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PubMed1994

Evolution of RNA editing in kinetoplastid protozoa.

The editing of RNA in trypanosomatid mitochondria involves the insertion and occasional deletion of uridine residues within coding regions of maxicircle messenger RNA transcripts. The extent to which the transcripts of homologous genes undergo editing differs in different species. In some, entire genes are edited (pan-editing), whereas in others, editing is limited to the 5' termini of editing domains (5' editing). Here we investigate which type of editing is ancestral and which is derived, by analysing RNA editing in the different lineages, using a kinetoplastid phylogeny reconstructed from nuclear small subunit ribosomal RNA sequences. We conclude that the ancestral cryptogenes were pan-edited, and we hypothesize that the 5'-edited homologues were generated by several independent events from partially edited RNAs, in which case editing may be a more primitive mechanism than previously thought.

Adenosine Triphosphatases↗
PubMed1996

Regulation of host cell function by glycosylphosphatidylinositols of the parasitic protozoa.

Antigenic variation, antigenic drift, molecular mimicry, intracellular localization and sequestration in privileged sites are important mechanisms of immune evasion by infectious organisms. Added to this however is the phenomenon by which pathogens deliberately regulate host cell function by the production of glycolipids with agonistic or antagonistic signal transduction capacity. Such pro-active glycolipids are often pathogenicity factors, but they also serve as immunomodulators and immunosuppressants, and these activities may serve as mechanisms of immune evasion. Here we review glycosylphosphatidylinositols and related structures, a novel class of glycolipid common to eukaryotic parasites and their hosts, which recent studies suggest may play a role in immune evasion and immunosuppression by regulating host cell function via the activation or suppression of endogenous host signalling pathways.

Animals↗