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PubMed2006

A quantitative assessment of a medicinal chemistry problem-based learning sequence.

OBJECTIVES: To establish an aggressive problem-based learning (PBL) format for the medicinal chemistry course and assess the outcomes of student learning. METHODS: To assess learning in the new format, precourse and postcourse examinations were given to students enrolled before and after problem-based learning was implemented, and appropriate statistical analyses were conducted. RESULTS: The PBL cohort did not learn the same amount of factual content yet performed the same on higher-order thought questions as the non-PBL cohort. CONCLUSIONS: Problem-based learning may not be the ideal method for teaching medicinal chemistry. This may be due to several factors including: student learning type, the lack of a cognitive framework for learning in the basic sciences, and time constraints.

Chemistry, Pharmaceutical↗
PubMed1986

Learning resources for medical computing.

For medical professionals to acquire computer literacy can be an arduous task. Resources for learning medical computing fall into four major categories: learning technical microcomputer use, computerizing an office practice, tracking patient care experience and integrating medical information systems. Both microcomputer use and tracking patient care experience are technical skills similar to learning any medical procedure with which physicians are already familiar. These skills can be acquired by consulting general, commercial resources such as computer stores, popular computer magazines or software manuals. Computerizing an office practice involves diagnosing office information problems by thoroughly analyzing how data flow during outpatient care. Medical information system design and management is a cognitive specialty in which principles of computer science and medical information management are applied to patient care experience.

Computer Literacy↗
PubMed1995

Application of mathematical morphology in angiologic studies.

Application of mathematical morphology in morphologic sciences was tested. Two aspects were evaluated, cognitive and utilitarian on analyzing enigmatic objects in TK and searching for particular elements in angiologic photos taken in infrared. The results prove many application possibilities of the method. Combination of modern techniques: infrared, Pickworths method, TK, and image transformation delivers many new data. Mathematical morphology selects interesting details and rejects redundant information.

Blood Vessels↗
PubMedDate not supplied

Dimensions and geometry of the temporomandibular joint and masseter muscles.

The bio-engineering team presents its suggestion of a method for the measurement of the temporomandibular joint and masseter muscles in order to determine the parameters necessary for exact sciences and indispensable for unified and objective cognitive studies. Ten formalin-fixed human cadavers served for the studies. The preparations were prepared by the modified method of anatomical procedure. Linear and angular measurements of temporomandibular joint and masseter muscles were carried out with the use of the three-dimensional Cartesian system of OXYZ coordinates in relation to frontal, sagittal and horizontal planes. The physiological cross-sections of the masseter, temporal, lateral and medial pterygoid muscles were also determined. The collected data make it possible to develop a mathematical three-dimensioned model of the osseo-articulo-muscular system of the mastication organ.

Cephalometry↗
PubMed1995

Self-reported alcohol intake and cognition in aging twins.

OBJECTIVE: To determine the relationship between long-term alcohol intake and cognitive functioning in aging Caucasian men. METHOD: A retrospective cohort and co-twin-control study of self-reported alcohol intake and cognitive testing using the National Academy of Sciences-National Research Council (NAS-NRC) Twin Panel of U.S. veterans (born between 1917 and 1927). The study included 4,739 twins with two self-reported drinking histories (1970s and 1980s) and a telephone mental status interview (1990 and 1991) that also included 145 individuals with a diagnosis of alcoholism. RESULTS: Age and education adjusted cognitive scores were lower (p < .05) in diagnosed alcoholics than in the remainder of the subjects. To compare age and education adjusted cognitive scores in alcohol intake, the 4,739 twins were divided, based upon questionnaire data, into nondrinkers and 5 quintiles of drinkers by average reported drinks of alcohol weekly (< 1.0, 1-3.3, 3.4-8.1, 8.2-16.0, > 16.0). Past drinkers had scores lower (p < .05) than nondrinkers and all but quintiles 1 and 5 of the drinkers. The light drinkers in quintile 1 and the heavy drinkers in quintile 5 scored lower (p < .05) than the moderate drinkers in quintile 4. Monozygotic twins in quintile 4 scored higher (p < .05) than their co-twins in quintiles 1-3. CONCLUSIONS: No evidence was found to indicate an association between moderate long-term alcohol intake and lower cognitive scores in aging individuals. There was a suggestion of a small protective effect of past moderate alcohol intake on cognitive function with aging.

Aged↗
PubMed2004

The information-processing approach to the human mind: Basics and beyond.

Cognitive psychology attempts to understand the nature of the human mind by using the information-processing approach. In this article, the fundamentals of the cognitive approach will be presented. It will be argued that the human mind can be described at three levels-computational, algorithmic-representational, and implementational-and that the cognitive approach has both important theoretical and practical/clinical implications. Finally, it will be suggested that the study of cognitive psychology can provide a foundation for other fields of social science, including the field of clinical psychology.

Cognition↗
PubMed2005

Cognitions in cognitive-behavioral psychotherapies; toward an integrative model.

There seems to be a lack of a coherent and integrative theory and theoretically informed manuals in cognitive behavioral therapies that could negatively impact both the program of CBT as a platform for psychotherapy integration, as well as its efficacy and effectiveness. Although CBT is the golden psychological treatment for various disorders, overall, about 30-40% of the patients are still non-responsive to these interventions and various schools debate their status as promoters of the best theoretical view. The objective of the present paper is to use cognitive psychology/science as a tool to clarify several theoretical confusions in CBT, with impact on a coherent science and practice of CBT. As a general conclusion, we believe that CBT has reached preeminence in the clinical field betting on cold cognitions. Despite obvious advantages and accomplishments, this approach seems to loose its heuristic value. We believe that the next phase of CBT development lies in the construct of hot cognitions (which would increase its effectiveness) and in cognitive psychology (which would contribute to a coherent science of CBT beyond various schools). These developments could offer CBT the chance to be a platform for the integration of psychotherapy.

Autobiographies as Topic↗
PubMed1998

Dynamic systems theory as a paradigm for the study of change in psychotherapy: an application to cognitive therapy for depression.

Dynamic systems theory provides a conceptual framework for the study of change in psychotherapy that is consistent with that used in other sciences. A dynamic systems model of change was proposed and evaluated in the context of cognitive therapy for depression. Consistent with this model, less client protection and more destabilization of depressive patterns predicted more improvement at the end of treatment. Less protection was associated with more therapist support/stabilization. More destabilization was associated with more affective intensity in the session and with more of a therapist focus on the historical antecedents of current problems, exposure to multiple sources of corrective information, and repeated practice of new skills. Although preliminary, this pattern of findings is consistent with the model proposed and with principles of dynamic systems from other sciences.

Adolescent↗
PubMed1984

Contribution to the theoretical problems of classification in the observational sciences.

The procedures of classification employed in the observational sciences, particularly in psychiatry, are situated with respect to two others: those which are utilized by the cognitive instrument and those of the logician. The problems posed in the observational sciences arise from the necessity of rendering explicit procedures which are used in situations inevitably presenting a certain degree of incertitude. A stochastic model of the patient-as-seen-by-the-observer is proposed. It is emphasized the prognostic assessment may be carried out without relying on any classification whatever, by means of an equation of multiple regression making use of symptoms as predictors. One then offers to explain why psychiatry strives to categorize symptoms and patients. Two problems are examined in the light of this discussion. The first one is whether it is better to work out a unique system of classification or to favor a plurality of such systems. In light of the preceding discussion, the latter alternative is to be preferred, whereby the notion of 'natural classification' is rejected. The second one has to do with the factors creating incertitude in the observer using a given system of classification.

Cognition↗
PubMed1997

What should biomedical sciences education in dental schools achieve?

Education for the first professional degree in dentistry is intended to produce graduates capable of offering a wide range of high quality dental services to the general public. More than that, it is expected that graduates will be firmly grounded in the scientific basis for their professional practices and be equipped to evaluate critically and integrate selectively new scientific findings that emerge during their professional lifetimes. In addition, they are expected to be able to work effectively with diverse patient populations and to conduct their practices with a high level of sensitivity to the ethical and psychosocial dimensions of patient care. Indiana University School of Dentistry has undergone a process of curriculum reform that has yielded a new first professional degree program. Its hallmarks are large, multidisciplinary courses (seven courses in the first two years) that are taught using a variety of strategies including problem-based learning in small groups as well as lectures. The biomedical sciences curriculum is concept-based. Students will demonstrate their understanding of science concepts and methods by applying them to the solution of research and health care problems. Biomedical sciences will be taught at a level that will provide a comprehensive understanding of the functioning of the human body in health and disease, allow students to assimilate the coming revolution in molecular medicine, and selectively use new diagnostics, preventives, and therapeutics that evolve as molecular biological technologies yield solutions to current medical and dental problems. Using the biomedical sciences curriculum as a vehicle, we will also achieve the goal of training dentists as critical thinkers, problem solvers, lifelong learners, and ethical practitioners, skillful in peer and self-evaluation, and cognizant of the psychosocial as well as biomedical perspective of health and disease.

Biological Science Disciplines↗
PubMed2004

Age effects of coronary artery bypass graft on cognitive status change among elderly male twins.

BACKGROUND: Research regarding long-term cognitive outcome following coronary artery bypass graft (CABG) is inconsistent, which may be due in part to differential genetic and environmental influences within most study samples. METHODS: The authors examined the effect of CABG on cognitive status change scores in members of the National Academy of Sciences-National Research Council Twins Registry of World War II veterans. Subjects were administered the modified Telephone Interview for Cognitive Status (TICS-m) at approximately 3-year intervals between 1990 and 2002 as part of an epidemiologic study of dementia. RESULTS: Based on co-twin control analyses using a repeated-measures analysis of variance matching twins discordant for CABG within the pair (n = 464 individuals) across three age categories (63 to 70, 71 to 73, 74 to 83), the authors found at follow-up that men who had CABG between ages 63 and 70 showed an increase in TICS-m scores and performed better than their co-twin who did not have the procedure. No significant differences were found within twin pairs for the older two age groups following CABG surgery. This age effect was replicated when comparing individuals positive for CABG surgery with nonfamilial, age- and education-matched controls who were negative for CABG. CONCLUSIONS: In this study of twin pairs who share many genetic and environmental risks for cerebrovascular problems, the results suggest that timing of the CABG procedure may be important to predicting positive cognitive outcomes.

Age Factors↗
PubMed2006

Human cognition assessment in drug research.

In this article cognition assessments as outcome measures in CNS drug development research are described. An outline is given of the various choices that can be made and the reasons for them, depending on the approach followed. First, a brief historical context is provided of the psychological sciences that have contributed to today's psychopharmacology of cognition assessment. Subsequently, the focus is on identifying cognitive domains and criteria for selecting appropriate tests. In applied cognitive performance assessment in human psychopharmacology, a number of approaches can be recognised, each associated with models that connect cognitive functions with physiological functions and neural structures. The product-oriented approach of cognition assessment is usually characterised by the use of a battery of several cognitive tasks as an assessment instrument and aims to demonstrate an effect of a pharmaceutical substance without much attempt to determine which cognitive process is primarily influenced by a drug. The process-oriented approach precisely defines the cognitive process in terms of at least a single factor linear model of a process (e.g. by manipulating levels of difficulty) and then compares how diseases and drugs modify the parameters of that process. The associated factor analytical-, resource-strategy- and staged information processing models respectively are described. Finally a brief review is presented on possible physiological markers or biomarkers of human cognitive functions.

Attention↗
PubMed2006

Social cognition in the first year.

Although the study of infancy has answered many important questions about the human capacity for social cognition, the relatively young field of developmental social cognition is far from reaching its adulthood. With the merging of developmental, behavioral and neurocognitive sciences, some growing pains are in store. New work demonstrates that research into early social cognitive development must integrate various research fields and methods in order to achieve a more robust understanding of the nature and parameters of human social cognition.

Attention↗
PubMed2005

The Medawar Lecture 2001 knowledge for vision: vision for knowledge.

An evolutionary development of perception is suggested-from passive reception to active perception to explicit conception-earlier stages being largely retained and incorporated in later species. A key is innate and then individually learned knowledge, giving meaning to sensory signals. Inappropriate or misapplied knowledge produces rich cognitive phenomena of illusions, revealing normally hidden processes of vision, tentatively classified here in a 'periodic table'. Phenomena of physiology are distinguished from phenomena of general rules and specific object knowledge. It is concluded that vision uses implicit knowledge, and provides knowledge for intelligent behaviour and for explicit conceptual understanding including science.

Biological Evolution↗