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Stability and variability in extinction.

Some studies have found that extinction leaves response structures unaltered; others have found that response variability is increased. Responding by Long-Evans rats was extinguished after 3 schedules. In one, reinforcement depended on repetitions of a particular response sequence across 3 operanda. In another, sequences were reinforced only if they varied. In the third, reinforcement was yoked: not contingent upon repetitions or variations. In all cases, rare sequences increased during extinction--variability increased--but the ordering of sequence probabilities was generally unchanged, the most common sequences during reinforcement continuing to be most frequent in extinction. The rats' combination of generally doing what worked before but occasionally doing something very different may maximize the possibility of reinforcement from a previously bountiful source while providing necessary variations for new learning.

Animals↗

Maturation of extinction behavior in infant rats: large-scale regional interactions with medial prefrontal cortex, orbitofrontal cortex, and anterior cingulate cortex.

The ability to express a behavior during the postnatal period may be related to developmental changes in the recruitment of particular neural systems. Here, we show that developmental changes in the functional interactions involving three cortical regions (the medial prefrontal cortex, orbitofrontal cortex, and anterior cingulate cortex) are associated with maturation of extinction behavior in infant rats. Postnatal day 17 (P17) and P12 pups were trained in a straight-alley runway on an alternating schedule of reward and nonreward [patterned single alternation (PSA)] or on a pseudorandom schedule of partial reinforcement (PRF); the pups were then injected with fluorodeoxyglucose (FDG) and shifted to continuous nonreward (extinction). Handled control groups exposed to the same training environment but not trained on a particular schedule were included. Among P17 pups, extinction proceeded faster in PSA pups relative to PRF pups. No differences were found between P12 groups. FDG uptake, an index of acute changes in functional activity, was quantified in the three cortical regions and 27 other brain regions of interest. A multivariate covariance analysis, seed partial least squares, revealed that functional relationships involving the three cortical regions and large-scale systems of regions throughout the rostrocaudal extent of the brain changed with training in P17 pups. The cortical regions were primarily uncoupled in the younger group. The data suggest that functional maturation of the frontal cortical regions and their interactions with other brain systems are related to the maturational shift in behavior.

Aging↗

[Interaction of stereotypic behavior in mice and effects of activation of presynaptic dopaminergic receptors in extinction and amnesia].

Using the methods of agonistic confrontations of C57BL/6J mice for formation of aggressive and submissive types of behavior and passive avoidance training we investigated the influence of activation of dopamine presynaptic receptors on retention of a memory trace during extinction and amnesia. Autoreceptor agonist (+)3PPP (2 mg/kg, intraperitoneal injection) impaired learning and retention of a memory trace during extinction and strengthened the amnestic influence of animal detention in a dangerous compartment on the training day only in aggressive mice. In submissive mice, (+) 3PPP improved the retrieval of passive avoidance during extinction but did not change the development of amnesia. This work was the first to demonstrate that the effects of dopamine autoreceptor activation on the passive avoidance retrieval depend on behavioral stereotype (aggressive or submissive). It is suggested that different basic states of the dopaminergic system in aggressive and submissive mice are responsible for different (+) 3PPP effects.

Aggression↗

[Visual extinction: a study by means of potentials evoked with movement].

INTRODUCTION: The term extinction refers to the phenomenon in which a patient with a lesion of the central nervous system ignores one of two stimuli in conditions of simultaneous bilateral stimuli. Various studies observe this phenomenon as the expression of a deficit in the process of selective attention, but there are few studies with potentials related to events (PRE). OBJECTIVES: To find the possible electrical correlation of the extinction phenomenon and the stage of processing at which this occurs. PATIENTS AND METHODS: We studied a patient with a right parieto occipital lesion and a control person of the same race, age, sex and educational level. We carried out two experiments. The first of these was to determine the direction of movement of two surfaces with red and green spots situated on both sides of a central fixation point. In the second experiment, the same task was carried out, but the two surfaces were superimposed, in the same place. In both cases the first movement occurred in the surface which was being attended to and the second might be this surface or the other. The proportion of correct answers were recorded for both movements. The PRE showed an attention disorder which affected the spatial distribution of attention with conservation of the attention to objects. CONCLUSIONS: The suppression of the P1 N1 components are the electrical correlate of the phenomenon of extinction which should occur during early stages of processing. Further investigations are necessary in a larger number of cases.

Attention↗

Extinction by retarded children following discrimination learning with and without errors.

Four groups of retarded children (N = 4 in each group) were trained to respond to a triangle with apex up (S+) and not to a triangle with apex down (S-), with and without errors. A free-operant procedure in which responding to S+ was intermittently reinforced and a trial procedure in which all responses to S+ were reinforced were compared. An extinction procedure in which responses were no longer reinforced was then introduced. Extinction resulted in substantial responding during S- for all groups, except the free-operant errorless group. S- responding during extinction did not differ between the errorless and error-trial groups and was maximum for the free-operant error group.

Achievement↗

L-type voltage-gated calcium channels are required for extinction, but not for acquisition or expression, of conditional fear in mice.

It has been shown recently that extinction of conditional fear does not depend acutely on NMDA-type glutamate receptors, although other evidence has led to the hypothesis that L-type voltage-gated calcium channels (LVGCCs) play a role in conditional fear. We therefore tested the role of LVGCCs in the acquisition, expression, and extinction of conditional fear of cue and context in mice. Using systemic injections of two LVGCC inhibitors, nifedipine and nimodipine, which both effectively cross the blood-brain barrier, we show that LVGCCs are essential for the extinction, but not for the acquisition or expression, of conditional fear in mice.

Animals↗

Eyelid conditioning and intellectual level: effects of repeated acquisition and extinction.

Groups of college students and moderately retarded persons averaging approximately equal age received eight alternating phases of acquisition and extinction trials with an electric pulse as the unconditioned stimulus for classical eyelid conditioning. The two conditioning groups did not differ significantly in attaining the acquisition criterion during any phase and showed systematic improvement in approaching the maximal rate of acquisition. However, the college students exhibited abrupt extinction in every phase, in contrast to retarded subjects. "Learning to learn" in the retarded group was more marked across acquisition than across extinction phases. Random control groups of the two subject classes displayed equal relative frequencies of nonconditioned blinks. Some of the findings clearly contradict a stimulus-context hypothesis of differences in learning rate associated with IQ level.

Acoustic Stimulation↗

[Extinction and amnesia in aggressive and submissive mice with various terms of agonistic interaction].

Dependence of the passive avoidance retrieval on the duration of agonistic interactions was analyzed in C57BL/6J mice in procedures of extinction and amnesia during formation of aggressive and submissive behavioral stereotypes. The resistance to amnestic stimulation was lower in aggressive mice with 10-day experience of victories than in aggressive animals after 20 daily confrontations. Prolongation of extinction in aggressive mice and fast extinction in submissive animals did not depend on the number of agonistic interactions.

Aggression↗

[Influence of D1 dopamine receptor activation on extinction of passive avoidance and amnesia in aggressive and submissive mice].

In mice with aggressive and submissive behavioral stereotypes, passive avoidance retrieval in extinction and amnesia was shown to be differently dependent on the activation of D1 dopamine receptors. In extinction, agonist of D1 receptors SKF 38393 injected before training or on 12-th day of testing in a dose of 5 mg/kg impaired the retrieval of a conditioned habit in aggressive mice and improved the retrieval in submissive mice. The opposite effects of D1 receptor activation depending on stereotype were also observed in a procedure of amnesia. In aggressive mice, SKF 38393 essentially reduced the resistance to amnesic effects characteristic of this stereotype. In submissive mice, SKF 38393 attenuated the amnesic effect of a detention in a dangerous compartment and restored the amnesic memory trace. Possible mechanisms of selective involvement of D1 receptors in retention of memory trace of aversive stimuli during extinction and amnesia in mice with different stereotypes of behavior are discussed.

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-ben↗

Extinction of orienting reaction in chronic alcoholics.

A polygraphic study on resistance to extinction of the somatic (EMG), autonomic (finger plethysmogram, galvanic skin reaction, respiration) and EEG (acoustic-evoked potential and EEG-blocking reaction) components of the orienting reaction elicited by a repetitive auditory stimulus was performed in 67 chronic alcoholics and in 70 matched normal subjects (control group). The study showed a significantly lower resistance to extinction of the orienting reaction in alcoholics than in control normal subjects. The severity of this extinction disturbance depended on the patients' age, type of alcoholism, alcohol consumption intensity and chronicity, as well as the type of resting EEG.

Acoustic Stimulation↗

Neonatal androgen effects on conditioned emotional response extinction of adult rats under various hormonal regimens.

Intact male rats and spayed female rats received 0.5 mg testosterone propionate in the first 24 hours after birth. They were divided into different groups, administered peanut oil, progesterone, oestradiol benzoate and testosterone propionate in adulthood. The animals were conditioned to fear with a shock paired sound. The experimental test consisted of investigating the conditioned emotional response (CER) extinction. It was verified that as to conditioned emotional response extinction, neonatally androgenized males were different from control males; neonatally androgenized females, testosterone propionate treated in adulthood were also different from control females. There was no significant difference between neonatally androgenized females oestradiol benzoate treated in adulthood and their control group. In comparing neonatally androgenized females having different hormonal treatment in adulthood, we verified that testosterone propionate treated females were significantly different from those treated with progesterone. On the other hand, neonatally androgenized females treated with oestradiol benzoate in adulthood were different from those that have had the same hormonal manipulation in neonatal period, but that were injected with progesterone in adulthood. It was concluded that conditioned emotional response extinction is facilitated by neonatal androgenization in non-oestrogenized male and female rats.

Age Factors↗

Effect of the dietary alpha-linolenate/linoleate balance on lipid compositions and learning ability of rats. II. Discrimination process, extinction process, and glycolipid compositions.

Donryu strain rats through two generations were fed semi-purified diets supplemented with safflower seed oil (rich in linoleic acid) or with perilla seed oil (rich in alpha-linolenic acid), or a conventional laboratory chow (normal control diet). Brightness-discrimination learning ability was determined to be the highest in the perilla oil-fed group, followed by the normal group, and then by the safflower group, extending our earlier observation in a different strain of rat that alpha-linolenic acid is a factor in maintaining high learning ability (Yamamoto, N., M. Saitoh, A. Moriuchi, M. Nomura, and H. Okuyama. 1987. J. Lipid Res. 28: 144-151). After the brightness-discrimination learning test was administered, extinction of learning was measured. The time required for extinction was significantly longer in the safflower group than in either the perilla group or the normal diet group. Thus, the dietary alpha-linolenate/linoleate balance affected both the learning and the extinction of learning. The glycolipids of the cerebrum, cerebellum, and olfactory lobe were analyzed. Although the fatty acid compositions of the sulfatide and gangliosides were significantly different in the three parts of the brain, relatively little difference was observed in the fatty acids of glycolipids between the safflower group and the perilla group, suggesting that gross changes in brain glycolipids are not responsible for the differences in learning abilities between these dietary groups.

Animals↗

[Changes in the phasic activity of neuron microsystems of the somatosensory cortex of the cat during extinction of activation reactions to unreinforced stimuli].

In chronic experiments on cats, three-phasic responses of neuronal microsystems in the cortical somatic area I were studied during habituation of the EEG activation reactions. Repeated stimuli of different modalities were used: electrical pulses to the forepaw, sounds, direct stimulation of the mesencephalic RF. Simultaneously with the extinction of EEG activation reactions, the three-phasic responses of the multiunit activity (MUA) also became progressively extinct: the 1st phase of primary excitation--only a little, the 2nd phase (inhibitory)--greatly, as well as the 3rd phase--the phase of secondary excitation (if it existed at the beginning). The MUA responses to all stimuli show that these neuronal microsystems are polysensory. Relatively to the nonspecific activating RF macrosystem, the investigated neuronal microsystems are autonomous because their two functionally opposed response phases--the 1st excitatory and the 2nd inhibitory--occur against the monotonous excitatory background of the EEG activation. But in some way the neuronal microsystems are connected with the RF-system because of the parallel development of the extinction process.

Acoustic Stimulation↗

Extinction reveals stimulus control: latent learning of feature-negative discriminations in pigeons.

Various discriminations based on the presence versus absence of a single feature are supposedly learned much better when the feature appears on reinforced rather than nonreinforced trials. However, failures to show discriminative acquisition with the feature on negative trials could reflect a deficiency in control of performance rather than a lack of learning. Five experiments supported this alternative possibility. Pigeons that had yielded little or no evidence of learning (with distinguishing features like a small white square on the response key or a tone located some distance away) revealed clear differences between keypecking to the formerly positive and negative stimuli when all food was removed from the situation. Besides extinction, several other procedures for decreasing the positive predictiveness of the most informative stimulus element also unmasked feature-negative learning, whereas general and specific contextual changes did not. Incompletely mastered feature-positive discriminations improved during extinction, too. The findings of better discrimination performance in extinction were related to analogous effects in previous generalization and discrimination research employing other tasks and arrangements. A sign-tracking analysis could not completely account for the present results.

Animals↗

Extinction, reinstatement and spontaneous recovery of conditioned suppression in rats and the stability of conditioned inhibitor performance.

Acquisition of the suppressive properties of a conditioned stimulus (CS), terminating with shock, and of the attenuating properties of the conditioned inhibitor (CI), signaling that shock will not be given at the end of the CS, proceed at similar rates. The attenuation of suppression exerted by the CI and the decrement of the suppression due to extinction differed in both the time course and the distribution of barpresses within the CS duration. After extinction the CS still retained some suppressing properties, which were limited to the last 20-30 s, whereas the CI attenuated the suppression throughout the duration of the CS. Extinction of the suppressive properties of the CS did not change the attenuating properties of the CI. The recovery of the suppressive properties of the CS after presentations of unsignaled reinstating shocks or after a long pause in experimental sessions was incomplete and shortlasting. Both procedures did not change the properties of the CS presented in compound with the CI.

Animals↗

[Effect of electric stimulation of the somatosensory cortex and caudate nucleus on extinctive inhibition of a conditioned alimentary reflex to sound].

In experiments performed on 9 dogs with alimentary method, extinctive inhibition was deepened and its elaboration was aceelerated by electrical stimulation of somatosensory and motor cortical areas and ventral segment of the caudate nucleus head. The extinction of the conditioned reflex was slowed down by stimulation of the anterolateral gyrus and the central segment of the caudate nucleus head. General motor excitation of animals during stimulation of the dorsal zone of caudate nucleus head impaired the elaboration of extinctive inhibition.

Animals↗

[Changes in the cholinosensitivity of sensomotor cortex neurons during conditioned reflex extinction].

Characteristics of neuronal responses of the sensorimotor cortex to ionophoretically administered neuromediators (acetylcholine, L-glutamate) were studied in rabbit in the course of extinction of conditioned defensive reflex. In the majority of neurones the extinction of the conditioned reflex is accompanied by a drop of cholinosensitivity. In a number of neurones the extinction of reflexes either does not change the reaction to acetylcholine, or enhances it. The analysis of these reactions permits to assume the existence of a group of neurones directly involved in the formation, fixation and storage of the temporary connection.

Acetylcholine↗

[Avoidance learning in a social situation- extinction resistance and defense reaction under stress. A pilot study].

Two successive experiments were conducted resulting from observations of the stability (resistance to extinction) of avoidance reactions and the manifestation of such reactions beyond the specific avoidance conditions in which they were acquired: a) 15 subjects were set the task to avoid an aversive acoustic stimulus for a helpless experimental partner. They could achieve this by reacting with contraction of either the forearm or the calf muscles in a difficult discrimination task. The stability of these avoidance reactions was assessed on different levels of forced extinction. Measures taken were HR, GSR and EMG of the avoidance reactions. Specific courses of the two autonomous measures evolved (Fig. 1,2). 14 of the 15 experimental subjects showed the avoidance behaviour during all phases of forced extinction. b) Six weeks after the experimental subjects had acquired the motor avoidance reactions all subjects were exposed to a relatively unspecific stress situation. Comparisons between experimental and control group (which consisted of the experimental partners) showed a tendency but not a significant difference as far as the reaction of the calf muscles was concerned. Contraction of the forearm muscles, however, occurred significantly more often in the experimental group. The subjects executed these reactions without being aware of it.

Adult↗