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At least 901 records · Page 50Linked to original sources
PubMed1994

Moguisteine: a novel peripheral non-narcotic antitussive drug.

1. The antitussive effects of moguisteine have been compared with codeine in several experimental models of cough in guinea-pigs and dogs. 2. Moguisteine and codeine dose-dependently (respective ED50 values are given in parentheses) inhibited cough induced in guinea-pigs by 7.5% citric acid aerosol (25.2 and 29.2 mg kg-1, p.o.), by 30 microM capsaicin aerosol (19.3 and 15.2 mg kg-1, p.o.), by mechanical stimulation (22.9 and 26.4 mg kg-1, p.o.) and by tracheal electrical stimulation (12.5 and 13.9 mg kg-1, p.o.). 3. Moguisteine was effective against cough induced by tracheal electrical stimulation in dogs (ED50 17.2 mg kg-1, p.o.); codeine was not tested because of its emetic effect. 4. After repeated dosing (12-15 days), moguisteine did not induce tolerance in either guinea-pigs or dogs. 5. Moguisteine did not interact with opiate receptors, since it did not show affinity for [3H]-naloxone binding sites and furthermore naloxone (5 mg kg-1, s.c.) did not antagonize its antitussive effects. 6. Moguisteine had no antitussive effect after i.c.v. administration (20 micrograms), whilst codeine (2-10 micrograms) and dextromethorphan (2.5-20 micrograms) were highly effective. 7. Our findings demonstrate that moguisteine is a novel peripherally acting non-narcotic antitussive agent, the mode of action of which remains to be elucidated fully.

Aerosols↗
PubMed1984

The outcome of pregnancies complicated by narcotic drug addiction.

The incidence of known narcotic drug addiction at 2 Maternity Hospitals in Melbourne was 0.06% (45 of 80,950 confinements). The obstetric results of these 45 pregnancies were unexpectedly favourable, the main complications being fetal growth retardation (27%) and premature birth before 37 weeks (27%). There were no fetal malformations and only 1 perinatal death. Follow-up information is necessary to ascertain if the main hazard to these infants lies in the environment to which they return.

Adolescent↗
PubMed1992

Narcotic addiction in pregnancy with adverse maternal and perinatal outcome.

A retrospective case controlled study was carried out on 51 Chinese gravidas who had abused narcotics and who were delivered in a teaching hospital in Hong Kong. Heroin was the most commonly abused drug. The number of patients who changed from heroin to methadone was small. The major antenatal complications were late antenatal booking (average 28 weeks), prematurity (41%), small for gestational age baby (27.5%), antepartum haemorrhage (13.7%) and high prevalence of venereal disease (23.5%). The babies born to drug addicted mothers were on average 629 g lighter at birth, 5 cm smaller in head circumference and 7 cm shorter in body length. Neonatal withdrawal symptoms occurred in 83% of all drug exposed neonates. The perinatal mortality rate was 19.6 per 1,000 total birth which was 2.5 times that of the control group. There was one maternal death in our series. Drug addiction in pregnancy poses a major risk to both mother and child.

Adult↗
PubMed1984

Central and peripheral inhibition of gastrointestinal transit in rats: narcotics differ substantially by acting at either or both levels.

The roles of local intestinal and centrally mediated opiate-specific mechanisms underlying gastrointestinal transit inhibiton by five typical narcotic analgesics were assessed by the rat charcoal meal test. The doses (mg kg-1 s.c.) reducing the progression of charcoal to 50% of drug-free controls in 5 min (ID50) were approximately 1 for morphine and methadone, 0.5 and 40 for diamorphine and pethidine (all given 25 min before charcoal) and 0.001 for etorphine (10 min before charcoal). The delay in test meal travel caused by these ID50 doses was completely prevented by i.p. naloxone. Intracerebroventricular (i.c.v.) naloxone fully antagonized pethidine and etorphine but had no effect on morphine. Morphine, but either pethidine nor etorphine, was antagonized by i.p. N-methyl naloxone (a peripheral antagonist). Diamorphine and methadone were partially antagonized by i.c.v. naloxone or i.p. N-methyl naloxone.

Analgesics, Opioid↗
PubMed1991

Inhibitory effects of non-narcotic antitussive drugs on cholinergically and non-cholinergically mediated neurogenic contractions of guinea-pig isolated bronchial muscle.

We have examined the actions of non-narcotic antitussive drugs on the response evoked by electrical field stimulation or by acetylcholine (ACh) and neurokinin A (NKA) on guinea-pig bronchial strip chain. Electrical field stimulation (1-32 Hz, 0.5 ms, 30 V for 5 s) evoked a biphasic contraction in a frequency-dependent manner, consisting of a cholinergically mediated fast contraction followed by a non-cholinergically mediated slow contraction. Dextromethorphan (1-300 microM) and tipepidine (0.1-100 microM) caused a concentration-dependent inhibition in the height of the biphasic contraction, but noscapine (1-300 microM) was less effective. Submaximal contractions of bronchial muscle evoked by exogenous ACh (1-30 microM) were inhibited by tipepidine (10-100 microM), but not by dextromethorphan (10-100 microM) or noscapine (10-100 microM), while those evoked by exogenous NKA (10-300 nM) were augmented by these drugs. The results indicate that in guinea-pig isolated bronchial muscle, dextromethorphan inhibited both neurally-mediated responses but not those to the exogenously applied agent. Tipepidine caused an inhibition similar to the non-cholinergically mediated response of dextromethorphan, it also caused a more profound inhibition of the cholinergically mediated response and selectively antagonized ACh. Noscapine had no effect.

Animals↗
PubMed1994

Anxiety and self-esteem as a function of abstinence time among recovering addicts attending Narcotics Anonymous.

Among 200 members of Narcotics Anonymous (NA), those who had been off drugs and in contact with NA for longer tended to have lower trait anxiety and higher self-esteem scores, the relationship in each case being approximately linear. Those abstinent for longer than about three years had levels of anxiety and self-esteem similar to those in a comparison group of 60 students.

Adult↗
PubMed1979

Chloroxymorphamine, and opioid receptor site-directed alkylating agent having narcotic agonist activity.

Chloroxymorphamine, the 6beta-N,N-bis(2-chloroethyl) derivative of oxymorphone, is a potent nonequilibrium narcotic agonist in the longitudinal muscle preparation of guinea pig ileum. The corresponding naltrexone analog,chlornaltrexamine, is a potent nonequilibrium antagonist of morphine. These receptor sitedirected alkylating agents possess considerable potenial as pharmacologic and biochemical probes of apoid receptors.

Alkylating Agents↗
PubMed2001

Are the Twelve Steps more acceptable to drug users than to drinkers? A comparison of experiences of and attitudes to Alcoholics Anonymous (AA) and Narcotics Anonymous (NA) among 200 substance misusers attending inpatient detoxification.

The present study is a cross-sectional interview-based investigation comparing experiences of and attitudes towards Alcoholics Anonymous (AA) and Narcotics Anonymous (NA) in a sample of 200 patients attending inpatient substance misuse detoxification services. Two hundred consecutive admissions were recruited; 100 each from one drug and one alcohol in-patient treatment service in which attendance at AA/NA was a voluntary adjunct to a generic treatment programme. Although there were no differences in the history of AA/NA attendance, the drug users (who were on average younger) reported significantly more positive attitudes towards AA/NA, more willingness to attend during their in-patient treatment and greater intention to attend following completion of their detoxification. In particular, despite no differences in spiritual/religious orientation, the drug users reported more positive views of the Twelve Steps. As AA/NA remain popular and accessible forms of substance misuse support, it is critical that we develop a clearer understanding of their impact and of the scope for their integration with generic forms of substance misuse treatment.

Adult↗
PubMed1981

A clinical, controlled study of l-alpha-acetylmethadol in the treatment of narcotic addiction.

The authors compared l-alpha-acetylmethadol (LAAM) with methadone for clinical effectiveness in the treatment of narcotic addiction. LAAM was as effective as methadone on all outcome measures, including length of stay in treatment. Two clinicopharmacologic properties of LAAM caused some patients to ask for a switch to methadone. The authors describe these phenomena and discuss their impact on the clinical effectiveness of LAAM.

Adult↗
PubMed2005

Narcotic-based sedation regimens for critically ill mechanically ventilated patients.

Sedatives and analgesics are routinely used in the intensive care unit to relieve pain and anxiety. These agents have numerous side effects and may contribute to poor outcomes such as increased length of mechanical ventilation, longer ICU stays and acute and long-term cognitive dysfunction. Modifying sedation paradigms utilizing either narcotic-based regimens with remifentanil or fentanyl, or by using alpha2 agonists such as dexmedetomidine may help in improving these outcomes in critically ill patients.

Procedural Sedation↗
PubMed1975

Changes in estradiol and cortisol production rates in men under the influence of narcotics.

The production rates of estradiol and cortisol in two male opiate addicts while on narcotic maintenance, were in the low normal or subnormal range. There was a sharp several-fold increase upon withdrawal with a subsequent fall to normal values after a period of abstinence. The changes in estradiol production rates were proportionally greater than those of cortisol and suggest that they were due to changes in testicular secretion of the precursor testosterone.

Adrenal Glands↗
PubMedDate not supplied

Ketamine-pancuronium-narcotic technic for cardiovascular surgery in infants--a comparative study.

Ketamine, pancuronium, and alphaprodine were used as the primary anesthetic agents in 71 infants requiring cardiovascular operations during a recent 1-year period. This group of patients was compared with a similar group anesthetized 3 years before with d-tubocurarine, halothane, and/or N20-O2. Stability of the circulatory system was well maintained with ketamine-pancuronium-narcotic (KPN) during the induction period. However, once surgical dissection of the heart and great vessels began, hypotension/bradycardia, ventricular fibrillation, and 48-hour mortality were similar for the two groups. Therefore, using these criteria for analysis, the KPN technic, in spite of claims for its minimal adverse effect on the cardiovascular system, did not prove superior to the halothane-N2O-O2-curare technic.

Alphaprodine↗
PubMed1975

Effect of fentanyl, a narcotic analgesic, on two components of the jaw opening reflex.

An action of fentanyl, a short-acting narcotic, on the reflex discharge in the digastric nerve induced by the inferior alveolar nerve stimulation was investigated in alpha-chloralose anesthetized cats. In the ipsilateral digastric reflex discharge, there were an early phase induced by stimulus exciting Aalpha fibers and a late phase appearing when Adelta fibers were also stimulated. Following dorso-lateral cordotomy at the obex level, an isolation of the spinal trigeminal nucleus caudalis, a total area in the digastric reflex discharge decreased, while its first peak amplitude was little affected, indicating a disappearance of the late phase and a preservation of the early phase. Fentanyl depressed both the total discharge area and the first peak amplitude. After dorso-lateral cordotomy, the depression of the area decreased considerably, whereas that of the amplitude decreased slightly. Results indicate that fentanyl depressed both the early phase which is activated by the Aalpha fiber stimulation, not via the subnucleus caudalis and the late phase which is activated by the Adelta fiber stimulation via the sub-nucleus caudalis or its surroundings. The latter action would be related to the analgesic action of fentanyl.

Animals↗
PubMed1976

Effects of narcotic analgesics on serotonin metabolism in brain of rats and mice.

The effects of narcotic analgesics on the brain 5-hydroxytryptamine (5-Ht) and 5-hydroxyindoleacetic acid (5-HIAA) levels of rats and mice were investigated in relation to our preceding data on the effect of humoral modulatorents. The results suggest that morphine accelerates the release of brain 5-HT both in rats and mice, and that neither methadone nor pethidine alters the brain 5-HT and 5-HIAA levels in rats. The morphine-induced increase in brain 5-HT turnover is likely to be involved in the morphine-induced decrease in locomotor activity and hypothermia in rats. The activity-decreasing effects of methadone or pethidine, on the other hand, are mediated by mechanisms different from those which mediate the effects of morphine. In contrast, an increase in brain 5-HT turnover in mice apparently does not play an important role on activity-increasing effects of morphine but rather participates in other pharmacological effects of morphine.

Analgesics, Opioid↗
PubMed1983

A new approach for assessment of narcotic physical dependence using urinary sex-dependent low molecular weight proteins in male rats.

Attempts have been made to examine the relationship between urinary excretion of sex-dependent low molecular weight proteins found only in male rats (LMWP) and morphine physical dependence. Chronic administration of morphine produced a dose-related decrease in urinary LMWP excretion, which was correlated to the intensity of withdrawal signs including body weight loss and abnormal behaviors recognized after naloxone challenge. Furthermore, a statistically high correlation was obtained between the decrease in urinary LMWP excretion and the loss of body weight precipitated by naloxone challenge. LMWP was identified immunologically in the livers, kidneys, and sera using an antibody against purified LMWP. The serum level of LMWP was increased rapidly following bilateral nephrectomy. After chronic treatment with morphine, the LMWP content in the livers, kidneys, and sera were decreased. These findings indicate that the decrease in urinary LMWP excretion induced by chronic administration of morphine can be a useful parameter to assess the development of physical dependence on narcotics on the peripheral level without requiring drug withdrawal and naloxone challenge. This decrease in urinary LMWP may be caused by the inhibition of LMWP synthesis in the liver.

Animals↗
PubMed1997

The universality of a self-help program of American origin: narcotics anonymous in Israel.

A phenomenological field study of Narcotics Anonymous (NA) in Israel focused on the way a self-help program, based on American Christian ideology was adopted in Israel. Acculturation problems were anticipated, due to cultural, demographic and religious differences. Participant observations and open-ended interviews supplied the raw data. Emphasis was placed on the factors and processes definable as typically American: voluntarism and pragmatism, personal sharing as a basis for relationships, spiritual rather than religious faith, the idea of a "personal God" guiding individuals, faith in God without religious tradition and formal ritualism. The results showed that, for the substance-dependents, the issue is generally irrelevant, and they accepted most "American" components of the program unquestioningly. However, two discrete features of Christian ideology required conscious incorporation by NA's Israeli members: (1) the concept of a "Loving God" who is non-punitive, which for many members was opposed to their traditions and upbringing, and (2) kneeling to pray, a recommendation which many members initially found problematic. The conclusion denotes a factor facilitating the transfer of therapeutic programs from one culture to another--that of personal suffering as a universal domain. It transcends all cultural boundaries and generates willingness to accept foreign concepts which reveal suffering and propose a pragmatic way to end it.

Alcoholics Anonymous↗
PubMed2005

Under the counter: the diffusion of narcotic analgesics to the inner city street.

During the past decade, there has been a well-documented rise in the non-medical use of prescription painkillers, often referred to as narcotics analgesics (NA). Relatively little is known, however, about who these users are, the range of health and social consequences associated with their use and the presence of illicit NA use on the inner city street. Results of a survey conducted with a sample of 242 street drug users indicated that NA use is now widespread in the inner city, and that it is associated with a number of serious health and psychiatric conditions. Other characteristics of this emerging drug user group are explored and the need for future research is highlighted.

Adolescent↗
PubMed1991

Alcoholics Anonymous-Narcotics Anonymous model inpatient treatment of chemically dependent adolescents: a 2-year outcome study.

Many hospital and residential chemical dependency treatment facilities utilize Alcoholics Anonymous (AA) and Narcotics Anonymous (NA) principles and practices in therapeutic programming. Although well-known and broadly endorsed and supported, such AA/NA approaches have received little research attention especially in regard to chemically dependent adolescents. The present study examined chemical usage and social-civil-productive functioning in 157 male and female chemically dependent adolescents at 6, 12 and 24 months after leaving an AA/NA-based treatment program. Results revealed that both treatment completers and noncompleters (those who left treatment prematurely against professional/medical advice) demonstrated less chemical use after their respective hospitalizations than before. Although significantly higher percentages of both male and female treatment completers were found abstinent/essentially abstinent at 6 months post discharge in contrast to noncompleters, abstinence rates, particularly for male subjects, declined sharply by 1 and 2 years after treatment. Results indicated that the AA/NA model is a promising approach in treating chemically dependent adolescents, but that much attention to relapse prevention methods is necessary.

Adolescent↗