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Temporal properties of the visual detectability of moving spatial white noise.

We obtained movement detection thresholds for two-dimensional random speck-patterns ("Julesz" patterns) homogeneously moving over the whole target field (5.21 x 5.31 degrees of visual angle). We alternated between two uncorrelated but otherwise similar patterns, one moving with velocity leads to V1, the other with velocity leads to V2, such that each pattern was on for T ms. We masked this pattern (signal) with spatio-temporal white noise ("snow"). The total r.m.s. contrast was kept constant, whereas the ration of the r.m.s. contrasts of signal and noise was varied. The square of this ratio was designated SNR. At low SNR values the pattern was not perceptually different from the snow alone. At high SNR values the subject detected spatio-temporal correlation (e.g., movement). In these experiments we determined the threshold SNR values as a measure of the detectability of spatio-temporal correlation as a function of the parameters T, leads to V1, and leads to V2. When leads to V1 and leads to V2 were sufficiently dissimilar one of three percepts occurred: for very large T the alternation could be followed, for very small T two transparent, simultaneously moving sheets of noise-pattern with different velocities could be seen. For intermediate T-values no systematic movement at all could be observed. At these T-values the threshold SNR was maximal. This "'critical" T-value decreased with increasing velocity. We found that it was possible to have more than one percept of uniform smooth movement at a single location in the visual field if these movements had velocity vectors with an angular difference of at least 30 deg or if their magnitudes differed by at least a factor of 4.

Acoustic Stimulation↗

Spatial properties of the visual detectability of moving spatial white noise.

We determined the spatial parameters that described the visual detection of spatio-temporal correlation in moving two-dimensional noise patterns. The target field (5.21 x 5.31 deg of visual angle) was divided into horizontal stripes of equal width D. Adjacent bars alternately contained noise patterns moving with velocity leads to V1 and leads to V2. We varied D, leads to V1 and leads to V2. Roughly three different percepts occurred. If the stripes were very broad the different movements in alternate stripes were perceived together with the division of the field into stripes. If the stripes were very narrow the division into stripes was not seen, but the moving noise patterns with velocities leads to V1 and leads to V2 were perceived as transparent sheets moving through each other. For intermediate stripe widths the target field looked incoherent and the subject was not clear about the percept. In this region the subject found it difficult and sometimes impossible to discriminate these patterns from a completely uncorrelated spatio-temporal white noise pattern (snow). To quantify the detectability, the patterns were masked with snow (spatio-temporal white noise). The r.m.s. contrast of the total stimulus was kept at a constant value, whereas the subject set the signal-to-noise ratio (SNR) to a threshold value. At certain bar width the thresholds reached a maximum value. Thse critical bar widths depended on the velocities leads to V1 and leads to V2. These critical bar widths were interpreted in terms of a simple general model for the detection of spatio-temporal correlation. In these terms the span of the elementary correlators rose monotonically with the velocity to which the correlator is most sensitive.

Acoustic Stimulation↗

Visibility of movement gradients.

We report on the sensitivity of human observers with respect to the detection of transients in otherwise uniformly moving two-dimensional random-dot patterns. The target field is divided into two halfs that each contains a moving random-dot pattern. The patterns in the two halffields are mutually uncorrelated. Parameters are the average velocity and the difference-velocity for the two halfs. These velocities are both vectors that can be varied in magnitude and in their direction with respect to the border of the two halffields. In order to quantify the sensitivity of the visual system to such patterns, we added (linear addition) spatio-temporal white noise ("snow") to the pattern. Then the sensitivity is quantified by way of the threshold signal-to-noise ratio necessary to discriminate the composite pattern from a single smoothly uniformly moving pattern. The signal-to-noise ratio specifies the square of the ratio between the signal r.m.s. contrast and the r.m.s. contrast of the masking stimulus (spatio-temporal white noise or "snow"). The r.m.s. contrast of the complex pattern (signal and noise) is kept invariant. We find that the detection performance is independent of the direction of either the average of difference-velocity with respect to the border, and can be completely described in terms of a minimum requirement for the magnitude of the difference-velocity. The magnitude of the difference-velocity must exceed the magnitude of the average velocity in order to lead to a perceivable transient. In this formulation the Weberlaw for the detection of velocity transients in uniformly moving noise patterns is applicable to both differences in magnitude and direction of the velocities.

Discrimination Learning↗

Comparison of the polymerase region of small round structured virus strains previously classified in three antigenic types by solid-phase immune electron microscopy.

We have used a reverse transcription-polymerase chain reaction with nested sets of primers to determine the nucleotide sequences of a 166 base pair segment of the RNA polymerase region of seven strains of small round structured viruses (SRSVs) from the United Kingdom. These SRSV strains were previously classified by solid-phase immune electron microscopy into three antigenic types--UK2, UK3 and UK4, which are comparable to the prototype strains Norwalk virus, Hawaii agent, and Snow Mountain agents, respectively. Based on their sequences, the seven strains from the United Kingdom could be divided into two groups. The first group included two strains of the UK2 type along with Norwalk virus and Southampton virus and the second group included three strains of UK3 and two strains of UK4 types. Viruses in the first group showed 75.3%-77.1% nucleotide and 89.1%-94.6% amino acid identity with Norwalk virus while those of the second group showed 60.8%-63.3% nucleotide and 67.3%-69.1% amino acid identity. Nucleotide and amino acid identity within the second group ranged between 91.6%-99.4% and 96.4%-100%, respectively. These results suggest that the SRSVs antigenically related with Norwalk virus, Hawaii agent, and Snow Mountain agent, can be classified into two genotypes on the basis of their sequences in the RNA polymerase region.

Adult↗

Genetic approaches to the study of memory in insects.

This article provides a short summary of studies carried out on mutant Drosophila with defects in learning ability, including our own experimental data on the role of the tryptophan oxygenase gene (this is a key enzyme, and is the first enzyme in the tryptophan-ommochrome metabolic pathway) in the inherited determination of learning ability and memory in the honey bee. A set of allelic mutations was used which inhibit the activity of this enzyme to different extents, resulting in the complete lack of kynurenines or particular levels of kynurenine deficiency in the mutant organisms. The effects of mutations at the snow locus (snow, s, snowlaranja, sla) on the dynamics of memory trace formation after single training sessions were studied in the honey bee and were related to the activity of the enzyme responsible for hydrolysis of cyclic nucleotides (phosphodiesterase). Relationships were found between the level of disruption in the dynamics of memory trace formation and changes in kynurenine content and phosphodiesterase activity.

Animals↗

Emphysematous cholecystitis: sonographic findings.

BACKGROUND: Emphysematous cholecystitis (EC) is a rare but life-threatening complication of acute cholecystitis, and an early diagnosis is required to prevent delay in patient management. Because sonography (US) is the first choice for diagnosing gallbladder diseases, US findings of EC should be understood more precisely. METHODS: We reviewed US findings of 11 surgically proven cases of EC (with small amounts of gas in three cases and large amounts in eight cases) and compared those with patients' clinical data. RESULTS: (1) In cases with small amounts of gas, US showed an echogenic line with a distinct ring-down artifact or a "powder snow-like" speckled posterior echo. (2) In cases with large amounts of gas, US showed a wide spiculated echogenic band with a powder snow-like speckled posterior echo or a speckled acoustic shadowing. In all cases, the presence of gas prevented visualization of the gallbladder wall. (3) US did not differentiate gas localized to the gallbladder wall and gas extending to the surrounding hepatic tissue. (4) Two diabetic cases showed gas throughout the intrahepatic bile ducts. In those cases, the time from diagnosis to recovery was relatively long. CONCLUSION: Our series showed some characteristic US patterns of EC. A good understanding of its US findings and appropriate emergent management will reduce the serious morbidity and mortality rates caused by EC.

Aged↗

Dissection of cry gene profiles of Bacillus thuringiensis isolates in Taiwan.

On the basis of the newly revised nomenclature system of cry genes, the PCR amplification method has been adopted to resolve the cry gene combinations of 294 Bacillus thuringiensis isolates from five selected areas of Taiwan. Our results indicate that cry1 (especially cry1A + 1B + 1F) and cry2 were the most abundant cry genes in Taiwan. In contrast, cry3 and cry6 genes were detected only on Yang Ming Mountain, while the cry13 gene was found only on Snow Mountain. In addition, some distinctive combinations of cry genes were detected in distinct areas of Taiwan, such as cry1C, cry1D, cry1C + 1D, cry4, cry1 + 4, cry1 + 11, cry4 + 11, and cry1 + 4 + 11 in the Taipei area; cry1A + 1C + 1F in the Taichung area; cry1E and cry1A + 1B + 1I on Yang Ming Mountain; cry1 + 13, cry1 + 2 + 11, and cry1 + 2 + 13 on Snow Mountain; and cry1 + 5 and cry1 + 2 + 5 on Jade Mountain. These data clearly indicate that the distribution of cry gene combinations of B. thuringiensis isolates seems to be geographically related.

Animals↗

Timing of parturition in two species of viviparous lizard: influences of beta-adrenergic stimulation and temperature upon uterine responses to arginine vasotocin (AVT).

The southern snow skink Niveoscincus microlepidotus is a viviparous alpine lizard with biennial reproduction, in which embryos are fully developed before winter but parturition is delayed until spring. We aimed to determine whether, in this species, in vitro uterine preparations are responsive to arginine vasotocin (AVT) and prostaglandin (PGF(2alpha)) in autumn and spring, and whether pre-treatment with the beta-adrenergic agonist isoproterenol decreases the effectiveness of AVT in stimulating uterine contractions. Using the spotted snow skink (Niveoscincus ocellatus), an annually breeding species, we aimed to determine influences of temperature and the beta-adrenergic system upon the response to AVT in vivo. In both N. microlepidotus and N. ocellatus females are more responsive to AVT than to PGF(2alpha), and that the response to AVT is decreased, but not prevented, by beta-adrenergic stimulation. In N. microlepidotus, uteri are equally responsive in both seasons to the hormones administered. In N. ocellatus environmental conditions, specifically, temperature, modulate the response to AVT in vivo with the time to parturition increasing as temperature decreases. We conclude that in these viviparous squamates the endocrine cascade leading to parturition is modulated by the beta-adrenergic system, and that this may reflect the mechanism by which the timing of parturition is tied to suitable environmental conditions.

Adrenergic beta-Agonists↗

Rhythmicity of torpor in a marsupial hibernator, the mountain pygmy-possum (Burramys parvus), under natural and laboratory conditions.

Circadian rhythms have been observed in most mammals, but their importance and function remain controversial with respect to daily cycles during hibernation. We investigated the timing of arousals from and entries into hibernation for both free-living and captive mountain pygmy-possums (Burramys parvus). Under both natural and laboratory conditions most arousals and entries were entrained with the light-dark cycle. Entries occurred mainly during the night and arousals preferably around dusk, which coincides with the onset of the normal activity phase for the nocturnal pygmy-possums. This entrainment prevailed throughout the hibernation season although only the laboratory animals were constantly subjected to photoperiodic stimuli, whereas under natural conditions hibernacula are shielded from photic cues and diurnal temperature fluctuations. Nevertheless, possums left their hibernacula frequently throughout winter and were occasionally trapped close to the snow surface suggesting that during the periods of post-arousal normothermia they can be exposed to environmental stimuli. It thus appears that the synchronisation with the photocycle was governed by a temperature-compensated circadian clock which was reset periodically during short activity periods. For the mountain pygmy-possum, entrainment with the photocycle probably has two functions: 1. Entrainment ensures that foraging bouts during the hibernation season remain synchronised with the dark phase. 2. Information about the prevailing climatic conditions sampled during short activity periods enables them to time final spring emergence from hibernation when snow melt begins and ensures that the breeding season can commence as early as possible.

Animals↗

Seasonality in daily body mass variation in a hoarding boreal passerine.

We studied the body mass variation from autumn to winter, in a free-living population of willow tits ( Parus montanus), a food-hoarding passerine living year-round in boreal forests. Our aim was to find out whether this population exhibits 'winter fattening' as part of the annual body mass cycle. 'True winter fattening' is considered to be a strategic response to winter conditions. The strategy includes an increase in both the morning mass and the daily mass increase, as winter approaches. A multivariate approach was used to find which predictors (year, date, age, sex, body size, temperature and snow depth) explained the mass variation in birds measured twice per day. Morning mass variation was explained by sex, age, wing length and snow depth. Independently, date explained morning mass variation only in adult males. None of the predictors explained the variation observed in daily mass increase in any age or sex class. Therefore, we failed to detect winter fattening in our study population of willow tits. Response to increasing night length is not due to higher absolute intake, but to higher energy acquisition rate and decreased night-time energy consumption. The results suggest that willow tits at high latitudes manage increasing energy demands on a short-term basis and respond flexibly to changing conditions by adjusting foraging efficiency and especially night-time energy expenditure.

Adipose Tissue↗

Using weather indices to predict survival of winter wheat in a cool temperate environment.

Seven years of winter survival data for winter wheat ( Triticum aestivum L.) were collected on a loam soil located on the Central Experimental Farm at Ottawa, Ontario (45 degrees 23'N, 75 degrees 43'W). The site was low-lying and subject to frequent winter flooding and ice-sheet formation. Two cultivars, a soft white and a hard red winter wheat, were planted in September. Crop establishment was measured in late fall and the percentage survival was measured in April of the following year. Meteorological data, which were available from the nearby weather site, were used to develop a large set of monthly weather indices that were felt to be important for winter survival. The objective of the study was to use genetic selection algorithms and artificial neural networks to select a subset of critical weather factors and topographic features and to model winter survival. The six weather indices selected were the total rain depth for December (mm), the total rain depth for February (mm), the number of days of the month with snow on the ground for January, the extreme minimum observed daily air temperature for March ( degrees C), the number of days of the month with snow on the ground for March, and the number of days of April with a daily maximum air temperature greater than 0 degrees C. It was found 89% of the variation in winter survival could be explained by these six weather indices, the cultivar, elevation and plot location.

Forecasting↗

Frequency of emergency room visits for childhood asthma in Ottawa, Canada: the role of weather.

The aim of this study was to evaluate associations between meteorological conditions and the number of emergency department visits for asthma in a children's hospital in Ottawa, Canada. A case-crossover study design was used. Hospital emergency department visits for asthma between 1992 and 2000 were identified based on patients' presenting complaints. We obtained hourly measures for the following meteorological variables: wind speed, temperature, atmospheric pressure, relative humidity, and visibility. Particular emphasis was placed on exploring the association between asthma visits and fog, thunderstorms, snow, and liquid and freezing forms of precipitation. In total, there were 18,970 asthma visits among children between 2 and 15 years of age. The number of visits and weather characteristics were grouped into 6 h case and control intervals. The occurrence of fog or liquid precipitation was associated with an increased number of asthma visits, while snow was associated with a reduced number (P<0.05). Stratified analyses by season found no association in any of the four calendar intervals between the number of asthma visits and visibility, change in relative humidity and change in temperature. In contrast, summertime thunderstorm activity was associated with an odds ratio of 1.35 (95% CI=1.02-1.77) relative to summer periods with no activity. Models that incorporate calendar and meteorological data may help emergency departments to more efficiently allocate resources needed to treat children presenting with respiratory distress.

Adolescent↗

Growing seasons of Nordic mountain birch in northernmost Europe as indicated by long-term field studies and analyses of satellite images.

The phenophases first greening (bud burst) and yellowing of Nordic mountain birch (Betula pubescens ssp.tortuosa, also called B. p. ssp. czerepanovii) were observed at three sites on the Kola Peninsula in northernmost Europe during the period 1964-2003, and at two sites in the trans-boundary Pasvik-Enare region during 1994-2003. The field observations were compared with satellite images based on the GIMMS-NDVI dataset covering 1982-2002 at the start and end of the growing season. A trend for a delay of first greening was observed at only one of the sites (Kandalaksha) over the 40 year period. This fits well with the delayed onset of the growing season for that site based on satellite images. No significant changes in time of greening at the other sites were found with either field observations or satellite analyses throughout the study period. These results differ from the earlier spring generally observed in other parts of Europe in recent decades. In the coldest regions of Europe, e.g. in northern high mountains and the northernmost continental areas, increased precipitation associated with the generally positive North Atlantic Oscillation in the last few decades has often fallen as snow. Increased snow may delay the time of onset of the growing season, although increased temperature generally causes earlier spring phenophases. Autumn yellowing of birch leaves tends towards an earlier date at all sites. Due to both later birch greening and earlier yellowing at the Kandalaksha site, the growing season there has also become significantly shorter during the years observed. The sites showing the most advanced yellowing in the field throughout the study period fit well with areas showing an earlier end of the growing season from satellite images covering 1982-2002. The earlier yellowing is highly correlated with a trend at the sites in autumn for earlier decreasing air temperature over the study period, indicating that this environmental factor is important also for autumn phenophases.

Betula↗

Injuries to the elderly in the traffic environment.

Two hundred ninety-seven persons, all aged 60 or over (180 women, 117 men), injured in the traffic environment, and treated at the Regional Hospital in Umeå, over a one-year period, were analysed. Injuries were grouped into three main categories: falls (52%), vehicle-associated events (44%), and "other" injury events (4%). In women, falls were a more common cause of injury than vehicle events, whilst in men there was a tendency for a converse relationship. Two-thirds of the falls involved slipping on ice and snow. Ice- and snow- related injuries (all categories) accounted for 37% of the total cost of all injuries in the elderly in the traffic environment. The main groups in the vehicle-associated injury category were cyclists (48%), car occupants (34%), other occupants (14%), and pedestrians (4%). Vehicle-associated injuries became more common with advancing age, resulted in the most severe and critical [Maximum Abbreviated Injury Scale (MAIS) greater than or equal to 4] injuries and the most fatalities, and cost (total and mean) more than falls. In conclusion, from the injury cost point of view, it is most important to prevent vehicle-associated injuries. However, when total frequencies are considered, falls deserve to be given just as much priority in injury prevention programs as vehicle-associated injuries, to make the traffic environment safer for this growing population.

Abbreviated Injury Scale↗

Artificial ski slope injuries: a 1-year prospective study.

Skiing is one of the fastest growing sports in the United Kingdom. A prospective study of 119 patients who sustained injuries while skiing on the Edinburgh artificial ski slope was performed. The ratio of injury of the arm to that of the leg was 4.2:1, which is the reverse of that found with snow skiing. In particular, thumb injuries accounted for 32 per cent of all injuries. Attention is drawn to the high incidence of damage to the ulnar collateral ligament of the metacarpophalangeal joint of the thumb, which is related to the construction of the 'snow slope' matting. The pattern of injury is described and the mechanisms of injury discussed.

Adolescent↗

Pathogenesis and clinical relevance of bone marrow embolism in medullary nailing--demonstrated by intraoperative echocardiography.

For the clarification of pulmonary impairment after medullary nailing of femoral fractures, the intramedullary pressure in the femoral cavity during the operative procedure was investigated. In addition, an intraoperative transoesophageal echocardiography was performed which revealed two phenomena occurring once the intramedullary pressure had increased: snow-flurry and configured emboli. An experimental study in sheep was performed in order to define the substrata of the sonographic echoes. The level of intrafemoral pressure which would result in bone marrow intravasation and the substrata of the echocardiographic echoes were studied in sheep by applying pressure to the femoral cavity. Sonography of the distal vena cava by laparotomy and macroscopic and histological investigation of the venous blood received throughout a proximal subdiaphragmal venotomy were undertaken. The intrafemoral pressure peaks correlated with the appearance of sonographic echoes in both patients and sheep. Snow-flurry is an indication of small amounts of bone marrow and already appears at an intramedullary pressure of 50 mmHg, which can easily occur during movement of non-stabilised fractures (values up to 90 mmHg were observed)--configured emboli consist of a core of bone marrow surrounded by thrombotic aggregate and only appeared at pressure increases of over 200 mmHg in the animal experiments. During medullary nailing in patients the intrafemoral pressure increases up to 200-600 mmHg in all reaming procedures. Configured emboli were seen in 8 of 20 patients being treated with reamed nailing. In five nailing procedures performed using the unreamed technique, no pressure increases greater than 70 mmHg and no configured emboli were observed. I.v. injected bone marrow results in pulmonary impairment.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

How do children tell? The disclosure process in child sexual abuse.

Children's disclosure of sexual abuse has been described as a quasi-developmental process that includes stages of denial, reluctance, disclosure, recantation, and reaffirmation (Sorenson & Snow, 1991, Summit, 1983). It has been reported that nearly 75% of sexual abuse victims initially deny abuse, and that nearly 25% eventually recant their allegations (Sorenson & Snow, 1991). The present study examined disclosures in 234 sexual abuse cases validated by Protective Services in El Paso, Texas. Denial of abuse occurred in 6% of cases, and recantation in 4% of cases in which a child had already disclosed abuse. Four of the eight victims who recanted appeared to do so in response to pressure from a caretaker. The Child Sexual Abuse Accommodation Syndrome described by Summit (1983) seems to be infrequent among the types of cases seen by child protection agencies. The present findings do not support the view that disclosure is a quasi-developmental process that follows sequential stages.

Adolescent↗

The use of epidemiology and clinical toxicology to assess environmental health problems.

Historically, epidemiology has played an important role in the changes that have taken place over time as epidemics of important infectious diseases have been replaced with modern epidemics of chronic, degenerative diseases such as elevated blood pressure, various types of cancers, diabetes, and stroke, among others. Two illustrations of the early uses of epidemiologic methods in investigations of disease outbreaks are described in the work of John Snow, who described outbreaks of cholera in the 1800s (1936, Snow on Cholera, Commonwealth Fund, New York), and J. Goldberger, who investigated the incidence of pellagra in the early 1900s (1964, Goldberger on Pellagra, M. Terris, ed., Louisiana State Univ. Press, Baton Rouge). The more contemporary use of epidemiology and clinical toxicology to assess the outcome of human exposure to environmental contaminants in the food supply are described for exposure to the polychlorinated biphenyls (PCBs) and to the polybrominated biphenyls (PBBs). Exposure to the PCBs has occurred in a variety of locations worldwide, with the greatest exposure taking place in individuals of many countries who consume fish and in Japan and Taiwan through contaminated cooking oil. Exposure to PBBs has essentially been limited to the State of Michigan where widespread contamination of cattle, dairy products, and poultry has taken place.

Environmental Pollutants↗