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PubMed1987

Monoamines in autism: an update of neurochemical research on a pervasive developmental disorder.

Recent neurochemical studies of norepinephrine (NE), dopamine (DA), and serotonin (5HT) in autism are reviewed. Most studies of the catecholamines, their metabolites, and associated enzymes have not found differences between autistic and normal subjects. However, a robust increase in platelet 5HT has been well replicated and characterized. Studies on the possible causes of the increased platelet 5HT in autism suggest that an alteration in platelet physiology is the cause of the increase. Future directions for research on the platelet are discussed as are other potentially fruitful methods for examining monoamine functioning in autism.

Autistic Disorder↗
PubMedDate not supplied

[Children of diabetic parents--on the question of developmental disorders in pregnancy with special reference to the so-called risk child].

On the basis of 3 different patient collectives the question of the birthweight of infants with one diabetic parent is considered, and in particular whether paternal diabetes is a causative factor in the birth of macrosomatic children. Diabetes in more distant relatives is also discussed. It is confirmed that there is a relationship between diabetic metabolism of the mother and macrosomatia of the newborn; however, no influence of paternal diabetes on the birthweight of the children can be found. According to this study, miscarriages and stillbirths are more frequent in women with diabetes mellitus than in the general population. The need for intensive monitoring of the metabolism of (pre)diabetic women during pregnancy is pointed out.

Abortion, Spontaneous↗