Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Narcotics”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 919 records · Page 51Linked to original sources
PubMed2004

Chronic toxicity and body residues of the nonpolar narcotic 1,2,3,4-tetrachlorobenzene in Chironomus riparius.

The use of internal concentrations as a dose parameter for baseline toxicity requires an understanding of the relationship between accumulation level and toxic effects, not only for acute but also for chronic exposure. In this study of chronic toxicity of the nonpolar narcotic 1,2,3,4-tetrachlorobenzene (TeCB) to Chironomus riparius, the chronic median lethal concentration (LC50) was determined to be 0.99 (0.54-1.82) microM, the median sublethal effect concentration (EC50) for growth was 0.76 (0.73-0.97) microM, and the chronic (sublethal) no-observed-effect concentration (NOEC) was 0.24 +/- 0.01 microM. An acute-to-chronic ratio of 9.8 was calculated from a previously determined acute LC50 value and this NOEC. The chronic critical body residue (CBR), 136 mmol/kg lipid, was the same as the acute CBR, previously determined. The similarity of the chronic and acute CBRs lends support to the exposure time independent aspect of baseline toxicity theory. An implication of this is that internal concentrations estimated by biomimetic sampling devices may be compared to acute CBR data to determine chronic baseline toxicity risk. Such sampling devices, solid-phase microextraction (SPME) fibers, were simultaneously exposed during the toxicity test. The results of this study suggest that body residues estimated with SPME may be used to predict baseline toxicity for various exposure durations.

Animals↗
PubMed1986

Non-narcotic analgesics. Use in pregnancy and fetal and perinatal effects.

Aspirin and related non-narcotic analgesics such as paracetamol (acetaminophen) are present in almost every 'Western' household and are so commonly used that the public often does not think of them as drugs. Although the toxic effects of overdoses are well recognised by the medical and related professions, the potential adverse effects of repetitive dosing, within the commonly recommended therapeutic range, are not. This is particularly true during pregnancy, where the relative overall general safety of the agents is overshadowed by the possible subtle but potentially pervasive effects on the fetus. Marketing publicity, particularly about recently introduced related agents, has at times failed to take into account these less obvious, but nevertheless potentially lethal, side effects. It is now likely that aspirin and/or paracetamol are used during pregnancy by most women and that the earlier figures are underestimates. Although animal studies have shown significant effects of non-steroidal anti-inflammatory agents (NSAIDs) on the fetal circulation, particularly on the developing pulmonary circulation, the data on human pregnancy are less convincing. Nevertheless, the possible association of these drugs with prolonged gestation, and an increased incidence of the syndrome of persistent pulmonary hypertension of the newborn and of intracranial haemorrhage, demand that prudence be exercised when using these drugs during pregnancy. At the very least, more conclusive evidence is necessary that fetal and neonatal complications are not increased.

Abnormalities, Drug-Induced↗
PubMed1986

Side effects of non-narcotic analgesics as a determinant of prescribing.

In the prescription of non-narcotic analgesics the physician's main responsibility is to make sure that the quality-of-life improvement expected from the drug's use justifies the associated risk, low though it is, of fatal side effects. The range of acceptable risk depends, naturally, on the dosage and duration of the treatment and on those characteristics of the patient which bear on the drug's efficacy and safety. In the treatment of acute pain an additional, very important, factor is the patient's remaining life expectancy. Quantification of maximal acceptable risks is aided by formal decision-analytic considerations. Such analyses indicate that maximal acceptable risks vary by several orders of magnitude among various clinical situations and that they are more liberal than intuition might generally suggest.

Acute Disease↗
PubMed1976

A follow-up study of 300 ex-clients of a drug-free narcotic treatment program in New York City.

This article deals with an attempt at evaluating the success of a drug-free narcotic treatment program in New York City through a follow-up study of 300 ex-clients of the program. Two hundred ex-clients out of the 300 target population were actually interviewed. The number of months the clients had remained in the treatment program was found to be a key factor in the outcome of the program. The length of time in the program was itself highly dependent upon the client's background: the higher the pretreatment pathology the lower the chance of treatment success.

Adolescent↗
PubMed1976

Methadone maintenance treatment of narcotic addiction: a unit of medical care based on over 50,000 patient treatment years.

The experience with methadone maintenance treatment by two major New York City methadone maintenance treatment programs using the Dole-Nyswander philosophy is reviewed. After more than 56,000 person-years in treatment over a 10-year period of time, a unit of medical experience exemplified by these two programs is evident. There was a high degree of patient acceptance, a small amount of recognized residual illicit drug abuse, and steeply reduced criminal activities of those patients who remained in treatment. A wide variety of other methadone treatment programs are recognized. Many use methadone differently from those in the present study. The treatment results reported herein may represent a standard by which narcotic (methadone and other) treatment programs can be assessed.

Crime↗
PubMed1980

Profile of narcotic abuse in peninsula Malaysia.

Demographic and drug abuse characteristics of 3,484 new drug abuse contacts presenting to the General Hospital, Kuala Lumpur, Malaysia are reported. The large majority were heroin inhalers. They were different from the traditional Eastern opium inhalers and similar to Western heroin injectors in that they were young, male, single, and frequently unemployed. These features and the relative underrepresentation of Chinese suggest that the Chinese of this study did not learn narcotic abuse from opium-smoking relatives.

Adolescent↗
PubMed1981

Alcoholism and alcohol dependence in narcotic addicts: a prospective study with a five-year follow-up.

In this paper we report on the prediction of mortality, alcohol dependence, and the rate of previously undiagnosed alcoholism in male and female narcotic addicts. These subjects (N = 200) were initially interviewed upon admission to the Clinical Research Center, National Institute of Mental Health, Lexington, Kentucky, and prospectively followed-up and reinterviewed 5 years later (N = 187). The results indicate that alcoholism and alcohol dependence are very prevalent in this sample of addicts. A history of diagnosable alcoholism obtained at admission was a significant predictor of mortality during the follow-up period whereas a history of heavy drinking was associated with increased mortality but not significantly. About one-half of the males and one-quarter of the females met criteria for alcohol dependence during the follow-up period. Both a prior diagnosis of alcoholism and a history of heavy drinking were significant predictors of episodes of alcohol dependence during the follow-up period. In addition, the proportion of subjects positive for alcoholism increased between two- and threefold during the 5-year period. Finally, a history of heavy drinking at any time within the 4 years immediately prior to admission significantly predicted subsequent episodes during the follow-up period.

Alcoholism↗
PubMed1998

The family experiences of narcotic addicts and their subsequent parenting practices.

This survey study of male and female narcotic addicts participating in methadone maintenance programs examined self-reported retrospective data on parental behavior experienced by addicts during their adolescent years. These findings were contrasted with the addicts' self-report of their current parenting practices with their own adolescent children. Results showed addicts as perceiving their mothers as significantly more functional in their parenting practices than their fathers on indices of parental involvement, attachment, and responsibility. Significant parenting differences between addicts and their parents were reported for the three indices mentioned, as well as for parent discipline and punitive actions, with the addicts rating their current parenting practices as more effective than those of their parents. Reported parenting practices were further analyzed in the context of how the ratings of parental functioning were related to problems of drug and alcohol abuse exhibited in the home. Findings are discussed in terms of the implications for prevention and treatment approaches for addicts and their children.

Adolescent↗
PubMedDate not supplied

High-dose narcotic anesthesia using sufentanil in swine for cardiac catheterization and electrophysiologic studies.

A protocol for high-dose narcotic anesthesia using sufentanil by intravenous infusion was developed in swine undergoing cardiac catheterization and intracardiac electrophysiologic studies. In experiments involving cardiac conduction system ablation, nine swine received intramuscular ketamine, 33 mg/kg, and intramuscular acepromazine, 1.1 mg/kg, as premedication. An infusion of sufentanil (15 mcg/kg/h) was started followed by a loading dose of sufentanil (7 mcg/kg) given as a bolus intravenously. A continuous infusion of sufentanil (15-30 mcg/kg/h) was used for maintenance anesthesia. Since the development of this protocol, we have been able to achieve stable hemodynamics and cardiac rhythms for intracardiac electrophysiologic studies.

Anesthesia, Intravenous↗
PubMed1986

Correlation between the number of placental opioid receptors, mode of delivery, and maternal narcotic use.

Human placental opioid receptors were assayed using the radioactive opioid agonist, etorphine, to determine the number of binding sites in villous tissue membrane preparations. Significant differences in receptor concentration per milligram of protein of tissue were found between placentas obtained following vaginal or abdominal delivery (P less than 0.002). Labor itself did not alter apparent receptor numbers. In patients with maternal narcotic abuse during pregnancy, no opioid binding could be detected regardless of the mode of delivery, suggesting possible receptor down-regulation.

Cesarean Section↗
PubMed1976

Reliability of self-reported age of first drug use: analysis of New York City narcotics register data.

New York City Narcotics Register data were analyzed to determine the consistency of self-reported age of first drug use among multiple reports on a single individual. There were 15,263 individuals with two or more reports between January 1973 and April 1974 which specified age of first drug use. Discrepancies were noted in 68% of cases; in 31% the responses differed by 3 or more years. Even among reports from a single agency, there were discrepancies in 45% of cases. The degree of consistency was only slightly better when the analysis was restricted to subjects 20 years of age and younger. No comparable inconsistency was observed with respect to self-reported year of birth.

Adolescent↗
PubMed1976

Reliability and validity of self-reported illegal activities and drug use collected from narcotic addicts.

In follow-up of 1,500 drug-using applicants to the NIMH civil commitment program under Titles I and III of the Narcotic Addict Rehabilitation Act, efforts were made to measure the reliability and validity of self-reported criminal and drug-taking behavior. Various methods to assure reliable and valid responses were developed and implemented. These methods included choice of interviewer, intraquestionnaire safeguards, interview-reinterview procedures, and use of police records and urinalysis reports. Overall, the results indicated that the responses for 829 respondents were reliable. The greatest limitation to the validity study was the incomplete and unreliable police records and urinalysis reports.

Alcohol Drinking↗
PubMed1976

Characteristics of new admissions to a narcotics treatment program: 1970-1974.

Study was made of the demographic and drug-using characteristics of new admissions to a narcotic treatment program over the course of a 4-year period. Samples were drawn of 100 new admissions during the month of April in each year from 1970 to 1974. Results indicate that the treatment program under study came to be working with caseloads increasingly court referred, increasingly nonminority, and less frequently prepared to volunteer for methadone maintenance treatment. New admissions claimed to have delayed entrance into treatment based on the geographic inaccessibility of treatment programs or the fact that they did not consider themselves ready for treatment. Implications for the provision of treatment to heroin users are discussed.

Adult↗
PubMed1977

Psychological test and demographic variables associated with retention of narcotic addicts in treatment.

The relationships of psychological and demographic variables to retention in treatment of narcotic addicts were examined. Age and race were not related to retention. The IQ's of subjects retained longer seemed to be higher but the relationship did not reach statistical significance with this sample size. Legal pressure was clearly associated with longer retention as were higher scores on the Suitable for Treatment Scale. Legal pressure seemed to exert its major influence early in treatment. Treatment center variables and patient variables probably interact to determine retention.

Adult↗
PubMed1978

Early adolescent antecedents of narcotic abuse.

A retrospective study of the sociocultural and behavioral characteristics of 200 persons under treatment for narcotic addiction was done and the results compared with those of 200 matched nonaddict peers. Twenty-eight of the original 104 items tested were found to discriminate between the two samples at the 5% level of significance. A factor analysis of these items indicated that a general delinquency behavior factor and three family background factors accounted for most of the variance in the data.

Adolescent↗
PubMed1978

Narcotic antagonist treatment: clinical experience with naltrexone.

Narcotic antagonist (naltrexone) treatment experience with 22 opioid addicts over a 29-month period shows that the mean duration of receipt of naltrexone was 6.2 weeks, and 12 subjects (55%) continued in treatment after cessation of naltrexone for an average of 5.6 weeks. Analysis of physical and behavioral measured revealed no toxicity, indicating that naltrexone appears to be a safe drug. Clinical evaluation of the patients receiving naltrexone suggests that ingestion of naltrexone provides a degree of external control, reducing the preoccupation with heroin and releasing energy for the pursuit of other goals. Subject follow-up at an average of 45.3 weeks after cessation of naltrexone indicated that 11 (58%) were known to be abstinent, and 9 (47%) subjects were employed compared with 3 (16%) employed at the onset of treatment.

Adolescent↗