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We present the case of a trauma patient whose persistently abnormal chest radiography led to exploratory bronchoscopy. After the discovery of a foreign body in the right lower lobe bronchus, an attempted retrieval resulted in accidental perforation of a cocaine bag and release of the drug, which may have been the cause of the patient's subsequent pneumonitis.
OBJECTIVES: Surgical staging and resection of lung cancer may be done as 1 operation (combined) or 2 (staged). This study evaluates the safety and efficiency of these treatment strategies. METHODS: From 1998 to July 2001, 343 patients underwent bronchoscopy, mediastinoscopy, and thoracotomy without induction chemoradiotherapy by 3 surgeons. Fifty-seven patients were staged and 286 combined. Staged patients had higher clinical stage (P <.001). Propensity-matched groups were compared to adjust for this and other differences. Factors associated with safety and efficiency were identified by propensity-adjusted multivariable analysis. RESULTS: Mortality and morbidity were similar for both strategies. Efficiency, measured by shorter operative time (1.2 hours) and lower cost (25%), was better for combined strategy (P <.001). Hospital stay was similar, but revenue was 12% higher for the staged strategy (P <.001). In propensity-matched comparisons excluding surgeon, results were similar to the above. Comparisons including surgeon demonstrated similar cost and revenue for both strategies. Increased mortality and morbidity were associated only with patient and tumor characteristics: male gender, worsening Eastern Cooperative Oncology Group performance status, and increasing pathological node classification. All measures of efficiency worsened with increasing pathological classifications. Staged strategy was associated with increased operative time and revenue, while one surgeon and patient smoking history were associated with increased hospital stay and costs. CONCLUSIONS: The combined strategy provides efficient, safe health care for clinically operable lung cancer patients, but it may not be as financially rewarding as the staged strategy. Treatment strategy is only 1 of many determinants of efficiency.
Some dysplasias in the bronchial epithelium are thought to be precancerous lesions that can develop into squamous cell carcinomas. In this investigation, we assessed the biological behavior of bronchial squamous dysplasia in order to define which dysplasias have the potential to progress to squamous cell carcinoma. Using autofluorescence bronchoscopy, we followed up periodically localized dysplasias and examined for correlation between histological outcome and smoking status during the follow-up period, telomerase activity, Ki-67 labeling index, and p53 immunoreactivity of initial biopsy specimens. Ninety-nine dysplasias from 50 participants mainly with sputum cytology suspicious or positive for malignancy were followed up. Of 99 dysplasias, 3 dysplasias progressed to squamous cell carcinoma, 41 dysplasias remained as dysplasia, 6 dysplasias changed to metaplasia, 14 dysplasias changed to hyperplasia, and 35 dysplasias regressed to bronchitis or normal bronchial epithelium. There were no significant associations between histological outcome and smoking status. Mean initial telomerase activity and Ki-67 labeling index values in the dysplasias increased in proportion to the severity of the histological outcome at the second biopsy. There was also a significant difference between p53-positive and p53-negative dysplasia in terms of histological outcome at the second biopsy. Our results suggested that dysplasias with high telomerase activity, increased Ki-67 labeling index, and p53-positivity tended to remain as dysplasia and might have the potential to progress to squamous cell carcinoma. Patients with dysplastic lesions with these characteristics should be carefully followed up.
Several drugs have been employed for sedation during flexible fiberoptic bronchoscopy (FOB). Clonidine attenuates stress-induced sympathoadrenal responses and has sedative properties. We investigate the effects of clonidine premedication on hemodynamic and comfort parameters of patients submitted to FOB under airway topical anesthesia only. Patients received placebo (n = 22; men = 16; median age = 50.5 years) or intravenous clonidine (3 microg/kg; n = 20; men = 15; median age = 46.0 years) 15 min before FOB. Blood pressure (BP), heart rate (HR), plasma norepinephrine (nor) and cortisol levels were measured before, during, and 1 h after FOB. Comfort was assessed by the examiner and by the patients using a visual numerical scale (0-10). The placebo group showed significant increases in systolic BP, HR, and nor levels during FOB (SBP = 125 mmHg x 145 mmHg; HR = 74 bpm x 85 bpm; nor = 316.2 pg/dl x 483.1 pg/dl), whereas clonidine group did not display such changes. Clonidine group showed a lower frequency of cardiac arrhythmias than the placebo group during and after FOB (supraventricular = 39% x 50%; ventricular = 22% x 40%). Levels of comfort were high and comparable in both groups. We concluded that although clonidine led to a somewhat better hemodynamic profile, it did not contribute to better comfort in this setting.
Fiberoptic bronchoscopy may be performed in patients with acute respiratory distress after thoracic surgical procedures as a measure to avoid intubation and subsequent positive-pressure ventilation in a patient with mucous impaction or as a method of intubating in a patient with a difficult airway. We describe the indications, the technique, and the potential complications.
Bronchoscopy in infants and children has been facilitated by recent technologic advances. Better optical systems, intense "cold" light sources, and miniaturization of instrumentation have all contributed to the more effective use of the bronchoscope as a diagnostic and therapeutic tool. Despite these advances, two persistent problems remain major concerns for the endoscopist and anesthesiologist. The first concern is selection of an appropriately sized instrument for the pediatric patient. Our measurements demonstrate that the stated size of a rigid bronchoscope's internal diameter may differ significantly from its actual size. In many instances the actual diameter may be significantly greater than the stated size. The second problem concerns difficult ventilation of the patient while the bronchoscope is in place. Our measurements indicate that major increases in resistance to gas flow through the bronchoscope can be encountered particularly when utilizing smaller caliber instruments with accessory sheaths and/or telescopes. Appropriate knowledge and planning preoperatively should minimize the potential hazards associated with these problems.
PURPOSE: To aid in identification of isolated tracheoesophageal fistulas (TEF), many surgeons have recommended the bronchoscopic placement of a ureteric or Fogarty catheter. This method can fail because of intraoperative dislodgment of the catheter. The authors present a new technique that enables us to definitively isolate and treat all H-type fistulas. METHODS: Six cases of isolated TEF are presented consisting of 4 H-type fistulas, a proximal pouch fistula, and a recurrent TEF. Three of the patients had undergone a total of four prior failed operations at outside institutions using attempted bronchoscopic catheter placement. On all six patients, bronchoscopy was first performed where the fistula tract was noted in the trachea and a guide wire was passed through the fistula. After orotracheal intubation, the authors performed rigid esophagoscopy; the guide wire was identified and brought out through the mouth. This created a wire loop through the fistula. With the use of x-ray we were then able to visualize the level of the fistula and determine whether a cervical or thoracic approach should be used. Identification of the fistula intraoperatively was then facilitated by traction on the loop by the anesthesiologist. RESULTS: Five of the six TEFs were repaired with neck exploration; one required right thoracotomy. In all patients, the fistula was identified and divided. There were no recurrences or other complications. CONCLUSION: This new technique is a simple and definitive method in identification and treatment of isolated TEF.
OBJECTIVE: The objective of this study was to determine in young children with recurrent wheezing poorly responsive to bronchodilator therapy whether flexible bronchoscopy (FB) and bronchoalveolar lavage (BAL) provide clinically useful information, whether age-specific differences are present in bronchoscopic and BAL fluid (BALF) findings, and whether differential cellular analysis of BALF is useful in suggesting an infectious or inflammatory process. DESIGN: This was a retrospective case series with descriptive and analytical components. The study population included children referred to a large tertiary care children's hospital subspecialty service for further evaluation of recurrent wheezing. Clinical and demographic data and findings of FB and BALF studies were collected from chart review. For purposes of data analysis patients were divided into 0- to 6-, 7- to 12-, and 13- to 18-month age groups. RESULTS: Thirty otherwise healthy children, 0 to 18 months of age with recurrent wheezing, who had undergone FB were identified; and 28 were found to have positive diagnostic findings. Airway abnormalities were found in 17 (57%) and tended to be more common in the 0- to 6-month age group. In the 27 who also had BAL performed, 3 (11%) had a positive bacterial culture, 9 (33%) a positive viral culture, and 5 (19%) an elevated lipid-laden macrophage index suggesting aspiration. Differential cellular analysis was abnormal in 11 (41%), a finding that was significantly associated with a positive bacterial culture, a positive viral culture, or an elevated lipid-laden macrophage index. CONCLUSIONS: In this population of young children with recurrent wheezing poorly responsive to bronchodilator therapy, FB and BAL yielded useful diagnostic findings in most children studied. In addition, in the presence of an infectious or inflammatory process, differential cellular analysis of BALF revealed an increased percentage of neutrophils.
To determine the diagnostic and therapeutic usefulness as well as safety of flexible fiberoptic bronchoscopy (FFB) in patients admitted to the critical-care unit (CCU), we conducted a review of all such procedures done in our CCU from 1985 to 1988. A total of 129 patients underwent 198 FFB, of which 76% were in mechanically ventilated patients. FFB was done for diagnostic purposes in 87, for therapeutic purposes in 93, and for both reasons in 18. Of the 71 diagnostic FFB performed for cultures, 27 (38%) were positive but only 18 (25%) influenced patient management. An additional 25 FFB were helpful in making therapeutic decisions even though the cultures were negative. Ten of 13 FFB performed for evaluation of airways and 1 of 3 done for hemoptysis were helpful. Of the 90 FFB done because of retained secretions, 37 (41%) showed mucous plugs or significant secretions, but clinical improvement was noted in only 17 (19%). Overall, FFB contributed substantially to patient management in 82 of the 198 procedures (41%). Seven patients had transient complications, but no deaths occurred. We conclude that FFB is safe and can be helpful in the CCU setting.
OBJECTIVE: To discuss the two diagnostic procedures used most frequently to obtain uncontaminated lower airway secretions during bronchoscopy. DESIGN: This article reviews the contributing risk factors of ventilator-associated pneumonia (VAP) and the recent studies that have assessed the usefulness of the protected specimen brush (PSB) and bronchoalveolar lavage (BAL) in the nonimmunocompromised host. RESULTS: A prompt, accurate diagnosis of VAP, including specific identification of the bacterial pathogen, remains a common challenge in the intensive-care unit. Standard clinical criteria are of suboptimal specificity for making decisions, including selecting antibiotic therapy. Bronchoscopic techniques of lung secretion sampling can be used in the intensive-care unit in an effort to overcome the effects of oropharyngeal contamination. The PSB and BAL, used appropriately, can help intensive-care clinicians formulate specific antimicrobial therapy. Evaluation of intracellular bacteria obtained by BAL has been reported to be useful in guiding empiric antibiotic therapy while the final results of cultures obtained with the PSB are pending. Prior antibiotic therapy, however, may confound the interpretation and clinical utility of results. CONCLUSION: Currently, for a patient taking antibiotic therapy, no reliable technique nor quantitative culture threshold exists to help in diagnosing suspected VAP or in guiding antibiotic therapy. If the clinical situation allows, antibiotic therapy should be discontinued for 48 hours; then, the PSB, BAL, protected BAL, or endobronchial aspiration should be used. These contemporary modalities, however, necessitate further clinical trials before widespread use is warranted.
Granular cell myoblastoma is an uncommon benign tumor. Most cases of endobronchial involvement are detected as they become symptomatic. Multiple tumors of the bronchial tree are quite rare, having been reported infrequently in the English literature. The authors report a case with two-year follow-up, which is unique in that the tumors were asymptomatic and were discovered incidentally at bronchoscopy.
Autofluorescence bronchoscopy (AFB) has been shown to be sensitive to detect preneoplastic lesions in central airways. Apart from bronchial mucosa thickness, tissue autofluorescence is also related to the biochemical properties of the target cells. Genetic studies have shown molecular abnormalities to be present in histologically normal mucosal specimens. Forty-six high-risk individuals, free of micro-invasive cancer at the initiation of the study, were included in this analysis and have been subjected to repeat bronchoscopic examinations every 4-6 months. They had previous curatively treated lung cancer (n=18), ENT tumor (n=11) or were at risk to acquire lung cancer primaries (n=17). Baseline AFB is scored for each suspicious lesion, thus the total score represents the number of AFB suspicious lesions present in each individual at risk. Baseline AFB score was correlated to outcome, i.e. the development of squamous-cell cancer (SCC) in each individual. So far, 11/46 (24%) of the individuals acquired SCC. Follow up has been 12-80 months. All five individuals with >/=3 lesions (100%, 12-36 months), five of the ten (50%, 12-48 months) individuals who had two lesions and one among the 12 (8%, 36 months) individuals with one suspicious AFB lesion, developed SCC. Up till now (12-80 months), the remaining 19 individuals without any suspicious AFB lesion have not acquired SCC. The average AFB score for the group of individuals which developed SCC was significantly different (P<0.001) from the remaining individuals who did not acquire SCC (2.64+/-1.1 vs. 0.6+/-0.7 S.D.). The number of suspicious lesions at baseline AFB is a good predictor for the development of SCC in the individuals at risk in our study population. This finding is compatible with field carcinogenesis and warrants a more upfront use of AFB in a lung cancer screening to sift the different risk-cohorts in a population mainly at risk for developing metachronous lung cancer.
The current revolution in technology, imaging, and information processing will be of major influence on bronchoscopy within the next two decades. Clinicians will be able to visualize structures in vivo that up to now only the pathologist could see. Clinicians will reach anatomic structures that are inaccessible by the bronchoscope, yet treat diseases that are still the domain of surgeons, medical oncologists, and radiotherapists. Clinicians will be able to communicate online worldwide, improving standards of patient care, teaching, and finally even perform interventional procedures by way of networks. Because of the exponential growth of sciences like nanotechnology and biotechnology, these changes will come very rapidly. The new quality of these intelligent instruments will demand a new ideological and ethical discourse on the future of science in general.
Over the past 15 years, much has been learned about the presence of airway inflammation in asthma through the use of investigative bronchoscopy. It has become quite clear that inflammation is present even in mild asthma. In addition to the eosinophils, T-lymphocytes and a variety of cytokines have been identified to play a prominent role in asthmatic inflammation. The concept of delayed asthmatic response after allergen exposure and its relationship to cellular inflammation and airway hyper-reactivity has become more clearly established. Our understanding of asthmatic airway inflammation, however, is incomplete. As interesting as the database has been so far, investigative FB has not defined a unique profile for patients with asthma. Specifically, lavage or endobronchial biopsy has not identified parameters that help in the diagnosis, assessment of disease severity, prognosis, or likelihood to respond to specific therapies. Also, the exact relationship between parameters in lavage compared with mucosal biopsy and how these are related to airway hyper-reactivity and the clinical syndrome of asthma remains poorly understood. In this regard, it must be confessed that currently FB with lavage and biopsy in asthmatics needs to be considered as a research tool for specimen retrieval to help characterize and express inflammation. Although these techniques have contributed immensely to our understanding of asthma pathogenesis, presently these techniques do not have any practical role or clinical usefulness.
The use of bronchoscopy for research into lung cancer is mostly limited by the imagination of the investigator. This technique allows the scientist direct access to tissue in a minimally invasive manner. We have discussed some of the applications of this technique in better understanding lung cancer. As we move onward in the areas of diagnosis and treatment of lung cancer, the bronchoscope will remain an important research tool.
Primary mediastinal non-Hodgkin lymphoma is a rare entity that can manifests with secondary pulmonary involvement. The case of a 37 years-old man patient with non-Hodgkin lymphoma mixed B-cell, which was diagnosed by means of bronchoscopic biopsy, is presented. His characteristics clinical and radiologic presentation, and diagnostic usefulness of fiberoptic bronchoscopy, is remarked. We revised clinical and pathologic features of interests for this lymphoproliferative disorders with thoracic involvement.
Inhalation injury is a relatively common complication of burn injury requiring early attention with respect to diagnosis and therapy, and frequent assessments of the tracheobronchial status. Clinical, radiological and laboratory findings often cannot fulfil these needs. Therefore the advantages of flexible fibreoptic bronchoscopy (FFB) in diagnosis and therapy of respiratory tract injury are shown by these case reports.
Tracheobronchopathia osteochondroplastica (TO) is a rare benign disorder affecting the trachea and occasionally the bronchi. We report a case of TO presenting as a respiratory insufficiency. Chest radiograph revealed an irregular narrowing of the intra thoracic trachea and a parenchymal consolidation of the left lower lobe. Magnetic resonance examination of the chest showed a diffuse irregular thickening of the trachea and central bronchi, which had an intermediate signal intensity with punctiform low signal intensity suggesting calcifications and no contrast enhancement. The diagnosis was confirmed by bronchoscopy and biopsies.