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At least 919 records · Page 51Linked to original sources
PubMed2004

Emtricitabine: a once-daily nucleoside reverse transcriptase inhibitor.

OBJECTIVE: To review the pharmacology, virology, pharmacokinetics, safety, and efficacy of the nucleoside reverse transcriptase inhibitor (NRTI) emtricitabine. DATA SOURCES: English-language reports were accessed using MEDLINE (1966-June 2003) and the Iowa Drug Information Service database (1966-June 2003) using emtricitabine and Coviracil as key words. (Coviracil was the proposed trade name for the product prior to approval.) The Internet was also searched using the terms HIV/AIDS conferences, then emtricitabine within the conference proceedings. STUDY SELECTION AND DATA EXTRACTION: Abstracts, posters, and oral presentations from scientific conferences, both published and unpublished, were included. Preference was given to published controlled trials. Studies providing a description of the pharmacology, virology, effectiveness, safety, or pharmacokinetics of emtricitabine were used in this review. DATA SYNTHESIS: Emtricitabine is an NRTI used to treat HIV-1 infection. Once-daily administration can decrease pill burden and potentially increase adherence to multidrug HIV therapy. Further, emtricitabine has shown equivalent or improved outcomes compared with lamivudine and stavudine. CONCLUSIONS: Emtricitabine is a safe and effective option for HIV-1 infection in adults as part of a multidrug regimen. It may be a better alternative than lamivudine for once-daily therapy because of its extended intracellular half-life and better than lamivudine and stavudine because of a possibly decreased potential for drug resistance.

Clinical Trials as Topic↗
PubMed2006

Publication rate of Trauma abstracts presented at an International Orthopaedic conference.

INTRODUCTION: Oral presentations at major conferences are often used to present new material and generate discussion. However, conference abstracts that ultimately fail to be published are of little use to the wider medical community. The aim of this study was to evaluate the publication rate of trauma papers presented at an international orthopaedic conference, and to assess the factors which predict publication. METHODS: All abstracts presented orally at the trauma sessions of the European Federation of National Associations of Orthopaedics and Traumatology (EFORT) Congresses in 1999 (Belgium) and 2001 (Greece) were assessed. A MEDLINE and EMBASE search was performed to identify articles written by the first, second and last authors of each abstract to identify a matching journal article. Subspecialty, country of origin of abstract, study type, journal of publication and publication year were tabulated. RESULTS: Two hundred and seventy eight trauma abstracts were presented orally, and 112 (40.3%) achieved subsequent publication. Abstracts on fractures of the proximal femur were the most common (18.7%) and had one of the highest rates of publication (44.2%). Greece and the UK provided the largest number of abstracts, and randomised trials were the study type with the highest rate of publication (80.0%). Thirty two percent of journal articles appeared within 1 year of the conference and 63% within 2 years. Injury was the journal most likely to publish the articles. CONCLUSION: About 60% of Trauma abstracts presented did not result in a subsequent full-text publication. The citation of conference proceedings should be discouraged, and clinicians should be wary of implementing information gleaned from conference presentations into their clinical practice.

Bibliometrics↗
PubMed1999

Treatment of estrogen deficiency symptoms in women surviving breast cancer. Part 1: Defining the problem. Proceedings of a conference held at the Boar's Head Inn Charlottesville, Virginia. September 21-23, 1997.

There are several million breast cancer survivors worldwide. In the United States, 180,000 women were diagnosed with breast cancer in 1997, and approximately 97,000 of these women have an extremely low chance of suffering a recurrence of their cancer. With an average age at diagnosis of 60 years and a 25-year expected duration of survival, the current number of breast cancer survivors in the United States may approach 2.5 million women. Since breast cancer is now being detected at an earlier stage than previously and since adjuvant chemotherapy may cause ovarian failure, an increasing number of women are becoming postmenopausal at a younger age after breast cancer treatment. This conference was convened in September 1997 to consider how menopausal breast cancer survivors should be treated at the present time and what future studies are needed to develop improved therapeutic strategies. A total of 47 breast cancer experts and 13 patient advocates participated. The proceedings of the conference will be published in six installments in successive issues of ONCOLOGY. This first part defines the problem and explores its magnitude and ramifications for patient management.

Breast Neoplasms↗
PubMed1999

Treatment of estrogen deficiency symptoms in women surviving breast cancer. Part 5: Selective estrogen receptor modulators and hormone replacement therapy. Proceedings of a conference. Charlottesville, Virginia, USA. September 21-23, 1997.

There are several million breast cancer survivors worldwide. In the United States, 180,000 women were diagnosed with breast cancer in 1997, and approximately 97,000 of these women have an extremely low chance of suffering a recurrence of their cancer. With an average age at diagnosis of 60 years and a 25-year expected duration of survival, the current number of breast cancer survivors in the United States may approach 2.5 million women. Since breast cancer is now being detected at an earlier stage than previously and since adjuvant chemotherapy may cause ovarian failure, an increasing number of women are becoming postmenopausal at a younger age after breast cancer treatment. This conference was convened in September 1997 to consider how menopausal breast cancer survivors should be treated at the present time and what future studies are needed to develop improved therapeutic strategies. A total of 47 breast cancer experts and 13 patient advocates participated. The proceedings of the conference are being published in six installments in successive issues of ONCOLOGY. This fifth part examines the potential role of antiestrogens and selective estrogen receptor modulators (SERMs) in breast cancer patients being treated for estrogen deficiency symptoms.

Antineoplastic Agents↗
PubMed2001

Management of influenza in patients with asthma or chronic obstructive pulmonary disease.

OBJECTIVE: To review the prevention and treatment of influenza in patients with asthma and/or chronic obstructive pulmonary disease (COPD). DATA SOURCES: Computer-assisted MEDLINE searches for article and manual searches of conference proceedings on influenza, influenza vaccination, rimantadine, amantadine, oseltamivir, zanamivir, asthma, and/or COPD. STUDY SELECTION: Published articles and pertinent conference abstracts in the areas mentioned in Data sources were selected. Articles included for review were studies conducted on humans. RESULTS: Annual vaccination against influenza is the currently accepted practice for influenza management in patients with asthma and/or COPD. However, despite the availability and use of vaccination, influenza continues to cause serious morbidity and increased mortality. The management of influenza in at-risk patients with the older antivirals such as amantadine or rimantadine has not been widely accepted because of the rapid emergence of resistant variants, their lack of effect against influenza B, and poor adverse event profile. A new class of influenza antivirals, the neuraminidase inhibitors, has recently become available for the management of influenza. The currently marketed neuraminidase inhibitors are zanamivir and oseltamivir. Clinical studies have shown that these neuraminidase inhibitors are effective for the treatment and chemoprophylaxis of influenza A and B. CONCLUSIONS: Vaccination against influenza remains the gold standard for the prevention of influenza in patients with asthma and/or COPD. The neuraminidase inhibitors zanamivir and oseltamivir are useful adjuncts to influenza vaccines for the management of influenza in these patients who are at high-risk of developing influenza related complications.

Antiviral Agents↗
PubMed1979

Problems and perspectives in perinatal carcinogenesis: a summary of the conference.

The proceedings of the Conference are summarized in the context of current understanding of perinatal susceptibility to carcinogenic agents. The consequences of exposure to either metabolism-dependent or direct-acting chemical carcinogens during fetal or neonatal life are quantitatively different from the effects of comparable doses of the same agents in adults. The nature of these differences and their relevance both for preventive medicine and for application to bioassay procedures for detection of suspected carcinogens are discussed for conventional (chemically reactive) carcinogenic compounds and for hormones. The degree of tissue differentiation at the time of exposure to a carcinogen and the genetics of the subject have been shown to affect susceptibility to induction of embryonal and differentiated types of tumors and by both chemical agents (including hormones) and viruses. The desirability of conducting parallel studies in two or more species when investigating mechanisms of perinatal/adult differences in susceptibility to carcinogens is emphasized.

Animals↗
PubMed1994

Medical informatics conference papers: a content analysis of research in a new discipline.

One of the hallmarks of a mature discipline is a varied and robust body of literature describing the research activities of the discipline. Medical informatics has rapidly become an accepted scientific discipline, having emerged from two long established disciplines (medical and computer science). This study looks at one form of scientific communication as a descriptive indicator of the maturity of medical informatics as a discipline. Conference proceedings were selected because they represent one of the first means of communication within a discipline in a semiformal format. Findings confirm that conference papers report research, development, and application projects across a wide range of topics; identify a possible trend toward increased funding; and show widespread use of empirical and quantitative research and analytical techniques. Deficiencies in the conference papers are also discussed.

Congresses as Topic↗
PubMed2003

Full publication of trials initially reported as abstracts in the Australian and New Zealand Journal of Medicine 1980-2000.

Abstract Failure to identify all relevant reports of controlled trials is a potential source of bias in systematic reviews of health-care interventions. The present study aims to identify how many reports of trials -initially published as conference abstracts in the Australian and New Zealand Journal of Medicine were subsequently published in full. We identified trial reports by handsearching conference abstracts published in the Journal from 1980 to 2000. We then searched the Cochrane Controlled Trials Register and PubMed to determine how many of these had been subsequently published in full. A total of 962 reports of controlled trials was identified from the conference proceedings of 17 medical societies. Of these, 589 (61%) reports of trials were subsequently published in full, and on average within 1-2 years. Handsearching conference abstracts identified a large number of reports of controlled trials, over one-third of which were unpublished and therefore not easily accessible.

Abstracting and Indexing↗
PubMed2004

Physical fitness training for stroke patients.

BACKGROUND: Stroke patients have impaired physical fitness and this may exacerbate their disability. It is not known whether improving physical fitness after stroke reduces disability. OBJECTIVES: The primary aims of the review were to establish whether physical fitness training reduces death, dependence and disability after stroke. The secondary aims of the review included an investigation of the effects of fitness training on secondary outcome measures (including, physical fitness, mobility, physical function, health and quality of life, mood and the incidence of adverse events). SEARCH STRATEGY: We searched the Cochrane Stroke Group Trials Register (June 2003). In addition, the following electronic databases were searched: Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, 2002 Issue 4), MEDLINE (1966 to December 2002), EMBASE (1980 to December 2002), CINAHL (1982 to December 2002), SPORTDiscus (1949 to December 2002), Science Citation Index Expanded (1981 to December 2002), Web of Science Proceedings (1982 to December 2002), Physiotherapy Evidence Database (December 2002), REHABDATA (1956 to December 2002) and Index to UK Theses (1970 to December 2002). We hand searched relevant journals and conference proceedings and screened reference lists. To identify unpublished and ongoing trials we searched trials directories and contacted experts in the field. SELECTION CRITERIA: Randomised controlled trials were included when an intervention represented a clear attempt to improve either muscle strength and/or cardiorespiratory fitness, and whose control groups comprised either usual care or a non-exercise intervention. DATA COLLECTION AND ANALYSIS: Data from eligible studies were independently extracted by two reviewers. The primary outcome measures were death, disability and dependence. The lack of common outcome measures prevented some of the intended analysis. MAIN RESULTS: A total of twelve trials were included in the review. No trials reported death and dependence data. Two small trials reporting disability showed no evidence of benefit. The remaining available secondary outcome data suggest that cardiorespiratory training improves walking ability (mobility). Observed benefits appear to be associated with specific or 'task-related' training. REVIEWER'S CONCLUSIONS: There are few data available to guide clinical practice at present with regard to fitness training interventions after stroke. More general research is needed to explore the efficacy and feasibility of training, particularly soon after stroke. In addition more specific studies are required to explore the effect of content and type of training. Further research will require careful planning to address a number of issues peculiar to this type of intervention.

Exercise Therapy↗
PubMed1991

Potential health effects of greenhouse effect and ozone layer depletion in Australia.

OBJECTIVE: To identify potential health effects of the greenhouse effect and ozone layer depletion in Australia. DATA SOURCES: Data were derived from a number of sources: (i) published articles accessed from relevant databases in the disciplines of health, public health and climatology over the past 20 years; (ii) published conference proceedings, review monographs and government reports covering the topic; (iii) a survey of experts in public health and climatology/geography (150 individuals were surveyed in the first phase with a 63% response rate); and (iv) a consensus conference in which 22 invited experts reviewed the results of the literature review and survey and a second conference in which 18 senior members of the health bureaucracy and public health profession considered the implications of the findings. STUDY SELECTION: Over 200 published articles or monographs were reviewed. Criteria for selection were whether the papers contributed information to the objectives of the review. DATA EXTRACTION: Because of the nature of the problem under investigation, predictions based on reasonable scientific assumptions were the major content of the review rather than conclusions based on scientific research. DATA SYNTHESIS: The major predicted health effects of long-term climatic change in Australia are skin and eye damage from increased ultraviolet radiation exposure, increased incidence of some respiratory diseases, vector-borne and water-borne diseases, and the social and physical effects of natural hazards and social and economic restructuring. The most vulnerable groups include the aged, the very young, the chronically ill, those living in poorly designed neighbourhoods and those working in outdoor occupations or heavy industry. CONCLUSIONS: The potential effects on health of long-term climatic change cover the broad spectrum of public health concerns. Detailed predictions of likely problems in specific geographic areas are not yet possible, but progressive development of such predictive capability is a high priority. Doctors will have an increasingly important role in monitoring local health status and participating in disease prevention and surveillance programmes.

Animals↗