Ossifying fibroma of the sella turcica.
Ossifying fibroma of the sellar turcica is extremely rare. There are only sporadic case reports in the literature. One such case simulating pituitary adenoma is presented in an 18-year-old girl.
Adenoma↗
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Establishment of human fibroma cell lines from a MEN1 patient by introduction of either hTERT or SV40 early region.
Establishment of tumor cell lines as model systems for studying tumor biology or as a part of immunotherapeutic anti-cancer strategies is of high importance, whereby the highest possible preservation of the original tumor cell phenotype is a prerequisite for these aims. Since overexpression of the catalytic subunit of human telomerase (hTERT) is known to minimally alter the cellular phenotype, we focused on the establishment of cell lines derived from human fibroma from a MEN1 patient by ectopic expression of hTERT. Additionally, a cell line was generated by introduction of the early region of SV40 (SV40 ER). Both approaches resulted in continuous cell lines, and neither T1-LOHG (hTERT) nor SV1-LOHG (SV40 ER) showed a transformed phenotype. While SV40 ER-transfected cells underwent dramatic changes in morphology and growth characteristics, hTERT-expressing cells indeed retained a phenotype highly similar to the parental cells. Nevertheless, hTERT overexpression resulted in increased growth rates after about 70 population doublings (PD) and alterations of mRNA levels of genes associated with tumor pathogenesis. Thus, our data suggest that ectopic hTERT expression leads to immortalization of LOHG-F, sustaining many characteristics of the non-transfected counterparts, but continuous growth in vitro is associated with changes of the cellular phenotype.
Antigens, Polyomavirus Transforming↗
Fibroma of the lacrimal sac.
A case of fibroma arising from the anterolateral wall of a healthy lacrimal sac on the left side in a 22-year-old male is reported. There was no epiphora. The tumor presented as a painless, nonreducible swelling in the lacrimal sac region. It was excised off leaving a patent sac. The diagnosis could be established only on histopathologic examination. Postoperative recovery was uneventful and there was no postoperative epiphora.
Adult↗
Oral fibroma in a captive python.
A massive growth in the lower jaw of an Indian python (Python molurus) was diagnosed from biopsy samples as a fibroma. Moderately satisfactory treatment was achieved by surgical excision.
Animals↗
[Non-osteogenic fibroma of bone (author's transl)].
The non-osteogenic fibroma of bone is comparatively rare, with its tumour character being indeterminate. It is always benign, has a characteristic X-ray and allows a reliable diagnosis to be made in almost all case. Surgical treatment is only exceptionally necessary because of the tendency for spontaneous healing.
Adolescent↗
[Pleural fibromas: a review based on 12 cases].
The authors report 12 cases of pleural fibroma, which is a rare benign tumor, usually discovered incidentally. However, these tumors are sometimes associated with a paraneoplastic syndrome, or may lead to compressive symptoms related to their large size. Radical resection is mandatory because recurrence may occur, sometimes several years later with a malignant behavior. Long-term follow-up is therefore necessary to detect any recurrence, particularly when certain prognostic factors are initially present.
Adult↗
[Psammomatoid ossifying fibroma. Apropos a case].
A 41-year-old woman had a left palatal tumor diagnosed as psammomatoid ossifying fibroma. This tumor is a rare subtype of benign fibro-osseous craniofacial lesion that occurs mainly in women, younger age groups, and the sinonasal tract. It has distinctive histomorphological features. The tumor is slow-growing but tends to be locally aggressive and to destroy adjacent anatomic structures. Surgical excision with broad margins is the treatment of choice.
Adult↗
Non-ossifying fibromas and giant cell reparative granulomas in a child with ocular-ectodermal syndrome.
We report on a patient with ocular-ectodermal syndrome who was previously described in 1993 [Am J Med Genet (1993) 45:764-766]. This boy has now developed additional manifestations, including giant cell granulomas and non-ossifying fibromas. This adds to the list of phenotypic manifestations of this condition.
Child, Preschool↗
Cemento-ossifying fibroma presenting as a mass of the parapharyngeal and masticator space.
We report a case of cemento-ossifying fibroma that presented as a large extraosseous mass in the masticator and parapharyngeal space. CT scanning and MR imaging showed a large extraosseous mass with central conglomerated, well-matured ossified nodules and fatty marrow. The central matured ossified nodules were of low density on CT scans and high signal intensity on T1- and T2-weighted MR images. Multiplanar reformatted CT scans revealed the origin of the mass to be at the extraction site of the right lower second molar tooth.
Diagnosis, Differential↗
Perifollicular fibroma.
Perifollicular fibroma(PFF) is a rare cutaneous hamartoma that shows differentiation in the connective tissue sheath of the hair follicle. It may be single (congenital or acquired) or multiple (late onset). We report a 14-year-old Korean boy with a congenital solitary PFF on the face, which supports the nevoid concept of origin rather than a reactive response to injury.
Adolescent↗
The natural course of an ossifying fibroma. A case report.
A patient with an ossifying fibroma in the mandible is presented, with a follow-up period of 38 years. The pathological findings and recommendations for therapy are discussed.
Adult↗
Peripheral fibroma with calcification--a case report.
A female patient aged 10 years reported with an intra oral swelling on the labial aspect of 32 & 33, appearing to originate from the marginal gingiva & interdental papilla. The swelling was pedunculated, mobile, non-tender, firm in consistency with an irregular surface. The colour of the gingiva was normal with slight ulceration. The swelling was excised & diagnosed histopathologically as peripheral cementifying/ossifying fibroma.
Child↗
Benign ovarian fibroma associated with free peritoneal fluid and elevated serum CA 125 levels.
This paper reports the clinical case of a patient with ovarian neoplasia, ascites effusion, and elevated serum CA 125 levels (411 U/ml). This condition simulated a malignant pathology on the grounds of preoperative diagnostic examinations. Surgical investigation diagnosed an ovarian fibroma and ascites. Ascites was resolved rapidly and the serum CA 125 levels decreased after surgical neoplasia removal. An ovarian neoplasia associated with ascites effusion and elevated serum CA 125 levels (also in the presence of suspect ecographic and tomographic features) do not necessarily imply a malignant neoplasia.
Ascites↗
MR findings of desmoplastic fibroma of the spine. A case report.
We report on the MR imaging findings in a case of spinal desmoplastic fibroma (DF). DF of the bone is a rare, locally aggressive tumor. It is commonly located in long bones, pelvis or mandible. DF involving the spine is extremely rare and difficult to distinguish from other bony lesions such as giant cell tumor, chordoma and fibrous dysplasia of the spine. This case of DF of the spine showed MR findings similar to those of DF arising in the metaphysis of a long bone.
Adult↗
Desmoplastic fibroma of the mandible in a 3-year-old child.
A 3-year-old white girl was seen because of an enlarging mass in the left side of the mandible. The mass was 10 cm in diameter and the entire left hemimandible was involved. Examination of tissue after incisional biopsy showed desmoplastic fibroma. Surgical removal of the tumor required a hemimandibulectomy. The mandible was replaced immediately with a stainless steel mesh prosthesis with an acrylic condyle. A year later, there was no evidence of recurrence. Though the mesh became exposed in one area, we believe that esthetics and function were best served by its use.
Child, Preschool↗
Sudden unexpected infant death due to fibroma of the heart.
A 7-month-old previously healthy female infant was found dead in her crib by her mother shortly after having been laid down to sleep following the noontime feeding. Because the child did not suffer from an acute illness and no other evidence pointed to a cause of death, it was initially assumed by the police that she had died of sudden infant death syndrome. At autopsy, however, the cause of death was determined to be cardiac arrhythmia secondary to fibroma of the heart.
Cause of Death↗
Immunocytochemical study of giant cell fibroma.
Giant cell fibroma (GCF) is a non-neoplastic lesion of the oral mucosa. The origin of stellate and multinucleate cells of GCF is not well known. The purpose of the present article was to investigate the immunoreactivity of these cells for leukocyte common antigen, vimentin, tryptase, HLA-DR, alpha-smooth muscle actin, CD68, and S-100. The results showed positive staining only for vimentin. This suggests that the stellate and multinucleate cells of GCF have a fibroblast phenotype.
Actins↗
Atypical peripheral ossifying fibroma. A case report.
The typical peripheral ossifying fibroma (POF) usually occurs on the free margin of the gingiva. POF is also thought to arise from the periodontal ligament. The case presented here is unique by virtue of its etiology, size and location.
Adult↗