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Locally extensive renal cell carcinoma--current surgical management of invasion of vena cava, liver, or bowel.

Review of a personal and combined experience in cases of renal cell carcinoma invading the vena cava, liver, or bowel, has been carried out. The methodology in each of these situations is described. The long term results for survival after vena cava invasion are less than 20% at 5 years--lower than previous optimistic estimates. The long term survival with invasion of the liver or bowel is negligible. However, excellent palliation is achieved and the urological surgeon should be prepared to carry out the additional resection of adjacent invaded liver or bowel to achieve palliative nephrectomy in such cases when the invasion is found at the operating table.

Adenocarcinoma↗

"Stone heart" in a neonate.

A neonate presented at this institution in September, 1978, with interrupted aortic arch complex, including ventricular septal defect, atrial septal defect, and patent ductus arteriosus. Additional anomalies included bilateral cleft lip and palate, low set ears, and bilateral colobomas. One-stage total correction of the interrupted aortic arch complex was undertaken with standard hypothermic techniques. The repair was completed within a 65 minute period of circulatory arrest at 18 degrees C, perfusion was re-established, and the patient was returned to normothermia. Tetanic contracture of the myocardium, stone heart, was evident at 27 degrees C. Cardiac action did not resume despite several therapeutic maneuvers, and the infant died on the operating table. Extensive calcium flooding was a notable feature on histological sections of the heart, associated with myofibrillar degeneration (contraction bands). This complication has never been reported before in a neonate with congenital heart disease. Deep hypothermia did not prevent ischemic contracture of the myocardium, and this complication must now be added to an already lengthy list of complications of neonatal heart surgery.

Abnormalities, Multiple↗

[Tracheal replacement with a swine prosthesis].

In 12 experimental operations the authors tested the biocompatibility of a xenologous trachea from a pig which was used to replace a 5 cm defect of the trachea in a dog. After special preparation eliminating the antigenicity of the pig trachea the thus prepared graft was sutured into the thoracic portion of the dog trachea. The experiment could not be evaluated in two instances because the dog died on the operating table. In the remaining ten cases it was found that all anastomoses healed perfectly. The fibrous tissues of the tunica propria of the graft was replaced by granulation tissue. Across the anastomoses newly formed capillaries penetrated into the trachea where they caused chondrolysis. This led to a breakdown of the central portion of the prosthesis and stenosis in the airways with terminal respiratory failure. The mucosa of the graft was at some sites covered by metaplastically altered epithelium. Even a reinforcing vascular prosthesis did not prevent the breakdown of the wall of the xenologous graft. An asset for future work is the finding of a well healed suture between the graft and the trachea and evidence that newly formed blood vessels penetrated into the prosthesis.

Animals↗

Spinal anesthesia for cesarean delivery. A comparison of two doses of hyperbaric bupivacaine.

BACKGROUND AND OBJECTIVES: Hyperbaric local anesthetic pools in the thoracic spinal curvature in supine patients. The authors hypothesized that patients receiving 12 or 15 mg of hyperbaric bupivacaine would achieve similar levels of sensory block but the spinal anesthetic would be denser and longer lasting in patients receiving the 15 mg dose. METHODS: Twenty eight healthy term parturients scheduled for elective cesarean delivery randomly received 12 or 15 mg hyperbaric 0.75% bupivacaine in 8.25% dextrose. Patients were in the right lateral position during drug injection and were then positioned supine with left uterine displacement on a horizontal operating table. A blinded anesthesiologist assessed the dermatome level of sensory analgesia to pinprick every 2 minutes for 20 minutes, then every 15 minutes until the sensory level regressed to T10. RESULTS: The mean level of sensory anesthesia was 2.2 spinal segments higher in patients receiving 15 mg versus 12 mg hyperbaric bupivacaine (24.8 +/- 3.7 versus 22.6 +/- 1.4 spinal segments; P = .031). Regression to T10 occurred more quickly in the 12 mg than in the 15 mg group (140.0 +/- 16.5 versus 162.1 +/- 33.8 minutes, P = .046). Patient height did not correlate with the maximum number of spinal segments blocked in either group. All patients had adequate surgical anesthesia. CONCLUSIONS: Parturients receiving 15 mg of hyperbaric bupivacaine developed a higher mean level and longer duration of sensory analgesia than those receiving 12 mg.

Adult↗

[Use of laryngeal mask in a female patient with expected difficult intubation, polyvalent allergy and high grade myopia].

Use of laryngeal mask in combination with gastric intubation permitted anesthesia for laparoscopic cholecystectomy in a female patient with disseminated osteochondrosis of the spine, expected difficult intubation, manifest polyvalent allergy, neurocirculatory dystonia of the hypertensive type, and high myopia. The risk of anesthesia was higher than surgical risk because of manifest concomitant diseases and aggravated anesthesiologic anamnesis. The operation was effective, anesthesia involved no complications, hemodynamics and gas exchange were stable, the patient awakened on the operation table and after recovery of adequate spontaneous respiration and muscular tone was transferred to resuscitation ward.

Anesthesia↗

Crossed testicular ectopia with fused bilateral duplication of the vasa deferential: an unusual finding in cryptochidism.

A case of a one year and ten month old boy with crossed testicular ectopia, fused vasa deferentia, and common processus vaginalis containing both testes is reported. This is the first case of transverse testicular ectopia we have come across since 1978. Diagnosis was made on the operation table as the child came for repair of right inguinal hernia. Right testis was palpable in the groin; the left testis was not palpable anywhere along the pathway of descent. Because of ductal fusion, both testes were brought down on the right side to avoid damage during separation and placed in either hemiscrotum through transceptal window.

Abnormalities, Multiple↗

[Correlations between folic acid, human papilloma virus (HPV) and cervix neoplasms].

The study aimed to verify the probable correlation between the incidence of cervical cancer and the presence of human papilloma virus (HPV) in relation to a state of folic acid hypovitaminosis. In this context, however, it is important not to overlook the important protective role played by vitamins A and C in cancer prevention, as mentioned in the paper. Numerous authors agree that this is a real finding in cervical pathology, as shown in our research, even if folic acid therapy does not alter the course and prognosis of disease. On the contrary, low blood levels of folic acid appear to increase the risk of contracting the disease. Extensive and radical surgery therefore appears to be even more justified in order to increase the probability of recovery on the operating table in view of the irrational and inexorable progress of this pathology, especially if metastases are already present.

Adult↗

[The principles of the surgery of parasagittal meningiomas: the current status of the problem].

Based on the data available in the literature and their own findings of 1200 operations for removal parasagittal meningiomas, the authors give recommendations on the planning of diagnostic and therapeutical measures for this common abnormality. Technical features of each stage of the operation (a patient's position on the operating table, section of the skin, trepanation, section of the dura mater, etc.) are discussed. It is stressed that there is a need for manipulations at the site of the tumour matrix just after removal of its basic mass. Plastic aspects of the upper sagittal syndrome are discussed in the paper too.

Adult↗

[Percutaneous transluminal angioplasty for progressing stroke caused by severe basilar artery stenosis: case report].

We encountered one case of progressing stroke caused by severe basilar artery stenosis. The patient was treated with emergent percutaneous transluminal angioplasty (PTA) with satisfactory results. A 54 year-old woman was admitted 15 minutes after the sudden onset of rt. hemiparesis, rt. hemidysesthesia, dysarthria and consciousness disturbance. CT scan on admission showed no abnormal findings. The consciousness level of the patient deteriorated rapidly from JCS 1 to JCS 20 within 30 minutes from the ictus. An emergent angiogram revealed severe basilar artery stenosis at its middle portion and poorly developed collateral circulation. One hour after the stroke occurred, PTA was performed. Using a 3mm diameter balloon catheter, we introduced the balloon into the stenotic lesion and inflated it 6 times from 4 atm to 8 atm pressure. The patient recovered immediately on the operating table improving from JCS 20 to JCS 1. Rt. hemiparesis also improved. Follow-up MRI showed a small area of ischemic change in the brain stem, but no large infarction appeared. The patient was discharged with no neurosurgical deficits after 30 days of PTA. PTA for basilar artery stenosis is still a controversial subject. One reason is the risk of basilar artery perforating branches occlusion by balloon catheter and the other is the difficulty of introducing a flexible balloon catheter into the basilar artery beyond the acute angulation of the vertebral artery. If those two problems were solved, PTA would be the first-choice therapy for basilar artery stenosis in both acute and chronic stages.

Acute Disease↗

[Anatomic correction of transposition of the great arteries in infants:experience of the first 10 operations].

In the period March 1992 to January 1993, ten patients with transposition of great arteries (TGV) whose age ranged from 9 days to 8 months and body weight 3.2 to 7.2 kg were operated on using the arterial switch. A single-stage anatomic correction was made in 2 patients with patent arterial duct, 4 with ventricular septal defect (VSD), one with multiple VSD. Three patients with common TGA underwent correction in 2 stages: arterial switch followed prior constriction of the pulmonary artery switch followed prior constriction of the pulmonary artery and subclavian-pulmonary anastomosis. In all cases of single VSD, it was closed with a flap made from the Gore-Tex material. In the whole series of operations, 2 patients died: one being on the operating table due to anesthesiological errors, the other due to coronary blood flow disorder 3 hours after surgery. Six of the 8 discharged patients were followed 3-8 months after surgery. Two patients needed digitalis. No sign of myocardial ischemia was detected in antibody. All the patients were found to have normal left ventricular pump function. These surgeries are the first in our country and so our little experience may be of interest for national specialists.

Arteries↗

Endolaser photocoagulation after vitrectomy on rabbit's eyes.

Ophthalmoscopic and histopathologic studies of endolaser photocoagulation after vitrectomy were carried out on rabbit's eyes. The endoprobe was connected to the Coherent "Novus 2,000" argon laser system. Under appropriate application the grayish white retinal lesions produced by argon green and argon all wavelength endolaser photocoagulation were similar ophthalmoscopically at a treatment power of 80-100 mw and exposure duration of 0.2s. Histopathologically, the characteristic changes of the retinal lesions produced by argon all wave-length were more significant than that produced by argon green endolaser photocoagulation. Scattered retinal photocoagulation can be done when the opaque medium is cleared on the operating table.

Animals↗

Intraoperative mapping of atrial activation before, during, and after the Mustard operation.

Thirty-eight patients with transposition of the great arteries underwent intraoperative mapping of atrial epicardium and endocardium during various stages of the operative procedure. The purpose was to determine the electrophysiological basis of the postoperative supraventricular arrhythmias associated with this operation. Comparisons were made between atrial activation patterns and times before and after each of the following stages: (1) cannulation, (2) atriotomy, (3) excision of atrial septum and coronary sinus, and (4) placement of intra-atrial baffle. The first stage produced no significant changes in atrial activation times or patterns but did demonstrate a shift of the functional pacemaker to the sulcus terminalis in 8 of 14 patients studied. Longitudinal atriotomy did not significantly lengthen atrial activation. Transverse atriotomy did not alter activation times of the His bundle but did significantly change patterns of epicardial and endocardial activation. Excision of the septum and coronary sinus always produced block in the posterior crista terminalis, and placement of a baffle worsened this block. Four patients developed nodal rhythm on the operating table and had both a posterior crista terminalis block and anterior septal block. Suggestions for modification in the surgical techniques were advanced to help prevent rhythm disturbances in paitients undergoing transvenous correction of transposition of the great arteries.

Arrhythmias, Cardiac↗

Human neuro-specimen banking 1961-1992. The National Neurological Research Specimen Bank (a donor program of pre- and post-mortem tissues and cerebrospinal fluid/blood; and a collection of cryopreserved human neurological specimens for neuroscientists).

The National Neurological Research Specimen Bank (The Bank) was established in 1961 to provide a vital service to neuroscientists. Our purpose is to support medical research which seeks the etiopathogenesis for devastating neurological disorders with no known cause, treatment or precise animal model. It serves as a bridge between the neurology clinician who diagnoses and cares for patients with incurable disease and the basic scientist who has need for specimens to find their etiopathogenesis. In the long run this service should advance neurologic diagnoses and serve as the basis for designing treatment. The Bank has grown to be the largest, most diverse neurological specimen bank of its kind in the world. It is a type of "tissue bank" where donor members "will" their central nervous system tissues to science. Then we collect, photograph, seal in air tight bags, quick freeze, cryogenically store and distribute on request the donated tissue to research scientists around the world. All tissue diagnoses are confirmed by clinical records and neuropathologic examination; further histology is conducted on request. In addition to brain and spinal cord tissues, the Bank has samples of other tissues. There are also samples of pre- and post-mortem CSF and sera from normal individuals and patients with various neurological disorders, especially serial specimens on multiple sclerosis patients and HIV-1 seropositive and at risk individuals. This paper outlines the global operations of our human brain bank, based on protocols developed and used by the authors. These operations include donor solicitation, tissue acquisition and documentation, tissue processing and storage, specimen dissemination to users, outcome assessment of banking, quality control, cost of our operation, table of organization and the future.

Blood Donors↗

Wire holder: a new adjunct for sternal closure.

A new 5 inch clamp with a tungsten carbide insert used for holding the sternal closure wires on an end-to-end fashion is described. This clamp provides a much better grip and longer wear than stainless steel owing to the tungsten carbide insert. The length of the clamp allows the surgeon a firm grip on the wire, and the wire can be easily twisted. Also, the small size of the clamp avoids the crowding which occurs with the regular Kocher clamps at the operating table.

Humans↗

[Positioning of the patient for esophageal hiatus surgery].

A prospective study was conducted to determine the best position of patients undergoing esophageal hiatus surgery. Three positions were compared: 1) use of a cushion; 2) use of the operating table block, and 3) the ordinary supine position. Twenty-four consecutive patients undergoing surgical approach to the esophageal hiatus were placed successively in the three positions. The distance between the xiphoid process and the hiatus area was shorter in positions 1 and 2 by an average of 0.8 cm as compared with position 3 (p < 0.001). The angle determined by the xiphoid process and a horizontal line passing through the hiatas area was 14 degrees and 8 degrees, more when the cushion and the block were used, respectively, as compared with the supine position (p < 0.01). We recommend the use of the cushion in hiatal surgery, affording better exposure and therefore a more comfortable approach to the hiatal area as compared with the supine position.

Adolescent↗

Laparoscopic ovariectomy in two horses with granulosa cell tumors.

Two mares were admitted for ovariectomy of unilateral granulosa cell tumors. Both mares were ovariectomized (1 unilateral and 1 bilateral) by use of a ventral abdominal laparoscopic technique. This approach required tilting the operative table 30 degrees to elevate the pelvis and to allow observation of the ovaries. Using a single laparoscopic portal and 3 to 4 instrument portals, a triangulation technique was used. The ovarian pedicles were isolated and secured via loop ligation. The ovaries then were divided from the ligated pedicle and placed within specimen bags for extraction. The specimen bags then were removed through a ventral midline celiotomy. Using this technique, it was determined that granulosa cell tumors or ovaries of up to 20 cm in diameter can be removed. Laparoscopic ovariectomy provided a means to provide tension-free dissection and ligation of the ovarian pedicle. In comparison to conventional techniques, this may improve suture security and reduce complications related to excessive pedicle tension. Improved observation during surgery, less pedicle tension, and minimal invasiveness made laparoscopic ovariectomy of these 2 mares advantageous.

Animals↗

Intracardiac air clearing in valvular surgery guided by transesophageal echocardiography.

BACKGROUND AND AIMS OF THE STUDY: Air embolism during open heart surgery seems to be a common occurrence and may be responsible for neuropsychological deficit or myocardial damage. MATERIAL AND METHODS: Forty-two consecutive patients undergoing valvular surgery were studied using the long axis view of the heart by two dimensional transesophageal echocardiography (TEE). The patients were randomized into two groups of 21 each. In group 1, the routine air evacuation method was used. In group 2, the same air evacuation method was used and controlled with a Doppler ultrasonic probe adjusted around the root of the aorta. At the end of air evacuation, intracardiac microbubbles and retained air were analyzed with TEE and when air was founded, its location was communicated to the surgeons who tried to remove it by shaking the heart and tilting the operating table for 15 minutes. The patients were assessed for detection of cardiac or neurological postoperative complications. RESULTS: The incidences of microbubbles and retained air were 57% and 43% in group 1, and 62% and 38% in group 2 respectively (ns). The mean grade of microbubbles was lower in group 2: 1.4 +/- 0.8 vs. 2.2 +/- 0.9, p < 0.05. TEE allowed to significantly decrease (p < 0.05) retained air and mean grade of microbubbles to 14% and 1.3 +/- 0.8 in group 1, and to 10% and 0.8 +/- 0.8 in group 2, without statistical difference between the two groups. Despite the help of TEE, manual attempts to eradicate retained air were unsuccessful in five patients (three in group 1, two in group 2). CONCLUSIONS: The use of aortic ultrasonic probe allowed to reduce the amount of microbubbles. TEE was a useful tool not only for the detection of retained air but also for locating it, and guiding the procedure to eliminate it.

Adolescent↗