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At least 919 records · Page 51Linked to original sources
PubMed2006

Lipoblastoma and lipoblastomatosis.

We report two cases of lipoblastoma of the buttock in a 10-month-old boy and a 20-month-old girl, the first with rearrangement of chromosome 8 and the second without cytogenetic abnormality, and one case of lipoblastomatosis of a leg in a 6-month-old boy with a normal karyotype but with a rearrangement of the PLAG1 gene. Lipoblastoma and lipoblastomatosis are two different presentation of the same rare benign soft tissue mesenchymal tumour arising from fetal white fat and occurring almost exclusively in young children under 3 years. These neoplasms have no malignant potential but may recur in cases of incomplete resection. Histological diagnosis sometimes used to be difficult because of the close resemblance of the lesion with myxoïd liposarcoma. Nowadays, cytogenetic analysis may contribute to the diagnosis by showing abnormalities of the long arm of chromosome 8, leading to rearrangement of the PLAG1 gene. Actual advances in cytogenetic molecular analysis may aid in accurate diagnosis.

Buttocks↗
PubMed1981

Case report. The pathogenesis of neurovascular complications following penicillin injection.

A 12-year-old patient presented following inadvertent intraarterial injection of benzathine penicillin. Complications manifested as an incomplete cauda equina lesion with ischaemia and necrosis over the buttock in the distribution of the injected artery. Angiography confirmed damage to the superior gluteal artery while histology revealed severe ischaemic damage without evidence of an allergic process. Spasm of the injected vessel with retrograde flow and occlusion by particulate matter can explain the clinical manifestations. The prognosis for these complications is poor and the best approach lies in prevention.

Arteries↗
PubMedDate not supplied

Relationship of spine deformity and pelvic obliquity on sitting pressure distributions and decubitus ulceration.

The distribution of pressure points in 16 patients with paraplegia, nine with ulcers, and six who were ulcer free were compared with the distribution in 15 normal individuals using an instrument capable of simultaneously measuring multiple pressure points under the buttocks and thighs. The nine patients with ischial and sacral decubiti showed redistribution of their sitting pressures posteriorly, asymmetrical loading of the ischiae, and higher than normal pressures under the sacrococcygeum. These abnormal pressures were associated with unbalanced scoliosis, pelvic obliquity, and the loss of physiological lordosis following a spinal fusion. We defined four criteria of risk for decubitus ulceration.

Buttocks↗
PubMedDate not supplied

Progressive coxa valga after childhood excision of the hip abductor muscles.

To our knowledge, progressive coxa valga, femoral anteversion, and hip subluxation after surgical resection of soft tissue tumors of the gluteal muscles have not been described. The importance of this paper is to document proximal femoral deformity and hip subluxation in children after tumor resection of the hip abductor muscles, to provide guidelines for diagnosis and management of this problem, and to avoid late complications of progressive joint incongruity. Late deformity was seen in two cases after limb salvage surgery for a soft tissue buttock tumor. In both cases, the gluteus medius and minimus muscles were completely resected and the tensor fascia lata and gluteus maximus were partially resected. The ages of the patients at initial treatment were 4 months old and 5 years old, and both patients were followed for a minimum of 4 years. Valgus deformity was seen as early as 15 months. One patient has had a varus osteotomy to correct severe coxa valga and hip subluxation; the other patient with moderate deformity is being followed clinically and radiographically.

Bone Diseases, Developmental↗
PubMed2000

Determination of generic body-seat interface shapes by cluster analysis.

The purpose of this study was to determine typical or generic shape patterns of the buttock-seat interface for elderly wheelchair users. The group of subjects was composed of 30 elderly people (aged 65 or older) and the shapes of the body-seat interface were measured by the electronic shape sensor (ESS). By analyzing the dissimilarity in geometrical shape descriptors or parameters, four distinct generic shapes were identified by means of the cluster analysis method. The results suggest that the generic shapes were mainly characterized by the lateral symmetry of the shapes. The determination of elderly people's seat interface shapes into distinct clusters may lead to a more comprehensive understanding of the seat support interface and more effective seat cushion designs.

Aged↗
PubMed1996

The in situ repair kinetics of epidermal thymine dimers and 6-4 photoproducts in human skin types I and II.

We assessed the in situ time-dependent loss of epidermal thymine dimers and 6-4 photoproducts in skin types I and II after exposure to two minimal erythema doses of solar-simulating radiation on previously unexposed buttock skin. Using quantitative image analysis, we evaluated biopsy sections stained with monoclonal antibodies. We then made comparisons, in the same volunteers, with unscheduled DNA synthesis, which is a direct marker of overall excision repair. Removal of thymine dimers was slow (half-life = 33.3 h), with high levels of lesions still present 24 h post-irradiation; some lesions were still present at 7 d. In contrast, removal of 6-4 photoproducts was rapid (half-life = 2.3 h), the decay kinetics of which correlated better with the decline in epidermal unscheduled DNA synthesis (half-life = 7.1 h). These data show that as in mouse, monkey, and in vitro models, the 6-4 photolesion is repaired preferentially in human epidermis in situ. They also raise the possibility that poor thymine dimer repair may be a feature of skin types I and II, who are more prone to skin cancer than are types III and IV. There was an inverse relationship between the onset of erythema and 6-4 photoproduct repair, suggesting that this repair process initiates erythema.

Adult↗
PubMed1981

Ultrastructure of the human dermal microcirculation. III. The vessels in the mid- and lower dermis and subcutaneous fat.

This paper describes the ultrastructure of the microcirculatory vessels in the mid- and lower dermis and subcutaneous fat. Reconstruction of vessel walls, tracing out the courses of individual vessels, and survey examination of vessels were carried out by various combinations of routine and serial, ultrathin, and 1-micron sections. Intracellular myofilamentous bundles associated with extracellular filaments were a characteristic feature of the endothelial cells in arterioles possessing an internal elastic lamina, but were only rarely seen in endothelial cells of venules. The ultrastructural features of these bundles and filaments suggested both contractile and anchoring functions. The elastic lamina of the arterioles was shown to be composed of individual elastic fibers oriented in the long axis of the blood vessel under the endothelium, rather than being a continuous sheet as in larger arteries and arterioles. The capillaries in the fat had walls of normal thickness (0.1-0.3 micron) similar to capillaries in other organs, in contrast to the dermal capillaries whose walls are 2-3 micron thick. The arterioles, capillaries, and venules in the fat were frequently devoid of veil cells in contrast to those in the dermis. Venous capillaries with bridged fenestrations were found in close proximity to eccrine sweat glands and hair bulbs in the forearm, trunk, and buttock skin.

Abdomen↗
PubMed1981

Proliferative response patterns of human fibroblasts after photoinjury with 4,5',8-trimethylpsoralen.

The extent of growth suppression and recovery following exposure to 4,5',8-trimethylpsoralen (TMP) plus UV-A irradiation was studied in 3 diploid human fibroblast strains. Inhibition of cellular proliferation was dose-dependent within the concentration range of TMP that was tested (1-4 X 10(-7) M), using a constant level of UV-A (0.24 J/cm2). The population generation (doubling) times for all cell strains were progressively lengthened under these conditions while maximal cell densities were reduced. At 2-4 X 10(-7) M TMP in the presence of UV-A, there was a triphasic pattern of growth which consisted of (1) proliferative activity during the first 24-36 hr, followed by; (2) complete growth inhibition for variable periods of time and; (3) a recovery period of log phase proliferation that was not as vigorous as measured for untreated cells. There were also declines in the percentage of cells labeled with 3H-Tdr at various times after TMP-UV-A treatment. These measurements were essentially identical for the three fibroblast strains evaluated. In that the cells employed for these investigations were derived from embryonic pulmonary tissue, neonatal foreskin and the buttock skin of an adult male, it seems unlikely that donor age and tissue source were important variables in determining growth response patterns after TMP-UV-A exposure. Because proliferative recovery was attenuated after this photochemical injury, we conclude that the biologic effect(s) of TMP-UV-A extend beyond the known period of psoralen-DNA cross-link removal.

Adult↗
PubMedDate not supplied

Baboon syndrome in childhood: easy to avoid, easy to diagnose, but the problem continues.

Baboon syndrome was first described as a particular type of systemic contact dermatitis, characterized by an exanthem with involvement of the buttocks and flexures. In children, it is an important entity to take into account for the differential diagnosis of viral exanthem. A large number of allergens have been implicated, although inhalation of mercury vapor is a common trigger. We present the findings in 14 patients younger than 14 years with baboon syndrome. We also look at the frequency in children and the most common causes and triggers in our area.

Adolescent↗
PubMed1992

Inoculation lupus vulgaris.

An 11-years-old girl with lupus vulgaris on the right buttock following inoculation is described. The diagnosis was formed by the history, morphological characteristics, Mantoux test, histopathology, and was supported by an affirmative response to short course intensive chemotherapy (6 months). This route of infection acquires special significance with the worldwide-spread of HIV infection.

BCG Vaccine↗
PubMed1998

Pyodermia chronica glutealis complicated by acromegalic gigantism.

We report a case of pyodermia chronica glutealis complicated by acromegalic gigantism associated with hyperprolactinemia. The serum prolactin, growth hormone, adrenocorticotropic hormone, and 11-deoxycortisol levels were elevated, but the estradiol and dehydroepiandrosterone-sulphate levels were within normal limits. However, the testosterone level was very low. Histopathologically, we found sinus tracts and scarring in a specimen from the buttocks. We could not immunohistochemically detect clear androgen, growth hormone, or prolactin receptors at any site. The patient was a man with a height of 197 cm and weight of 140 kg, he had clinical features of active acromegaly such as excessive sweating and increased thickness of soft tissue. He was also diagnosed with diabetes mellitus. Under such conditions, bacteria could easily grow and lesions might have been aggravated by the heavy pressure from his weight, a possible causes of his pyodermia chronica glutealis.

Acromegaly↗
PubMed1998

Multiple cutaneous epithelioid hemangioendothelioma: a case with spindle cells.

A case of multiple cutaneous epithelioid hemangioendothelioma (EH) in a Japanese male is reported. The patient was a 52-year-old Japanese bureaucrat. Clinically, about 10 purplish-red, elastic soft or hard papules and nodules had appeared on both lower extremities and the left buttock over the past 20 years. They were excised, but some of them recurred. Histologically, the papules and nodules were well-circumscribed tumors located in the superficial and deep dermis. They appeared to arise from medium-sized vessels and were composed of proliferations of characteristic epithelioid endothelial cells with intracytoplasmic vacuolization and spindle cells. No other extracutaneous tumors were found. We diagnosed the present case as multiple cutaneous EH with spindle cells. The presence of epithelioid endothelial cells and absence of pleomorphism and mitoses of nuclei of spindle cells made differential diagnosis from Kaposi's sarcoma possible. The protracted clinical course seems characteristic of EH in various organs including skin.

Blood Vessels↗
PubMed1999

Annular vasculitis in association with sarcoidosis.

We report a case of cutaneous vasculitis with annular features in association with sarcoidosis. A 36-year-old woman presented with fever, polyarthralgias, erythema nodosum, bilateral hilar lymphadenopathy, and induration of a long-standing scar on the face. In addition, she developed annular, erythematous, and purpuric patches over her thighs and buttocks that were histologically characterized by a small vessel leukocytoclastic vasculitis. The presence of circulating immune complexes in the early stages of sarcoidosis might be related to the occurrence of the vascular damage.

Adult↗
PubMed2000

Dermatitis herpetiformis in a Japanese patient with anaplastic large cell lymphoma.

We report a 73-year-old Japanese man with dermatitis herpetiformis which developed after diagnosis of anaplastic large cell lymphoma. The patient suffered fever, sweating, shivering, and multiple enlarged cervical lymph nodes. The diagnosis of anaplastic large cell lymphoma was confirmed by the histologic features of a biopsied cervical lymph node. The patient underwent combination chemotherapy. However, one month after the initial therapy, pruritic erythematous skin lesions with peripheral vesicles appeared on his buttocks. A skin biopsy showed subepidermal blister formation associated with polymorphonuclear and mononuclear cell infiltrates. Direct immunofluorescence examination of the area adjacent to the lesion showed granular deposits of IgA at the dermoepidermal junction. While it is well-known that dermatitis herpetiformis can develop into lymphoma, there have been only a few reports of its appearance after a diagnosis of lymphoma. This case suggests that dermatitis herpetiformis may be induced by anaplastic large cell lymphoma.

Aged↗
PubMed1988

Plasma morphine concentrations after intramuscular injection into the deltoid or gluteal muscles.

The absorption of morphine 10 mg after intramuscular injection into the gluteal and deltoid muscles was investigated. Ten patients received the injection into the deltoid and 10 were given the injection into the upper outer quadrant of the buttock. Blood was taken at frequent intervals up to 2 hours after the injection for plasma morphine analysis by high performance liquid chromatography. Morphine concentrations were generally higher in the gluteal group although the mean peak concentrations (62.8 ng/ml in the gluteal group and 52.3 ng/ml in the deltoid group) were similar. Peak morphine concentrations varied from 22.5-99.3 ng/ml in the gluteal group and 26.5-84.5 ng/ml in the deltoid group. The area under the concentration-time curve was significantly greater in the gluteal group than in the deltoid group but this difference disappeared when allowance was made for differences in body weight of the two groups. We conclude that the absorption of morphine from the deltoid and gluteal sites is similar.

Adult↗
PubMed1983

Anatomical mapping of epidermal Langerhans cell densities in adults.

The densities of T6 antigen-bearing Langerhans cells in 112 biopsies of human skin from sixteen surgical out-patients and four cadavers were determined for eight anatomical regions. The regional mean densities (+/- s.e.m.) of epidermal Langerhans cells per mm2 were: head and neck, 489 +/- 27; chest, 466 +/- 22; back, 466 +/- 11; upper extremities, 458 +/- 25; lower extremities, 431 +/- 30; buttocks, 411 +/- 11; genitalia, 298 +/- 45; soles, 58 +/- 12. No statistically significant differences were found between any of these Langerhans cell densities except for that of the soles which was lower than those of all other regions (P less than 0.002). No significant differences were detected between the mean densities of patients and cadavers, Caucasians and Hispanics or males and females.

Adult↗
PubMed2003

Granulocyte colony-stimulating factor-producing cutaneous angiosarcoma with leukaemoid reaction arising on a burn scar.

We report a 46-year-old man with a giant tumour in a burn scar on his buttock. Pathological examination revealed that the dermis was filled with anastomosing vascular channels and round- or spindle-type atypical cells, which were compatible with the diagnosis of cutaneous angiosarcoma. Based on prominent leucocytosis (up to 113 000 microL-1), we measured serum granulocyte colony-stimulating factor (G-CSF). The highly elevated serum G-CSF of 303 ng L-1 (normal, 6.1-21.5 ng L-1) and positive immunohistochemical staining of the tumour tissue for G-CSF indicated that G-CSF was produced by the cutaneous angiosarcoma. To our knowledge, this is the first reported case of G-CSF-producing cutaneous angiosarcoma.

Adult↗
PubMed1977

Human fat cell adenylate cyclase: regional differences in adrenaline responsiveness.

The effect of adrenaline on adenylate cyclase activity in membranes prepared from human abdominal and gluteal adipose tissue was examined. Basal enzyme activity averaged 1.0 mmol cAMP/mg protein/15 min in abdominal tissue and 0.68 nmol cAMP/mg protein/15 min in ghosts from the buttock. Maximally effective concentrations of sodium fluoride (20 mmol/1) induced an eight-fold increase in both membrane preparations. The maximal response to adrenaline (1.0 mmol/1) averaged 170% in ghosts of abdominal tissue compared with 60% in gluteal membranes. The concentrations of adrenaline required to produce half-maximal stimulation were similar in membrane preparations of both regions (about 5 X 10(-5) mol/1).

Abdomen↗