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At least 919 records · Page 51Linked to original sources
PubMed1998

1898: the Golgi apparatus emerges from nerve cells.

A century ago, Camillo Golgi discovered in neurons an intracellular network of anastomosing threads, impregnated by the chromoargentic reaction he had devised to stain the nervous tissue. This structure, designated by Golgi as 'internal reticular apparatus', was soon detected in a wide variety of eukaryotic cells. However, skepticism arose on the existence of the Golgi apparatus in the first decades of this century, when it was fiercely debated whether this structure represented a genuine new cell constituent or an artifact due to the deposit of metallic impregnation on diverse cytoplasmic structures. The reality of the Golgi apparatus became established unequivocally only with the application of electron microscopy; with the visualization of its fine structure, the apparatus finally achieved the status of cytoplasmic organelle, and thus, linked with Golgi's name, entered the modern era of investigation on its components, chemistry and function.

Animals↗
PubMed1984

Sister Mary Joseph's nodule: a clinical and histologic study.

The clinical and histologic findings in eighty-five cases of tumors metastatic to the umbilicus were studied. Clinically, the lesions were seen as firm, indurated nodules, sometimes with fissuring or ulceration. In twelve cases, the initial presentation of the internal primary malignancy was an umbilical nodule. Histologic material from the metastatic umbilical tumor was studied in all cases but was diagnostic of the primary carcinoma in only twenty-one. In seventeen cases, the primary site was never reliably determined, while stomach, large bowel, ovary, and pancreas were the most frequent primary sites in the other cases. Most patients died within months after the appearance of the umbilical tumors, thus emphasizing the ominous significance of this sign of metastatic, usually intra-abdominal, malignant disease.

Adenocarcinoma↗
PubMed2004

[The defense and illustration of proper nouns in cardiology].

THE PROS AND CONS: The fact that proper nouns are used in medicine is regularly criticised (notably because of the lack of scientific rigour). However, such use in cardiology remains an active tradition for three, historical, precision and linguistic, reasons. SIGNIFICATION: In general, the proper nouns pay a tribute to a famous physician. They reflect the scientific support to Cardiology provided by each country. THE OUTCOME OF PROPER NOUNS: Some proper nouns become inescapable and classic, others become outmoded whilst new ones regularly appear. A proper noun can become forgotten with the regression of a disease, a decline in clinical semiology or in that of a technique.

Cardiology↗
PubMed2001

Wilhelm Ebstein and Ebstein's malformation.

In 1866, Wilhelm Ebstein published a scholarly description of a tricuspid valve anomaly with dilation of the right atrium and patent foramen ovale that bears his name. However, his original report was almost overlooked. Despite a wide range of publications on the history of cardiac pathology and cardiac surgery, the international literature provides only scarce information regarding the personality of Wilhelm Ebstein and his original description of the anomaly that bears his name. In this article, we present biographical data of Wilhelm Ebstein and discuss how his original description of autopsy findings correlates with our current knowledge of this congenital disorder. It is the excellent correlation of Ebstein's pathologic findings with clinical notes of his colleague and Ebstein's hypotheses of the pathophysiology that made his publication a landmark in the description of a new entity. In addition, Ebstein's report provided a strong basis for the development of repair techniques for this rare anomaly 100 years later.

Ebstein Anomaly↗