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At least 919 records · Page 51Linked to original sources
PubMed2000

My son, the nurse?

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Career Choice↗
PubMed2000

An outbreak of Influenza A virus in a hilltribe village of Mae Hong Son Province Thailand, 1997.

An outbreak of Influenza A virus occurred in a hilltribe village between July 18th and August 8th, 1997. The overall infection rate was 92.5 per cent. The household infection rate was higher in the crowded part of the village. The symptoms analyzed after all, were fever (100%), cough (99%), headache, myalgia (78.1%) and rhinorrhea (50.5%). The patients were self - recovery within 5-7 days. Isolation and Haemagglutination inhibition test (HI) were undertaken to identify the causative agent. The results were positive for influenza A/Wuhan/359/95(H3N2) - like strain. The outbreak did not spread to the town, possibly because of the differences in environmental condition. Predisposing factors of the village that may have influenced the outbreak were crowded living quarters, cold (8 - 10 degrees C) and moist weather, poor personal hygiene and improper sanitation.

Disease Outbreaks↗
PubMed2000

Son of HMO.

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Community Participation↗
PubMed2001

Investigation of suspected deficient Fas-mediated apoptosis in a father and son.

BACKGROUND: A 2-year-old boy presented with symptoms consistent with a diagnosis of autoimmune lymphoproliferative syndrome (ALPS). His father had been splenectomized at age 12 with similar symptoms. ALPS is a rare hereditary syndrome that may result from a functional defect in Fas-mediated apoptosis. METHODS: Peripheral blood lymphocytes (PBL) and splenic lymphocytes from the patient and PBL from his father and a normal control were analyzed for surface Fas expression. They were then stimulated with an anti-Fas monoclonal antibody (DX2). Apoptosis was assayed by flow cytometry at 0, 20, 28, and 34 h. RESULTS: There was no significant difference in expression of Fas (CD95) in the PBL of the patient, his father, or the normal control, or the splenic lymphocytes. Compared with the normal control, the PBL of the patient and his father failed to progress to apoptosis. They also contained a markedly elevated proportion of CD3+CD4-CD8- "double-negative" cells. CONCLUSIONS: PBL from both the patient and his father expressed CD95, but failed to proceed to apoptosis after stimulation, suggesting a functional defect. These results and the clinical presentation are consistent with published descriptions of ALPS.

Adult↗
PubMed2001

A comparison of correlates of DSM-IV alcohol abuse or dependence among more than 400 sons of alcoholics and controls.

BACKGROUND: Alcohol dependence and abuse are defined as separate disorders. However, relatively few data are available about whether the same characteristics predict both syndromes. METHODS: Complete data were available from the 15 year follow-up of 411 men who originally had been evaluated from a university population at about age 20. Both baseline data gathered prospectively and the retrospective ratings in six domains of life functioning were analyzed for their relationship to the development of alcohol abuse or dependence during the follow-up. RESULTS: Baseline characteristics of a family history of substance use disorders, the quantity and frequency of drinking, the history of alcohol-related problems, and the level of response to alcohol all predicted future alcohol abuse or dependence, but only an alcoholic second-degree relative or a first-degree drug-dependent family member differentially predicted dependence. Logistic regression analyses revealed that similar baseline characteristics combined to predict dependence and, separately, abuse. When the domains of functioning during the 15 years were included, positive alcohol expectancies, poor coping mechanisms, low level of social support, and drinking in the environment contributed to both dependence and abuse, although the relationship was stronger for dependence. CONCLUSIONS: The predictors and correlates of alcohol abuse and dependence in this group of men were similar. Further research in additional populations and on other drugs is needed to determine if the two syndromes overlap sufficiently to be combined.

Adult↗