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Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

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A survey of electronic drug information resources and identification of problems associated with the differing vocabularies used to key them.

Drug information resources are increasingly becoming electronically available. They differ in scope, granularity, and purpose. These considerations have shaped the selection of dissimilar drug name keys, complicating access. An abbreviated and simplified historical context of the development of official controlled vocabularies and their relationships is followed by a review of the kinds of information available in several electronic drug information resources. The key vocabularies used are discussed with examples. Problems using the differing terms of the resource vocabularies are identified.

Abstracting and Indexing↗

From ICD9-CM to MeSH using the UMLS: a how-to guide.

One purpose of the Unified Medical Language System (UMLS) is to facilitate conversion of terms from one controlled medical vocabulary to another. We examined our ability to convert International Classification of Diseases, 9th Edition, Clinical Modifications (ICD9-CM) to Medical Subject Headings (MeSH) using the UMLS. We describe a method which mapped 30.4% of ICD9-CM to UMLS. Of these, 95.0% were linked to MeSH, of which translation was straightforward in 90.4%. We discuss the use of these translations for retrieval from MeSH-indexed databases, such as Medline.

Disease↗

[Scientific writing: the choice of references].

Only "acceptable" references can be cited, i.e. references that the reader can find easily. Only published work must be referenced, and the author must only cite those papers he or she has actually read. These should be avoided, as they are always difficult to obtain. Conference abstracts are published either in the conference report handed to participants alone, or in special issues of journals. Only the latter should be cited, when necessary. References to oral presentations are not accepted. References to personal communications should not be included in the list of references. The author cited must have given express permission. "Secondhand" references, i.e. those the author has not taken time to read yet quotes nonetheless, are prohibited. Manuscripts submitted for publication should not be cited. Articles accepted for publications can be referenced as "In press; "name of journal"".

Bibliographies as Topic↗

Common side effects.

Explore the source record for details and available documents.

Drug-Related Side Effects and Adverse Reactions↗

A review of postmenopausal hormone therapy recommendations: potential for selection bias.

OBJECTIVE: To survey the advice given to physicians in regard to postmenopausal hormone therapy, and thus to find out indirectly whether selective prescribing may have contributed to the findings of health effects. DATA SOURCES: Surveys on the health benefits of postmenopausal therapy were identified from previous reviews. Experts in various fields were consulted regarding relevant textbooks, and recommended booklists were used. METHODS OF STUDY SELECTION: Most of the surveys were conducted in the United States and concerned only estrogens; therefore, we focused on these data. Advice given to United States physicians on estrogen prescribing was abstracted from the Physicians' Desk Reference, five textbooks, and other sources written between 1945-1990. DATA EXTRACTION AND SYNTHESIS: In advice given to physicians, there was concern that estrogens could cause cancer. In addition, it was not recommended to give estrogens to women in poor general health. Advice concerning cardiovascular diseases and estrogens was contradictory and variable. CONCLUSIONS: If the advice observed reflects the prescribing practices of physicians, then surveys on the health impact of estrogen therapy may have underestimated the risk of breast cancer and overestimated the prevention of fractures. The impact on studies of cardiovascular diseases is less clear, and other mechanisms of selection bias may have been more important.

Breast Neoplasms↗

Information-seeking behavior: a survey of health sciences faculty use of indexes and databases.

This study investigated information-seeking behavior, including use of major bibliographic tools by medical, pharmacy, nursing, and science faculty at the University of Illinois at Chicago. The study assessed the impact of availability of locally mounted databases, determined needs for modification of instructional programs, identified the need for promotional material, and established a baseline for subsequent studies. Results reflected a wide variation in the number and format of secondary services used by faculty. Over 70% of all faculty from the colleges of medicine, pharmacy, and nursing used Index Medicus or MEDLINE. There were statistically significant differences between colleges in their use of mediated and end-user searching of MEDLINE. Colleges exhibited significant differences in use of Current Contents, PsycLIT, ERIC, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Chemical Abstracts, and Science Citation Index. Statistically significant differences also were found among several clinical departments. The study concluded that, as new formats to bibliographic tools become available, traditional formats continue to be used; training sessions must be tailored to the audience; and the availability of local resources and their use by faculty needs to be understood.

CD-ROM↗

The Physicians' Desk Reference. Problems and possible improvements.

The Physicians' Desk Reference (PDR) is a widely used source of drug information by American physicians and patients, but as we shall discuss, it suffers from numerous shortcomings. The PDR is a collection of written and pictorial information that is provided and paid for by pharmaceutical manufacturers. The written material for a given drug is a compilation of data and recommendations that are identical to those in the drug's package insert. The wording and directives that are included in these package inserts (and thus in the PDR) represent information that the pharmaceutical companies are permitted to present following discussion and approval by the Food and Drug Administration (FDA), Rockville, Md. The PDR is thus a negotiated effort of commercial enterprises and governmental regulators.

Aged↗

An 1836 career guide to dentistry.

In a guide to careers published in 1836 one chapter is dedicated to dentistry. It gives a basic account of teeth and of the work of the dentist.

Career Choice↗

A compilation of Good Laboratory Practice questions and (where to get the) answers.

Since the inception of the Food and Drug Administration's Good Laboratory Practice Regulations and Environmental Protection Agency's Good Laboratory Practice Standards, many "questions and answer" documents have been produced. Our purpose in this presentation is to pull together some of these reference documents and provide a cross-reference index to sort through the many topics and questions. The combined reference resource and index provide the quality assurance professional a useful Good Laboratory Practice information tool.

Facility Regulation and Control↗