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At least 919 records · Page 51Linked to original sources

The truth about silver.

Interest in silver as a topical agent in wound healing is undergoing a renaissance. Having basic information regarding silver's chemical properties and potential actions in the wound bed is important to its appropriate clinical use. Such information is also relevant to the interpretation of silver's in vitro antimicrobial (antiseptic) effects, which in turn relate to issues involved in the evaluation of the clinical effects of silver in vivo. Gaining an understanding of the basic science of silver products and the different challenges inherent to in vitro versus in vivo antimicrobial evaluations will allow clinicians to address several key questions inherent when considering the use of silver as a topical antimicrobial: 1) Are there different forms of silver? 2) How does the amount of silver released into the wound environment correlate with clinical benefit? 3) How does the rate of silver release correlate with clinical benefit?

Anti-Infective Agents, Local↗

Silver dressings in clinical practice.

Silver is among several topical antiseptics that are once again gaining popularity due, in part, to the rise of antibiotic-resistant genotypes. Because of differences in wounds and the variety of products--including various silver vehicles--available to treat them, all of the dressing characteristics appropriate for the specific wound being managed must be considered. This article addresses why silver is (and is not) a good choice for particular wounds and offers suggestions about what silver products best serve individual situations.

Aged↗

A guide to the properties and uses of silver dressings in wound care.

Silver-release dressings are extensively used for wound management, particularly in the treatment of burns, chronic leg ulcers and wounds requiring an antibacterial. A variety of products is now available. The properties and uses of these dressings are discussed, followed by a review of advances over recent years

Bandages↗

[SERS spectra of vitamin A acid in silver solution].

Vitamin A acid (VAA) was firstly dissolved in chloroform, and then the organic solution containing the samples was mixed with silver sol at the desired concentration. After sufficient shaking, collect SERS spectra of VAA with silver sol layer solution. The attribution of the peaks was illustrated by comparing SERS spectra with NR (Normal Raman) spectra, and the mechanism and orientation of adsorption were also discussed according to the peaks which was absent in NR spectrum but observed in SERS spectrum. To verify the feasibility of the method for the quantitative analysis, SER spectra at different concentration of VAA were collected. The intensities measured with the band at 1583 cm(-1) were plotted as a function of concentration. It was found that an effective limit for the detection of VAA could be as low as to 1.0 x 10(-7) mol x L(-1), the calibration curve was linear in the range from 1.0 x 10(-6)-5 x 10(-5) mol x L(-1). The proposed method has the potential to quantitative assay of the drugs having SERS effects but undissolvable in water.

Pharmaceutical Solutions↗

[The study of adsorption of L-aspartic acid on silver sol by surface-enhanced Raman scattering].

The adsorption state and the characteristics of L-aspartic acid adsorbed on silver sol were studied by the Surface-Enhanced Raman Scattering (SERS) method. Strong Raman signals were detected in the experiments. The results suggested that L-aspartic acid adsorbed on the silver surfaces through carboxyl and nitrogen atoms since the signals were mainly due to the carboxyl and the nitrogen of the molecule of L-aspartic acid. The adsorption of carboxyl on the silver surfaces is chemical adsorption, which is based on the mechanism of charge-transfer, while the adsorption of nitrogen on the silver surfaces is physical type, which is due to the electromagnetic mechanism. The intensity of surface-enhanced Raman scattering of L-aspartic acid adsorbed on silver surface was also analyzed, and it was found that the intensity of surface-enhance Raman scattering will change with different concentrations of L-aspartic acid adsorbed on the silver surfaces. The intensity will reach the top value when the concentration of L-aspartic acid was 10(-3) mol x L(-1). When the concentration of L-aspartic acid decreased to 10(-4) mol x L(-1), the intensity of surface-enhanced Raman scattering became a little weaker than that with 10(-3) mol x L(-1). With further decrease in the concentration of L-aspartic acid, the intensity of surface-enhanced Raman scattering also decreased gradually. When the concentration of L-aspartic acid decreased to 10(-6) mol x L(-1), the intensity of surface-enhanced Raman scattering was very low. The above study will be helpful to the further study of peptide and other complex biological systems.

Adsorption↗

[Study on spectrophotometric determination of silver(I) with 2-(2-quinolinylazo)-1,5-dihydroxidebenzene].

The color reaction of silver(I) with 2-(2-quinolinylazo)-1,5-dihydroxidebenzene (QADHB) and the solid phase extraction of the colored chelate with Waters Sep-Park C18 cartridge were developed. In the presence of pH = 5.0 sodium citrate-sodium hydroxide buffer solution and sodium dodecyl sulfonate (SDS) medium, QADHB can reacts with silver to form a chelate of a molar ratio 1:2 (silver to QADHB). This chelate can be enriched by the solid phase extraction with Waters Sep-Park C18 cartridge. The retained chelate can be eluted from cartridge with ethanol. In ethanol medium, the molar absorptivity is 6.99 x 10(4) L x mol(-1) x cm(-1) at 550 nm. Beer's law is obeyed in the range of 0-1.2 microg x mL(-1). This method can be applied to the determination of silver in water with satisfactory results.

Benzene↗

[Study on solid-phase-extraction spectrophotometric determination of silver with p-sulfobenzylidene-rhodanine].

The color reaction of silver with p-sulfobenzylidene-rhodanine (SBDR) was studied. Based on the color reaction of SBDR with silver (I) and the solid phase extraction of its colored complex with Waters Porapak Sep-Park-C18 cartridge, a new method for the determination of micro-amount of silver (I) was studied. In the presence of pH = 2.8 citric acid-sodium hydroxide buffer solution and Tween-80 medium, SBDR can react with silver (I) to form a stable 2:1 complex. The colored complex can be extracted by C18 cartridge and eluted by ethanol (containing 5% acetic acid), and then can be determined by spectrophotometry. The molar absorptivity is 7.53 x 10(4) L x mol(-1) x cm(-1) at 520 nm. Beer's law is obeyed in the range of 0-1.2 microg x (25 mL)(-1). This method can be applied to the determination of silver in water with satisfactory results.

Environmental Monitoring↗

[Argyrosis in dermatologic practice].

The article covers follow-up of 7 patients suffering from occupational argyrosis and 1 patient with domestic argyrosis. Clinical signs of the disease are presented. Mainly skin and mucous membranes are involved. Conclusions concern diagnosis and treatment of the condition.

Aged↗

[Synthesis of Ag2S nanoparticles at room temperature and their characterization with XPS].

Nanocrystalline silver sulfide was successfully synthesized at room temperature and ambient pressure via a novel, safe, convenient and inexpensive redox reaction, using silver oxide, sulfur and polyformaldehyde as reactants and ethylenediamine as solvent. The products were characterized with XPS, XRD and TEM. XRD spectrum demonstrates a monoclinic Ag2S; TEM shows the products are rod-like nanoparticles with average diameter of 100 nm, its corresponding SAED reveals clear diffraction spots indexed as (120) and (303); XPS confirms the formation of Ag2S and indicates the sample's surface stoichiometry of Ag:S=1:0.453. The control experiments show polyformaldehyde and ethylenediamine are both important in the formation of products. Ethylenediamine accelerates the reactions via dissolving silver oxide and sulfur and neutralizing the by-product formic acid.

Ethylenediamines↗

[Biomaterials and tissues material in the treatment of prosthetic grafts infections].

An article is presented the treatment of vascular prosthetic grafts infections. An the graft infection treated by the replacement of infected prosthesis with autogenic venous material or with venous and arterial allograft harvested from brain-dead organ donors together with multiple organ procurement is presented. Autogenous material has an ability a better healing in infected tissues and used with absorbable sutures may lead to complete recovery from vascular graft infection - a severe and often lethal complication. An article is presented the treatment of vascular prosthetic grafts infections with the use of more resistant prostheses of infection - silver coated prosthesis, prosthesis with antibiotic and polytetrafluoroethylene prostheses.

Animals↗

[The interface fluorescence and resonance scattering spectral properties of Ag2S nanoparticles in liquid phase].

S2- and Ag+ form stable Ag2S nanoparticles in the presence of sodium dodecyl sulphate (SDS). It exhibits a strong resonance scattering peak at 470 nm and a strong fluorescence peak at 470 nm when excitation wavelength is at 200 nm. The effects of TAA and Ag+ concentration on the fluorescence intensities are consistent with those on the resonance scattering signals. The resonance scattering and fluorescence intensities all increase with Ag+ concentration in the range of 0-8.0 x 10(-5) mol x L(-1). The results verified that there is a correlation between the fluorescence and resonance scattering. The fluorescence is the interface fluorescence of Ag2S nanoparticles in liquid phase.

Fluorescence↗

[Comparison of the cytotoxicity in vitro among six types of nano-silver base inorganic antibacterial agents].

OBJECTIVE: To evaluate the biocompatibility of nano-silver base inorganic antibacterial agents and compare the cytotoxicity in vitro among six types of nano-silver base inorganic antibacterial agents. METHODS: FUMAT T200-4, HN300, Novaron, Kangwang, MOD and SR1000 were diluted to different concentrations, such as 100 g/L, 50 g/L, 25 g/L and 12.5 g/L. The cytotoxicity in vitro of these agents on rat's fibroblast was assayed with MTT method. And the grades of cytotoxicity were compared. RESULTS: High concentrations of nano-silver base inorganic antibacterial agents had cytotoxic effects on rat's fibroblasts L-929. As the concentration decreased, the cytotoxicity decreased. No cytotoxic effects were observed at or below the concentration of 25 g/L. FUMAT T200-4, Kongwang and SR1000, with the carrier of phosphate zirconium, had less cytotoxity than the others. CONCLUSIONS: Nano-Silver base inorganic antibacterial agents, such as FUMAT T200-4, Kangwang, SR1000, have good biocompatibility. And they have the possibility of clinical application. The safe concentration of these agents is at or below 25 g/L.

Animals↗