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913 records · Page 51Linked to original sources
PubMed1995

New muscle relaxants.

The Council on Scientific Affairs of the California Medical Association presents the following epitomes of progress in anesthesiology. Each item, in the judgment of a panel of knowledgeable physicians, has recently become reasonably firmly established, both as to scientific fact and clinical importance. The items are presented in simple epitome, and an authoritative reference, both to the item itself and to the subject as a whole, is generally given for those who may be unfamiliar with a particular item. The purpose is to assist busy practitioners, students, researchers, and scholars to stay abreast of progress in medicine, whether in their own field of special interest or another. The epitomes included here were selected by the Advisory Panel to the Section on Anesthesiology of the California Medical Association, and the summaries were prepared under the direction of Dr Jackson and the panel.

Androstanols↗
PubMed1994

A literature review of the newest muscle relaxant: ORG 9426.

This article reviews the literature on the newest muscle relaxant, ORG 9426. It has completed clinical trials in the United States and is awaiting final approval from the Food and Drug Administration. Research is presented in regards to the potency, chemical structure, mechanism of action, neuromuscular effects, cardiovascular effects, and possible drug interactions of ORG 9426. Its effect on renal and liver failure patients and on the pediatric and elderly population is also documented. The pharmacodynamics and pharmacokinetics are compared with other neuromuscular blocking agents based on current reports. ORG 9426 is a promising, effective, and rapidly acting muscle relaxant that offers several advantages over other neuromuscular blocking agents presently available.

Adult↗
PubMed1997

[Contribution of flow cytometry to allergologic diagnosis].

The technique of Flow Cytometry for activation of basophils (TAB), expressed as the marker CD63, is at present one of the pathways of research applied to drug allergy. In this work are reported the results of TAB of Pneumoallergens and Hymenoptera venoms. TAB can define better than total IgE the atopy of the subject: in effect the fluorescence of the basophils is emphasized in comparison with non-atopic subjects. This hypothesis has been confirmed by a study of three groups of subjects. With regard to drug allergy, it is important to study patients in whom the observations have been documented very objectively by clinical history and positive skin tests to the drug, compared with a negative reference to the same drug. So, TAB has been shown to be very useful in diagnosis of allergy to certain drugs, such as the Myorelaxants.

Allergens↗
PubMed1998

[Common variable immunodeficiency associated with autoimmune thrombocytopenia: anesthetic management].

A 44-year-old man diagnosed of common variable immunodeficiency associated with thrombopenia due to autoimmunity required anesthesia for anal fissure repair and hemorrhoidectomy. Hemostatic complications developed after surgery, with extreme thrombopenia (1,000 platelets/pl) and analytical changes that necessitated administration of six units of platelets from apheresis, as well as immunoglobulins, antifibrinolytic agents (e-aminocaproic acid) and granulocytic colony stimulating factors. Anesthesia for such patients is reviewed, with emphasis on careful management of the airways, preparation of sufficient material for surgery (rapid transfusion equipment, large caliber intravenous catheters, sterile material) and orientation of anesthetic technique toward general anesthesia through a laryngeal mask.

Adjuvants, Anesthesia↗