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At least 919 records · Page 51Linked to original sources
PubMed1991

The use of minoxidil to attempt to prevent alopecia during chemotherapy for gynecologic malignancies.

Minoxidil 2% topical solution applied twice a day is known to induce hair growth and prevent hair loss in normal male pattern baldness. Based on this potential, this pilot study tested the effect of Minoxidil on hair loss during chemotherapy for gynecologic cancers. Ten women about to start alopecia-inducing chemotherapy protocols were entered into this non-randomized prospective trial. By study design, each patient served as her own control, as only a portion of the scalp was treated with Minoxidil. Four of the ten patients were unevaluable for failing to comply with the twice-a-day Minoxidil application schedule. Of the six evaluable patients, five experienced complete or severe symmetrically diffuse hair loss, all of which occurred within four weeks of initiating chemotherapy. One patient had no hair loss in either the treatment or control area. Application of the topical Minoxidil in all ten patients had no untoward side effects, skin changes or hypotension. Thus, in this pilot study, 2% Minoxidil was non-toxic but showed no benefit in the prevention of chemotherapy-induced alopecia.

Administration, Topical↗
PubMedDate not supplied

Intervening with alopecia: exploring an entrepreneurial role for oncology nurses.

This article discusses the development of an innovative role for oncology nurses in assisting patients with their personal information and image needs that arise from alopecia secondary to the treatment of cancer. An independent oncology nursing consultative service was initiated after a survey of patients was conducted (N = 40) to assess alopecia knowledge, needs, and referral source. Nurses (N = 16) attending a local Oncology Nursing Society (ONS) chapter meeting were surveyed to assess their intervention patterns and knowledge of hair and scalp care during hair loss. To respond to needs identified through the surveys, the consultative service developed a patient education program and booklet, as well as professional education sessions. Management and evaluation of this practice continues to provide a learning experience.

Alopecia↗
PubMed1990

[The psychoemotional aspects of the pathogenesis of androgenetic alopecia in women].

Psychoemotional status of women suffering from androgenetic alopecia was studied by clinico-psychological and clinico-experimental methods. Differences in personality characteristics, depending on the disease severity, length, and pattern, were revealed. These data evidence the significance of personality characteristics in the genesis of androgenetic alopecia.

Adult↗
PubMed1990

[Metastatic alopecia].

Two cases of metastasic alopecia from breast adenocarcinoma were reported. Clinical and differential aspects from other types of alopecia are also commented.

Adenocarcinoma↗
PubMed1990

Alopecia with rickets: an end organ unresponsiveness to 1,25-dihydroxyvitamin D--a case report.

Two siblings of a rare syndrome of vitamin D dependent type II rickets are reported for the first time from India. The clinical and biochemical picture was characterised by florid rickets, alopecia, hypocalcemia and resistance to therapy with high dosages of vitamin D3. Due to lack of facilities for estimation of 1,25(OH)2D, alopecia remains the only clue to the diagnosis of this rare syndrome in association with resistant rickets.

Alopecia↗
PubMed1990

[Treatment of cicatricial alopecia by the method of tissue expansion].

The tissue extension method was applied in 13 patients with cicatricial alopecia of the scalp. Eighteen Soviet-made tissue expanders were used. Clinical experience showed that the sequelae of burns of the scalp attended by alopecia should be treated by tissue extension. The growth of hair can be restored on up to half of the scalp surface by expansion of the local tissues by their direct transfer and by additional formation of grafts for contour plastics. Plastics by expanded tissues is indicated for closure of naked bones of the vault of the skull.

Alopecia↗
PubMed1985

Familial alopecia areata--genetic susceptibility or coincidence?

Three generations of a not consanguineous Italian family and 40 subjects suffering from alopecia areata (AA) and residing in Northern Italy were studied. There were 321 healthy control subjects of both sexes. Six family members from three generations were affected with alopecia universalis. The subjects were HLA-phenotyped using different HLA-A, B and C antigen specificities. No significant association was found between HLA-A, B and C antigens and AA patients at the population level. Segregation analysis showed that affected members shared a common haplotype, HLA-Aw32, B18,-.

Alopecia Areata↗
PubMed1986

Circulating lymphocyte subsets in patients with alopecia areata.

Lymphocyte subsets in peripheral blood of fourteen patients with patchy alopecia areata or alopecia universalis were estimated using monoclonal antibodies and immunofluorescence. The median percentage of circulating Leu 2a, 3a, 4 and 7 positive cells ("T-suppressor/cytotoxic", "T-helper/effector", total T-cells and killer and natural killer cells) were normal.

Adolescent↗
PubMed1987

A preliminary study of the effect of 11a-hydroxyprogesterone on the hair growth in men suffering from androgenetic alopecia.

Ten male patients suffering from androgenetic alopecia were treated during one year with a lotion containing 1% 11a-hydroxyprogesterone. Eight untreated patients served as control group. The parameters used were hair root status, hair shaft diameter of anagen hair roots and number of hairs with a diameter less than 40 micron. After therapy the cranial region showed an increase in the number and mean hair shaft diameter of anagen hair roots and in the number of hair roots with a diameter less than 40 micron. The number of hair roots in catagen/telogen decreased, the number of dysplastic/dystrophic hair roots remained unchanged. After therapy the cranial region in the controls showed a decrease in number and mean hair shaft diameter of anagen roots, and in the number of dysplastic/dystrophic hair roots. There was an increase in number of hair roots in catagen/telogen and of hair roots with a diameter less than 40 micron. The results warrant the conclusion that the above mentioned therapy would seem to be effective in men suffering from androgenetic alopecia.

Administration, Topical↗
PubMed1989

[Hypothyroidism and hyperprolactinemia as a possible cause of androgenetic alopecia in the female].

31 female patients suffering from androgentic alopecia were examined by means of the TRH test with regard to hypothyroidism and hyperprolactinemia. Before, as well as 20 and 40 minutes after, application of thyroxine releasing hormone (TRH), the serum concentrations of the hypohyseal thyroxine stimulating hormone (TSH) and prolactin (PRL) were measured by radioimmunoassay (RIA). In 7 of the patients (23%), we found increased TSH levels after stimulation with TRH--indicative of hypothyroidism. In 9 of the patients (29%), we observed increased PRL levels after TRH stimulation, indicating prolactinemia. TSH and PRL can interact with androgen metabolism at various levels. Thyroxine may influence the unbound, metabolically active testosterone via the sex hormone binding globulin (SHBG). Prolactine, which is stimulated by TRH, promotes the suprarenal cortisol and androgen production. In 48% of the patients, we found either hypothyroidism or hyperprolactinemia. This suggests that both conditions may contribute to the clinical picture of female androgenetic alopecia, as they interfere with the androgen metabolism.

Adult↗
PubMed1989

Hyperpigmented acral papular mucinosis, systemic lupus erythematosus and universal alopecia.

A 42-year-old man presented with systemic lupus erythematosus, universal alopecia and non-pruritic hyperpigmented papular mucinosis. The latter was most evident on acral areas. In hyperpigmented areas of the face the immunofluorescence showed deposits as in LE and with alcian blue and colloidal iron an abundance of mucin was demonstrated in the dermis. A lesion on the back showed only papular mucinosis. Fifteen cases of LE and papular mucinosis reported in the literature are reviewed. Our patient differs with respect to the marked pigmentation of his lesions, their localization and the association with universal alopecia.

Adult↗
PubMed1989

Topical cyclosporin A in alopecia areata.

We conducted a trial of topical application of 10% cyclosporin A in an oil preparation in 10 patients with alopecia areata and alopecia universalis. After 12 months of therapy, no beneficial response was observed in any of the 10 patients.

Administration, Cutaneous↗
PubMed1989

[The treatment of alopecia areata with sinusoidal modulated currents].

The technique of alopecia areata treatment with sinusoidal modulated currents is simple and may be used on an outpatient basis. The Amplipul's-4 apparatus sensors have been placed in the cervical sympathetic node area. The current parameters have been as follows: P-1, III PP for 2-3 min, then IV PP for 2-3 min, modulation frequency 100-80 Hz and depth 50-75%, the pulse length within 2-4 sec provided the current strength is sufficient. The course of treatment included 10-12 sessions. Parallel with this physiotherapeutic modality, the patients were administered FiBS (a liman mud biogenic stimulant), vitamins B1 and B6, and andecalin. Clinical effect has been achieved in 46 of the 53 patients with a short duration of the disease. The authors' observations confirm the contribution of the sympathetic nervous system function to the genesis of alopecia.

Adolescent↗
PubMedDate not supplied

[Electron microscopy of blood vessels in alopecia areata].

The use of electron microscope in the study of the diseased skin of four patients with Alopecia areata has detected changes in the endothelial cells with narrowed capillary lumen. The authors have brought these findings in connection with the decreased blood circulation in lesions of patients with Alopecia areata which necessiates the use of vasodilatator agents in their therapy. Etiopathogenesis of the disease has been discussed.

Adult↗
PubMed1989

[Thallium-induced alopecia].

A case of accidental Thallium intoxication showing, as the only sign, alopecia of the scalp with depigmentation of the hair, is described. A 21 year old woman developed acute loss of hair after ingestion of contaminate tomatoes. No further signs of intoxication were evident. The diagnosis has been made by evidencing Thallium in the urine (colorimetric method) and in the hair (atomic absorption spectrophotometry). Moreover, the clinical and histopathological findings of Thallium alopecia are described.

Adult↗
PubMed1989

Km1 allotype association with one subgroup of alopecia areata.

The distribution of the immunoglobulin kappa light-chain determinant, Km1, was examined in 52 patients with alopecia areata, 22 of whom possessed serum antibodies to thyroid antigens. The allotype frequency was significantly higher than that found in a referent population of 105 healthy subjects. Furthermore, it was determined that within the patient population, the Km1 allotype was associated with the absence of detectable serum autoantibodies. In such patients, this association may be due to linkage disequilibrium between the chromosome 2 gene coding for Km1 and a chromosome 2 gene coding for susceptibility to alopecia areata.

Alopecia Areata↗
PubMed1985

Calcitriol-resistant rickets with alopecia.

Four children of two kindred had alopecia associated with severe rickets, resistant to treatment, and caused by defective cytoplasmic and nuclear receptors for the active vitamin D metabolite calcitriol (1,25-dihydroxyvitamin D3). Scalp biopsy specimen revealed a normal number and light microscopic features of the hair and hair follicles. Calcitriol-resistant rickets should be added to the list of inherited disorders of hair growth, and the association of rickets with alopecia needs to be considered in the differential diagnosis of hair loss.

Alopecia↗