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Results for “RADIATION PROTECTION”

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At least 919 records · Page 51Linked to original sources
PubMed2003

Radiation protection of HepG2 cells by Podophyllum hexandrum Royale.

Radioprotection by an aqueous extract of Podophyllum hexandrum (RP-1) was investigated in HepG2 cells by evaluating colony forming efficacy (CFE), redox status of mitochondria, reactive oxygen species (ROS), generation of nitric oxide (NO), peroxidation of lipids and intracellular glutathione. Lower concentrations of RP-1 (0.1 and 1 microg/ml) rendered maximum radioprotection when administered 1 or 2 h before irradiation. Higher concentrations (5 and 10 microg/ml) however were less effective when administered 1 or 2 h before irradiation, but were more effective with increased time intervals (4 or 8 h) between RP-1 administration and irradiation. RP-1 pre-treatment also significantly inhibited radiation-induced MTT reduction in a concentration and time-dependent manner by decreasing gamma radiation-induced leakage of electrons from electron transport chain. Pre-irradiation administration of RP-1 significantly reduced both ROS and NO generation and enhanced glutathione levels, thereby inhibiting lipid peroxidation.

Cell Cycle↗
PubMed1983

Radiation protection of stimulated human lymphocytes by nicotinamide.

Nicotinamide (NA) when added to human lymphocytes in vitro together with a mitogen, protected against the inhibition by gamma and UV radiation of stimulated cell growth. When stimulated by phytohemagglutinin (PHA), concanavalin A (Con A) or pokeweed mitogen (PWM) maximum protection has been observed with approximately 1 mM NA (dose reduction factor of 2-3). To obtain protection the cells had to be stimulated immediately after irradiation in the presence of NA. It is suggested that the intracellular level of NAD+ may be rate limiting for excision repair in human lymphocytes irradiated in the G0 phase. This level is presumably increased by exogenously supplied NA, leading to enhanced repair of DNA damage and increased survival.

Cell Division↗
PubMed1991

Radiation protection strategies in HERMES missions.

This paper describes the environment of radiations for the HERMES spaceplane and the doses received by men for several missions. Safeguard strategies are then studied to avoid dangerous dose levels. In particular, an anomalously large solar event with eruption of energetic protons may lead to inacceptable dose levels. Strategies, with regards to the orbits characteristics, are discussed.

Cosmic Radiation↗