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Results for “FLUORIDE POISONING”

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At least 919 records · Page 51Linked to original sources
PubMed1980

Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis?

A case of skeletal fluorosis induced by prolonged treatment with niflumic acid, a fast-acting non-steroid antiinflammatory agent, is reported in a 35-year-old woman suffering from rheumatoid arthritis and treated, in addition, with corticosteroids. The case report discussed is, to our knowledge, the third of its kind regarding bone fluorosis resulting from use of this nicotinic derivative. This clinically asymptomatic case of skeletal fluorosis was discovered, as in the 2 previously reported cases, by the examination of bone X-ray (performed as part of the routine work-up for rheumatoid arthritis) which showed evident osteosclerosis. Quantitative histologic study of iliac crest biopsy revealed marked increase in trabecular bone volume and osteoid volume, suggestive of fluorosis. Abnormally high urine and bone fluoride confirmed the diagnosis. After ruling out a hydrotelluric source of fluorine, the patient's fluorosis was linked to chronic use of niflumic acid, following the publication in 1978 of the 2 previously reported cases affected by this drug. The fluorine contained in niflumic acid induced a marked densification of trabecular bone in all 3 cases. Long-term clinical and pharmacokinetic studies will be required to determine whether or not niflumic acid can be employed in the prevention or treatment of both of apparently idiopathic osteoporosis or corticosteroid-induced osteoporosis.

Adult↗
PubMed1978

[Bone fluorosis].

It is reported on a 80-year-old man with a pronounced bone fluorosis which was ascertained by X-ray findngs, dissection, and determination of the fluor content of the bones. Since there was no professional flour exposition a so-called neighbourhood fluorosis was to be assumed. It was caused by an already naturally increased fluor content of drinking water, which was essentially increased by the sewage of a fluor plant. In addition to this an increased fluor emission was present, since the patient has lived for more than 30 years in the nearest environment of the plant. By suitable measures the prescribed values of the fluor content of drinking water and of the fluor emission have to be kept.

Aged↗
PubMed1980

[Evaluation of the mineral content of peripheral bones (radius) by photon-absorption technique in normals as well as in patients with various types of bone diseases (author's transl)].

The evaluation of the mineral content of peripheral bones by measuring the photon absorption of the radius has proven to be a valuable method for routine clinical work: for diagnosis, follow-up and control of therapy. While there was a significant difference in the findings of normal persons compared with those of patients suffering from osteoporosis, renal osteodystrophy, osteogenesis imperfecta and skeletal fluorosis, there was no difference between normals and these patients suffering from Bechterew, Scheuermann, coxarthrosis, spondylosis, skoliosis and rheumatoid arthritis. Normal values for the mineral content and width or the radius at the junction of the middle and lower third--based on 8000 examinations--are mentioned.

Adolescent↗
PubMed1978

[Bone fluorosis without occupational exposure in chronic renal insufficiency].

Report on a 70-year-old male with bone fluorosis which was ascertained radiologically, by section and fluor analysis in the bone ash. With empty professional anamnesis as cause was found the presence of a chronic renal insufficiency with simultaneously increased fluor content of drinking water. The decreased renal excretion of fluoride might have led to the pathological development in the bones. It is referred to the significance of extra-medical fluor load and the knowledge of the renal function when halogen is therapeutically used.

Aged↗
PubMed1994

[Effect of excessive fluoride intake on mental work capacity of children and a preliminary study of its mechanism].

We made an investigation in 157 children, aged 12-13, born and grew up in a coal burning pattern endemic fluorosis area and an experiment on excessive fluoride intake in rat. The results showed: (1) Excessive fluoride intake since early childhood would reduce mental work capacity (MWC) and hair zinc content: (2) The effect on zinc metabolism was a mechanism of influence on MWC by excessive fluoride intake; (3) Excessive fluoride intake decreased 5-hydroxy indole acetic acid and increased norepinephrine in rat brain; whether this is also a mechanism of the influence on MWC awaits confirmation.

Adolescent↗
PubMed1978

[Risk of absorption of fluoride in electrode arc welding].

The AA. in order to investigate the risk of fluoride absorption examined two factories in which arc-welding electrodes were used. They measured: a) fluoride content in two most used electrodes; b) airborne fluoride concentrations and dustness in the presumed respiratory area of welders with or without fume and dust capture devices; d) airborne fluoride concentrations and dustness three meters away from the welding place during unprotected work with basic electrodes; e) concentrations of fluoride in urine during a workweek in welders (n = 63) and in a control group (n. = 25). The AA. conclude that, in spite of the high teoretical risk of breathing fluoride, the intake of this compound is very low if welders are protected by easy devices.

Air Pollutants↗
PubMed1995

[The interrelationship of the thyroid and immune statuses of workers with long-term fluorine exposure].

Thyroid and immune statuses were studied in workers continuously exposed to fluorine. The examinees with euthyroid condition had immune disorders with an allergic tendency (increased number of B-lymphocytes, immunoglobulins A). In workers with subclinical hypothyrosis (tri-iodothyronine reduced in 51%), the immune alterations were more evident, T-lymphocytes count rose, but their functional activity declined, indicating impaired cooperation of immunocytes as a result of imperfect control under low concentrations of tri-iodothyronine.

Adult↗
PubMed1994

[Epidemiology of bone fluorosis of hydrotelluric origin].

Although endemic fluorosis occurs in many countries, epidemiological studies have been limited by funding problems, a lack of awareness of the public health impact of the disease, and the absence of inexpensive defluoridation methods. The effects of fluorides on human bone are reviewed and the methodological problems raised by epidemiological studies of endemic skeletal fluorosis are discussed.

Bone Diseases↗
PubMed1995

[Rare causes of ossification of the posterior common vertebral ligament causing cervical compression. Apropos of 2 cases].

The ossification of the posterior longitudinal is always responsible of cervical myelopathy. Radiological study and the CT scan, are able to precise the level, the morphologic and associated abnormalities of this lesion. Two cases of ossification of the posterior longitudinal ligamentum with cervical myelopathy are reported. The radiologic studies determined the etiology, in the first case, it was fluorosis and the second DISH disease.

Aged↗
PubMed1994

[Effects of pollution with fluoride on bone dynamics of periosteum in iliac of domestic pigs].

Studies on bone dynamic parameters of iliac periosteum and endosteum in domestic pigs with fluorosis caused by coal-burning contamination were conducted. Bone dynamics of 12 pigs with experimental fluorosis and nine controls both labelled with double tetracycline was investigated. Results showed the distance between two labels on iliac periosteum of domestic pigs with fluorosis shortened and, rates of mineralization and bone matrix formation slowed. It suggested fluorosis played significantly inhibitory roles in bone formation on the periosteal membrane of pig iliac.

Air Pollution↗