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PubMed1993

The shear strength of polymethyl methacrylate bonded to titanium partial denture framework material.

Premachined titanium frameworks are used in implant-supported fixed complete-arch prostheses. Traditionally, retentive mechanisms are incorporated in the wax patterns to provide retention between polymethyl methacrylate and the cast framework. Nontraditional forms of retention are needed with machined frameworks. This study determined whether three different surface characteristics of titanium improve the bond shear strength of polymethyl methacrylate. Thirty rod shaped specimens of titanium were divided into three equal groups: group 1 received no pretreatment; group 2 was pretreated with 110 microns alumina air abrasive; and group 3 was pretreated with 110 microns alumina air abrasive plus silane (clear). Denture resin was processed around each specimen. A Shell-Nielsen shear test was then performed at a crosshead speed of 0.5 mm/minute to determine the bond shear strength in kilograms per square centimeter. The bond shear strength of group 3 was 63% greater than group 1 (significant, p < 0.01; ANOVA-Scheffé interval 63 kg/cm2). The results of this study indicated that surface pretreatment of titanium with 110 microns alumina air abrasive plus silane coating significantly enhances the bond shear strength of polymethyl methacrylate.

Aluminum Oxide↗
PubMed1992

Frictional coefficients of ion-implanted alumina against ion-implanted beta-titanium in the low load, low velocity, single pass regime.

The frictional coefficients were measured for four wire alloys against the flats of polycrystalline alumina cylinders using a low load, low velocity, single pass device. Ion-implantations of titanium into polycrystalline alumina flats and nitrogen into beta-titanium wires reduced the static and kinetic coefficients from 0.50 and 0.44 before implantation to 0.20 and 0.25 after implantation, respectively. These results are similar in magnitude to frictional coefficients for unimplanted, control couples of stainless steel, cobalt-chromium, and nickel titanium wires against polycrystalline alumina flats. For orthodontic applications, we conclude that more efficient and reproducible appliances can be engineered for tooth movement if ion-implantation is used to reduce the abrasion of beta-titanium by polycrystalline alumina.

Aluminum Oxide↗
PubMed1993

Studies on laser- and plasma-welded titanium.

In recent years, titanium has become a material of major interest in prosthetic dentistry. Due to its chemical properties, titanium has to be processed differently from conventional alloys. In this paper, two different methods of welding were investigated. Specimens machined from pure titanium rods were fused either by laser welding or plasma welding. Hardness profiles and light microscopy images were taken in the region of the weld. The mechanical properties were tested by alternating bending fatigue tests up to 3 million cycles. Light microscopy images and hardness profiles showed a larger heat-affected zone after plasma welding compared to laser welding. No significant differences comparing fatigue strength could be found between the two methods of welding. However, extreme loads led to earlier fatigue in the plasma-welded specimens. SEM images of the laser-welded joints showed fractures in the welding zone, while the plasma-welded specimens fractured mostly beyond the heat-affected zone. From these results, it can be assumed that both methods are suitable for welding titanium. At the moment, laser welding is the more suitable technique in dentistry because of its lower thermal alteration of the workpieces.

Dental Soldering↗
PubMed1989

Ultrastructural differences of the interface zone between bone and Ti 6Al 4V or commercially pure titanium.

Commercially pure (CP) titanium and Ti 6Al 4V alloy were sputtered onto polycarbonate plastic implants to analyse hard tissue reactions to the two metals. The implants were inserted in the tibial metaphyses of five rabbits. Three months later they were removed and processed for light microscopy (LM) and transmission electron microscopy (TEM) investigations. At the LM level, disordered woven bone was seen in the interface zone of Ti 6Al 4V, whereas organized bone was observed in direct contact with the CP titanium implants. TEM examination of Ti 6Al 4V sections revealed a 500-1000 A thick collagen-free proteoglycan layer compared to 200-400 A for CP titanium. A surface analysis test was performed to compare the magnetron sputtered film with bulk Ti 6Al 4V alloy. This test revealed no major differences between the experimental implant and the bulk alloy. More natural-like tissue reactions were observed to CP titanium than to Ti 6Al 4V alloy.

Alloys↗
PubMed1989

Osteocompatibility of platinum-plated titanium assessed in vitro.

Suppression of dissolution is important to increase the biocompatibility of titanium implants. Therefore, the possibility of application of platinum-coated titanium as a biomaterial was explored in in vitro experiments using the MC3T3-E1 osteogenic cell line. The data obtained from long-term cultures indicated that pure platinum or titanium thickly coated with platinum inhibited calcification significantly, suggesting that the platinum ion fails to improve the osteocompatibility of titanium implants.

Alkaline Phosphatase↗
PubMed1993

Histological reaction to titanium alloy and hydroxyapatite particles in the rabbit tibia.

The interfacial membrane harvested from failed joint replacements contains particulate debris from the materials used for the implant. To define the tissue response to particulate titanium alloy and hydroxyapatite (HA) alone, 16 mature New Zealand white rabbits were divided into 2 groups of 8 rabbits. Using sterile technique, a drill hole was placed anteromedially in the tibia, 1 cm distal to the knee joint bilaterally. The marrow was scooped out and 0.25 mg of either titanium alloy particles or HA particles were inserted in the right tibia. The titanium alloy particles had a diameter averaging 4.0 +/- 4.4 microns (mean +/- standard deviation) and an aspect ratio (the ratio of the maximum length divided by the maximum width) of 1.84. The HA particles had a diameter of 4.4 +/- 3.3 microns and an aspect ratio of 1.76. The left leg was prepared in a similar fashion, but no biomaterial was implanted. The animals were killed after 16 wk. The harvested tibiae were processed with decalcification and the plastic-embedded sections were subjected to histomorphological analysis. Black titanium alloy particles were present within the bone marrow fat between haematopoietic cells, and within scattered macrophages. The surrounding bone appeared to be unaffected. Within the spongiosa, the HA particles were surrounded by small numbers of mononuclear histiocytes or encased within a shell of new appositional bone. Where HA deposits were exposed to the endosteal aspect of bone, there was scalloping of the surface of the HA in a pattern suggestive of resorption or dissolution of the HA particles.(ABSTRACT TRUNCATED AT 250 WORDS)

Alloys↗
PubMed1993

Effect of pore sizes and cholesterol-lipid solution on the fracture toughness of pure titanium sintered compacts.

Commercial pure titanium has been widely used as an implant material because of its excellent biocompatibility and good ductility. To determine the effect of pore size on the fracture resistance of porous titanium compacts, a series of fracture toughness (KQ) tests were performed on commercial pure titanium powder compacted to 0.17 and 0.62 GPa. Pore sizes ranged from 25 to 103 microns, with porosity between 8.5 and 35%. Two sets of fracture toughness tests using disc-shaped compacts (ASTM E 399-90) were performed, the first in air at 37 degrees C and the second with compacts treated in cholesterol-lipid solution at 37 degrees C. The KQ value of compacts with a smaller mean pore size (ca. 50 microns) was approximately twice that of the compacts with a larger mean pore size (100 microns). The effect of cholesterol-lipid solution treatment was detrimental, perhaps due to preferential lipid absorption by the titanium oxide and/or the presence of chlorides. For the smaller pore size compacts, the KQ values decreased by up to 20%. For the larger pore size compacts, the effect of cholesterol-lipid solution was less significant. Morphologically, compacts with smaller pore size had a predominantly ductile fracture with significantly higher dimple density than the larger pore size compacts.

Cholesterol↗
PubMed1996

Platelet binding and protein adsorption to titanium and gold after short time exposure to heparinized plasma and whole blood.

Protein adsorption from human plasma and platelet binding and activation were studied at short blood-titanium/gold contact times. The protein adsorption was studied by ellipsometry-antibody techniques in situ, and adhering platelets were visualized with fluorescein isothiocyanate-labelled anti-CD 61 antibodies. Adhering platelets were quantified by counting labelled cells in microscopic image fields. The spreading of platelets was studied by scanning electron microscopy. The results show that after 1 min of plasma exposure, fibrinogen, IgG and albumin were detectable with antibodies on both surfaces. The amount of deposited fibrinogen and complement decreased with time on titanium, and the amount of adsorbed anti-high molecular weight kininogen increased. No complement was detected on gold surfaces after plasma incubation, and the antibody binding pattern also remained unchanged after prolonged plasma exposure. The surface-bound platelets were found to spread on the gold but not on titanium surfaces. C1q has been shown to induce the expression of P-selectin, i.e. cause secretion reactions in platelets. In this study secreted platelet-microvesicles were found on gold, but not on the titanium surfaces that bound significant amounts of C1q. Thus, the results of the present study indicate that the mixture of fibrinogen, C1q and kininogens, whilst causing adhesion and aggregation, does not result in the activation and microvesicle secretion of platelets. Platelet activation on biomaterial surfaces thus seems to be governed by the mixture of proteins present on that surface, and no one particular protein need cause a known reaction in platelets as obtained when platelets are exposed only to that particular protein.

Adsorption↗
PubMed1996

Immunohistochemical studies on the distribution of albumin, fibrinogen, fibronectin, IgG and collagen around PTFE and titanium implants.

Time-dependent distribution of extracellular proteins (albumin, fibrinogen, fibronectin, collagen-I and IgG) in the interface zone between implant and soft tissue has been investigated utilizing a recently developed method. Commercially pure (c.p.) titanium and polytetrafluoroethylene (PTFE) implants were inserted in the abdominal wall of rats for 1, 6 and 12 weeks followed by a mild fixation, cryoprotection, rapid freezing in LN2-cooled propane, cryosubstitution and low-temperature infiltration with UV curing of the methacrylate LR-Gold. Before sectioning, the bulk part of the titanium was removed by an electrolytical dissolution technique (electropolishing), while the PTFE implants were removed by a fracture technique. Employing a cryosubstitution method combined with postembedding immunohistochemistry, a light microscopic analysis was allowed. The selected proteins had an apparently varying distribution in the implant-close tissue and their distribution changed during the follow-up period. There was also a difference in the distribution pattern for each protein around titanium and PTFE implants. Insertion of the c.p. titanium implants elicited an inflammatory reaction in many respects similar to a normal wound healing response, while the PTFE implants caused a more pronounced, persistent inflammation.

Abdominal Muscles↗
PubMed1995

Infection adjacent to titanium and bone cement implants: an experimental study in rabbits.

A pure titanium cylinder or a piece of bone cement was implanted in each upper tibial metaphysis of 20 rabbits. After 4 months radiograms were taken and 10(4), 10(6), or 10(8) Staphylococcus aureus were injected into each leg through central holes in the implants in three groups of animals. Four weeks later new radiograms, bacteriological and histological biopsies were obtained. Three animals died before the end of the experiment. In animals which received 10(6) or 10(8) S. aureus radiographic signs of infection were found in 11/22 legs with both titanium and bone cement implants. No radiolucent zones developed around the implants. Bacteriological cultures from bone close to the implants were negative in all legs with titanium implants and positive in four legs with cement implants. Seven cultures were negative in spite of radiographic changes. It is concluded that after a proper time for wound healing the bone around unloaded implants of both titanium and bone cement is fairly resistant to infection. In some cases, healing of an infection in the surrounding bone seems possible.

Animals↗
PubMed1996

Tissue reaction to Dacron velour and titanium fibre mesh used for anchorage of percutaneous devices.

Dacron velour is often used to anchor a percutaneous device, like the catheter used in peritoneal dialysis. However, exit-site infections complicate this method of dialysis and are supposed to be related to the design of the catheter. In animal experiments, a percutaneous device provided with a titanium fibre mesh to anchor the implant was not affected by infectious complications. The purpose of this study was to compare the differences in soft tissue reaction to Dacron velour and titanium fibre mesh under the same experimental conditions. Therefore, we placed implants, provided with either Dacron or titanium mesh, subcutaneously in the dorsum of goats. The implants were left in situ for 4 months. Histological and histomorphological evaluations were performed. It was found that the soft tissue response inside the Dacron was mainly inflammatory, while the titanium mesh evoked good biocompatible behaviour. We concluded that the limited fibrous tissue ingrowth into the Dacron cuff has to be the reason for the observed high failure incidence of a percutaneous device.

Administration, Cutaneous↗
PubMed1991

Bone replacement with porous hydroxyapatite blocks and titanium screw implants: an experimental study.

The aim of this experimental study was to examine whether porous hydroxyapatite (HA) blocks, fixed with titanium screw implants, could be used as a bone graft substitute. Twenty minipigs received coralline HA blocks for augmentation of surgically created defects in edentulous mandibles. Each block was fixed with two titanium screw implants. Two types of porous HA blocks that differed in pore diameter were used. A high rate of HA loss occurred in the group of animals that had received the HA block with small pore sizes, and fractures of the block occurred in the vicinity of the titanium implants in 12 of the remaining 13 cases. Histologic examination showed that the HA blocks with larger pore size were homogenously penetrated by bone that extended into the central pores and even incorporated the dislocated block fragments. The titanium implants were in close contact with the newly formed bone in these blocks. Little contact between bone and implants was seen in the HA blocks with the smaller pore size. The results indicate that, with improved mechanical properties, a combined augmentation with porous HA blocks and screw implants may be useful in primary reconstruction of bone defects.

Alveolar Ridge Augmentation↗
PubMed1995

Frontonasal suture expansion in the rabbit using titanium screws.

PURPOSE: This study investigated the ability to use titanium screws to provide stable skeletal points in the growing craniofacial region of the rabbit for suture expansion. These screws provided sites for direct application of external forces to alter growth and anatomic form. MATERIAL AND METHODS: Twenty-one rabbits (30 days old) were divided into three groups: control (n = 9), experimental (n = 9, and sham (n = 3). Four four-holed AO/ASIF commercially pure titanium craniofacial plates were contoured into an L-shape with a 90 degree angle at the midpoint. The plates were placed bilaterally in the frontal and nasal bone sites and secured with 2.0-mm diameter, 4-mm long, commercially pure titanium screws in both the sham and experimental groups. After 4 week of healing, a spring mechanism with a distraction force of 55 g was activated between ipsilateral plates and across the frontonasal sutures bilaterally in the experimental group for 5 weeks. No force was applied between the plates in the sham group. A preliminary evaluation of the bone-implant interface and the changes in the suture was done histologically. Morphologic changes were measured using cephalometric radiographs and direct anatomic measurements. RESULTS: The experimental group showed a significant increase in growth across the frontonasal suture in comparison with the sham group (P < .05). In addition, an increase in the length of the nasal and frontal bones in the expanded group was observed in comparison with the control and sham groups (P < .05). Histologically, a mixture of woven and lamellar bone was seen in the suture region and lamellar bone was seen in the screw-bone interface. CONCLUSION: This study indicates that titanium screws in the developing rabbit skull can provide stable sites for the direct application of external forces, producing secondary changes in skeletal morphology. This laboratory models provides a useful system for the further study of growth modification using such external mechanical forces.

Animals↗
PubMed1994

Study of corrosion between a titanium implant and dental alloys.

The infiltration of saliva into the multi-metallic structures on titanium implants brings different types of alloys into temporary or permanent contact. In this way a galvanic cell is established as a result of their potential difference. The galvanic cell phenomenon is compounded by another type of corrosion resulting from the geometry of the assembly: localized crevice corrosion. Fifteen galvanic couples (Ti/gold-based alloys, Ti/palladium-based alloy and Ti/non-precious alloys) were studied. Various electrochemical parameters (Ecorr, Ecommon, Ecouple corr, Ecrevice, icorr, icouple corr and Tafel slopes) were analysed. The galvanic currents measured are of the same order of magnitude (except Ti/stainless steel). They remain low. Application of the mixed-potential theory shows that titanium in coupling with the alloys studied will be under either cathodic or anodic control. According to the results obtained, an alloy that is potentially usable for superstructures in a galvanic coupling with titanium must fulfil a certain number of parameters: in a coupling, titanium must have a weak anodic polarization; the current generated by the galvanic cell must also be weak; the crevice potential must be markedly higher than the common potential.

Chromium Alloys↗
PubMed1992

Mechanical failure of hydroxyapatite- and polysulfone-coated titanium rods in a weight-bearing canine model.

Three types of material that have shown potential as coatings for orthopaedic implants were studied. Using a weight-bearing canine model, Ti-6A1-4V femoral intramedullary rods coated with (1) sintered titanium beads, (2) plasma-sprayed hydroxyapatite, and (3) silyl coupled polysulfone beads were evaluated for mechanical strength and bone ingrowth. The model was designed to secure optimal prosthetic stability by obtaining maximal bony ingrowth during an initial non-weight-bearing phase, then stressing the implant during a full-weight-bearing phase. None of the rods coated with titanium beads failed. All 17 polysulfone-coated rods failed, 13 of them at the interface between the polysulfone coating and the titanium core. Of 18 rods coated with hydroxyapatite, 15 suffered implant breakdown at the interface between the hydroxyapatite coating and the titanium core. This may be due to dissolution of the plasma-sprayed hydroxyapatite in vivo. Testing of retrieved specimens from both hydroxyapatite- and polysulfone-coated implants showed that the shear strength at the coating-rod interface had decreased to less than 40% of the shear strength at manufacture. Despite mechanical failure, histologic study showed extensive bone ingrowth or apposition onto both the polysulfone and hydroxyapatite coatings.

Animals↗
PubMed1991

Static frictional force and surface roughness of nickel-titanium arch wires.

Surface roughness and static frictional force resistance of orthodontic arch wires were measured. Nine nickel-titanium alloy arch wires were studied. One beta-titanium alloy wire, one stainless steel alloy wire, and one cobalt-chromium alloy wire were included for comparison. Arithmetic average roughness in micrometers was measured with a profilometer. Frictional force resistance was quantified by pushing wire segments through the stainless steel self-ligating brackets of a four-tooth clinical model. The cobalt-chromium alloy and the nickel-titanium alloy wires, with the exception of Sentalloy and Orthonol, exhibited the lowest frictional resistance. The stainless steel alloy and the beta-titanium alloy wires showed the highest frictional resistance. The stainless steel alloy wire was the smoothest wire tested, whereas NiTi, Marsenol, and Orthonol were the roughest. No significant correlation was found between arithmetic average roughness and frictional force values.

Chromium Alloys↗
PubMed1992

Load-deflection characteristics of nickel-titanium alloy wires after clinical recycling and dry heat sterilization.

The desirable mechanical properties of nickel-titanium alloy wires and their relatively high cost has prompted many clinicians to recycle these wires. Clinical recycling exposes the wires to several weeks or months of mechanical stresses and elements of the oral environment, as well as sterilization between uses. In a previous study it was noted that clinical recycling combined with cold sterilization alters the load-deflection characteristics and surface topography of nickel-titanium wires. Whether similar changes in mechanical properties occur in wires subjected to repeated clinical use and dry heat sterilization is not yet clear. The purpose of this investigation was to determine the effects of in vivo recycling interposed by dry heat sterilization (together referred to as clinical recycling, CR) on the load-deflection characteristics of nickel-titanium alloy wires. To differentiate the effects of dry heat sterilization (DHS) from those of CR on the behavior of these wires, a series of wires were also subjected to DHS only. Two types of nickel-titanium wires, namely Nitinol and NiTi were subjected to a three-point bending test in an as-received condition (T0), after one cycle (T1), and two cycles (T2) of DHS or CR. Ten wires comprised each subsample. Statistical analyses were done by one-factor repeated measures analysis of variance and Scheffe F test. Both DHS alone, as well as CR, produced significant changes in the loading and unloading characteristics of Nitinol and NiTi wires. However, the changes in the load-deflection characteristics of these wires after DHS only were relatively small, and the clinical significance of these changes is open to question.(ABSTRACT TRUNCATED AT 250 WORDS)

Alloys↗
PubMed2006

Hydroxyapatite grafting promotes new bone formation and osseointegration of smooth titanium implants.

Titanium is the ideal metal for intra-osseous dental implants. It permits the natural formation of an oxide layer on its surface and thereby it prevents the release of potentially toxic molecules. New formation of bone around implants, partially placed into the bone marrow cavity, is a gradual process that runs from the endosteum to the surface of the implant. Deposition of hydroxyapatite crystals on collagen type I fibrils is initiated by acidic proteins and leads to bone mineralization. This study analyzed the effects of hydroxyapatite upon peri-implant bone formation after insertion of smooth titanium implants. Screw-shaped smooth titanium implants of 3.75 mm thickness and 8.5 mm length were inserted into the metaphysis of rabbit tibia, either together with bovine hydroxyapatite into the right tibia or in controls without hydroxyapatite into the left tibia. Polyfluorochrome tracers (alizarin complex, calcein, tetracycline) were injected subcutaneously at different time intervals after implantation to evaluate the time frame of bone new formation over a period of 8 weeks. All samples were processed for histology and analyzed by fluorescence and polarizing microscopy. Our results showed a higher quantity of mature type I collagen fibers around implants and an acceleration of bone formation in the presence of hydroxyapatite. Mainly immature organic matrix was formed at the surface of implants in controls. The presence of hydroxyapatite seems to promote the maturation of collagen fibers surrounding the titanium implants and to support osteoconduction. Moreover, new formation of bone was faster in all samples where implants were inserted together with hydroxyapatite.

Animals↗