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The diagnostic value of laparoscopy in 2365 patients with acute and chronic pelvic pain.

OBJECTIVE: To discriminate the etiology in 2365 patients with acute and chronic pelvic pain (APP, CPP). METHODS: Diagnostic laparoscopy was carried out in 736 patients (31.1%) with APP and in 1629 (68.9%) with CPP. In 315 patients (13.3%) the diagnostic procedure was extended to operative laparoscopy. RESULTS: The most frequent laparoscopic findings in patients with APP were acute salpingitis and pelvic adhesions (22.8%) and ectopic pregnancy (19%), while in patients with CPP the most frequent findings were pelvic adhesions (35.4%) and endometriosis (24.6%). In 7.5% of patients with APP and 24% with CPP, laparoscopy did not reveal any pathological finding in the pelvis. Among the 315 patients in whom operative laparoscopy was carried out, 40% suffered from APP and 60% from CPP. In the 446 patients (18.9%) without laparoscopic findings no treatment was given, while of the remaining 905 patients 40% were subjected to laparotomy and 60% received conservative treatment. The total incidence of side effects reached 4.7% and serious side effects resulting from emergency laparotomy occurred in 0.15% of patients with pelvic pain. CONCLUSION: Our results in a large group of patients with pelvic pain show that there are discrepancies in the incidence of laparoscopic findings between patients with APP and CPP. Discrepancies between the two groups of patients were also found during operative laparoscopy, the treatment administered after laparoscopic diagnosis and the complications encountered.

Acute Disease↗

Maternal hyperglycemia in pregnant rats: its effect on growth and carbohydrate metabolism in the offspring.

Mild hyperglycemia during the last half of pregnancy was achieved by administration of streptozotocin to pregnant rats on the fifth day of gestation. Citrate buffer (vehicle for streptozotocin) was administered to control rats also on the fifth day of gestation. The pups born to the streptozotocin-treated mothers had higher birth weight, pancreatic insulin content, plasma insulin, and C-peptide concentrations compared with pups born to control mothers. The plasma glucose concentrations of the pups were similar between the two groups. The pups who were identified as macrosomic (birth weight greater than 1.7 SD than the mean of the control pups) maintained an accelerated postnatal growth through the first 10 weeks of age in female rats and in the first 3, and at 5 and 6 weeks of age for the male rats. The accelerated growth in the female rats was associated with higher perirenal-ovarian and salpingeal fat weight at 6 weeks. At 10 weeks of age, higher plasma insulin and glucose concentrations were observed following oral glucose challenge in both male and female macrosomic rats than in the control rats. At 12 weeks of age, only the female macrosomic rats showed abnormal glucose response due to peripheral insulin resistance. In the male rats at 12 weeks of age, a higher plasma insulin concentration in the macrosomic group was associated with a normal plasma glucose response to oral glucose challenge. We conclude that mild maternal hyperglycemia in rats resulted in fetal hyperinsulinemia and accelerated fetal growth.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

Ectopic pregnancy: not only a tubal disease.

Case histories of women with an obstetrical history and a current ectopic pregnancy (EP) were studied. When causal factors for EP such as salpingitis or inadequate contraception were ruled out there was a higher incidence of spontaneous abortion, ectopic pregnancy, and early labor (P less than 0.01) compared to matched controls. When the results of the first pregnancy after EP were studied the incidence of spontaneous abortion and early labor was higher (P = 0.01) than in matched controls.

Abortion, Spontaneous↗

Atypical presentation of female genital tract tuberculosis.

Three patients with atypical presentation of female genital tract tuberculosis are reported. Tuberculous hydrosalpinx with abdominal peritonitis, concomitant ectopic gestation with active salpingitis and tuberculous endometritis presenting as postmenopausal vaginal discharge are uncommon clinical manifestations. The age distribution, the importance of careful histological examination and the available methods for follow-up are discussed in the appropriate cases.

Adult↗

Tubal schistosomiasis as a cause of ectopic pregnancy in endemic areas?; a report of three cases.

Tubal schistosomiasis as a cause of ectopic pregnancy is uncommon. We are reporting three cases of tubal pregnancies in which the histopathological examination showed a bilharzial disease of the tube. Schistosomiasis to Schistosoma haematobium occurs in Gabon with an incidence of 8% to 44% of the adult population, and schistosoma ova have been found in 2.5% of histopathological examinations in removal of any genital tissue. Even if schistosomiasis was not the main causative agent of infertility, in this population which has the lowest fertility index in subsaharan Africa, it might impair an already altered tubal function by salpingitis. We suggest that parasitic examination should be made as a part of the management program of infertility and after an ectopic pregnancy in endemic areas.

Adult↗

The vaginal pH and leucocyte/epithelial cell ratio vary during normal menstrual cycles.

A higher proportion white blood cells (WBC) than vaginal epithelial cells in wet smears has been accepted as a sign which, together with clinical signs, can be useful in the diagnosis of infections in the genital tract such as cervicitis or salpingitis. However, little is known about the normal variation among healthy women without any symptoms or signs of genital-tract infection. By taking frequent wet smears from three healthy asymptomatic women during four menstrual cycles we found that vaginal leucocytosis usually occurred once each cycle. Normal vaginal leucocytosis must thus be taken into consideration when evaluating wet smear of patients for genital tract infections.

Adult↗

What do we know about the origin of CA 125?

The murine monoclonal antibody OC 125 recognizes an epitope on a molecule called Cancer Antigen 125 (CA 125). The CA 125 antigen is expressed in amnion and its derivatives of fetal coelomic epithelia (such as Müllerian epithelia, peritoneum, pleura and pericardium) and in many adult tissues (such as the epithelium of fallopian tubes, endometrium, endocervix, pleura and peritoneum). The normal endometrium produces CA 125 and this production can contribute significantly to the level of circulating CA 125 at the time of menstruation. During peritoneal irritation (hyperstimulation, salpingitis, ruptured ectopic pregnancy, laparotomy) peritoneally derived CA 125 significantly contributes to circulating CA 125 concentrations, giving elevated CA 125 values. The use of the CA 125 serum assay as a single diagnostic tool is restricted by the fact that the antigen CA 125 is produced by normal epithelia (of peritoneum, endometrium and benign ovarian cysts) and not only by the ovarian cancer cell.

Antigens, Tumor-Associated, Carbohydrate↗

Laboratory evaluation of acute upper genital tract infection.

OBJECTIVE: To evaluate the diagnostic test characteristics of common tests used to diagnose upper genital tract infection. METHODS: Subjects included women who either met the Centers for Disease Control and Prevention's minimal criteria for acute pelvic inflammatory disease or who had other signs of upper genital tract infection (i.e., atypical pelvic pain, abnormal uterine bleeding, or cervicitis). The subjects were evaluated with a baseline interview, comprehensive laboratory testing, and either an endometrial biopsy or laparoscopy for definitive diagnosis of upper genital tract infection. Patients were considered positive for upper genital tract infection if they had any of the following findings: 1) histologic evidence of acute endometriosis or salpingitis, 2) laparoscopic visualization of purulent exudate in the pelvis without another source, or 3) positive testing for Neisseria gonorrhoeae or Chlamydia trachomatis from the endometrium, fallopian tubes, or pelvis. RESULTS: One hundred twenty women with adequate endometrial samples were evaluated between August 1993 and September 1995. The median age of the study population was 24 years: 38% were white, 52% were smokers, 81% were insured by Medicaid or were uninsured, and 67% were single. Sensitivities for elevated white blood cell count (WBC), erythrocyte sedimentation rate, C-reactive protein, and increased vaginal white blood cells are 57, 70, 71, and 78%, respectively. If any one test is abnormal, the sensitivity is 100% and specificity is 18%. If all four tests are abnormal, sensitivity is 29% and specificity is 95%. CONCLUSION: Testing for increased vaginal white blood cells was found to be the most sensitive laboratory indicator for upper genital tract infection, whereas serum WBC was the most specific. No one diagnostic laboratory test is pathognomonic for upper genital tract infection. Combinations of positive tests can improve diagnostic specificity and positive predictive value, but with a diminution of sensitivity and negative predictive value. Combinations of negative tests can reliably exclude upper genital tract infection.

Acute Disease↗

Clinical analysis of reproductive failure among female buffaloes (Bubalus bubalis) under village management in Andhra Pradesh.

Analysis of the clinical data of 20, 439 infertile graded Murrah female buffaloes (Bubalus bubalis ) of small and marginal farmers in Andhra Pradesh, examined over a period of two years, revealed that 2.50, 73.77 and 23.73 percent of the animals had reproductive disorders which were of anatomical, functional and non-specific infectious nature, respectively. Highest frequencies were of infantile tracts, ovarian quiescence and endometritis in each group, which together constituted 79.13 percent. The average gross incidence of various conditions encountered in order of frequency was: ovarian quiescence (56.36%), endometritis (20.68%), silent ovulations (5.3%), anovular heats (4.35%), sub-oestrus (3.48%), luteal persistency (3.37%), genital infantilism (2.09%), vaginitis (o.99%), salpingitis (0.98%), cystic ovarian degeneration (0.91%), bursal adhesions (0.75%), cervicitis (0.3%), hypoplasia of the ovaries and tracts (0.24%), paraovarian cysts (0.15%) and hydrosalpinx (0.03%). The incidence of quiescent ovaries followed seasonal trend with significant differences between seasons of the year both in heifers and cows. Between herds and between years, no marked difference in the incidence of different reproductive disorders was observed. It was estimated that 2.93 percent of the animals had disorders which rendered them unfit for breeding and, hence, sterile. Freemartinism was recorded in four cases. The comparative clinical features of freemartinism and cystic ovarian dgeneration in buffalo cows were described. The factors predisposing for higher incidence of endometritis in the species were also discussed.

Journal Article↗

Ultrasound examination of adolescent females with lower abdominal pain.

We evaluated pelvic ultrasound examination in adolescent females as an aid in the diagnosis of acute and chronic lower abdominal pain resulting from suspected gynecologic disease. Of 41 subjects, 35 (85.4%) had a final diagnosis of a gynecologic disorder. Pelvic ultrasound examination was positive in 19 of 35 (54.3%). Ten positive tests had relatively specific findings that supported (seven) or helped change (three) the initial clinical diagnosis. Nine positive tests had nonspecific findings that were consistent with (six) or helped change (three) the initial diagnosis. Twenty-one negative tests helped change the initial diagnosis (13); ruled out complications of acute salpingitis (five); or discriminated between alternative diagnoses (three). One test was falsely positive. Ultrasonography was most clearly cost-effective when surgery was being considered. We conclude that pelvic ultrasound examination may be a useful diagnostic adjunct in this type of adolescent patient.

Abdomen↗

Diagnostic imaging of fertility disorders.

It is estimated that as many as 15% of married couples are affected by fertility disorders. The number of such couples seeking medical help has increased dramatically in the past 10 years due to both relative and absolute factors. The increase in population, the rising rate of sexually transmitted diseases, and the reduced availability of adoptable infants all contribute to the magnitude of this problem. The role of diagnostic imaging in the effective and compassionate care of couples desiring offspring is the subject of this review. Infertility is a disorder of a couple, not of two individuals. The diagnostic evaluation, therefore, must include both partners. Hysterosalpingography and ultrasound constitute the mainstay of the evaluation of the female member. The various techniques and complications of hysterosalpingography are reviewed. The normal appearance of the uterine cavity together with a review of the numerous anomalies and variations that might be encountered are presented. Along similar lines, the possible filling defects, synechiae, postoperative changes, and other alterations that may be encountered in imaging the uterine cavity are described. Evaluation of the fallopian tubes is of paramount importance, primarily to assess patency but also to assess the possibility of patent but diseased salpinges or disease of the surrounding peritubal tissue. Recently, interventional techniques using radiographic and sonographic control have been developed and are beginning to demonstrate promising results in the management of fallopian tube obstruction. These procedures, adapted from previously established radiographic interventive techniques, are discussed. The role of diagnostic imaging of the male partner is of lesser magnitude. Clinical assessment and semen evaluation generally permit adequate assessment of the male factor. Occasionally, however, vasography and seminal vesiculography are called into play. More frequently, sonographic evaluation to establish the presence of varicoceles is necessary. Such techniques are reviewed, as well as the interventional approaches for ablating varicoceles. The application of conventional and transvaginal sonography in the management of gynecologic fertility disorders is reviewed. Follicular monitoring, guided follicle aspiration, assessment of the status of the endometrium, guided embryo transfer and tubal cannulation, and evaluation of other pelvic disorders are significant factors in the appropriate management of the infertile couple.(ABSTRACT TRUNCATED AT 400 WORDS)

Diagnostic Imaging↗

An atypical presentation of the Fitz-Hugh-Curtis syndrome.

We present an unusual case of the Fitz-Hugh-Curtis syndrome as manifested in a young woman with right upper quadrant pain. The presentation was atypical and misleading because of the presence of a colonic ileus and the lack of salpingitis by pelvic exam. Diagnosis was made by exclusion of other abdominal disease processes, the detection of Chlamydia trachomatis antibody from a cervical specimen, and a dramatic response to appropriate antibiotic therapy.

Abdominal Pain↗

Pelvic inflammatory disease in adolescents.

Pelvic inflammatory disease (PID) is an infection of the upper female genital tract. It encompasses an array of inflammatory disorders, including endometritis, parametritis, salpingitis, oophoritis, tubo-ovarian abscess, peritonitis, and perihepatitis. In most adolescents with acute severe infections it is difficult to differentiate some of these entities; thus the term PID is used commonly. Perihepatitis (Fitz-Hugh-Curtis syndrome) and tubo-ovarian abscess are acute complications, whereas chronic complications include infertility, ectopic pregnancy, and chronic pain.

Adolescent↗

Total and subtotal abdominal hysterectomy.

Hysterectomy is one of the most frequently performed operations in the world, accounting for 500,000-600,000 procedures annually in the USA; the abdominal route for hysterectomy is the preferred route in 60-80% of these operations. Although the number of total abdominal hysterectomies performed annually has decreased, the number of subtotal abdominal hysterectomies increased by >400%. The major indications for abdominal hysterectomy include abnormal uterine bleeding, myomata uteri, adenomyosis, endometriosis, neoplasia, and chronic salpingitis. The basis for selection for subtotal versus total hysterectomy has little in the way of factual data to support it and may actually present some significant disadvantages, such as continued menstruation and cervical prolapse. The detailed technique for performing intrafascial abdominal hysterectomy relies heavily on precise knowledge of pelvic anatomy and compulsive detail to tissue handling. The consistent and correct usage of prophylactic antimicrobials, measures to prevent thromboemboli, and procedures to avoid urinary retention are key to the overall success of the surgery.

Female↗

[Fertiloscopy: Clermont-Ferrand's experiment].

OBJECTIVE: Evaluation of fertiloscopy's place in the management of female infertility. PATIENTS AND METHODS: Retrospective study including 229 women presenting primary or secondary infertility without pathology raising of an evident surgical sanction and benefitting from a fertiloscopy. Perioperative data analysis (context of the infertility, operating technique, complications). RESULTS: Two hundred and three fertiloscopic procedures succeeded (88.6%), revealing lesions in 58 cases (28.6%) requiring a laparoscopy. These are represented by adherences (21 cases), endometriosis (17 cases), an abnormality of the tubal permeability (10 cases), complete or partial failure to visualize the adnexae (6 cases) and ovarian cysts visualization (4 cases). Five complications (2.5%) without major consequence will be deplored: two rectal injuries, two hemorrhagic complications and a postoperative salpingitis. Most of procedures (97.5%) have been performed in an ambulatory setting except when a geographic remoteness did not allow it (5 patients). DISCUSSION AND CONCLUSION: Fertiloscopy is a safe and reliable procedure. It can be substituted to laparoscopy in the routine assessment of infertile women management in case of not obvious surgical indication.

Adolescent↗

Chromosome analysis of ectopic human conceptuses.

Maternal factors (e.g. salpingitis) are known to be associated with ectopic gestations; however, few studies have considered the chromosomal complements or morphologic features of ectopic conceptuses. We studied 23 ectopic conceptuses removed from fallopian tubes during surgical resection. The chromosomal complements were normal (four with 46,XY; four with 46,XX) in all cases in which an intact embryo was identified, as well as in the single case characterized by disorganized embryonic tissue. Ten of the 14 ectopic conceptuses in which only a gestational sac and placental villi were identified also show normal chromosomal complements (seven with 46,XX; three with 46,XY); in the remaining four cases, variations from the normal chromosomal complement were found (46,XX/47,XX,+9; 45,X/46,XX; 46,XX/47,XX,+mar; and 92,XXXX). The former two probably signify underlying fetal abnormalities; however, the latter two could have reflected, respectively, in vitro aberrations or tetraploidy characteristic of normal amnion. Pooled data from this study and two previous reports indicate that ectopic conceptuses probable have no higher frequency of chromosomal abnormalities than in utero conceptuses of comparable embryonic ages.

Adolescent↗

Noncontraceptive health benefits of oral steroidal contraceptives.

Prospective and retrospective epidemiologic studies involving oral contraceptives have been reviewed to determine the existence and extent of their benefits other than prevention of pregnancy. There is less menstrual blood loss, which reduces the risk of iron deficiency anemia by about 50%. The incidence of menorrhagia, irregular menses, and intermenstrual bleeding is also significantly reduced in users of oral contraceptives. Studies have shown an approximate 50% reduction in risk of endometrial cancer in oral contraceptive users, as well as a significant reduction in various types of benign breast disease. Because oral contraceptives inhibit ovulation, functional ovarian cysts are nearly eliminated, and the incidence of dysmenorrhea and premenstrual tension is significantly reduced. Oral contraceptives also protect women from developing ovarian carcinoma, rheumatoid arthritis, and salpingitis. From this review we conclude that the benefits of oral contraceptives in young healthy women for far outweight their more widely publicized, infrequent risks.

Adult↗

Differential diagnosis of abnormal uterine bleeding.

The causes of abnormal uterine bleeding include a wide spectrum of diseases of the reproductive system and nongynecologic causes as well. The differential diagnosis of abnormal excessive uterine bleeding includes organic causes that may be subdivided into reproductive tract disease, iatrogenic causes, and systemic disease. Reproductive tract disease that may result in abnormal uterine bleeding comprises the complications of pregnancy (threatened, incomplete, or missed abortion, ectopic pregnancy, trophoblastic disease, placental polyp, and subinvolution of the placental site), malignant tumors (endometrial, cervical, vaginal, vulvar, and oviduct malignancies and granulosa theca cell ovarian tumors), infection (endometritis, salpingitis), and other benign pelvic disorders (traumatic lesions of the vagina, severe vaginal infections, foreign bodies, cervical polyps, cervical erosion, cervicitis, submucous uterine leiomyomas, adenomyosis, endometriosis, and endometrial polyps). Iatrogenic causes of abnormal uterine bleeding include sex steroids, hypothalamic depressants, digitalis, phenytoin, anticoagulants, and intrauterine contraceptive devices. Systemic diseases that may cause abnormal uterine bleeding include hypothyroidism, cirrhosis, and coagulation disorders. Abnormal uterine bleeding that occurs in a woman of reproductive age should be considered the result of complication of pregnancy until proved otherwise. Abnormal uterine bleeding occurring in a woman of perimenopausal or postmenopausal age should be considered the result of a malignancy until proved otherwise. Menorrhagia occurring in an adolescent should be attributed to a coagulopathy until proved otherwise. When an organic cause of abnormal uterine bleeding cannot be found, then by exclusion the diagnosis of dysfunctional uterine bleeding is assumed. Coagulation disorders, particularly von Willebrand disease, are more common than many physicians realize. Women with a history of high-risk factors, all adolescents with menorrhagia, women with anovulatory dysfunctional uterine bleeding who fail medical or surgical therapy, and women with ovulatory dysfunctional uterine bleeding without an anatomic uterine lesion should be screened for a coagulopathy.

Diagnosis, Differential↗