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At least 919 records · Page 51Linked to original sources
PubMed2007

Unprotected anal intercourse and substance use before and after HIV diagnosis among recently HIV-infected men who have sex with men.

OBJECTIVE: The objective of this study was to assess associations between unprotected anal intercourse (UAI) and substance use before and after HIV diagnosis among recently HIV-infected MSM. STUDY DESIGN: Two hundred seven MSM completed computer-assisted self-interviews regarding type and timing of sexual activity and substance use with their last 3 partners. Date of HIV diagnosis was extracted from medical records. Generalized estimating equations, including interaction terms, were used to assess associations between substance use and UAI before and after HIV diagnosis. RESULTS: Among partners with whom sexual activity occurred before diagnosis, UAI was associated with methamphetamine use alone (odds ratio = 7.12) and a combination of methamphetamine and other substances (odds ratio = 4.06). However, after HIV diagnosis, UAI was associated with use of substances other than methamphetamine (odds ratio = 3.36), but not methamphetamine alone. CONCLUSIONS: Use of illicit substances may be differentially associated with UAI based on knowledge of HIV status and could have implications for prevention of HIV transmission.

Adolescent↗
PubMedDate not supplied

Investigation of the hormonal axis hypothalamus-pituitary-gonads in 20 dialyzed men. GnRH-test in dialyzed men.

20 male patients suffering from end-stage chronic renal failure and maintained on hemodialysis were investigated for pituitary response to GnRH. The GnRH-Test was performed simultaneously with hemodialysis; however, hemodialysis was started 60 min. after the injection of GnRH. Basal values of LH and FSH were significantly higher (P less than 0.0001 and 0.005, respectively) than the normal range, while basal values of testosterone were in the subnormal range or depressed (P less than 0.0001). Poststimulatory values of LH were significantly lower (P less than 0.01) than normal and--other than normal--did not decline within 180 min. following injection of GnRH (P less than 0.001). The same pattern was seen for FSH, however, no statistical significance could be secured. Testosteron was elevated 30 min. after stimulation with GnRH (P less than 0.001).

Adolescent↗
PubMed1995

Autonomic reactivity and alcohol-induced dampening in men at risk for alcoholism and men at risk for hypertension.

Both sons of male alcoholics with multigenerational family history of male alcoholism (MFH) and sons of essential hypertensives (HTs) exhibit elevated psychophysiological reactivity to stress when compared with male controls (FH-). MFHs also demonstrate a significant baseline heart rate increase and stress-response dampening following alcohol consumption. The present study investigates the specificity of this alcohol-induced psychophysiological response pattern by testing these two risk groups in a shock response paradigm, both sober and alcohol-intoxicated. A repeated measures analysis of variance on sober and alcohol-intoxicated heart rate reactivity yielded a significant risk by alcohol interaction, indicating that alcohol consumption led to a greater decrease in reactivity in the MFH group compared with the HT and FH- groups. Similar results were obtained for muscle tension measures. MFHs also displayed greater increases in resting baseline heart rate and muscle tension when alcohol intoxicated. The results may reflect a sensitivity to negatively and positively reinforcing effects of alcohol specific to individuals with multigenerational familial histories of alcoholism.

Adult↗