic problems. The two cases of metastases of digestive origin reported by the authors join a series not very important to this day and presenting a rather dark prognosis. The authors consider the surgical problems as regard to aetiology which determines the length of survival. As a rule, an isolated metastasis of the thyroid gland requires a total thyroidectomy, if only to avoid the compressive effect occurring very rapidly. On the other hand, if the thyroid invasion is a part of a general formation of metastases, removal of the gland will not alter the prognosis.

Adult↗
PubMed1998

[Rate of complications with systematic exposure of the recurrent laryngeal nerve and parathyroid glands in operations for benign thyroid gland diseases].

OBJECTIVE: The influence of the operation technique on the complication rate of thyroid operations is still a subject of discussions. In this study, we analysed therefore the most important complications, i.e. palsy of the recurrent laryngeal nerve and hypoparathyroidism, specially under the aspect of routine exposition of the recurrent laryngeal nerve and parathyroids. METHODS: 116 patients with goiter operations of the year 1995 (12 different surgeons) were analysed. Age of patients was between 7 and 72 years, mean age 45 years. The operations performed were 70 subtotal resections (benign goiter), 33 near-total-resections (diffuse autonomy or Graves' disease), 33 hemithyroidectomies (scintigraphically "cold" nodules), 4 adenoma resections with combinations of these resections in 24 cases. RESULTS: 4.3% of the patients (5/116 patients) developed an unilateral recurrent nerve palsy immediately after operation. Persisting recurrent nerve palsy occurred only in 1.7% (2/116) of these cases. Postoperative nerve palsy was mainly found after extensive resections (2/33 near-total-resections) or operations of recurrent goiter (2/6 re-operations), rarely after routine operations (1/70 subtotal resections). Hypocalcemia was found in 9.5% of the patients (11/116), of which 9 cases were asymptomatic (7.8%) and 2 symptomatic by tetany (1.7%). Persisting hypocalcemia for longer than one week was found in 3.5% (4/116), permanent hypoparathyroidism in 1.7% (2/116) of the patients. CONCLUSIONS: Routine systematic exposure of recurrent laryngeal nerves and parathyroids reduces the incidence of complications in thyroid surgery to a minimum. The risk of recurrent nerve palsy increases with extent and difficulty of the operation, with the highest risk for nerve lesions seen in re-operations and near-total-resections.

Adolescent↗
PubMedDate not supplied

[Characteristics of immunoaffinity chromatography and a new method for isolation of human thyroid peroxidase from subcellular fractions of thyroid gland].

A system for quantitative determinations of human thyroid peroxidase (TPO) in biological fluids has been obtained, based on the use of enzyme-linked immunosorbent assay. Immunochemical properties of TPO were studied under variable conditions, and a new method for isolating the protein from microsomes, mitochondria, and cytosol of thyroid glands of patients with diverse thyroid diseases was developed. The procedure involves solubilization of subcellular fractions with detergents, their sonication, two sequential runs of chromatography (on sorbents with immolbilized monoclonal antibodies against TPO and goat anti-human immunoglobulin antibodies), treatment with ribonuclease, and dialysis. Highly purified preparations of intact TPO and a product of its limited trypsinolysis are expected to be used as research tools and components of high-sensitivity immunoassays.

Antibodies, Monoclonal↗
PubMed1979

[Experimental investigation with 198Au colloid as to lymph communications between the retrobulbar space and the thyroid gland (author's transl)].

The problem of a direct connection of lymph drainage between the retrobulbar space and the thyroid gland was examined using the lymphotropic radioactive tracer 198Au colloid. Twelve rabbits were examined. Six animals were injected with 50 muCi 198Au colloid into the right thyroid lobe and six animals into the right retrobulbar space. Distribution and total body radioactivity was measured in vivo using a scintillation camera with a computer. After 6 hrs tissue specimens of different organs were measured in a well-counter. The discharge of activity from the thyroid after 6 hrs was significantly higher than that from the retrobulbar space (63% versus 33.5%). This was probably due to a higher vascularisation and to a higher degree of lymph drainage of the thyroid. The lymph drainage of the thyroid gland as well as of the retrobulbar space occurred mainly via the lymphonodi cerv. proff. No significant activity was found in the retrobulbar space after thyroid injection or in the thyroid after retrobulbar injection. It may be concluded from these results that there are no direct lymph connections between the retrobulbar space and the thyroid gland. However, indirect communications via the deep cervical lymph nodes cannot be excluded in the event of reverse lymph flow.

Animals↗
PubMed1993

[The significance of the ultrasound examination in surgery of the thyroid gland].

The authors emphasize the importance of ultrasonographic examination of the thyroid gland for the diagnosis of disease as well as for planning and implementation of the operation. They evaluate the importance of 154 sonographic examinations which were made during the last three years in 545 operations of the thyroid. For the surgeon anatomical parameters of the pathological tissue are important with special emphasis on the relation with surrounding tissues and affection of the lymphatic system. The examination is irreplaceable, in particular in reoperations of the thyroid gland and nodular syndrome.

Humans↗
PubMedDate not supplied

[Functional activity of the thyroid gland after immunization with the homologous tissue of the pancreas].

An insufficiency of the insular apparatus of the pancreas developed in rabbits in response to the immunization with a homologous tissue of the pancreas. A correlation existed between the thyroid gland function and the endocrine portion of the pancreas. The results of study of the functional activity of the thyroid gland under conditions of immunization with a homologous tissue of the pancreas are presented. The data obtained in the course of the experiment pointed to the changes in the thyroid gland characteristic of the intensification of its function: the height of the epithelium increased, the diametre of the follicles and the index of the colloid accumulation diminished. Experimental results confirmed the literature data on the existence of an inverse relationship between the functional activity of the insular apparatus of the pancreas and the thyroid gland function.

Animals↗
PubMed1985

Primary squamous cell carcinoma of the thyroid gland--a case report.

Primary squamous cell carcinoma of the thyroid gland is rare. We report here a case of primary squamous cell carcinoma of the thyroid gland in a middle aged woman who had a thyroid nodule of 12 years duration with a recent rapid increase in size and associated with pressure symptoms. There was massive enlargement of the thyroid with retrosternal extension and fixity. Cervical nodes were also enlarged. The X-rays revealed calcification. A palliative thyroidectomy was done leaving the residual tumour behind. Endotracheal intubation and tracheostomy were required for respiratory distress in the postoperative period.

Carcinoma, Squamous Cell↗