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At least 919 records · Page 51Linked to original sources
PubMed1990

Highly selective vagotomy in the treatment of peptic ulcer diathesis.

The results of highly selective vagotomy in 174 Indian patients have been analysed. Compared to other procedures on the stomach, HSV has a definite advantage both on long term as well as on short term basis. HSV has therefore become the procedure of choice in the treatment of duodenal ulcer disease provided the expertise is available locally. HSV has also been used now in the treatment of ulcer complications and benign gastric ulcer disease.

Duodenal Ulcer↗
PubMed1990

[Meteorologic effects on hemorrhagic diathesis in hemophilia. 1. Demonstrating weather effects based on a complex weather phase scheme].

In haemophilia frequently spontaneous haemorrhages occur without recognition of an evoking cause. Various bleeding-disposing factors are discussed, among others also influences of weather. For the investigation of the meteorotropic relations 1,802 episodes of haemorrhages in 223 haemophiliacs were coordinated to a complex scheme of weather phases. An undisturbed course of the weather was in general connected with a decrease of bleeding, whereas in an influence of low pressure with advection of cold air an increase of the haemorrhages was established. Conspicuous was furthermore the negative biotropism of the radiation-intensive sunny fine weather in summer, which is probably to be traced back to the thermic load in this weather situation.

Atmospheric Pressure↗
PubMed1990

[Meteorologic effects on hemorrhagic diathesis in hemophilia. 2. Weather effects on hemophilia with special reference to the atmospheric temperature-humidity complex].

The meteotropism of haemophilic haemorrhages was investigated for 1,802 episodes of bleeding in 223 patients with the help of selected parameters of the atmospheric temperature-humidity complex and the air pressure. The accumulation of haemorrhages under the influence of tropic air masses was particularly conspicuous. In low blood pressure the frequency of bleeding also increased, whereas high-pressure conditions showed a decrease of bleeding. The study clearly confirms that the haemorrhagic tendency in haemophilia is influenced by weather. Therefore a medico-meteorologic forecast should be taken into consideration for haemophiliacs.

Atmospheric Pressure↗
PubMed1990

The effect of combined factor XI deficiency with von Willebrand factor abnormalities on haemorrhagic diathesis.

To account for the lack of correlation between the level of factor XI (FXI) in deficient patients and haemorrhagic manifestations, we correlated the prevalence of combined FXI and von Willebrand's factor (vWF) deficiency in 212 FXI-deficient patients. Fifty-four patients had a combined FXI and vWF deficiency: 16 patients had severe and 38 patients had mild FXI deficiency. In a group of 28 patients with comparably mild FXI deficiency, 14 bleeders had significantly lower mean vWF, Ag, ristocetin cofactor and ristocetin induced platelet aggregation than 14 non-bleeders selected on the basis of comparable FXI levels. These findings suggest that the combination of FXI and vWF deficiency is common and may affect the bleeding tendency in mild FXI deficiency.

Adolescent↗
PubMedDate not supplied

[Contact urticaria with transition to protein contact dermatitis in a cook with atopic diathesis].

Protein contact dermatitis is a rare disease within the group of occupational dermatoses. However, it is of some importance to people in food handling occupations. Skin symptoms usually manifest as immediate-type reactions (type-I-reaction according to Coombs and Gell), but changes to type IV-reactions are known. This applies especially to people with atopic eczema who have contact to fish proteins. This can be derived from a case presented here and a few similar observations described in the literature.

Animals↗
PubMedDate not supplied

Gilles de La Tourette's syndrome and some forms of obsessive-compulsive disorder may share a common genetic diathesis.

Family aggregation and twin studies suggest that Gilles de La Tourette's syndrome (TS) and some forms of obsessive-compulsive disorder (OCD) are etiologically related. Neuroanatomically, the structures of the basal ganglia, thalamus and cortex have also been implicated in both TS and OCD suggesting a common neural substrate for these disorders. Neurochemical and neuropharmacological studies have provided less compelling data concerning this heuristically important association. Clinical studies have largely focused on the role of the nigrostriatal, mesolimbic and mesocortical dopaminergic systems in the pathophysiology of TS. In the case of OCD, serotoninergic systems originating in the raphe nuclei and projecting rostrally, have received considerable attention. Recent neuropathological studies of TS have implicated the endogenous opioid peptide, dynorphin, in the pathophysiology of TS. Animal studies have shown that dynorphin can modulate both dopaminergic and serotonergic systems. We have undertaken a cerebrospinal fluid (CSF) study to determine if abnormalities in dynorphin A concentration can be observed in drug-free TS and OCD patients. Preliminary results from this study suggest: 1) that TS patients have an elevated level of CSF dynorphin A (1-8) compared to normal controls; 2) that their level of CSF dynorphin is correlated with the severity of their OCD symptoms; 3) that some, but not all, OCD patients also have high levels of this neuropeptide in their CSF.

Chromosome Mapping↗
PubMed1990

[A case of neoplastic diathesis].

A female patient is described who during 7 years had three operations for neoplasms situated in various sites and exhibiting different histological structure. Seven years ago malignant melanoma was excised from her left thigh, three years later hysterectomy was done for carcinoma, 18 months later an epithelioid carcinoma was removed from the retroperitoneal space.

Carcinoma↗
PubMed1989

Malignant diathesis from jejunal-ileal carcinoids.

A facet of carcinoid tumors often not recognized is their close association with other, noncarcinoid malignancies. The clinical course of two patients with multiple ileal-jejunal carcinoids and multiple other noncarcinoid malignancies is described. These patients were found to have elevated circulating levels of gastrin, bombesin, glucagon, enteroglucagon, pancreatic polypeptide, and peptide tyrosine tyrosine. These regulatory peptides have been demonstrated to promote trophic effects on the gastrointestinal tract as well as malignant tumors. We propose that the release of these bioactive hormones into the portal and systemic circulation by carcinoid tumors may play some role in their association with these multiple second tumors.

Adolescent↗
PubMed1989

[Medical hemostasis. I. the treatment of hemorrhages and hemorrhagic diathesis in veterinary practice].

Bleeding patients are regularly encountered, often as an emergency, in veterinary practice. In many cases local causes will be responsible for the bleeding, but in some there will be a generalised haemostatic defect. The approach to the bleeding patient, suspected of a generalised haemostatic defect, requires a detailed history and careful physical examination in order to differentiate between hereditary and acquired haemostatic disorders and, in the case of an acquired haemostatic disorder, to detect which underlying disease caused the defect and which parts of the haemostatic system are involved. In the majority of cases, however, laboratory testing will be necessary to define the defect. As these tests are not readily available in most veterinary clinical situations, efforts are made to suggest a rational therapeutic approach to the bleeding patient, which is based on clinical diagnosis. Several locally applied substances may provide assistance in the control of persistent bleeding, when the mechanisms of blood coagulation are otherwise intact. When haemostatic defects are present, however, topical agents alone are of little or no value; replacement therapy with blood or preferentially blood products will be indicated. In addition to vitamin K1 (especially in cases of coumarin poisoning), blood (products) and agents for topical use, there are only very few agents having a well-defined effect on haemostasis, which are of proven clinical value. On the other hand, a rather large number of drugs are being propagated as haemostatics. This is the first of two papers on the treatment of haemorrhagic disorders in veterinary practice. Diagnosis, local treatment and replacement therapy with plasma or blood(products) are discussed. Drugs which are contra-indicated in bleeding patients, are also referred to. The second paper will critically evaluate the commercially available haemostatics.

Animals↗