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Results for “pre-eclampsia”

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PubMed1977

Amniotic fluid cortisol in high-risk human pregnancies.

Amniotic fluid cortisol (AFC) levels were measured in 76 normal and 67 high-risk human pregnancies. When compared to normal gestations, diabetic pregnancies were found to be associated with lower AFC levels, while toxemic, early Rh-sensitized, and other stressed pregnancies had higher mean cortisol values. Serially followed normal and high-risk pregnancies showed a progressive rise in AFC with increasing gestational age. Significant correlation between AFC concentrations and lecithin/sphingomyelin (L/S) ratios was noted in normal, diabetic, and toxemic gestations. These results are concordant with the hypothesis that cortisol may be involved in fetal lung development.

Amniotic Fluid↗
PubMed1977

The conservative management of toxemia: a brief report of effective perinatal concepts.

Toxemia remains inscrutable. Modern perinatal medical facilities have, however, been able to reduce perinatal mortality in this and other chronic illnesses affecting mother and baby by the increased ability to assess fetal maturity and monitor continued welfare. Modern advances in neonatal intensive care have aided inestimably in improving the results. A 5-year experience with a conscientious but conservative approach to toxemia is presented, with perinatal mortality identical to that of the overall population at 11/1000 live births. Results are compared to older data on neonatal mortality from toxemia, emphasizing the importance of cooperative efforts by the obstetrician and neonatologist in any successful perinatal program.

Female↗
PubMed1977

[Perinatal mortality in twin birds (author's transl)].

A retrospective investigation of 146 twin births (1% of all births in our obstetric hospital in 15 years) was presented. Compared with a normal control group, the average age of the women with twin pregnancies was higher on the whole and the number of primaparate was lower. Half of the women had an EPH gestosis. Forty-one percent of the births were premature. Perinatal mortality was 9.5% (first twin: 6.4%; second twin: 13.6%). The higher rate of complications accompanying twin pregnancies during the pregnancy itself and during the birth make intensive supervision necessary.

Adult↗
PubMed1977

The management of severe preeclampsia and eclampsia with intravenous diazoxide.

Twelve patients with either severe preeclampsia (9) or eclampsia (3) were treated with intravenous diazoxide, 300-mg bolus, for the reduction of diastolic blood pressure (less than or equal 110 torr) after the usual and customary measures had been initiated to include parenteral MgSO4 and diazepam. Diazoxide precipitously decreased both systolic and diastolic blood pressure proportionately (35-50%); the nadir was invariably reached in 5-15 minutes. Diastolic pressure never fell below 50 torr, and mean arterial pressure always exceeded 70 torr. Oliguria was not apparent. The vasodepressor response was fairly persistent for 4 hours in all but 3 patients; 2 of these received a second 300-mg dose. Significant changes in fetal heart activity (bradycardia, dysrhythmia) were observed in only 1 patient. Labor was immediately ablated in all patients, but could be restimulated with oxytocin. All pregnancies were terminated within 7 hours (mean, 3.7 hours), seven of them by cesarean section. Eleven newborns did well. We conclude that the immediate reduction in maternal arterial blood pressure is without apparent hazard to the mother as well as the fetus.

Adolescent↗
PubMed1977

Effects of magnesium sulfate on toxemic patients in labor.

One hundred forty-four toxemic patients were studied by continuous electronic maternal and fetal monitoring. Ninety-seven were treated by intravenous bolus of 2 g MgSO4 every 1-2 hours, and 47 by intravenous drip MgSO4 at a rate of 1 g/hour. Clinical doses of MgSO4 do not affect maternal ECG, temperature, uterine contractions, or fetal heart rate. Intravenous bolus administration is frequently associated with slowing of maternal respirations and hypotension and occasionally with transient apnea.

Body Temperature↗
PubMed1977

Hypertension in pregnancy and perinatal mortality.

The effect of various forms of hypertension on perinatal mortality has been investigated. Non-essential, non-proteinuric hypertension had relatively little effect on perinatal mortality, whereas essential and proteinuric forms of hypertension had a marked influence. Diastolic blood pressures of less than 110 mmHg did not influence perinatal mortality. Fetal loss from hypertensive disease was largely accounted for by fetoplacental inadequacy, accidental haemorrhage and preterm delivery. Management more suited to individual needs and induction of labour, once biological and lung maturity has been achieved, is advocated.

Adolescent↗
PubMed1979

[Comparative examinations of high-molecular maternal serum protein bodies during pregnancy--a contribution to biochemical pregnancy control (author's transl)].

The maternal Serum concentrations of beta 1 SP 1, IgM and alpha 2-macroglobulin were determined in relation to the gestation age, using the simple radial immunodiffusion method in 102 non-pathologic pregnancies and 35 pregnancies involving risk factors. To assess the clinical relevance of these determinations, we examined to what extent the changes in concentration of beta 1 SP 1 IgM and alpha 2-macroglobulin would permit a prognostically useful conclusion on the placenta function and foetal condition. All patients with lowered beta 1 SP 1-serum concentrations were examined for their antepartua CTG-evaluation, as well as the type of termination of parturition. The normal distribution for beta 1 SP 1 showed a continuous rise in serum concentration up to the 37th pregnancy week. During the last 3 weeks, beta 1 SP 1 remained almost constant. For the cases with EPH-gestosis and placenta insufficiency, a beta 1 SP 1-concentration below the normal distribution level was found in the large majority of all cases. In diabetes mellitus during gravidity, twin gravidity and MHN, the determination of beta 1 SP 1 is not of any decisive prognostic significance. The maternal serum levels of IgM showed no significant differences when comparing normal pregnancy and risk pregnancy. The serum concentration of alpha 2-macroglobulin increased in both groups of patients with increasing gestation age. Of the three examined protein bodies, we consider beta 1 SP 1 to be a good, additional parameter for the assessment of the trophoblast function.

Female↗