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PubMed1983

[Andrologic anomalies in various gastrointestinal diseases].

In several gastroenterological diseases andrological anomalies have become known. From this point of view up to now the liver cirrhosis has been examined most frequently. In patients with cirrhosis apparently the two functions of the testicles are disturbed. On the one hand, a decreased or missing fertility is to be assumed, on the other hand, a cirrhosis does not always exclude the procreative capacity. The hormone analyses plead for the fact that the hypogonadism might rather be conditioned testicularly, in which case the direct toxicity of alcohol may be of importance. In haemochromatosis the hypogonadism develops by a combined mechanism. The cystic fibrosis of the pancreas is practically always associated with a male infertility. In Crohn's disease a disturbance of the spermatogenesis is observed. Even the salazo-sulphapyridine therapy is accompanied by unfavourable influences on the spermiogramme. Cimetidine used in the ulcer therapy shows a certain antiandrogenic effect and after a longer time may evoke impotence and other undesirable andrological side-effects which we, however, did not realize in 4 weeks treatment periods.

Cimetidine↗
PubMed2003

Serum IgE and IgG responses to food antigens in normal and atopic dogs, and dogs with gastrointestinal disease.

In human food allergy, with or without concurrent atopy, there may be significant increases in serum allergen-specific IgE. Serological methods have been tried but are not currently recommended for diagnosis of suspected food allergy in dogs. The aim of this study was to investigate humoral immune responses to food antigens in dogs. Serum IgG and IgE antibodies specific for food antigens were measured by enzyme linked immunosorbent assay (ELISA) using polyclonal anti-dog IgG and IgE reagents. Antigens tested were beef, chicken, pork, lamb, chicken, turkey, white fish, whole egg, wheat, soybean, barley, rice, maize corn, potato, yeast and cow's milk. Three groups were examined: normal dogs, dogs with atopic dermatitis (AD); and dogs with one of four types of gastrointestinal (GI) disease: small intestinal bacterial overgrowth (SIBO), inflammatory bowel disease (IBD), food-responsive disease, and infectious diarrhoea. Statistically significant differences in food-specific antibodies were not detected between the GI subgroups. There were statistically significant differences in the IgE concentration between the normal dogs, and dogs with atopic or GI disease, for all of the antigens tested. There were statistically significant differences in the average IgG concentrations between the normal dogs, and dogs with atopic or GI disease, for all of the antigens tested, except egg and yeast. The relationship of antigen responses for pooled data was analysed using principle component analysis and cluster plots. Some clustering of variables was apparent for both IgE and IgG. For example, all dogs (normal and diseased) made a similar IgG antibody response to chicken and turkey. Compared with other groups, atopic dogs had more food allergen-specific IgE and this would be consistent with a Th(2) humoral response to food antigens. Dogs with GI disease had more food allergen-specific IgG compared with the other groups. This may reflect increased antigen exposure due to increased mucosal permeability which is a recognised feature of canine intestinal disease.

Animals↗
PubMed1986

Dietary and supplementary intake of nutrients by patients with gastrointestinal diseases.

The dietary and supplementary intake of food, energy, and nutrients were examined in 54 patients after various gastrointestinal operations and in 33 patients with gastritis, peptic ulcer, or undefined abdominal pain. Forty-six of the operated and 21 of the nonoperated patients had to avoid certain foods (p less than 0.001, chi 2-test), mainly milk, beans, cabbage and other vegetables, bread, and fried foods. Only a few patients got discomfort from coffee, fatty foods, and meat. The intake of energy was at the level of light physical work. The dietary intake of iron, vitamin A, and niacin did not reach the level of the recommended daily allowance (RDA). One-half of the patients used vitamins and supplements, which increased their intake over the level of RDA. It is important to inform patients before operations about the possibility of persistent abdominal symptoms after the operation.

Abdomen↗
PubMed2002

Gastrointestinal disease and the kidney.

Renal disease at any stage, from insufficiency to end-stage renal disease requiring dialysis or following renal transplantation, is often accompanied by significant gastrointestinal (GI) symptoms. Conversely, patients with GI disease may present with significant renal complications. Patients with end-stage renal disease, patients undergoing dialysis, and recipients of renal grafts are at increased risk for GI complications, including erosive disease and GI bleeding. Selection of pharmacotherapy for GI conditions in patients with concomitant renal disease is complicated by three factors: (1) the potential for a significant negative impact on renal function, which is already compromised; (2) the requirement for dosing alteration in renal insufficiency; and (3) the potential for drug-drug interactions with concomitant medications. Proton pump inhibitors appear to be the most suitable acid-suppressing therapy for patients with renal disease; recently developed drugs in this class (e.g. rabeprazole) may be the best choice for treatment of patients with both acid-related GI conditions and renal disease.

Gastrointestinal Diseases↗
PubMed1978

Drug-induced gastrointestinal disease.

Clinicians administering potent therapeutic agents must be aware of their side-effects. The gut is an important site of adverse drug reactions and drug-induced disease must always be considered in the differential diagnosis of patients presenting with gastrointestinal symptoms. A careful drug history must therefore be taken in all such patients. Symptoms can often be related to drug ingestion, but late effects also occur. The presence of blood in vomitus or stool is pathognomonic of serious pathology which may be drug-induced and requires further investigation. Upper gastrointestinal haemorrhage and pseudomembranous colitis are potentially fatal manifestations of drug therapy. Gastrointestinal symptoms can often be avoided if therapy is taken with meals or in a smaller dose, but drug withdrawal is always the first line of management in patients whose symptoms may be drug-induced.

Adrenal Cortex Hormones↗