Genetic polymorphisms in four isolated communities in Kinki district.
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Blood donors from the Centre Régional de Transfusion Sanguine de Rennes were investigated for the phenotypic distribution of seven enzymatic systems : adenylate kinase, adenosine deaminase, esterase D, 6-phosphogluconate dehydrogenase, glutamate-pyruvate transaminase, phosphoglucomutase, and glyoxalase I. Two unusual phenotypes were observed: phenotype 6-1 for adenosine deaminase and phenotype 3-1 for transaminase GPT. For five of these enzymes, the statistical analysis points out significant differences in one or several of the European populations described in the literature.
Cytidine deaminase in human white blood cells has three electrophoretic phenotypes representing the homozygous and heterozygous expression of two common alleles, CDA1 and CDA2, at an autosomal locus. To explain the multibanded pattern of the heterozygote, the enzyme is assumed to have a tetrameric structure.
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The experiments were carried out on White Leghorn, White Rock and Cornish chickens during the 1974--1975 season. The aim of the investigation was to study polymorphism of blood esterases in chickens in relation to their resistance to Salmonella pullorum and S. gallinarum. The data obtained indicate the following: 1) an additional, inheritant alyesterase fraction (A1) Appears in blood serum of resistant chickens after their contamination with Salmonella; 2) most chickens, which are resistant to Salmonella, have heterozygous genotype for blood serum cholinesterase.
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