Chemical oxidation and in vitro metabolism of 1-(4-chlorophenylazo) piperidine and its heteroalicyclic analogues [proceeding].
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Animals↗
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Piperidine-containing histamine H3 receptor antagonists of the carbamate series: the influence of the additional ether functionality.
Recently novel leads for histamine H3 receptor antagonists of the non-imidazole type have been described. As a continuation of this research eleven new carbamate derivatives possessing an additional ether functionality were prepared. The compounds were evaluated in vitro for their antagonist activity on isolated organs of guinea-pig (GP) H3 as well as H2, H1, and M3 receptors, respectively. All compounds investigated possessed moderate antagonist affinities at guinea-pig histamine H3 receptors (pA2 6.11-6.76). An ether functionality introduced in different places of the lipophilic part of carbamates differently influenced activity and selectivity toward H3, M3, and other histamine receptors tested.
Animals↗
[Convulsive action of nucleus of keto-piperidine in the molecule of strychnine].
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Cell Nucleus↗
[Convulsive action of the keto-piperidine nucleus in the strychinine molecule].
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Cell Nucleus↗
[Studies on synthetic sympatholytics of ergotamine series; new compounds of amine and amide function and tetrahydro-beta-naphthylamine derivatives containing piperidine and morpholine radicals].
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2-Naphthylamine↗
[Synthesis of spasmolytic alkanolamine esters of alpha-phenyl-alpha-piperidine acetic acid].
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Acetates↗
[Ethyl 1-methyl-4-(m-hydroxyphenyl)-piperidine-4-carboxylate in preanesthesia and in the treatment of postoperative pain].
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Analgesics↗
[Rapid evaluation of the toxicity of a series of compounds; toxicity of some derivatives of N-(2-aminoethyl)-piperidine].
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Piperidines↗
[Clinical trial of a new piperidine compound as soporific].
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Chlorpromazine↗
[(2-Diphenylmethyl-piperidine hydrochloride and the methyl ester of 2-chloro-2-phenyl-2-(2-piperidyl)-acetic acid), drugs with waking effect in anesthesia].
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Acetates↗
Studies on cholinergic blocking substances. VIII. Pharmacological actions of certain polymethylene-, bis- and azapentylene-bis-pyrrolidine and piperidine derivatives.
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Autonomic Agents↗
[Pharmacologic properties of new synthetic curare simulants; sulfonium analogue of methonium salts, derivatives of pyridine carbonic and piperidine carbonic acids].
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Carbon↗
[Clinical observations on a new piperidine derivative of hypnotic sedative action].
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Anti-Allergic Agents↗
[Anthelmintic action of fatty acid salts of ethylenediamines, diethylenediamine, piperidine and morpholine].
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Anthelmintics↗
[Clinical proof of a new soporific of the piperidine series].
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Hypnotics and Sedatives↗
[Behavior of basal metabolism after pre-anesthesia medication with derivatives of dibenzoparathiazine and piperidine].
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Anesthesia↗
[First results of a new treatment of Parkinson's disease and of parkinsonism; therapeutic effect of 3-phenyl-3-(beta-diethylamino-ethyl)-2, 6-dioxo piperidine alone and with reserpine and ritalin; preliminary note].
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Antihypertensive Agents↗
[Effects on neuromuscular transmission and pharmacological properties of secondary diamines derived from piperidine].
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Diamines↗