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At least 919 records · Page 51Linked to original sources
PubMed1977

[Liverfunction and serum concentration of electrolytes in patients operated for morbid obesity (author's transl)].

50 patients with morbid obesity underwent a Jejuno-Ileostomy. The liver function was tested before operation and postoperatively up to 24 months. Simultaneously the concentration of potassium, natrium, calcium, magnesium and chloride was examined. The concentration of bilirubin did not show any important changes. Thymol turbidity was within the limit. 3 months after the operation an increase of the activity of SGPT and SGOT was noted, as well as the increase of BSP retention. 6 months after the operation a decrease of concentration of potassium and calcium in serum was observed. 3 patients developed tetany. 12 months after the operation no changes in the concentrations of ions in the blood serum have been noted and the tests of the liver showed an improved function compared with the pre-operative period.

Adolescent↗
PubMed1979

[Liver function studies under the influence of hormonal contraceptives (sequential preparations)].

20 fertile women who were treated with mestranol as oestrogen and both gestagenes chlormadinonacetate and norethisteronacetate were investigated. Alkaline phosphatase, ASAT, ALAT, alpha-amylase, cholesterol, bilirubin, serumproteins, indocyanine green half time, paper electrophoresis of serumproteins, thymol and zinc sulfate turbidity tests were examined during the first therapy cycle. Elevation of ALAT activity (6,3 I U/l to 12,14 u/l) was found during treatment with mestranol/chlormadinonacetate. A depression of ALAT (up to 5,34 u/l) was observed under additional therapy with gestagene chlormadinonacetate. Statistical significance was noted only for ALAT and alpha 1 globuline under sequential therapy with mestranol/norethisteronacetate.

Adolescent↗
PubMed1996

[Antiseptic properties of essential oil of Lippia sidoides Cham. Application to the cutaneous microflora].

Two samples of essential oils of Lippia sidoides Cham. have been tested for their antibacterial and antifungal properties against some microorganisms living on the skin of feet and armpits. The essential oils and also their main components, thymol and carvacrol, show strong antagonistic activities. Corynebacterium xerosis developing axillary odour is specially inhibited. But on the other hand no specific activities have been observed upon the feet microflora.

Anti-Infective Agents, Local↗
PubMed1977

[Leukocyte alkaline phosphatase in epidemic hepatitis].

The carried out investigations on 70 patients with epidemic hepatitis, 52 of them treated with prednisolon and 18-symptomatically revealed the following: the normal alkaline phosphatase, established prior to the treatment, was elevated with the applied prednisolon treatment and showed no significant alteration in the patients without cortico-therapy. No correlation was found between leukocyte alkaline phosphatase and serum alkaline phosphatase transaminase, serum bilirubin and thymol test. No relationship was found between the severity of the ailment course and the leukocyte alkaline phosphatase.

Adolescent↗
PubMed1996

Liver function tests in recurrent P. vivax malaria.

Blood samples were collected from 61 P. vivax infected fresh and recurrent malaria patients and liver function parameters studied. Plasma albumin, A/G ratio were found decreased significantly (p < 0.001) when compared to controls. Among the group of recurrent malaria patients with more than five attacks lowest values were found and the decrease was directly correlated with the number of attacks. The enzyme activities of plasma LDH, SGPT and thymol turbidity were found increased significantly with the increase in the number of attacks (p < 0.001). The increase was more pronounced in more than 5 attack (R3) group. The levels of total, conjugated and free bilirubin and the enzyme activities of SGOT, alkaline phosphatase were also found increased significantly in all the recurrent malarial groups, when compared to controls, without any correlation between the number of attacks. The isoenzyme pattern of plasma LDH was not altered in either fresh or recurrent malarial attack groups when compared to controls.

Adolescent↗
PubMed1977

[Biochemical properties and antibiotic resistance of the staphylococci isolated from cows with subclinical mastitis].

A total of 33 strains of staphylococci, isolated from Black Pied cows with subclinical mastitis (conformed by the brom-thymol test), were studied to establish their biochemical properties and resistance to antibiotics as well as the occasional correlation between enzyme activity and resistance. It was found that no such dependences existed so far as the biochemical indices of the investigated strains were concerned. All strains proved strongly sensitive to chrolamphenicol, tylan, kanamycin, neomycin, streptomycin, oleandomycin, erythromycin, ampicillin, and were resistant to tetracycline and polymixin. The resistance of staphylococci to antibodies is probably manifested in connection with some of their biochemical properties. It has been found that resistant strains of staphylococci are more active biochemically.

Animals↗
PubMedDate not supplied

[Determination of the content of common protein in biological samples using chemical stabilizers].

Proteins of biological samples in the process of storage are subject to microbe contamination as well as the destruction by their own lipoprotein lipases. It is established that N-thymol compounds of formulas 52 and 82 stabilize blood serum samples of donors and preserve the content of total protein in them unchanged for 7, 15 and 40 days, respectively. The obtained stabilizers can be used when studying protein metabolism in the organism of cosmonauts performing long-term space flight, depots of nuclear submarines, participants of long-term Alpine, desert, polar and other expeditions.

Altitude↗
PubMed1977

A longitudinal study on the occurrence of autoantibodies in the course of acute hepatitis B.

The presence or absence of autoantibodies in acute hepatitis B was investigated longitudinally in a prospective study of 38 patients, 37 of whom recovered completely. Antibodies to nuclei, bile canaliculi or mitochondria were not found in any of the 354 investigated sera. Smooth muscle antibody (SMA) was present in 23 patients for median 4 weeks and from (median) -1 to +3 weeks from peak SGPT. Titers reached from 1:10 to 1:400, with a median of 1:50. In the patient with persistent HBs-antigenemia, SMA - present in low titer (1:10) - persisted as well. Besides smooth muscle cells, other localisations were: glomerular (15 patients), around hepatocytes ('polygonal' 11 pts), around renal tubuli (10) and in the gastric mucosal layer (8). These fluorescence patterns, the presence of which was not correlated to the SMA titer height, disappeared either earlier than or simultaneously with smooth muscle cellular fluorescence. A maximal titer greater than 1:50 was associated with a thymol turbidity ten times the upper limit of normal or more (i.e. greater than 25 S-H U) and with the peak serumgammaglobulin about simultaneously with peak SGPT. The presence of SMA was not correlated with extrahepatic manifestations nor with the peak values attained for ESR, SGPT, alkaline phosphatase or bilirubin.

Acute Disease↗
PubMedDate not supplied

Liquid chromatographic determination of safrole in sassafras-derived herbal products.

A liquid chromatographic (LC) method was developed for determining safrole in herbal products derived from sassafras (Sassafras albidum), as well as related compounds such as isosafrole and dihydrosafrole. The procedure involves solvent extraction and isolation of analyte by reversed-phase LC with UV detection at 235 nm. Safrole is resolved from related compounds and other sample constituents including thymol, a component of thyme. A linear concentration range of 0.003-0.200 mg/mL was obtained for safrole, isosafrole, and dihydrosafrole. Limits of detection (LOD) and quantitation (LOQ) were e0.0015 and 0.0051 micrograms/mL for safrole, 0.0018 and 0.0061 micrograms/mL for isosafrole, and 0.0038 and 0.0125 micrograms/mL for dihydrosafrole, respectively. Intraday relative standard deviations (RSDs) for safrole (n = 5) from various samples ranged from 1.30 to 5.39% at analyte levels of 0.01-1.5%. Safrole contents of 26 samples including root bark powder, leaves, oils, tea concentrate, herbal extract tinctures, and herbal powder capsules ranged from < LOD for most leaf samples to 92.4% for an oil. Recoveries of safrole from fortified samples ranged from 83.6% for an oil to 117.2% for a tincture preparation. Safrole contents of 0.09-4.66 mg/cup were found for brewed teas prepared from sassafras root bark powders and tinctures.

Chromatography, Liquid↗
PubMed1997

Marginal seal composition in amalgam restored teeth of varying marginal leakage.

An in vitro study was performed to ascertain the marginal seal elemental composition of amalgam restored extracted teeth of known marginal leakage. Occlusal cavities were cut in 400 caries free extracted teeth and left unlined or lined with one of 5 bases. A varnish was applied to half the cavities followed by restoration with a low copper or high copper amalgam to produce 20 restoration combinations. The teeth were stored in 1 per cent NaCl and thymol for 3 and 12 months at 20 degrees C whereafter a standard fluorescent dye marginal leakage test was performed on 320 specimens (eight teeth per treatment). Restoration combinations were grouped into 4 seal classes depending on percentage marginal seal achieved for each combination: 0-25 per cent; 26-50 per cent; 51-75 per cent and 76-100 per cent. The 80 remaining teeth (2 teeth per treatment) were fractured to expose the restoration and cavity surface, covered with marginal seal material and this was analysed by energy dispersive X-ray analysis. Elemental seal composition was compared to percentage marginal seal achieved using ANOVA and Tukey's test with significance set at p < 0.05. Numbers of elemental analysis specimens falling into each marginal seal class was 0-25 per cent = 48; 26-50 per cent = 18; 51-75 per cent = 10; 76-100 per cent = 4. Of the 16 elements detected, nine were significantly linked to sealing/leakage: Ca, Cl, Cu, Mg, Hg, P, Ag, Sn and Zn. The findings have a bearing on the improved longevity of amalgam restorations.

Analysis of Variance↗
PubMed1998

[Estimation of cell proliferation in hepatocellular carcinoma and in background liver cirrhosis, by using MIB-1 LI].

The 23 hepatectomized patients with hepatocellular carcinoma (HCC) were studied. Samples were biopsied from both cancerous portion and from non-cancerous cirrhotic portion at operation. MIB-1 LIs were measured in these biopsied samples. Then the relationships between MIB-1 LIs and pathologic feature, clinical data, and prognosis were investigated. LIs of the cancerous portion (10.2 +/- 6.8%, Mean +/- SE) were significantly (p < 0.001) greater than those of non-cancerous cirrhotic portion (3.8 +/- 2.1%). LIs of the cancerous portion in the patients who were dead with in 18 months after their hepatectomies, were significantly (p < 0.05) greater than those in the patients who survived more than 18 months after operations. LIs of the cancerous portion in the patients whose samples revealed Edmondson & Steiners classification grade III, were significantly (p < 0.05) greater than those in the patients whose samples revealed grade II. LIs of the cancerous portion in the patients whose serum AFP levels showed high level (> or = 100 ng/ml) were significantly (p < 0.005) greater than those in the patients whose serum AFP levels showed low level (< 100 ng/ml). And LIs of the non-cancerous portion in the patients whose thymol turbidity test (TTT) showed high level (> 5K-U), were significantly (p < 0.005) greater than those in the patients whose TTT levels showed within normal range. LIs of the non-cancerous potion in the patients whose zinc sulphate turbidity test (ZTT) showed high level (> 12K-U), were significantly (p < 0.01) greater than those in the patients whose ZTT levels showed within normal range. LIs of the non-cancerous portion in the patients whose PT levels were prolonged (14 sec <), were significantly (p < 0.05) greater than those in the patients whose PT levels were within range. MIB-1 LIs were proved to be a good marker for estimation of biological behaviour of HCC tumors.

Aged↗
PubMed1998

[Solid phase microextraction (SPME) of sample preparation during of a complex biological matrix in biotransformation studies].

Within the scope of the investigation of drug metabolism in keratinocytes solid phase microextraction (SPME) was investigated as a suitable method for sample preparation. The application of SPME is based on the fact, that a amount of analyte is absorbed by the polymer fiber at equilibrium, and the fiber is localized on a tip of a GC-syringe. The stable nitroxyl radical TEMPO (2,2,6,6-tetramthylpiperidine-1-oxyl) and its apolar metabolite 2,2,6,6-tetramethylpiperidine were analyzed by SPME and subsequent GC using thymol as internal standard. By means of the headspace-technique and an apolar fiber the recovery rate of TEMPO and the metabolite was nearly 100% and the precision was high. However, the results of the direct SPME were unsatisfactory. In comparison with conventional liquid/liquid extraction and solid phase extraction SPE the SPME proved the best results with regard to recovery rate and precision. Furthermore, the main advantages of SPME are the renunciation of organic solvents, the saving of time, the possibility to reuse the fiber about 100-150 times and the option for a complete automatisation of the extraction procedure.

Biotransformation↗
PubMed1976

[Studies on the functional ability of swine liver perfused with human blood in machine recirculation attempt. 2. Behavior of serochemical parameters].

In the present paper is reported on the behavior of different serochemical parameters in heterologous perfusion of the liver of pigs. The perfusion of the animal livers was carried out with preserved human blood in 11 recirculation experiments (closed machine circulations). In addition to this an empty circulation with human blood without attachment to an animal liver was carried out, whereby otherwise the arrangement of the experiment was the same, in order to take into consideration the effects of the blood traumatisation in the interpretation of the results. The enzymes GOT and LAP proved as sensible indicators of the lesion of the liver cells occurring in the perfusion of the liver of the pigs. The behavior of the mitochondrial GDH as well as of the lysosomal enzymes SP and BETA-GC which scarcely increased during the recirculations in the perfusate blood, however, allows the conclusion that there did not appear a severe lesion of the liver cells (necrobiosis) during several hours of perfusion. A cholestasis did not develop during the perfusions, when one takes as basis the behavior of the enzymes AP, GGTP and AAP indicating cholestasis. Compared with GOT the enzyme GPT showed by far less elevations in the perfusate blood so that with increasing duration of the perfusion the De-Ritis-quotient significantly increased. Increased LDH-activities above all revealed the increasing during perfusion haemolysis and less reliably a lesion of the liver of the pig. The increase of ADA in the perfusate blood proved as nearly exclusively conditioned by haemolysis. Total protein, albumins, immunoglobulins, cholinesterase and thymol turbidity test remained unchanged in the course of the perfusions.

Acid Phosphatase↗
PubMed1998

Detection of metabolites of a veterinary counter-irritant in canine urine.

Routine paper chromatographic screening of the urine of racing greyhounds exposed to BIGELOIL, a veterinary counter-irritant, revealed metabolites suggestive of menthol, an ingredient of BIGELOIL. To determine whether BIGELOIL use caused these metabolites, 2 Dalmatian dogs were exposed to BIGELOIL. Thin-layer chromatographic screening of their urine confirmed that exposure to BIGELOIL by either dermal or oral routes causes the same metabolites as those observed in the racing greyhounds. Metabolites suggestive of thymol were also present in some samples. We conclude that, if metabolites suggestive of menthol are detected in urine of animal athletes, further analysis for the other performance-affecting ingredients of BIGELOIL should be undertaken.

Administration, Cutaneous↗