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Effect of acute swimming exercise on lactate levels and its relation with zinc in pinealectomized rats.

It is argued that melatonin secreted from the pineal gland regulates the levels of zinc, which is an important trace element. Decreases in zinc levels of pinealectomized rats supports this relationship. There is an increasing amount of evidence suggesting that the pineal gland can have important effects on physical activity. The objective of the present study was to explore the changes in serum lactate levels in pinealectomized rats subjected to acute swimming exercise and its relation with zinc. Forty adult male rats of Spraque Dawley strain were equally allocated to four groups. Group 1: General Control Group. Group 2: Pinealectomized Control Group. Group 3: Swimming Control Group. Group 4: Pinealectomized Swimming Group. Serum zinc, melatonin and lactate levels were determined in the blood samples collected from the animals by a decapitation method. Zinc and melatonin levels were higher in Group 1 than in Groups 2, 3 and 4 (p < 0.01), higher in Group 3 than in Groups 2 and 4 (p < 0.01) and higher in Group 2 than in Group 4 (p < 0.01). The highest lactate levels were found in Group 4 (p < 0.01). Lactate levels in Group 3 were higher than those in Groups 1 and 2 (p < 0.01), while the levels in Groups 1 and 2 did not differ. Pinealectomy results in a significant increase in lactate levels in rats subjected to an acute swimming exercise. This increase in lactate levels may be associated with the decrease observed in zinc levels after pinealectomy.

Animals↗
PubMed1986

Descending projections and excitation during fictive swimming in Xenopus embryos: neuroanatomy and lesion experiments.

We describe the distribution of "descending" interneurons in late Xenopus laevis embryos after retrograde filling with horseradish peroxidaze via their ipsilateral, descending axons in the spinal cord. These multipolar neurons, with dendrites spread throughout the marginal zone, form a longitudinal column extending from midtrunk spinal cord into the brainstem to the level of the vagus. In the hindbrain these neurons are part of the uncrossed reticulospinal projection. They are most numerous in the caudal brainstem, their density falling by half at the eighth postotic segment. To examine their possible role in swimming we reduced the population of descending interneurons by making progressive transections of the brainstem or spinal cord at the first to fifth postotic segments. These led to progressive reduction in the initial frequency of fictive swimming in immobilized embryos, even when the brainstem was divided sagittally. Transecting the spinal cord at the fourth postotic segment did not reduce initial frequency rostral to the lesion. The effects of these lesions on the duration of fictive swimming episodes were similar. The results suggest that descending interneurons could provide excitatory drive during swimming and that some reticulospinal and spinal interneurons may form single homogeneous populations.

Animals↗
PubMed2002

Chronic inositol treatment reduces depression-like immobility of Flinders Sensitive Line rats in the forced swim test.

Inositol, a precursor of the PIP cycle that was reported to have therapeutic effects in depressive patients and to be effective in two animal models of depression, was evaluated in the forced swim test using the genetic Flinders Sensitive Line (FSL) rats model of depression. Groups of rats were tested in a 2 x 2 design with Strain (FSL or Control) as one factor and Drug (Inositol or Placebo) as the second factor. Rats received chronic treatment (daily for 14 days) with inositol (1.2 g/kg) or placebo (1:2 glucose/mannitol solution). On day 14 rats were exposed to the forced swim test for 5 min and their behavior videotaped. Tapes were analyzed for three levels of activity: immobility, swimming, and vigorous struggle. Inositol countered the exaggerated immobility of FSL rats in the forced swim test, without affecting control animals. Data support our previous suggestion of inositol as a potential antidepressant.

Animals↗
PubMed1994

Hippocampal mossy fibers and swimming navigation in mice: correlations with size and left-right asymmetries.

Individual differences in the extent of the infrapyramidal mossy fiber projection (IIP-MF) correlate with performance in tasks sensitive to hippocampal lesions, notably two-way avoidance, radial maze learning, and swimming navigation. Previous studies of swimming navigation suggested that the capacity of reversal learning and measures of directionality might also be related to asymmetries in the distribution of the IIP-MF. In order to verify these findings, the authors crossed the Collins High- and Low-lateralized mice (known to differ in mossy fiber morphology and brain asymmetries) and obtained a F2-generation characterized by strong individual differences in these traits. Twenty-three (13 females, 10 males) mice were tested during 3 days for acquisition of swimming navigation (16 trials) toward a central platform, and during two days (12 trials) for their capacity of reversal learning toward a shifted platform. Morphometry of Timm-stained hippocampi revealed several, partially independent correlations: Larger IIP-MF projections were associated with prolonged crossing over the former platform position during the entire reversal learning; larger IIP-MF projections on the left were correlated with more precise crossing of the former platform position during the first 45 seconds of reversal learning; both extent and asymmetry of IIP-MF correlated positively with overnight improvement of reversal learning; the size of the entire mossy fiber projection (CA4, suprapyramidal and IIP-MF) correlated positively with the time spent in the platform quadrant and measures of initial orientation during acquisition of the task; and the mice showed an ipsilateral turning bias (spin) toward the side with the larger mossy fiber projection. The authors conclude that an intact hippocampus mediates differential processes underlying swimming navigation, and that left and right subfields may have differential functions.

Animals↗
PubMed1992

Effect of swimming on prednisolone-induced osteoporosis in elderly rats.

We investigated the possible ameliorating and preventive effect of swimming on prednisolone-induced osteoporosis in elderly rats. A total of 48 female Sabra strain rats were randomly assigned to the following groups and treatments: (1) control (C), (2) swimming (S), (3) prednisolone-treated (CP), and (4) swimming + prednisolone (SP). An additional 8 rats were sacrificed and examined at the onset of the study. Groups C and S were sham injected; groups CP and SP were injected with prednisolone (Ultracorten), 80 mg/kg three times per week for 10 weeks. Groups S and SP swam 1 h daily, 5 days per week for 10 weeks. SP rats swam simultaneously with prednisolone administration. At the end of the swimming period, in vivo bone mineral content (BMC) measurements were performed on rat vertebrae L4-5 by single-photon absorptiometry. Later, the humerus and femur were removed for the following measurements: morphometric, bone density (BD) by Compton scattering technique, bone ion content by atomic absorption, and hydration fraction by proton magnetic resonance (PMR). We found that the humeral BD of S rats was greater by 14% for group S over C and 3% greater for group SP over CP (P less than 0.05). Vertebral BMC was higher by 15% in group S over C and 11% higher for group SP over CP (P less than 0.05). Femoral calcium (mg/g dry bone) ion content was higher by 5% in group S over C and 8% in group SP over CP group (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Aging↗
PubMed1986

Effects of sustained swimming on rainbow trout muscle structure, blood oxygen transport, and lactate dehydrogenase isozymes: evidence for increased aerobic capacity of white muscle.

Groups of rainbow trout (Salmo gairdneri, Richardson) were continuously swum at 20 cm s-1 (1.0 body lengths s-1) for 0, 3, 30, and 200 days. No significant changes in fish condition factor, combined red and white muscle mass, muscle fibre size or fibre size distribution were observed. After 200 days of swimming there was a significant 2.2 fold increase in red muscle mass. Number of capillaries per red muscle fibre increased significantly in each group by a maximum of 27% after 200 days exercise. Number of capillaries per white muscle fibre increased significantly by 95% after 200 days exercise. Blood lactate, haemoglobin (Hb) concentration haematocrit, erythrocyte adenosine triphosphate, and whole blood oxygen affinity P50 were unchanged by swimming. After 30 and 200 days swimming there was a shift in expression of white muscle lactate dehydrogenase (LDH) isozymes from LDH-A to LDH-B. Within the duplicated LDH-B isozyme complex, there was a shift in expression from LDH-B to LDH-B' subunits. These results suggest that sustained swimming at 1(-1) bl s-1 increased the aerobic capacity of red and particularly white (fast) muscle of rainbow trout but did not alter the gas transport characteristics of the blood.

Aerobiosis↗
PubMed2002

Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous rats.

The purpose of these experiments was to test the hypothesis that attenuating the endogenous increase of the 5alpha-reduced progesterone metabolite 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) in the hippocampus will alter anxiety and depression behavior of proestrous rats. In Experiment 1, anxiety (open field) and depression (forced swim test) behavior was compared of rats that should have high (proestrous) and low (diestrous and male rats) endogenous hippocampal 3alpha,5alpha-THP. Proestrous rats exhibited more anxiolytic-like (increased central entries in the open field) and anti-depressant-like (less immobility in the forced swim test) behavior than diestrous or male rats. In Experiments 2 and 3, respectively, systemic and intrahippocampal finasteride, a 5alpha-reductase inhibitor which attenuates progesterone's metabolism to 3alpha,5alpha-THP, versus vehicle administration to proestrous rats was compared for effects on open field and forced swim test behavior. Systemic or intrahippocampal finasteride decreased central entries in the open field and increased immobility in the forced swim tests compared to vehicle administration. In Experiment 4, the effects of systemic and intrahippocampal finasteride vs vehicle administration on hippocampal 3alpha,5alpha-THP of proestrous rats was examined. Finasteride, SC or intrahippocampally, reduced 3alpha,5alpha-THP in the hippocampus compared to vehicle administration. Together these data suggest that variations in 3alpha,5alpha-THP levels in the hippocampus may mitigate proestrous changes in anxiety and depressive behavior of cycling rats.

Animals↗
PubMed2001

Directed motion in the sea: efficient swimming by reef fish larvae.

Directed motion of marine organisms is examined with a focus on efficient behaviour, where efficient swimming minimizes either energetic expenditure or transit time. The swimming behaviour of late pelagic stage reef fish larvae is modelled to illustrate relevant concepts. To swim efficiently in the sea, an organism should exploit current-driven movements of the medium. Favourable currents should be ridden and unfavourable currents avoided. Relatively short movements to control advection can have a greater effect than longer swimming bouts used for independent horizontal locomotion. If larvae exploit the vertical structure of the water column, then the extent to which they can influence their dispersal will be substantially increased.

Animals↗
PubMed1985

Control of locomotion in marine mollusc Clione limacina. I. Efferent activity during actual and fictitious swimming.

The marine mollusc Clione limacina swims by making rhythmic movements (with a frequency of 1-5 Hz) of its two wings. Filming demonstrated that the wings perform oscillatory movements in the frontal plane of the animal. During both the upward and downward movements of the wing, its posterior edge lagged behind the anterior one, i.e. the wing plane was inclined in relation to the longitudinal axis of an animal. As a result of this inclination, the wing oscillations in the frontal plane produce a force directed forwards. In restrained animals with the body cavity opened (a whole-animal preparation), the wing position, electrical activity in the wing nerve and activity of two identified efferent neurons (1A and 2A) were recorded during locomotory wing movements. There were two bursts of activity in the wing nerve during the locomotory cycle, the first one corresponding to the excitation of efferent neurons controlling the wing elevation, and the second one, to the excitation of efferent neurons controlling the lowering of the wing. Neurons 1A and 2A fired reciprocally at the beginning of the phase of elevating and lowering the wing, respectively. During excitation of one of the neurons, an IPSP appeared in its antagonist. A pair of isolated pedal ganglia of Clione was capable of generating the locomotory rhythm ("fictitious swimming"). In fictitious swimming, as in actual swimming, there were two bursts of activity in the wing nerve per locomotory cycle, and the 1A and 2A neurons fired reciprocally. Homologous neurons from the left and right ganglia fired inphase.(ABSTRACT TRUNCATED AT 250 WORDS)

Action Potentials↗
PubMed1990

Analysis of determinants of swimming economy in front crawl.

The purpose of this study was to investigate the relationship between swimming economy, energy cost to move the body per unit distance (CS) at a given velocity (v) and the potential determinants, i.e. performance level, body size, swimming technique and v. A total of 101 males were studied. Three performance levels (A, B, C) were determined, ranging from the slower (A) to the faster times (B, C). At level C and at 1.1 m.s-1, CS 1.1, was reduced by 55% and 25% when compared with levels A and B and when calculated per unit of surface area (SA) and unit of hydrostatic lift (HL). For the whole group of swimmers, CS 1.1 = 21.88 SA-2.15 HL + 5.9 (r = 0.56, P less than 0.01). Among the 101 swimmers, three other groups were selected to evaluate specifically the influence of arm length and swimming technique on CS, i.e. arm or leg swimmers and sprinters versus long-distance swimmers, CS was significantly (P less than 0.05) lower for long-arm swimmers, arm and long-distance swimmers than for short-arm, leg and sprint swimmers by 12%, SD 3.3%, 15%, SD 3.8% and 16.5%, SD 3%, respectively. For all groups, CS increased with v on average by 10% every 0.1 m.s-1. It is concluded that technical ability cannot be interpreted directly from CS. Performance levels, body size, swimming technique and v at which the measurements are obtained must be also taken into account.

Adolescent↗
PubMed1996

Effect of long-term intense swimming training on the upper body peak oxygen uptake of prepubertal girls.

The purpose of the present investigation was to determine the effect of a long-term intense swimming programme on the aerobic potential of prepubertal girls. Five girls [GS, aged 9.3 (SD 0.5) years] participated in a 40-month intense training period. The girls trained on average 10-12 h*week(-1), approximately 1 h-1.5 h twice a day, 5 days each week. Nine girls [CG aged 9.3 (SD 0.4) years] who were engaged in various activities (on average 1-4 h*week(-1)), but not in sports involving upper body muscle mass, served as the control group. All the children completed, on a special swim bench, an incremental maximal exercise prior to (pretest) and after (post-test) the swimming programme. Biometric parameters and the peak oxygen uptake (VO(2peak)) were determined using the same procedure at the pre- and post-test sessions. There was no significant difference between the two groups for any of the variables at the beginning of the study. The biometric characteristics remained similar at the post-test session, indicating that intense swimming training early in life has no influence on the physical growth of prepubertal children. The VO(2peak) expressed in absolute values, however, increased over a year in GS and CG by 38 percent and 13 percent, respectively. The improvement in CG VO(2peak) was related to normal growth and development while that of GS was much higher (P<0.01) than would have been expected due to growth factors alone. The reason for such an improvement could be attributed to an increase in the stroke volume and/or in the difference of the arteriovenous concentration of oxygen since the maximal O(2) pulse was different between CG and GS only at the post-test. Moreover, it increased after 10 months only in GS (delta maximal O(2) pulse: GS 1.09, P<0.01; CG 0.27 NS, ml.beat(-1)). Thus, the results of this study show that physiological adaptations can occur in prepubertal children as a consequence of intense physical training.

Child↗
PubMed1992

Effect of a five-week swimming program on rat bone: a histomorphometric study.

To specify the exercise-induced changes on different skeletal sites, the effect of a 5-week endurance swim training was studied in rats. Eighteen Lyon strain (Sprague-Dawley) 5-week old female rats were divided into nine sedentary and nine swimming rats. Each swim training session was increased by 15 minutes from 2-6 hours per day. A histomorphometric study was performed at the primary and secondary spongiosa of the distal femur and at the secondary spongiosa of lumbar and thoracic vertebral bodies. After training, bone loss was observed in the secondary spongiosa of lumbar vertebral bodies (24.7%) and in the primary spongiosa of distal femur (15.2%). A tendency to bone loss was also detected in the secondary spongiosa of distal femur (10.8%), whereas no change was detected in thoracic vertebral bodies. In secondary spongiosa, bone loss was accompanied with a thinning of trabeculae. Total eroded surfaces and osteoid surfaces were significantly decreased in the three studied skeletal sites, suggesting a decreased bone turnover. The decreased thickness of osteoid seams in both lumbar vertebrae and distal femur could mean that the osteoblastic activity has also been altered at the cell level, leading to thinning of trabeculae. Five-week swim training with such duration and intensity of exercise appears unable to increase bone volume in rats and, therefore, causes adverse effects. The three studied bones seemed to adapt differently to experimental conditions. The lack of ground reaction forces induced by water immersion might have contributed to the observed bone loss. "Normal" gravity would be an important cofactor in the osteogenic effects of exercise.

Adaptation, Physiological↗
PubMed1990

Blood lactate responses in older swimmers during active and passive recovery following maximal sprint swimming.

The purpose of this study was to determine the effect of age on three blood lactate parameters following maximal sprint swimming. The parameters examined were maximal blood lactate concentration, time to reach maximal blood lactate concentration, and half recovery time to baseline lactate concentration. These parameters were examined in 16 male competitive masters swimmers (n = 4 for each age group: 25-35, 36-45, 46-55, and 56 plus years) during both passive and active recovery following a maximal 100 m freestyle sprint. Passive recovery consisted of 60 min sitting in a comfortable chair and active recovery consisted of a 20-min swim at a self-selected pace. Capillary blood samples were obtained every 2 min up to 10 min of recovery then at regular intervals to the end of the recovery period. Curves of blood lactate concentration against time were drawn and the three parameters determined for each condition for each subject. There were no significant differences between age groups in any of the lactate parameters examined. A significant difference (P less than 0.05) was noted in each of the parameters between active and passive recovery over all age groups. As expected, active recovery produced lower maximal blood lactate concentrations, lower time to maximal blood lactate values, and lower half recovery times. These data suggest that intensive swimming training may prevent or delay the decline with age in the physiological factors affecting blood lactate values following a maximal sprint swim. Older sprint swimmers appeared to be capable of producing and removing lactic acid at the same rate as younger swimmers.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1982

Blood metabolites during prolonged exercise in swimming and leg cycling.

This study was designed to compare the influence of two modes of exercise (swimming and leg cycling) on the blood concentrations of metabolic substrates and metabolites during a 45-min exercise period. Eight college students (mean age = 21.6 +/- 1.2 year) exercised at 70% of VO2 max, in water using the front crawl on one occasion, and on a cycle ergometer using the legs on another. Blood samples were drawn at 0, 15, 30, and 45 min and analyzed for free fatty acids, glycerol, glucose, pyruvate, and lactate concentrations. Mean oxygen uptakes (2.23 vs 2.12 l . min-1) and heart rates (152 vs 150 b . min-1) for cycling and swimming respectively were not significantly different. Lactate and pyruvate were significantly (p less than 0.01) higher during swimming as compared to cycling. Free fatty acids, glycerol, and glucose were not significantly different between the two modes of exercise (p greater than 0.05). Assuming venous blood concentrations provide some indication of metabolic events, these data are compatible with a tendency to a higher relative carbohydrate oxidation rate during swimming as compared to cycling during prolonged exercise at the same relative work intensities.

Adult↗
PubMed1989

Discovery of antidepressant activity by forced swimming test may depend on pre-exposure of rats to a stressful situation.

Antidepressant-induced anti-immobility effects have been assessed in animals exposed or not to a pretest session using the forced swimming test. Desipramine, maprotiline, mianserine (15 and 30 mg/kg), nomifensine (2.5 and 5 mg/kg), d-amphetamine (1 and 2 mg/kg) and muscimol (1 and 2 mg/kg), unlike imipramine (15 and 30 mg/kg), LY-171555 (0.1 and 0.2 mg/kg) and scopolamine (0.5 and 0.1 mg/kg), did not reduce immobility time in rats which had not received the pretest session. On the other hand, all of the drugs tested reduced immobility time in rats exposed to a pretest session. In addition, the degree of antiimmobility effects of desipramine (20 mg/kg) and nomifensine (5 mg/kg) increased proportionally with the level of water (0, 4, 15 and 30 cm) to which animals were exposed at the time of pretest. Furthermore, desipramine reduced immobility time in rats pre-exposed to types of stress different from forced swimming, cold, restraint or foot-shock. All drugs were injected intraperitoneally three times, 24, 5 and 1 h before testing. The present findings suggest that a stressful pretest session may reveal pharmacological properties of antidepressants in the forced swimming test. This is also substantiated by the fact that diazepam (2.5 and 5 mg/kg) administered 30 min before the swimming pretest antagonized the anti-immobility effect of 15 mg/kg desipramine.

Animals↗
PubMed1991

Fuel homeostasis in the harbor seal during submerged swimming.

1. The turnover rates and oxidation rates of plasma glucose, lactate, and free fatty acids (FFA) were measured in three harbor seals (average mass = 40 kg) at rest or during voluntary submerged swimming in a water flume at 35% (1.3 m.s-1) and 50% (2 m.s-1) of maximum oxygen consumption (MO2max). 2. For seals resting in water, the total turnover rates for glucose, lactate, and FFA were 23.2, 26.2, and 7.5 mumols.min-1.kg-1, respectively. Direct oxidation of these metabolites accounted for approximately 7%, 27%, and 33% of their turnover and 3%, 7%, and 18% of the total ATP production, respectively. 3. For swimming seals, MO2max was achieved at a drag load equivalent to a speed of 3 m.s-1 and averaged 1.85 mmol O2.min-1.kg-1, which is 9-fold greater than resting metabolism in water at 18 degrees C. 4. At 35% and 50% MO2max, glucose turnover and oxidation rates did not change from resting levels. Glucose oxidation contributed about 1% of the total ATP production during swimming. 5. At 50% MO2max, lactate turnover and anaerobic ATP production doubled, but the steady state plasma lactate concentration remained low at 1.1 mM. Lactate oxidation increased 63% but still contributed only 4% of the total ATP production. Anaerobic metabolism contributed about 1% of the total ATP production at rest and during swimming. 6. The plasma FFA concentration and turnover rate increased only 24% and 37% over resting levels, respectively, at 50% MO2max. However, the oxidation rate increased almost 3.5-fold and accounted for 85% of the turnover.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenosine Triphosphate↗
PubMed1988

Flow field, swimming velocity and boundary layer: parameters which affect the stimulus for the lateral line organ in blind fish.

The data presented support the hypothesis that the flow field supplies the stimulus to the lateral line organ (LLO) in blind cave fish (Anoptichthys jordani). Two basic predictions from the theoretical analysis of the flow field were confirmed: (i) individual blind cave fish prefer particular swimming velocities, (ii) the velocity preferred depends on the cross-sectional area (CSA) of the fish, i.e. the smaller the CSA the higher the swimming velocity. This relationship was found also in experimentally blinded fish of other species. Furthermore, when placed in unfamiliar surroundings, blind cave fish swim at higher velocities than in familiar surroundings for a certain habituation period. The boundary layer which surrounds the fish attenuates the amplitude of the hydrodynamic stimulus because of its damping properties. Computations of the current velocity distribution within the boundary layer indicate that the stimulus for freestanding neuromasts is considerable even during swimming in open water.

Animals↗
PubMed1993

Effect of hand paddle aids on oxygen uptake during arm-stroke-only swimming.

Cardiorespiratory responses during arm-stroke-only swimming with and without the aid of paddle were compared in seven trained swimmers. Water flow rate was started at 0.80 m.s-1 and was increased by 0.05 m.s-1 every 2 min up. to 1.00 m.s-1. Subsequently, the flow rate was increased by 0.05 m.s-1 every minute until exhaustion. At given submaximal water flow rates, oxygen uptake, heart rate (fc), pulmonary ventilation (VE) and respiratory frequency (fR) during swimming using hands alone (H) were significantly higher than when aided by paddles (P). There were no significant differences in tidal volume (VT) between H and P. The subjects were able to swim significantly faster using paddles (P < 0.05); however, no significant differences between H and P were found in peak oxygen uptake (VO2peak, Fc, VE, FR, VT and the blood lactate concentration at which VO2peak was obtained (P > 0.05). These results would suggest that the ability to swim faster with paddles does not depend on higher energy production but may be attributed to higher propelling efficiency.

Adult↗