[Prevention is the guarantee of animal conservation].
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Rejection of tissue- and organ-grafts is due to the existence of tissue- or transplantation-antigens which are present in principle on every nucleated body-cell. These tissue antigens represent the phenotypical expression of a complex system of genes which are localized on an autosomal chromosome: the histocompatibility system. These systems may usually be compared with bloodgroup systems. Besides the successful use of tissue typing in transplantation, it became apparent that histocompatibility systems may have another function. Among others, tissue typing may be correlated with resistance to and susceptibility to particular diseases. However, it is not clear so far whether tissue antigens play a role themselves or only serve as genetic markers in this regulation of the immune response. The two possibilities are introduced, together with some instances. Finally, on the basis of possible veterinary and economic importance, studies on histocompatibility systems in pets and farm animals are reviewed, a number of possible uses being suggested.
A review of the literature concerning chlamydial infection in birds and animals, particularly domestic animals is presented. Following a general discussion of the agent, the nature of chlamydial infection and diagnostic criteria, information regarding disease is summarized for each species. The possibility of zoonotic transmission is also discussed.
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High levels of seropositivity, in all probability attributable to Ehrlichia, were recorded in the serum of domestic ruminants throughout districts in South Africa where Amblyomma hebraeum, the vector of the heartwater agent, does not occur. The antibodies, detected with the indirect fluorescent antibody (IFA) and the indirect ELISA tests, cross-reacted with Cowdria ruminantium, which was used as antigen in both tests. A combination of the IFA and ELISA tests, currently employed to detect antibodies to C. ruminantium, facilitates the handling of appreciable numbers of sera and ensures maximum reliability.
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Following an earlier report that an Ehrlichia-like agent isolated from an adult Hyalomma truncatum female became more pathogenic and elicited a disease in sheep indistinguishable from heartwater after having been passaged through Amblyomma hebraeum, a similar phenomenon is herewith recorded. An ehrlichial agent demonstrated in the blood smear of a serologically positive, naturally infected lamb, changed in behaviour and assumed the characteristics of Cowdria after passage through A. hebraeum. Cross-immunity between sheep that had recovered from infection with the transformed agent and several stocks of Cowdria ruminantium confirmed the close relationship between the putative ehrlichial agent and Cowdria. Seven other sheep/tick passage lines resulted in high antibody titres and resistance to challenge with C. ruminantium in the sheep in the case of 2 of them, suggesting a similar change in behaviour of the agents passaged through Amblyomma.