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PubMed2000

Comparative screening with a sensitive guaiac and specific immunochemical occult blood test in an endoscopic study.

BACKGROUND: HemoccultSENSA (HOS), the sensitive guaiac fecal occult blood test (FOBT) for colorectal neoplasia, is faulted for its low specificity, which might be improved by substituting or adding FlexSure OBT (FS), the immunochemical test for human hemoglobin. (Both tests are manufactured by Beckman-Coulter Inc., Primary Care Diagnostics, Palo Alto, CA.) The authors compared both FOBTs in an endoscopic study to determine which FOBT to recommend for a population-screening program. METHODS: Both FOBTs, without dietary restrictions, were prepared by 1410 screenees or nonbleeding symptomatic patients (3%). All underwent colonoscopy (51.8%) or flexible sigmoidoscopy (if asymptomatic and both FOBTs were negative). RESULTS: HOS sensitivity for significant neoplasia, cancers, or adenomas >/= 1 cm (20 cases) was similar to that of FS (50% vs. 35%, not significant). However, HOS specificity was lower (95% vs. 99%, confidence interval (CIs) 94-96 vs. 98-99, P < 0.05). In those 11 cases in which both HOS and FS were positive, specificity for significant neoplasia was 100% but sensitivity decreased to 25% (less than HOS alone, P < 0.05). HOS was more sensitive than FS for any neoplasia (55 cases), including adenomas < 1 cm (35% vs. 18%, CIs 22-47 vs. 8-28, P < 0.05), but less specific (96% vs. 99%, CIs 95-97 vs. 98-100, P < 0.05). CONCLUSIONS: Guaiac HOS, which does not require dietary restrictions, is significantly more sensitive for any colorectal neoplasm than the immunochemical FS; it identifies more adenomas with a specificity that is low but acceptable for population screening.

Adenoma↗
PubMed1998

[Environmental lead exposure in the Venetian population from 1976-1992].

Blood lead levels observed in the general population of Venice and the surrounding area are reported for the period between 1976 and 1992. A time dependent decrease of blood lead levels is evident and parallels the step wise decrease of lead levels in gasoline which took place between 1981 and 1991. The observed lowering time trend of blood lead levels could possibly be ascribed, perhaps not negligibly, to technological improvements, the development of new analytical procedures and the continuous practice of quality control.

Adolescent↗
PubMedDate not supplied

Future prospects of population-based mammographic screening.

Mammographic screening is one worthwhile way of reducing deaths from breast cancer among women diagnosed in ages 50-69. Our knowledge is less clear for women below 50 and above 70. Major research issues include whether by new approaches we can achieve a definitive mortality reduction in women under 50 and investigations of the efficacy of screening in the elderly. The optimal interval time has yet to be decided. When screening is taken to previously unscreened populations, effects on many parameters have to be followed, e.g., sensitivity, specificity, positive predictive value, gains, and costs. We do not as yet know what the implications of finding large numbers of women with in situ cancer are. Keeping high standards in population-based programs also means fighting potential drawbacks: minimizing the proportion of "unnecessary" biopsies and anxiety, avoiding over-treatment of cancers with excellent prognosis, preventing false reassurance or that women with suspicious findings are left without advice. Potential drawbacks of screening are best dealt with within a team of specialists on breast cancer diagnosis and treatment. Mammographic screening has become widely accepted as one important way of reducing breast cancer deaths, and this success has been dependent on the fact that its development has been science driven. To continue to develop, the tradition of critical evaluation and unsentimental bold testing of new ideas has to be carried on.

Adult↗
PubMed2001

Preterm delivery and the severity of violence during pregnancy.

OBJECTIVE: To determine the severity and consequences of physical violence during pregnancy among participants in a health department prenatal care coordination program. STUDY DESIGN: The prospective cohort study included all program participants from 1994 to 1996. Care coordinators screened participants for physical violence during pregnancy using a validated, systematic assessment protocol three times during prenatal care. The protocol was linked with prenatal records, delivery records and infant records to document complications and infant outcomes. Multiple logistic regression was used to assess the relationship between severe physical violence during pregnancy and pregnancy outcome while controlling for confounding factors. RESULTS: Among the 550 participants, 13.5% reported violence during pregnancy; it included 6.7% severe violence (hitting, kicking, injury with a weapon and abdominal injury) and 6.7% moderate violence (threats, slapping, shoving and sexual abuse). Severe physical prenatal violence was significantly associated with spontaneous preterm labor, preterm delivery, very preterm delivery, very low birth weight, preterm/low birth weight, mean birth weight, mean newborn hospital charges, five-minute Apgar < 7, neonatal intensive care unit admission, and fetal or neonatal death. Body site injured, timing of violence and number of violent incidents were significant factors associated with violence during pregnancy and preterm delivery. CONCLUSION: Because severe physical violence during pregnancy was a significant problem in this population, intervention programs are needed to reduce prenatal violence and its consequences.

Adolescent↗
PubMed2001

Home- and community-based long-term care: lessons from Denmark.

PURPOSE: Denmark is cited as a model in the development of home- and community-based systems for the frail elderly population. We examined the results of this natural experiment and considered implications for U.S. policy. DESIGN AND METHODS: We used international comparative policy analysis, including site visits and semistructured interviews with Danish leadership in conjunction with a review of published literature, reports, and administrative data from Denmark and the United States. RESULTS: After 12 years of implementing integrated systems for home- and community-based services in 275 municipalities, growth in Danish long-term care expenditures has leveled off; expenditures appear to be decreasing for the over-80 population and have dropped as a percentage of the gross domestic product. Access to and quality of long-term care services appear to remain generally satisfactory. During this period, comparable expenditures in the United States have increased, and deficits in access and quality persist. IMPLICATIONS: These findings should be of interest to state and federal policy makers considering strategies to reduce the rate of growth in Medicaid and Medicare expenditures for elders and to expand home- and community-based services.

Aged↗
PubMed2000

DANMAP: monitoring antimicrobial resistance in Denmark.

The objectives of the Danish Integrated Antimicrobial Resistance Monitoring and Research Programme (DANMAP) are to monitor trends in resistance among bacteria from animals, food and humans, to monitor the consumption of antimicrobial agents and to determine the association between consumption and occurrence of resistance and to model transmission of resistance from animals to humans. DANMAP is based on the examination of representative bacterial isolates of animal and human pathogens, of zoonotic bacteria and of indicator bacteria. For food animals, both diseased and the healthy populations are studied. Isolates from all three reservoirs are examined for their susceptibility to a basic panel of antibiotics that includes representatives of the major classes of compounds, making comparison of resistance levels in the reservoirs possible. Isolates are stored in a strain collection and are available for further study. The data are stored in databases as MIC values or mm inhibition zones with all identifiers. A system for recording all use of the veterinary medicines, VETSTAT, is currently under implementation. For production animals, the consumption will be recorded for each herd, providing a basis for detailed modelling of the effect of consumption on resistance.

Animal Diseases↗
PubMed2003

Design and standards for genetic evaluation of swine seedstock populations.

The purpose of this article is to describe a program for evaluation of seedstock populations in the swine industry. Differences among seedstock populations for economically important traits must be identified in order for pork producers to efficiently use available genetic resources. National genetic evaluation programs have the potential to identify the important differences among populations and to increase the rate of genetic improvement in a population. Program results provide performance benchmarks that stimulate testing and selection procedures by seedstock suppliers that further increase the rate of genetic improvement. A Terminal Sire Line Genetic Evaluation Program was designed and conducted in the United States by the National Pork Producers Council (Des Moines, IA) to compare seedstock populations for use in crossbreeding systems. High levels of statistical accuracy for program results were established; the ability to detect differences of 0.25 SD per trait, a power of test of 75%, and a 5% significance level were selected. Pure breeds and breeding company sire lines were nominated for the program. Semen was collected from nominated boars and distributed to cooperating commercial producers during eight 1-wk breeding periods. Pigs were produced in 136 commercial herds and transported to testing facilities at 8 to 23 d of age. Nine of the 11 sire lines originally entered in the program completed the sampling requirements for statistical analysis. High levels of statistical accuracy and a large, representative sample of boars with restrictions on genetic relationships ensured that the program results included unbiased, highly accurate sire line data for growth, carcass, meat quality, and eating quality traits of economic importance. This program has shown commercial producers that they have several choices of sire lines for changing their crossbreeding programs in desired trait areas. Commercial product evaluation must be an ongoing process, and this program serves as a model for future testing and evaluation of diverse genetic seedstock populations.

Animals↗
PubMed1986

[A population survey on mass screening program for gastric cancer. Part 2. Why don't they receive mass screening examination?].

The attitude of non-examined residents to a mass screening program for gastric cancer has been surveyed by a self-administered questionnaire among 3660 residents in a small town near Kitakyushu City. Among 1159 subjects who had not received any type of examination during the past 3 years, the answers of 638 subjects who completed the questionnaire were analyzed in this study. Reasons for not being examined were classified into 4 types; "unnecessary", "rejected", "inconvenient" and "others". The most frequent reason for not taking part in the screening program was "inconvenient" which means that there were some difficulties for them to participate in the program even if they wanted to. This reason was followed by "unnecessary" and "rejected". "Inconvenient" was the main reason for not being examined among people in their forties and fifties and/or among those who have jobs. Among elderly people, "unnecessary" had the highest frequency. "Rejected" was the least important reason in all age groups. In each age group "rejected" was found more frequently among females than males. As the type of reason for not being examined was different among groups, it is essential to work out different countermeasures for each group in order to raise the participating rate.

Adult↗
PubMed2003

Monitoring virus strain variation following infection with VZV: is there a need and what are the implications of introducing the Oka vaccine?

Varicella zoster virus (VZV) is a stable virus showing relatively little variation. Nevertheless, recent data have shown there to be at least four distinct viral strains. For the most part these are geographically segregated, but in areas of the world such as the UK, where mixed populations live, there is evidence for spread of all the genotypes. Little is known about the biological differences, if any, between these strains, yet recent data have shown that even a single nucleic acid change can affect the biological behaviour of the virus. The Oka vaccine has been licensed for mass vaccination in the US and for limited use in the UK, particularly in seronegative healthcare workers. Virological surveillance is needed to support these programmes and study the effect on virus spread. Evidence for VZV superinfection of latently infected individuals with different strains, and the increasing detection of VZV in association with clinical conditions such as viral meningitis, suggest more data are needed on the transmissibility and biological properties of the virus.

Biomarkers↗
PubMed1997

Blood lead levels in urban children of Katowice Voivodship, Poland: results of the population-based biomonitoring and surveillance program.

The paper presents the results of the large-scale blood lead levels survey in pre-school urban children living in industrial area of Poland (Katowice Voivodship, Upper Silesian Industrial Zone-USIZ). The program, established in 1993, involves education, screening and medical care of case-children, as its major elements. Until December 1995 six thousand nine hundred sixty nine children aged 2-6 years have been examined in three towns (Chorzów, Kalowice, Sosnowiec). Geometric mean value of blood lead level (PbB) was slightly but not statistically significantly larger in boys (6.68 +/- 1.51 micrograms/dl) than in girls (6.58 +/- 1.54 micrograms/dl). In a multiple regression analysis the following variables explained variation in PbB: town (p = 0.0001), age (p = 0.005), floor on which apartment was located (p = 0.0001), number of siblings (p = 0.0001), apartment quality (p = 0.0001), carpet in a child's room (p = 0.0001), consumption of locally grown vegetables (p = 0.007), frequent trips outside the region (p = 0.0001). The results were verified with PbB as dichotomous variable. The occurrence of PbB above 10 micrograms/dl (frequency, 14.2%-17.2%) was associated with floor on which apartment was located, number of siblings, apartment's quality, the presence of carpet in child's room and frequent trips outside the region. The occurrence of PbB above 15 micrograms/dl (frequency: 2.5%-4.2% of children) was associated with the same variables and additionally, with the place of residence and intensity of vehicle traffic. The findings yield reliable population-based estimates of the risk of over-exposure of "non-hot-spot" urban children to environmental lead and highlight the important role of factors that could be classified as environmental and socio-economical determinants of blood lead level. Among environmental factors deposits of lead are still a problem in a densely populated industrial center of USIZ and the use of leaded gasoline adds to the magnitude of exposure.

Analysis of Variance↗
PubMed2005

Trypanosomiasis control, Democratic Republic of Congo, 1993-2003.

In the Democratic Republic of Congo (DRC), human African trypanosomiasis (HAT) reached unprecedented levels in the 1990s. To assess recent trends and evaluate control efforts, we analyzed epidemiologic and financial data collected by all agencies involved in HAT control in DRC from 1993 to 2003. Funds allocated to control populations, as well as to the population screened, doubled from 1993 to 1997 and from 1998 to 2003. The number of cases detected decreased from 26,000 new cases per year in 1998 to 11,000 in 2003. Our analysis shows that HAT control in DRC is almost completely dependent on international aid and that sudden withdrawal of such aid in 1990 had a long-lasting effect. Since 1998, control efforts intensified because of renewed donor interest, including a public-private partnership, and this effort led to a major reduction in HAT incidence. To avoid reemergence of this disease, such efforts should be sustained.

Democratic Republic of the Congo↗
PubMed1988

A general health policy model: update and applications.

This article describes the development of a General Health Policy Model that can be used for program evaluation, population monitoring, clinical research, and policy analysis. An important component of the model, the Quality of Well-being scale (QWB) combines preference-weighted measures of symptoms and functioning to provide a numerical point-in-time expression of well-being, ranging from 0 for death to 1.0 for asymptomatic optimum functioning. The level of wellness at particular points in time is governed by the prognosis (transition rates or probabilities) generated by the underlying disease or injury under different treatment (control) variables. Well-years result from integrating the level of wellness, or health-related quality of life, over the life expectancy. Several issues relevant to the application of the model are discussed. It is suggested that a quality of life measure need not have separate components for social and mental health. Social health has been difficult to define; social support may be a poor criterion for resource allocation; and some evidence suggests that aspects of mental health are captured by the general measure. Although it has been suggested that measures of child health should differ from those used for adults, we argue that a separate conceptualization of child health creates new problems for policy analysis. After offering several applications of the model for the evaluation of prevention programs, we conclude that many of the advantages of general measures have been overlooked and should be given serious consideration in future studies.

Aged↗
PubMed2006

[Incidence of hip fracture in Germany--person-related analysis of health insurance population].

BACKGROUND AND PURPOSE: An increasing number of hip fractures were reported world wide during the last decades. Up to now incidence data are rare for Germany. The aim of this study is to determine actual person-related age- and sex-specific rates of hip fractures in Germany. METHODS: The linkable and person-specific but non-identifying database of a German statutory health insurance company, Gmuender ErsatzKasse (GEK), was used. All subjects who were admitted to hospital with a primary diagnosis of hip fracture (ICD-10: S72.0-S72.2) in 2004 were identified. Incidence rate ratios (IRR), age- and sex-specific rates (per 1000 person-years) were calculated. Annual numbers of hip fractures for all persons covered by statutory health insurances (Gesetzliche Krankenversicherung- GKV) and the German population were estimated. RESULTS: The incidence of hip fracture increases exponentially with age. Hip fractures occur 129 times more often (IRR: 129.07; 95 % CI: 66.55 - 269.78) in women aged 90 - 94 years and 79 times more often (IRR: 78.97; 95 % CI: 30.02 - 185.87) in men aged 90 - 94 years compared to those aged 50 - 54 years. Approximately 101 037 (95 % CI: 91 779 - 110 294) persons are annually admitted to hospital in Germany due to this event. CONCLUSION: Hip fractures are common in the elderly and especially in women. Because of demographic changes and a possible secular trend an increasing number of hip fractures are to be expected in the future.

Adolescent↗
PubMed2000

[Study on the mortality of injury in Chinese population in urban and rural areas from 1990 to 1997].

OBJECTIVE: To describe the characteristics and trend of injuries among urban and rural Chinese population. METHODS: Data from annual Chinese national health statistics (1990 - 1997) were analyzed. RESULTS: The overall mortality of injury in China increased from 36.8/10(6) to 76.7/10(6) from 1990 to 1997. Injury was the forth leading causes of death in urban areas and the fifth in rural areas. The death rate of injury declined in the urban while increasing in the rural areas. The rural death rate of injury was about two times of that in urban and the difference was increasing over time. The death rate of men was higher than that of women and the ratio was 1.3 - 1.9. Children below 4 years old and people above 60 years old showed the highest rates. The first three leading causes of death of injuries in urban areas were traffic accident, suicide and fall, while in rural areas were suicide, traffic accident and drowning. The death rate caused by suicide was 6.5/10(6) - 27.1/10(6) and the rate in rural areas was 2.7 to 4.0 times of that in urban areas. The mortality of suicide declined in urban while increased in rural areas. The mortality of traffic accidents had a tendency of increase in both urban and rural areas. CONCLUSION: Injury has been one of the leading cause of death but without effectively control programs for population in Urban and Rural areas in China, special in rural areas.

Accidents, Traffic↗
PubMed2006

How to develop and implement pandemic preparedness plans? The need for a coherent European policy.

How should public health authorities confront the threat of pandemic influenza? Is massive stockpiling the answer? If so, the costs could be overwhelming. Or is vaccination of pre-selected segments of the population the best approach? If so, then what about the tough ethical question that must be addressed: for whom--and by whose decision? Are local and national health authorities operating on the same wavelength? Just how all-encompassing should a national preparedness plan be? Finally, can we count on one national government to shuttle vaccines across Europe's internal borders where they are needed to deal with an outbreak--or will hoarding and panic ensue? These issues and more were the focus of debate during the conference's session on preparedness plans, chaired by Dr. D. Fedson, former professor of medicine at the University of Virginia. As participants observed, Europe faces an alarming diversity of approaches and states of readiness from one country to the next, which cries out for a coherent European policy.

Disaster Planning↗
PubMed1998

Infant and young child feeding practices among African pastoralists: the Datoga of Tanzania.

Breast-feeding and weaning practices were observed for a cohort of 81 children under 3 years of age in the context of a longitudinal study of social, ecological and nutritional factors affecting growth in a semi-nomadic population of pastoralists in northern Tanzania (WaDatoga of Mbulu District). The adequacy of indigenous infant and young child feeding practices was assessed in relation to current international recommendations. Objectives were to provide baseline data for future investigations of any changes in young child feeding practices which accompany population shifts towards settlement and non-pastoral modes of subsistence, and to improve understanding of the strengths and limitations of indigenous feeding practices in this type of population. It was found that while breast-feeding was universally initiated, other aspects of young child feeding practices do not meet current international recommendations. Prelacteal feeds are commonly used, supplementary feeding with non-human milks usually occurs before 4 months of age, use of solid foods normally begins later than 6 months, and breast-feeding does not continue until 2 years of age for the majority of children. The data have implications for the design of breast-feeding promotion and improved weaning food interventions among African pastoralists.

Breast Feeding↗
PubMed2000

Recent trends in leprosy in a large district of West Bengal, India, revealed by a modified leprosy elimination campaign (MLEC), 1998.

A Modified Leprosy Elimination Campaign (MLEC) in September 1998 in the District of Midnapore, West Bengal, covered a population of 8.1 million people and detected 8181 new cases. Available data from 7328 cases were studied to observe the trend for leprosy in this area. Data are presented on sex and age distribution, classification and the proportions of multibacillary (MB), paucibacillary (PB) and single skin lesion (SSL) cases discovered in a period of only 8 days. The large numbers of people examined in this district and the high total of new cases revealed are in keeping with experience in other parts of the State and in other parts of India. However, many cases were found in endemic areas and these will receive special attention in a second MLEC, planned for January 2000.

Adolescent↗
PubMed2003

The relentless spread of tuberculosis in Zambia--trends over the past 37 years (1964-2000).

OBJECTIVE: To review trends in the rates of tuberculosis (TB) case notifications over a 37-year period. DESIGN: A retrospective study of Ministry of Health records on TB notifications between 1 January 1964 and 31 December 2000. SETTING: Zambia, sub-Saharan Africa. METHODS: Retrospective analysis of case-notification data for TB of the Zambia Ministry of Health annual returns. OUTCOME MEASURES: Annual TB case-notification rates and trends over the past 37 years. RESULTS: TB case-notification data from 1964 to 2000 show a 12-fold increase over the past two decades, and apparent gains in controlling TB seen in the 1960s and 1970s have been reversed over the past two decades. A stable situation during the period 1964-1984 (case-notification rate remained around 100 per 100,000 population) was followed by an exponential increase since the mid-1980s. The absolute number of new TB cases increased from 8,246 in 1985 (124/100,000) to 38,863 (409/100,000) in 1996 and 52,000 (512/100,000) in 2000. Comparison of case-notification rates over the past 2 decades with neighbouring countries (Zimbabwe, Malawi and Tanzania) show that Zambia has one of the highest case-notification rates in the region. CONCLUSIONS: Zambia, like many countries in Africa, is in the midst of a serious TB epidemic and there are no signs that it is abating. This increase was most likely due to the impact of the HIV/AIDS epidemic and subsequent breakdown of TB services. Concerted donor-government efforts should invest appropriately in long-term plans for TB control.

AIDS-Related Opportunistic Infections↗